Hepatobiliary & Pancreatic Diseases International最新文献

{"title":"Local recurrence rate as quality indicator in surgery for pancreatic cancer?","authors":"Carlo Alberto Pacilio , Alessandro Cucchetti , Giorgio Ercolani","doi":"10.1016/j.hbpd.2024.03.003","DOIUrl":"10.1016/j.hbpd.2024.03.003","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 5","pages":"Pages 548-550"},"PeriodicalIF":3.6,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140167511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing immunosuppression in liver transplantation: A narrative review","authors":"Samuele Iesari ,&nbsp;Francesca Laura Nava ,&nbsp;Ilaria Elena Zais ,&nbsp;Laurent Coubeau ,&nbsp;Mariano Ferraresso ,&nbsp;Evaldo Favi ,&nbsp;Jan Lerut","doi":"10.1016/j.hbpd.2024.03.001","DOIUrl":"10.1016/j.hbpd.2024.03.001","url":null,"abstract":"<div><p>Immunosuppression is essential to ensure recipient and graft survivals after liver transplantation (LT). However, our understanding and management of the immune system remain suboptimal. Current immunosuppressive therapy cannot selectively inhibit the graft-specific immune response and entails a significant risk of serious side effects, i.e., among others, <em>de novo</em> cancers, infections, cardiovascular events, renal failure, metabolic syndrome, and late graft fibrosis, with progressive loss of graft function. Pharmacological research, aimed to develop alternative immunosuppressive agents in LT, is behind other solid-organ transplantation subspecialties, and, therefore, the development of new compounds and strategies should get priority in LT. The research trajectories cover mechanisms to induce T-cell exhaustion, to inhibit co-stimulation, to mitigate non-antigen-specific inflammatory response, and, lastly, to minimize the development and action of donor-specific antibodies. Moreover, while cellular modulation techniques are complex, active research is underway to foster the action of T-regulatory cells, to induce tolerogenic dendritic cells, and to promote the function of B-regulatory cells. We herein discuss current lines of research in clinical immunosuppression, particularly focusing on possible applications in the LT setting.</p></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 5","pages":"Pages 441-448"},"PeriodicalIF":3.6,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140167667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meetings and Courses","authors":"","doi":"10.1016/S1499-3872(24)00013-4","DOIUrl":"https://doi.org/10.1016/S1499-3872(24)00013-4","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 2","pages":"Pages I-II"},"PeriodicalIF":3.3,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1499387224000134/pdfft?md5=e94d588dac371d2ce2eaf15b432ecf09&pid=1-s2.0-S1499387224000134-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140052056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mirizzi syndrome: Problems and strategies","authors":"Jun Wu ,&nbsp;Shuang-Yong Cai ,&nbsp;Xu-Liang Chen ,&nbsp;Zhi-Tao Chen ,&nbsp;Shao-Hua Shi","doi":"10.1016/j.hbpd.2024.01.005","DOIUrl":"10.1016/j.hbpd.2024.01.005","url":null,"abstract":"<div><p><span><span>Mirizzi syndrome<span><span><span> is a serious complication of gallstone disease. It is caused by the impacted stones in the gallbladder neck or </span>cystic duct. One of the features of Mirizzi syndrome is severe inflammation or dense fibrosis at the Calot's triangle. In our clinical practice, </span>bile duct, branches of </span></span>right hepatic artery<span><span><span> and right portal vein clinging to gallbladder </span>infundibulum<span> are often observed due to gallbladder infundibulum adhered to right hepatic hilum. The intraoperative damage of branches of right hepatic artery occurs more easily than that of bile duct, all of which are hidden pitfalls for surgeons. Magnetic resonance cholangiopancreatography (MRCP) and </span></span>endoscopic retrograde cholangiopancreatography<span> (ERCP) are the preferable tools for the diagnosis of Mirizzi syndrome. Anterograde cholecystectomy in Mirizzi syndrome is easy to damage branches of right hepatic artery and bile duct due to gallbladder infundibulum adhered to right hepatic hilum. Subtotal cholecystectomy is an easy, safe and definitive approach to Mirizzi syndrome. When combined with the application of ERCP, a laparoscopic management of Mirizzi syndrome by well-trained surgeons is feasible and safe. The objective of this review was to highlight its existing problems: (1) low preoperative diagnostic rate, (2) easy to </span></span></span>damage bile duct<span> and branches of right hepatic artery, and (3) high concomitant gallbladder carcinoma. Meanwhile, the review aimed to discuss the possible therapeutic strategies: (1) to enhance its preoperative recognition by imaging findings, and (2) to avoid potential pitfalls during surgery.