Hepatobiliary & Pancreatic Diseases International最新文献

{"title":"Exosome-mediated regulation of macrophage polarization: A novel therapeutic strategy for diabetic wound healing","authors":"Jia-Le Ma , Ling-Xiao Wang , Hao Yu , Zhi-Kang Zhu , Jia-Hong Xu , Jia-Qi Lou , Shou-Jie Wang","doi":"10.1016/j.hbpd.2025.05.005","DOIUrl":"10.1016/j.hbpd.2025.05.005","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 115-118"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive diagnostic biomarkers of viral hepatitis based on multi-omics technology: Recent advances and challenges","authors":"Xiang-Yan Liu ,&nbsp;Jian-Fang Lu ,&nbsp;Zhuo-Yi Wang ,&nbsp;Shu-Sen Zheng","doi":"10.1016/j.hbpd.2025.10.010","DOIUrl":"10.1016/j.hbpd.2025.10.010","url":null,"abstract":"<div><div>Liver is prone to viral infection. Viral hepatitis can be roughly divided into hepatitis A, B, C, D and E. Accurate diagnosis of viral hepatitis is crucial for accurate treatments. Different types of biomarkers, including non-invasive biomarkers have been explored for the diagnosis of viral hepatitis. With the fast development of multi-omics technology, non-invasive biomarkers can be detected from blood, saliva, urine, stool, and other body fluids. The advantages of non-invasive biomarkers are: 1) non-invasive; 2) convenient to test and 3) repeatable. The application of non-invasive biomarkers significantly improves the diagnostic accuracy of viral hepatitis. The non-invasive biomarkers can be sugars, proteins, nucleic acids, and even microorganisms. In this review, we summarized recent advances in identifying non-invasive biomarkers using multi-omics technology and discussed their potential diagnostic values for viral hepatitis.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 15-22"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145496338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meetings and Courses","authors":"","doi":"10.1016/S1499-3872(25)00238-3","DOIUrl":"10.1016/S1499-3872(25)00238-3","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages I-II"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yttrium-90 radioembolization therapy prior to liver transplantation for hepatocellular carcinoma improves patient outcomes","authors":"Rui Tang,&nbsp;Guang-Dong Wu,&nbsp;Ang Li,&nbsp;Yu-Cheng Hou,&nbsp;Xuan Tong,&nbsp;Qian Lu","doi":"10.1016/j.hbpd.2025.11.003","DOIUrl":"10.1016/j.hbpd.2025.11.003","url":null,"abstract":"<div><div>For early hepatocellular carcinoma (HCC), curative therapies include surgical excision and radiofrequency ablation. Other treatment modes for advanced HCC involve transarterial chemoembolization. For HCC patients who do not fit the Milan criteria or are waiting for liver transplantation (LT), studies of transarterial radioembolization with Yttrium-90 (Y-90) demonstrated that Y-90 may accomplish a good downstaging or bridging effect before LT and can even achieve complete pathological necrosis. The present review discussed Y-90 radioembolization as a local regional treatment option for advanced and unresectable HCC, with a focus on neoadjuvant intervention before LT.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 4-14"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional visualization helps surgoens to make surgical decision: The 3D-ViDru trial - a randomized trial","authors":"Esther Giehl-Brown ,&nbsp;Frederic Konrad ,&nbsp;Steffen Löck ,&nbsp;Johannes Schweipert ,&nbsp;Felix Schön ,&nbsp;Jens-Peter Kühn ,&nbsp;Jürgen Weitz ,&nbsp;Carina Riediger","doi":"10.1016/j.hbpd.2025.12.003","DOIUrl":"10.1016/j.hbpd.2025.12.003","url":null,"abstract":"<div><h3>Background</h3><div>Successful liver resection in oncologic surgery depends on safety, precision, and efficacy, all of which require a thorough understanding of liver anatomy. Contrast-enhanced computed tomography (CT)-generated three-dimensional (3D) models have been proposed as a valuable tool to enhance this understanding. However, a systematic comparison of different display modalities across professional groups has not yet been performed.