Human Immunology最新文献

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Integration of HLA evolutionary divergence with post-transplant biomarkers enhances prediction of non-relapse mortality in pediatric haploidentical hematopoietic stem cell transplantation HLA进化分化与移植后生物标志物的整合增强了对儿童单倍同型造血干细胞移植非复发死亡率的预测
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111386
D. Guan , J. Wen , L. Dou , X. Li , Z. Wang , D. Wang , H. Xiong , B. Zhang , D. Liu , Y. He , X. Liu
{"title":"Integration of HLA evolutionary divergence with post-transplant biomarkers enhances prediction of non-relapse mortality in pediatric haploidentical hematopoietic stem cell transplantation","authors":"D. Guan , J. Wen , L. Dou , X. Li , Z. Wang , D. Wang , H. Xiong , B. Zhang , D. Liu , Y. He , X. Liu","doi":"10.1016/j.humimm.2025.111386","DOIUrl":"10.1016/j.humimm.2025.111386","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111386"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe refractory thrombocytopenia post full matched female sibling donor hematopoietic stem cell transplant 重度难治性血小板减少后完全匹配的女性同胞供体造血干细胞移植
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111445
P. Rao , B. Peton , M. Carter , J.F. Garcia-Gomez , M. AlMalki , K. Gendzekhadze
{"title":"Severe refractory thrombocytopenia post full matched female sibling donor hematopoietic stem cell transplant","authors":"P. Rao , B. Peton , M. Carter , J.F. Garcia-Gomez , M. AlMalki , K. Gendzekhadze","doi":"10.1016/j.humimm.2025.111445","DOIUrl":"10.1016/j.humimm.2025.111445","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111445"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HLA molecular mismatch categories revised and validated using updated HLAMatchmaker™ software 使用更新的HLAMatchmaker™软件修改和验证HLA分子错配类别
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111424
E. Wong , J.E. Cooper , R. Balshaw , I.W. Gibson , J. Ho , J. Shaw , M. Karpinski , A. Trachtenberg , D. Pochinco , A. Goldberg , P. Birk , M. Pinsk , D.N. Rush , P.W. Nickerson , C. Wiebe
{"title":"HLA molecular mismatch categories revised and validated using updated HLAMatchmaker™ software","authors":"E. Wong , J.E. Cooper , R. Balshaw , I.W. Gibson , J. Ho , J. Shaw , M. Karpinski , A. Trachtenberg , D. Pochinco , A. Goldberg , P. Birk , M. Pinsk , D.N. Rush , P.W. Nickerson , C. Wiebe","doi":"10.1016/j.humimm.2025.111424","DOIUrl":"10.1016/j.humimm.2025.111424","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111424"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacts of HLA matching and a proposal to increase equity HLA配型的影响及增加公平性的建议
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111432
C. Jett, C.J. Amato-Menker, M. Philogene
{"title":"Impacts of HLA matching and a proposal to increase equity","authors":"C. Jett, C.J. Amato-Menker, M. Philogene","doi":"10.1016/j.humimm.2025.111432","DOIUrl":"10.1016/j.humimm.2025.111432","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111432"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-level donor-specific HLA antibodies do not impact engraftment after pediatric hematopoietic cell transplantation: a case series 低水平供体特异性HLA抗体不影响儿童造血细胞移植后的植入:一个病例系列
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111428
A.C. Lima , G.F. Rampim , I.H. Noronha , T.B. Mourão , A. Seber , L.L. Quintino , M. Matos , C.M. Lustosa , C.M. Alferi , E.H. Goto , C.N. Breviglieri , R. de Marco , M. Gerbase-DeLima
{"title":"Low-level donor-specific HLA antibodies do not impact engraftment after pediatric hematopoietic cell transplantation: a case series","authors":"A.C. Lima , G.F. Rampim , I.H. Noronha , T.B. Mourão , A. Seber , L.L. Quintino , M. Matos , C.M. Lustosa , C.M. Alferi , E.H. Goto , C.N. Breviglieri , R. de Marco , M. Gerbase-DeLima","doi":"10.1016/j.humimm.2025.111428","DOIUrl":"10.1016/j.humimm.2025.111428","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111428"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of DSA and non-HLA antibodies after daratumumab treatment of antibody-mediated rejection in pediatric heart transplant recipients 达拉单抗治疗儿童心脏移植受者抗体介导的排斥反应后DSA和非hla抗体的降低
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111440
Q. Xu , A. Zeevi , C. Bentlejewski , S.A. Miller , S.C. West , K. Rose-felker , M.D. Zinn , B. Feingold
{"title":"Reduction of DSA and non-HLA antibodies after daratumumab treatment of antibody-mediated rejection in pediatric heart transplant recipients","authors":"Q. Xu , A. Zeevi , C. Bentlejewski , S.A. Miller , S.C. West , K. Rose-felker , M.D. Zinn , B. Feingold","doi":"10.1016/j.humimm.2025.111440","DOIUrl":"10.1016/j.humimm.2025.111440","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111440"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HLA-DRB1 variation in P4 and staphylococcus aureus surveillance HLA-DRB1在P4和金黄色葡萄球菌监测中的变化
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111365
P. La , D. Dorfsman , Y. Tao , T. Davenport , J. Kair , A. Drabik , F. Ruffin , D. Dykxhoorn , V. fowler , W.K. Scott , A.M. Jackson
