Hepatobiliary & Pancreatic Diseases International最新文献

{"title":"Six-hour local 4 °C dual hypothermic oxygenated machine perfusion improves the preservation of porcine liver after cardiac death using an ex vivo reperfusion model","authors":"Xiao-Yu Tan ,&nbsp;Wei-Jian Kuang ,&nbsp;Fei-Wen Deng ,&nbsp;Zhi-Ping Huang ,&nbsp;Qing Ouyang ,&nbsp;Xiao-Tao Huang ,&nbsp;Wai I Ho ,&nbsp;Ming-Ju Liang ,&nbsp;Feng Huo ,&nbsp;Huan-Wei Chen","doi":"10.1016/j.hbpd.2025.02.003","DOIUrl":"10.1016/j.hbpd.2025.02.003","url":null,"abstract":"<div><h3>Background</h3><div>The use of grafts from donation after circulatory death (DCD) overcomes the inadequate donor organ supply. Our team developed a transportable dual hypothermic oxygenated machine perfusion (DHOPE) device, which initiates DHOPE at a recipient center to reduce static cold storage (SCS) time and the risk of graft failure in DCD liver transplantation.</div></div><div><h3>Methods</h3><div>Six porcine livers per group with 30 min of warm ischemia exposure were preserved via SCS or DHOPE for 6 h and then reperfused for 12 h with whole blood to mimic transplantation. Hepatocellular and biliary function and injury were assessed in perfusate and bile samples. Molecular biomarkers and histology were compared between groups.</div></div><div><h3>Results</h3><div>Reperfusion portal vein pressure, in a flow-constant manner, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyltransferase (γ-GGT) release were significantly lower in the DHOPE group than in the SCS group at all time points. Higher bile production paralleled the lower levels of ALP and γ-GGT in the DHOPE group. The DHOPE group secreted more total bilirubin (TBIL) in bile, resulting in decreased TBIL in the perfusate, and livers preserved with DHOPE exhibited better cholangiocellular function. Furthermore, improvements in hypoxia, the inflammatory response, cell-free microRNAs and energy metabolism were observed in the DHOPE group. There were fewer apoptotic cells and TGF-β1-positive cells in the liver parenchyma and extrahepatic bile duct in the DHOPE group than in the SCS group.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the efficacy of local 4 °C DHOPE to protect porcine liver grafts from 30-min warm ischemia damage.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 3","pages":"Pages 294-302"},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous versus sequential transcatheter arterial chemoembolization combined with microwave ablation for hepatocellular carcinoma: A retrospective propensity score-matched analysis","authors":"Hong-Yu Wang ,&nbsp;Gui-Xiong Zhang ,&nbsp;Wen-Zhe Fan ,&nbsp;Jin-Wei Li ,&nbsp;Shu-Fang Hao ,&nbsp;Yu-Shu Ouyang ,&nbsp;Jia-Ping Li ,&nbsp;Wen-Dao Liu","doi":"10.1016/j.hbpd.2025.02.001","DOIUrl":"10.1016/j.hbpd.2025.02.001","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter arterial chemoembolization (TACE) combined with ablation has better clinical outcomes than monotherapy in patients with hepatocellular carcinoma (HCC). However, prolonged time intervals can lead to recanalization and neoangiogenesis, which may interfere with the synergistic effects of combination therapy. This study aimed to investigate whether TACE simultaneously combined with microwave ablation (MWA) is more effective than sequential therapy in patients with HCC.</div></div><div><h3>Methods</h3><div>A total of 129 HCC patients who underwent TACE combined with MWA were included in this study. Based on the time interval between the first combination therapy of TACE and MWA, patients were divided into the simultaneous and sequential groups. Propensity score matching (PSM) was performed to reduce bias between the groups. Overall survival (OS), time-to-progression (TTP), tumor response, and liver function were compared.