</div></div><div><h3>Methods</h3><div>In this prospective, monocentric randomized trial, we compared high-resolution two-dimensional (2D) CT images of liver malignancies with their corresponding standardized, non-colored 3D virtual and printed models in facilitating anatomical and spatial understanding as well as surgical decision-making. A total of 91 participants, including 40 surgeons, 10 radiologists, and 41 students, evaluated six clinical cases (three centrally and three peripherally located liver malignancies). Each participant assessed one central and one peripheral case per display modality, presented in a random order.</div></div><div><h3>Results</h3><div>Compared to 2D CT images, both 3D virtual and printed models significantly improved the identification of tumor location (<em>P</em> &lt; 0.001), enhanced the comprehension of spatial relationships with adjacent liver and portal veins (<em>P</em> &lt; 0.001 and <em>P</em> = 0.019, respectively), and facilitated clinical decision-making (<em>P</em> &lt; 0.001). No significant difference was observed between virtual and printed models in terms of effectiveness. Within the different groups, surgeons and students, but not radiologists, more accurately identified tumor location and spatial relationships with adjacent liver and portal veins using 3D models. Subjectively, most surgeons and students preferred 3D printed models over virtual models and 2D CT images.</div></div><div><h3>Conclusions</h3><div>This study demonstrated that standardized, non-colored 3D virtual and printed models equally help preoperative anatomical understanding and decision-making, particularly for surgeons and students. By isolating the influence of display modality, our findings clarify prior inconsistent results and support the integration of cost-effective 3D visualization by applying virtual models into surgical planning and education. Preference for printed models despite comparable efficacy highlights the importance of user-centered implementation strategies.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 52-61"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and oncologic outcomes of open versus minimally invasive distal pancreatectomy for resectable pancreatic body and tail cancer","authors":"Hajime Imamura,&nbsp;Tomohiko Adachi,&nbsp;Ayaka Kinoshita,&nbsp;Takashi Hamada,&nbsp;Hajime Matsushima,&nbsp;Takanobu Hara,&nbsp;Akihiko Soyama,&nbsp;Susumu Eguchi","doi":"10.1016/j.hbpd.2025.10.007","DOIUrl":"10.1016/j.hbpd.2025.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Minimally invasive distal pancreatectomy (MIDP) is increasingly being used, although its oncologic safety for pancreatic ductal adenocarcinoma (PDAC) remains controversial. In Japan, MIDP for PDAC has limited endorsement due to insufficient data. This study aimed to compare the perioperative and long-term outcomes of open distal pancreatectomy (ODP) and MIDP for PDAC.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients with resectable pancreatic body and tail cancer treated with ODP or MIDP (laparoscopic or robotic) between January 2007 and July 2022. The surgical procedures (ODP and MIDP) were compared and the patient characteristics, perioperative outcomes, and long-term outcomes were analyzed. We also compared the outcomes of patients with neoadjuvant chemotherapy (NAC) and without NAC.</div></div><div><h3>Results</h3><div>A total of 72 distal pancreatectomies were performed (37 ODPs and 35 MIDPs). In the upfront group, MIDP resulted in significantly less blood loss than ODP (<em>P</em> &lt; 0.01), despite similar operative time. There was no statistically significant difference in the 2-year recurrence-free survival (RFS) rates between ODP and MIDP (39.7% vs. 57.8%, <em>P</em> = 0.60) or in the overall survival (OS) rates (66.7% vs. 74.1%, <em>P</em> = 0.43). Similarly, in the NAC group, MIDP resulted in significantly less blood loss than ODP (<em>P</em> = 0.01); ODP and MIDP had similar 2-year RFS rates (41.7% and 60.0%, <em>P</em> = 0.75) and OS rates (50.0% and 70.0%, <em>P</em> = 0.36). The interval from surgery to adjuvant chemotherapy initiation did not significantly differ between the ODP and MIDP subgroups in both the upfront group (<em>P</em> = 0.13) and the NAC group (<em>P</em> = 0.14). The incidence of recurrence was 64.8% for ODP and 42.8% for MIDP (<em>P</em> = 0.06). Both procedures showed similar distributions of local and distant recurrence.