Human Immunology最新文献_第7页

NLRP3 genetic variants and their impact on psoriasis susceptibility, severity, and risk of psoriatic arthritis NLRP3基因变异及其对银屑病易感性、严重程度和银屑病关节炎风险的影响

IF 2.2 4区医学

Human Immunology Pub Date : 2025-11-01 Epub Date: 2025-11-08 DOI: 10.1016/j.humimm.2025.111610

Cássio Rafael Moreira , Camila Cataldi de Alcântara , Ligia Marcia Mario Martin , Marcell Alysson Batisti Lozovoy , Andréa Name Colado Simão , Edna Maria Vissoci Reiche

{"title":"NLRP3 genetic variants and their impact on psoriasis susceptibility, severity, and risk of psoriatic arthritis","authors":"Cássio Rafael Moreira , Camila Cataldi de Alcântara , Ligia Marcia Mario Martin , Marcell Alysson Batisti Lozovoy , Andréa Name Colado Simão , Edna Maria Vissoci Reiche","doi":"10.1016/j.humimm.2025.111610","DOIUrl":"10.1016/j.humimm.2025.111610","url":null,"abstract":"<div><div>Psoriasis (PsO) is a chronic, immune-mediated inflammatory disease with systemic manifestations. Its etiology involves an interaction between genetic, immunologic, and environmental factors. The NLRP3 inflammasome plays a key role in innate immune responses and has been implicated in PsO pathogenesis. However, data regarding <em>NLRP3</em> gene polymorphisms and their relationship with PsO, particularly in the Brazilian population, remain limited. The aim was to investigate the association between the <em>NLRP3</em> rs10157379 and rs10754558 gene variants with susceptibility and severity of PsO, as well as the risk of developing psoriatic arthritis (PsA). A case-control study was conducted with 154 individuals with PsO and 154 healthy controls. Clinical and demographic data were collected, and genotyping of the <em>NLRP3</em> rs10157379 T > C and rs10754558 G > C variants was performed using real-time polymerase chain reaction. No significant association was observed between either variant and PsO susceptibility or severity. However, the rs10754558 CG genotype was associated with a reduced likelihood of PsA [odds ratio (OR): 0.32; 95 % confidence interval (CI): 0.10–0.95, p = 0.041], while the GG genotype conferred a higher likelihood (OR: 3.26; 95 % CI:1.03–10.32, p = 0.044). No associations were identified for the rs10157379 variant. In conclusion, the <em>NLRP3</em> rs10157379 and rs10754558 variants were not associated with PsO susceptibility or severity. However, the rs10754558 variant may influence the chance of joint involvement in individuals with PsO. These findings underscore the potential role of <em>NLRP3</em> variants in PsA development and highlight the importance of genetic background in PsO pathophysiology.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 6","pages":"Article 111610"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual liver-heart transplantation for highly allosensitized heart failure patients 高度异体化心力衰竭患者的双肝心脏移植

IF 2.2 4区医学

Human Immunology Pub Date : 2025-11-01 Epub Date: 2025-09-22 DOI: 10.1016/j.humimm.2025.111587

Shin Lin , Elaine Chou-Wu , Mark Sturdevant , Yiing Lin , Jay Pal , Idoia Gimferrer

引用次数: 0

Genotyping BK virus in kidney transplant recipients using novel algorithm 肾移植受者BK病毒基因分型新算法

IF 2.2 4区医学

Human Immunology Pub Date : 2025-11-01 Epub Date: 2025-10-27 DOI: 10.1016/j.humimm.2025.111607