</div></div><div><h3>Results</h3><div>Before PSM, the simultaneous group had a higher tumor load. Following PSM, 36 and 40 patients remained in the simultaneous and sequential groups, respectively. The median TTP and OS were 12.9 vs. 10.6 months (<em>P</em> = 0.262) and 44.0 vs. 26.5 months (<em>P</em> = 0.313) for the simultaneous and sequential groups, respectively. After 4–8 weeks, there were 16 complete responders and 17 partial responders in the simultaneous group and 15 and 22 patients in the sequential group, respectively (<em>P</em> = 0.504). The median complete response duration was 11.3 and 9.2 months for the simultaneous and sequential groups, respectively (<em>P</em> = 0.882). These results did not differ in BCLC stratified subgroups. Patients with small tumor sizes (≤ 5 cm), tumor nodules ≤ 3, well-defined boundaries, and early-stage tumors were more likely to achieve complete response (all <em>P</em> &lt; 0.05). After 4–8 weeks, the liver function was significantly improved compared to that before or one day after treatment.</div></div><div><h3>Conclusions</h3><div>TACE simultaneously combined with MWA is safe and effective but not superior to sequential therapy.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 3","pages":"Pages 286-293"},"PeriodicalIF":3.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and effectiveness of balloon catheter-assisted ultrasound-guided percutaneous microwave ablation in difficult-site liver cancer","authors":"Qi-Yu Zhao ,&nbsp;Teng Guo ,&nbsp;Jing-Jing Hu ,&nbsp;Li-Ting Xie ,&nbsp;Wei-Lu Chai ,&nbsp;Guo Tian ,&nbsp;Tian-An Jiang","doi":"10.1016/j.hbpd.2024.09.012","DOIUrl":"10.1016/j.hbpd.2024.09.012","url":null,"abstract":"<div><h3>Background</h3><div>Balloon catheter isolation is a promising auxiliary method for thermal ablation treatment of liver cancer. We aimed to explore the safety and effectiveness of balloon catheter isolation-assisted ultrasound-guided percutaneous microwave ablation (MWA) in treating liver cancer in difficult anatomical locations.</div></div><div><h3>Methods</h3><div>Data of 132 patients with 145 difficult-site liver cancer treated with ultrasound-guided percutaneous MWA were retrospectively analyzed. Participants were classified into the isolation (<em>n</em> = 40) and non-isolation (<em>n</em> = 92) groups based on whether the patients were treated using a balloon catheter prior to ablation. The major complication rates, local tumor residuals (LTR), and tumor follow-up for local tumor progression (LTP) at 6 and 12 months post-ablation were compared between the two groups.</div></div><div><h3>Results</h3><div>The rates of major postoperative complications did not significantly differ between the isolation and non-isolation groups (2.5% vs. 4.3%, <em>P</em> = 0.609). The postoperative LTR rates were significantly different between the isolation and non-isolation groups (4.8% vs. 17.5%, <em>P</em> = 0.032). Balloon catheter isolation [odds ratio (OR) = 0.225, 95% confidence interval (CI): 0.085–0.595, <em>P</em> = 0.009] and tumor diameter (OR = 2.808, 95% CI: 1.186–6.647, <em>P</em> = 0.019) were identified as independent factors influencing LTR rate. The cumulative LTP rates at 6 and 12 months after ablation showed no significant differences between the isolation and non-isolation groups (2.6% vs. 7.9%, <em>P</em> = 0.661; 4.9% vs. 9.8%, <em>P</em> = 0.676, respectively). Cox proportional hazards regression analysis showed that tumor diameter was an independent risk factor for cumulative LTP rate (OR = 3.445, 95% CI: 1.406–8.437, <em>P</em> = 0.017).</div></div><div><h3>Conclusions</h3><div>Balloon catheter isolation-assisted MWA was safe and effective in the treatment of difficult-site liver cancer. Additionally, tumor diameter significantly influenced LTR and LTP rates after ablation.