{"title":"HLA-DRB1 variation in P4 and staphylococcus aureus surveillance","authors":"P. La , D. Dorfsman , Y. Tao , T. Davenport , J. Kair , A. Drabik , F. Ruffin , D. Dykxhoorn , V. fowler , W.K. Scott , A.M. Jackson","doi":"10.1016/j.humimm.2025.111365","DOIUrl":"10.1016/j.humimm.2025.111365","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111365"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MHC matchmaker: an in silico based histocompatibility algorithm for clinical xenotransplantation trials MHC媒人:用于临床异种移植试验的基于计算机的组织相容性算法
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111366
J. Ladowski, N.De Bie, H. Chapman, B. Rogers, A.M. Jackson
{"title":"MHC matchmaker: an in silico based histocompatibility algorithm for clinical xenotransplantation trials","authors":"J. Ladowski, N.De Bie, H. Chapman, B. Rogers, A.M. Jackson","doi":"10.1016/j.humimm.2025.111366","DOIUrl":"10.1016/j.humimm.2025.111366","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111366"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A glance at the geographical distribution of histocompatibility laboratories 组织相容性实验室的地理分布一览。
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111307
Valia Bravo-Egana , Joseph Abraha , Yanping Huang , Taba Kheradmand , Sam Ho
{"title":"A glance at the geographical distribution of histocompatibility laboratories","authors":"Valia Bravo-Egana ,&nbsp;Joseph Abraha ,&nbsp;Yanping Huang ,&nbsp;Taba Kheradmand ,&nbsp;Sam Ho","doi":"10.1016/j.humimm.2025.111307","DOIUrl":"10.1016/j.humimm.2025.111307","url":null,"abstract":"<div><div><span>Histocompatibility laboratories (HLs) provide essential histocompatibility and </span>immunogenetics<span> (H&amp;I) testing in support of organ and stem cell transplantation<span><span><span>, diagnosis of diseases and risk assessment of drug-induced adverse reactions associated with HLA variants, and beyond. Their </span>geographical distribution<span> and the accreditation organizations that provide regulatory oversight have never been profiled. To understand the characteristics of HLs and their global distribution, a taskforce was established by the American Society for Histocompatibility and Immunogenetics (ASHI) Accreditation Review Board (ARB) to gather this data. Our study indicates there are at least 593 HLs routinely providing testing services across 58 countries and 6 continents, with two major organizations, ASHI and EFI, providing accreditation. The data presented here indicates that the distribution of HLs highly depends on the size and economic development of the countries and geographical areas where they are located. This report highlights the benefits of standardization and potential for cooperation among HLs and professional histocompatibility and </span></span>immunogenetics societies and organizations worldwide.</span></span></div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111307"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the adequacy of immunosuppression in pediatric liver transplantation with immune Monitoring: Are we there yet? 在免疫监测下评估儿童肝移植免疫抑制的充分性:我们做到了吗?
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111580
Anushka Das , Mia Feller , Jaeil Ahn , Nada Yazigi , Khalid Khan , Alexander Kroemer , Thomas Fishbein , Olga Timofeeva , Udeme D. Ekong
{"title":"Assessing the adequacy of immunosuppression in pediatric liver transplantation with immune Monitoring: Are we there yet?","authors":"Anushka Das ,&nbsp;Mia Feller ,&nbsp;Jaeil Ahn ,&nbsp;Nada Yazigi ,&nbsp;Khalid Khan ,&nbsp;Alexander Kroemer ,&nbsp;Thomas Fishbein ,&nbsp;Olga Timofeeva ,&nbsp;Udeme D. Ekong","doi":"10.1016/j.humimm.2025.111580","DOIUrl":"10.1016/j.humimm.2025.111580","url":null,"abstract":"<div><div>Current approaches used for pediatric liver transplant (LT) surveillance have diagnostic limitations. We used pleximmune™ immune reactivity index (IRI) and anti-HLA donor specific antibody (DSA) to predict the adequacy of immunosuppression (IS) relative to risk of acute cellular rejection (ACR) at 1-year post LT. This is a retrospective chart review of children who underwent LT between January 1, 2016, through December 31, 2020, and had at least one pleximmune<sup>TM</sup> measurement performed within 60-days of a liver biopsy. There were 45 liver biopsies with accompanying pleximmune<sup>TM</sup> in 31 children. An inverse correlation was observed between tacrolimus level and IRI (R = -0.34; p = 0.039). The sensitivity, specificity, positive and negative predictive values of IRI for diagnosis of ACR was 55 %, 65 %, 33 % and 81 % respectively. The combination of DSA and IRI had a specificity of 92 % and negative predictive value of 89 % for ACR. In conclusion, a high IRI identifies recipients with low tacrolimus levels. Thus, the associations observed in this non-standardized cohort support the use of pleximmune<sup>TM</sup> IRI in combination with DSA, for hypothesis generation in future studies involving post liver transplant graft immune surveillance.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111580"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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