</span></p></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 3","pages":"Pages 234-240"},"PeriodicalIF":3.3,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139646677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tri-modal death distribution towards personalized management of intraductal papillary neoplasm of the bile duct patients: Every story has its own conclusion","authors":"Vor Luvira","doi":"10.1016/j.hbpd.2024.01.004","DOIUrl":"10.1016/j.hbpd.2024.01.004","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 3","pages":"Pages 313-316"},"PeriodicalIF":3.3,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139517133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review","authors":"Wellington Andraus,&nbsp;Francisco Tustumi,&nbsp;Alexandre Chagas Santana,&nbsp;Rafael Soares Nunes Pinheiro,&nbsp;Daniel Reis Waisberg,&nbsp;Liliana Ducatti Lopes,&nbsp;Rubens Macedo Arantes,&nbsp;Vinicius Rocha Santos,&nbsp;Rodrigo Bronze de Martino,&nbsp;Luiz Augusto Carneiro D'Albuquerque","doi":"10.1016/j.hbpd.2024.01.003","DOIUrl":"10.1016/j.hbpd.2024.01.003","url":null,"abstract":"<div><h3>Background</h3><p><span>Perihilar cholangiocarcinoma (phCCC) is a dismal </span>malignancy<span><span>. There is no consensus regarding the best treatment for patients with unresectable phCCC. The present review aimed to gather the current pieces of evidence for </span>liver transplantation<span> and liver resection as a treatment for phCCC and to build better guidance for clinical practice.</span></span></p></div><div><h3>Data sources</h3><p>The search was conducted in PubMed, Embase, Cochrane, and LILACS. The related references were searched manually. Inclusion criteria were: reports in English or Portuguese literature that a) patients with confirmed diagnosis of phCCC; b) patients treated with a curative intent; c) patients with the outcomes of liver resection and liver transplantation. Case reports, reviews, letters, editorials, conference abstracts and papers with full-text unavailability were excluded from the analysis.</p></div><div><h3>Results</h3><p><span>Most of the current literature is based on observational retrospective studies with low grades of evidence. Liver resection has better long-term outcomes than systemic chemotherapy or palliation<span> therapy and liver transplantation is a good alternative for selected patients with unresectable phCCC. All candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahepatic diseases. As a general rule, patients presenting with a tumor having a longitudinal size &gt; 3 cm or extending below the cystic duct, </span></span>lymph node disease<span>, confirmed extrahepatic dissemination; intraoperatively diagnosed metastatic disease<span>; a history of other malignancies within the last five years, and did not complete chemoradiation regimen and were medically unfit should not be considered for transplantation. Some of these criteria should be individually assessed. Liver transplantation or resection should only be considered in highly experienced hepatobiliary centers, and any decision-making must be based on a multidisciplinary evaluation.</span></span></p></div><div><h3>Conclusions</h3><p>phCCC is a complex condition with high morbidity. Surgical therapies, including hepatectomy and liver transplantation, are the best option for better long-term disease-free survival.</p></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 2","pages":"Pages 139-145"},"PeriodicalIF":3.3,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139517226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic vein reconstruction during hepatectomy: A feasible and underused technique","authors":"Manish Ahuja ,&nbsp;Kunal Joshi ,&nbsp;Chris Coldham ,&nbsp;Paulo Muiesan ,&nbsp;Bobby Dasari ,&nbsp;Manuel Abradelo ,&nbsp;Ravi Marudanayagam ,&nbsp;Darius Mirza ,&nbsp;John Isaac ,&nbsp;David Bartlett ,&nbsp;Nikolaos A Chatzizacharias ,&nbsp;Robert P Sutcliffe ,&nbsp;Keith J Roberts","doi":"10.1016/j.hbpd.2024.01.002","DOIUrl":"10.1016/j.hbpd.2024.01.002","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 4","pages":"Pages 421-427"},"PeriodicalIF":3.3,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139471053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of hepatectomy following the Omicron variant infection for vaccinated-patients: A retrospective cohort study","authors":"Wu-Gui Yang,&nbsp;Yu-Fu Peng,&nbsp;Yu-Bo Yang,&nbsp;Bo Li,&nbsp;Yong-Gang Wei,&nbsp;Fei Liu","doi":"10.1016/j.hbpd.2024.01.001","DOIUrl":"10.1016/j.hbpd.2024.01.001","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 5","pages":"Pages 515-520"},"PeriodicalIF":3.6,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139469149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meetings and Courses","authors":"","doi":"10.1016/S1499-3872(23)00227-8","DOIUrl":"https://doi.org/10.1016/S1499-3872(23)00227-8","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"23 1","pages":"Pages I-II"},"PeriodicalIF":3.3,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1499387223002278/pdfft?md5=83fd946bab704a2a99b76da5aec8ec82&pid=1-s2.0-S1499387223002278-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of thymic carcinoma metastasize to liver","authors":"YF Jiang, J Wu, DY Chen","doi":"10.1016/j.hbpd.2023.12.003","DOIUrl":"https://doi.org/10.1016/j.hbpd.2023.12.003","url":null,"abstract":"Abstract not available","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"100 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139072289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}