</div></div><div><h3>Conclusions</h3><div>MIDP caused less blood loss and had similar oncologic safety compared with ODP. MIDP could become a feasible, minimally invasive option with sufficient oncologic safety for pancreatic body and tail cancers.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 83-90"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different approaches of laparoscopic anatomic hepatectomy of segment 7 for hepatocellular carcinoma: A multicenter study","authors":"Xing-Ru Wang ,&nbsp;Qi-Fan Zhang ,&nbsp;Wei Cheng ,&nbsp;Xiao Liang ,&nbsp;Jun Cao ,&nbsp;Yong-Gang Wei ,&nbsp;Jian-Wei Li ,&nbsp;Hong-Guang Wang ,&nbsp;Chinese Research Group for Minimally Invasive Anatomical Liver Resection (The Workshop of Liver Future [W.O.L.F.])","doi":"10.1016/j.hbpd.2025.10.009","DOIUrl":"10.1016/j.hbpd.2025.10.009","url":null,"abstract":"<div><h3>Background</h3><div>Laparoscopic anatomic hepatectomy of segment 7 (LAH-S7) is a challenging surgery. In this study we aimed to investigate surgical and oncological outcomes of various approaches of LAH-S7 in patients with hepatocellular carcinoma (HCC). A particular focus was placed on identifying the Glissonean pedicle of segment 7 (G7) and the intersegmental plane. Given the scarcity of comprehensive reviews or comparative studies on clinical outcomes, we also sought to analyze the experiences and advantages associated with different approaches in relation to the anatomic variations of G7.</div></div><div><h3>Methods</h3><div>The clinical data of 124 patients who underwent LAH-S7 for HCC across seven tertiary referral medical centers in China were retrospectively analyzed. Three surgical approaches were categorized based on the procedures used for G7 identification: the indocyanine green (ICG) fluorescence positive staining approach (IFPA), the Glissonean approach (GA), and the hepatic vein-guided approach (HVGA). Subsequently, the postoperative short-term results and oncological outcomes of the three different approaches were compared.</div></div><div><h3>Results</h3><div>The distribution of surgical approaches among the patients was as follows: IFPA in 16 (12.9%), GA in 62 (50.0%), and HVGA in 46 (37.1%) patients. Complications were observed in 27 (21.8%) patients. The 1-, 3-, and 5-year overall survival (OS) rates were 99.1%, 89.2%, and 84.7%, respectively. The 1-, 3-, and 5-year recurrence-free survival (RFS) rates were 99.0%, 84.7%, and 69.3%, respectively. The OS and RFS rates were comparable across the three approaches.</div></div><div><h3>Conclusions</h3><div>Following a standardized surgical procedure, LAH-S7 is demonstrated to be safe and yields favorable oncological outcomes. Surgeons performing LAH-S7 should select the appropriate surgical approach based on the anatomical characteristics and variations of G7.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 42-51"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145496187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic-assisted hepato-pancreatoduodenectomy for a case of type IIIb hilar cholangiocarcinoma (with video)","authors":"Yun-Fei Duan ,&nbsp;Cai-Lin Xue ,&nbsp;Yun Zhuang ,&nbsp;Jin Peng ,&nbsp;De-Cai Yu","doi":"10.1016/j.hbpd.2025.12.006","DOIUrl":"10.1016/j.hbpd.2025.12.006","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 104-108"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging findings of primary hepatic leiomyosarcoma","authors":"Hua-Chun Song ,&nbsp;Shu-Yuan Tian ,&nbsp;Qing Pan ,&nbsp;Yong-Hong Yu","doi":"10.1016/j.hbpd.2025.09.003","DOIUrl":"10.1016/j.hbpd.2025.09.003","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 100-103"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional technology in biliary tract reconstruction for cholangiocarcinoma after hepatectomy","authors":"Wen-Ya Li ,&nbsp;Mu-Qing Yang ,&nbsp;Jia-Hao Pei,&nbsp;Wei-Feng Tan","doi":"10.1016/j.hbpd.2025.10.008","DOIUrl":"10.1016/j.hbpd.2025.10.008","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"25 1","pages":"Pages 94-96"},"PeriodicalIF":4.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}