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 84-91"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided liver biopsy in liver transplant recipients: A preliminary experience","authors":"Wei Rao ,&nbsp;Yue-Ping Jiang ,&nbsp;Jin-Zhen Cai ,&nbsp;Man Xie","doi":"10.1016/j.hbpd.2024.03.005","DOIUrl":"10.1016/j.hbpd.2024.03.005","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 108-110"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140330298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particular Chinese contributions to extracorporeal liver surgery","authors":"Abudusalamu Aini ,&nbsp;Qian Lu ,&nbsp;Hao Wen ,&nbsp;Wen-Tao Wang ,&nbsp;Tuerganaili Aji ,&nbsp;Zhi-Yu Chen ,&nbsp;Lei-Da Zhang ,&nbsp;Zhan-Yu Yang ,&nbsp;Jia-Yin Yang ,&nbsp;Hai-Ning Fan ,&nbsp;Wei-Lin Wang ,&nbsp;Xiang-Cheng Li ,&nbsp;Yu Zhang ,&nbsp;Jia-Hong Dong","doi":"10.1016/j.hbpd.2024.12.005","DOIUrl":"10.1016/j.hbpd.2024.12.005","url":null,"abstract":"<div><div>Extracorporeal liver surgery (ELS), also known as liver autotransplantation, is a hybrid (cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently became more embraced and popularized among leading centers. ELS could be summarized into three major categories, namely, <em>ex-situ</em> liver resection and autotransplantation (ELRA), <em>ante-situm</em> liver resection and autotransplantation (ALRA) and auxiliary partial liver autotransplantation (APLA). The successful development of ELS during the past 37 years is definitely inseparable from continuous efforts done by Chinese surgeons and researchers. Especially, the precision liver surgery paradigm has allowed to transform ELS into a modularized, more simplified, and standardized surgery, to upgrade surgical skills, to improve peri-operative outcome and long-term survival, to increase the capability of surgeons to select more complex diseases and to expand the level of medical service to the population. This review highlights the Chinese contributions to the field of ELS, focusing thereby on features of different surgical types, technical innovations, disease selection and surgical indication, patient prognosis and future perspectives.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 57-66"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of ultrasonic lithotripsy system and video-assisted retroperitoneal debridement in treatment of laterally located pancreatic walled-off necrosis","authors":"Bei Lu,&nbsp;Jun-Jie Yin,&nbsp;Jing-Rui Wang,&nbsp;Xiao Xu,&nbsp;Yang Cai","doi":"10.1016/j.hbpd.2024.05.004","DOIUrl":"10.1016/j.hbpd.2024.05.004","url":null,"abstract":"","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 104-107"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141255865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplantation using an otherwise-wasted partial liver resection graft","authors":"Yong-Sheng Xiao ,&nbsp;Yi-Feng He ,&nbsp;Xiao-Wu Huang,&nbsp;Zhao-You Tang,&nbsp;Jia Fan,&nbsp;Jian Zhou","doi":"10.1016/j.hbpd.2024.09.008","DOIUrl":"10.1016/j.hbpd.2024.09.008","url":null,"abstract":"<div><div>Liver transplantation represents a complex surgical procedure and serves as a curative treatment for patients presenting an acute or chronic end-stage liver disease, or carefully selected liver malignancy. A significant gap still exists between the number of available donor organs and potential recipients. The use of an otherwise-wasted resected liver lobe from patients with benign liver tumors is a new, albeit small, option to alleviate the allograft shortage. This review provides evidence that resected liver lobes may be used successfully in liver transplantation.