Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111386
D. Guan , J. Wen , L. Dou , X. Li , Z. Wang , D. Wang , H. Xiong , B. Zhang , D. Liu , Y. He , X. Liu
{"title":"Integration of HLA evolutionary divergence with post-transplant biomarkers enhances prediction of non-relapse mortality in pediatric haploidentical hematopoietic stem cell transplantation","authors":"D. Guan , J. Wen , L. Dou , X. Li , Z. Wang , D. Wang , H. Xiong , B. Zhang , D. Liu , Y. He , X. Liu","doi":"10.1016/j.humimm.2025.111386","DOIUrl":"10.1016/j.humimm.2025.111386","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111386"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111424
E. Wong , J.E. Cooper , R. Balshaw , I.W. Gibson , J. Ho , J. Shaw , M. Karpinski , A. Trachtenberg , D. Pochinco , A. Goldberg , P. Birk , M. Pinsk , D.N. Rush , P.W. Nickerson , C. Wiebe
{"title":"HLA molecular mismatch categories revised and validated using updated HLAMatchmaker™ software","authors":"E. Wong , J.E. Cooper , R. Balshaw , I.W. Gibson , J. Ho , J. Shaw , M. Karpinski , A. Trachtenberg , D. Pochinco , A. Goldberg , P. Birk , M. Pinsk , D.N. Rush , P.W. Nickerson , C. Wiebe","doi":"10.1016/j.humimm.2025.111424","DOIUrl":"10.1016/j.humimm.2025.111424","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111424"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111432
C. Jett, C.J. Amato-Menker, M. Philogene
{"title":"Impacts of HLA matching and a proposal to increase equity","authors":"C. Jett, C.J. Amato-Menker, M. Philogene","doi":"10.1016/j.humimm.2025.111432","DOIUrl":"10.1016/j.humimm.2025.111432","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111432"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111428
A.C. Lima , G.F. Rampim , I.H. Noronha , T.B. Mourão , A. Seber , L.L. Quintino , M. Matos , C.M. Lustosa , C.M. Alferi , E.H. Goto , C.N. Breviglieri , R. de Marco , M. Gerbase-DeLima
{"title":"Low-level donor-specific HLA antibodies do not impact engraftment after pediatric hematopoietic cell transplantation: a case series","authors":"A.C. Lima , G.F. Rampim , I.H. Noronha , T.B. Mourão , A. Seber , L.L. Quintino , M. Matos , C.M. Lustosa , C.M. Alferi , E.H. Goto , C.N. Breviglieri , R. de Marco , M. Gerbase-DeLima","doi":"10.1016/j.humimm.2025.111428","DOIUrl":"10.1016/j.humimm.2025.111428","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111428"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111307
Valia Bravo-Egana , Joseph Abraha , Yanping Huang , Taba Kheradmand , Sam Ho
{"title":"A glance at the geographical distribution of histocompatibility laboratories","authors":"Valia Bravo-Egana , Joseph Abraha , Yanping Huang , Taba Kheradmand , Sam Ho","doi":"10.1016/j.humimm.2025.111307","DOIUrl":"10.1016/j.humimm.2025.111307","url":null,"abstract":"<div><div><span>Histocompatibility laboratories (HLs) provide essential histocompatibility and </span>immunogenetics<span> (H&I) testing in support of organ and stem cell transplantation<span><span><span>, diagnosis of diseases and risk assessment of drug-induced adverse reactions associated with HLA variants, and beyond. Their </span>geographical distribution<span> and the accreditation organizations that provide regulatory oversight have never been profiled. To understand the characteristics of HLs and their global distribution, a taskforce was established by the American Society for Histocompatibility and Immunogenetics (ASHI) Accreditation Review Board (ARB) to gather this data. Our study indicates there are at least 593 HLs routinely providing testing services across 58 countries and 6 continents, with two major organizations, ASHI and EFI, providing accreditation. The data presented here indicates that the distribution of HLs highly depends on the size and economic development of the countries and geographical areas where they are located. This report highlights the benefits of standardization and potential for cooperation among HLs and professional histocompatibility and </span></span>immunogenetics societies and organizations worldwide.</span></span></div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111307"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111580
Anushka Das , Mia Feller , Jaeil Ahn , Nada Yazigi , Khalid Khan , Alexander Kroemer , Thomas Fishbein , Olga Timofeeva , Udeme D. Ekong
{"title":"Assessing the adequacy of immunosuppression in pediatric liver transplantation with immune Monitoring: Are we there yet?","authors":"Anushka Das , Mia Feller , Jaeil Ahn , Nada Yazigi , Khalid Khan , Alexander Kroemer , Thomas Fishbein , Olga Timofeeva , Udeme D. Ekong","doi":"10.1016/j.humimm.2025.111580","DOIUrl":"10.1016/j.humimm.2025.111580","url":null,"abstract":"<div><div>Current approaches used for pediatric liver transplant (LT) surveillance have diagnostic limitations. We used pleximmune™ immune reactivity index (IRI) and anti-HLA donor specific antibody (DSA) to predict the adequacy of immunosuppression (IS) relative to risk of acute cellular rejection (ACR) at 1-year post LT. This is a retrospective chart review of children who underwent LT between January 1, 2016, through December 31, 2020, and had at least one pleximmune<sup>TM</sup> measurement performed within 60-days of a liver biopsy. There were 45 liver biopsies with accompanying pleximmune<sup>TM</sup> in 31 children. An inverse correlation was observed between tacrolimus level and IRI (R = -0.34; p = 0.039). The sensitivity, specificity, positive and negative predictive values of IRI for diagnosis of ACR was 55 %, 65 %, 33 % and 81 % respectively. The combination of DSA and IRI had a specificity of 92 % and negative predictive value of 89 % for ACR. In conclusion, a high IRI identifies recipients with low tacrolimus levels. Thus, the associations observed in this non-standardized cohort support the use of pleximmune<sup>TM</sup> IRI in combination with DSA, for hypothesis generation in future studies involving post liver transplant graft immune surveillance.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111580"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}