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 29-34"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New chapter in reform and development of organ donation and transplantation in China: Embracing past, grounding in national conditions, upholding steadfast belief, and looking forward to future","authors":"Hong-Tao Zhao ,&nbsp;Shu-Sen Zheng ,&nbsp;Jia Fan ,&nbsp;Jia-Hong Dong ,&nbsp;Zhong-Hua Chen ,&nbsp;Wu-Jun Xue ,&nbsp;Qi-Fa Ye ,&nbsp;Hai-Bo Wang ,&nbsp;Jing-Yu Chen ,&nbsp;Zhe Zheng ,&nbsp;Feng Huo ,&nbsp;Xiao-Shun He ,&nbsp;Miao Pu ,&nbsp;Jie Zhao ,&nbsp;Jie-Fu Huang","doi":"10.1016/j.hbpd.2024.11.007","DOIUrl":"10.1016/j.hbpd.2024.11.007","url":null,"abstract":"<div><div>The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization (WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 6-13"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of ischemia-free liver transplantation","authors":"Ming-Xi Zhang ,&nbsp;Qiang Zhao ,&nbsp;Xiao-Shun He","doi":"10.1016/j.hbpd.2024.10.002","DOIUrl":"10.1016/j.hbpd.2024.10.002","url":null,"abstract":"<div><div>Ischemia-reperfusion injury (IRI) is an inherent issue in organ transplantation. Because of the allograft shortage, more and more extended criteria donor (ECD) organs are used, unfortunately these grafts are more susceptible to IRI. Although machine perfusion technology has brought hope to alleviate IRI, this technology is still unable to eradicate IRI-related organ damage. Ischemia-free liver transplantation (IFLT) can completely avoid IRI, thereby improve graft function and recipient outcome, and allow to expand organ pool. This review summarized the latest progresses in IFLT, and speculated the future development of this concept.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 18-22"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential living donor liver transplantation after liver resection optimizes outcomes for patients with high-risk hepatocellular carcinoma","authors":"Itsuko Chih-Yi Chen ,&nbsp;Leona Bettina P Dungca ,&nbsp;Chee-Chien Yong,&nbsp;Chao-Long Chen","doi":"10.1016/j.hbpd.2024.10.003","DOIUrl":"10.1016/j.hbpd.2024.10.003","url":null,"abstract":"<div><h3>Background</h3><div>Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. While liver transplantation (LT) provides the best long-term survival, it is constrained by organ scarcity and strict criteria. Liver resection (LR) is often the initial treatment for patients with solitary tumors and preserved liver function. The high recurrence rates associated with LR has prompted the exploration of sequential living donor liver transplantation (seqLDLT) after LR as a strategy for HCC patients with high-risk of recurrence.</div></div><div><h3>Methods</h3><div>We analyzed data from 27 adult patients who underwent seqLDLT after LR for HCC at Kaohsiung Chang Gung Memorial Hospital (KCGMH) between June 1994 and December 2023. Patients were selected based on high-risk histopathological features post-LR or as part of downstaging strategy. Outcomes measured included overall survival (OS) and disease-free survival (DFS).</div></div><div><h3>Results</h3><div>Among 765 HCC patients who underwent LDLT, 204 received LR before LDLT, and 27 underwent seqLDLT. Five patients (19%) underwent living donor liver transplantation (LDLT) following LR as a downstaging strategy while the rest received seqLDLT as a preemptive strategy. The median age was 53.5 years with 85% males. Chronic hepatitis B was the predominant underlying disease (74%). The 1-, 3-, and 5-year OS and DFS rates were 100%, 96.0%, 96.0% and 100%, 96.2%, 96.2%, respectively, with two patients experiencing HCC recurrence. One patient died from HCC recurrence. High-risk histopathological features included microvascular invasion (52%), satellite nodules (15%), multiple tumors (26%), tumors &gt; 5 cm (19%), and a total tumor diameter &gt; 10 cm (7%).</div></div><div><h3>Conclusions</h3><div>SeqLDLT offers a promising, tailored approach for managing HCC with adverse histopathologic features. Combining seqLDLT, downstaging strategies, and multidisciplinary treatments can achieve satisfactory OS and DFS in carefully selected patients, highlighting the need for refined criteria to identify the best candidates.</div></div>","PeriodicalId":55059,"journal":{"name":"Hepatobiliary & Pancreatic Diseases International","volume":"24 1","pages":"Pages 50-56"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}