Deema Ibrahim Fallatah , Hafeez Aderinsayo Adekola , Steve Christmas

{"title":"Genotyping BK virus in kidney transplant recipients using novel algorithm","authors":"Deema Ibrahim Fallatah , Hafeez Aderinsayo Adekola , Steve Christmas","doi":"10.1016/j.humimm.2025.111607","DOIUrl":"10.1016/j.humimm.2025.111607","url":null,"abstract":"<div><div>This study investigated the prevalence of BKV subtypes in kidney transplant recipients and evaluates their association with viral load and BKVAN risk. A total of 32 kidney transplant recipients with confirmed BKV infection were included in the study. BKV DNA was extracted from urine and plasma samples and genotyped using phylogenetic analysis and a novel genotyping algorithm. Viral loads were compared between subtypes, and the occurrence of BKVAN was analyzed in relation to genotype distribution All samples belonged to genotype I, with 78.5 % classified as Ib-2 and 21.4 % as Ib-1. No genotype II, III, or IV strains were detected. Although the Ib-1 subtype exhibited higher mean viral loads in both urine and plasma, the differences were not statistically significant (p = 0.055 and p = 0.07, respectively). Two patients developed BKVAN, both infected with the Ib-2 subtype. The genotyping algorithm demonstrated a 98 % concordance rate with phylogenetic analysis, confirming its reliability. The predominance of BKV genotype Ib-2 among kidney transplant recipients aligns with global trends. While no significant association between genotype and viral load was found, all BKVAN cases were linked to the Ib-2 subtype, suggesting a potential role in disease progression.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 6","pages":"Article 111607"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The benefits of HLA technologists attending an ASHI meeting HLA技术人员参加ASHI会议的好处

IF 2.2 4区医学

Human Immunology Pub Date : 2025-11-01 Epub Date: 2025-11-14 DOI: 10.1016/j.humimm.2025.111609

Bruce Young

引用次数: 0

A single-center, randomized, double-blind, positive-controlled, phase IV clinical trial to assess the immunogenicity and safety of adsorbed tetanus toxoid vaccine in individuals aged ≥16 years 一项单中心、随机、双盲、阳性对照的IV期临床试验，旨在评估吸附式破伤风类毒素疫苗在16岁以上人群中的免疫原性和安全性

IF 2.2 4区医学

Human Immunology Pub Date : 2025-11-01 Epub Date: 2025-11-14 DOI: 10.1016/j.humimm.2025.111612

Qinghu Guan , Jun Liu , Miaomiao Tang , Qingliang Li , Haiyan Yang , Zeyu Zhang , Shiyi Liu , Xuejuan Wang , Cong Wu , Tian Zeng , Yajie Zhou , Yuanxue Gao , Hu Chen , Yajun Yang , Wei Chen , Shengli Meng , Ruizhi Zhang

{"title":"A single-center, randomized, double-blind, positive-controlled, phase IV clinical trial to assess the immunogenicity and safety of adsorbed tetanus toxoid vaccine in individuals aged ≥16 years","authors":"Qinghu Guan , Jun Liu , Miaomiao Tang , Qingliang Li , Haiyan Yang , Zeyu Zhang , Shiyi Liu , Xuejuan Wang , Cong Wu , Tian Zeng , Yajie Zhou , Yuanxue Gao , Hu Chen , Yajun Yang , Wei Chen , Shengli Meng , Ruizhi Zhang","doi":"10.1016/j.humimm.2025.111612","DOIUrl":"10.1016/j.humimm.2025.111612","url":null,"abstract":"<div><h3>Background</h3><div>Tetanus prevention is effectively managed in infants and young children, yet there remains a need for enhanced measures to improve tetanus prevention among adults.</div></div><div><h3>Methods</h3><div>This phase IV, single-center, randomized, double-blind, positive-controlled trial evaluated an adsorbed tetanus vaccine in individuals aged ≥ 16 years, stratified into 16–18 years, 19–49 years, and ≥ 50 years cohorts.</div></div><div><h3>Results</h3><div>Pre-vaccination seroprotection rates (SPR, ≥0.1 IU/mL) demonstrated age-dependent declines (44.00 %→18.47 %→5.38 %), paralleled by decreasing geometric mean concentrations (GMC: 0.079 IU/mL → 0.052 IU/mL → 0.033 IU/mL). A single booster dose achieved universal seroprotection (100 % SPR) and near-complete seroconversion (SCR ≥ 99.48 %) across all groups, elevating GMCs to 6.831 IU/mL (16–18 years), 3.400 IU/mL (19–49 years), and 1.430 IU/mL (≥50 years), while two doses in the ≥ 50 years cohort further increased GMC to 2.938 IU/mL with 100 % SCR. The vaccine exhibited a favorable safety profile, with mild vaccination-site pain (7.2 %) and pruritus (4.2 %) as predominant reactions, no vaccine-related serious adverse events, and self-limiting systemic effects (pyrexia: 1.6 %; myalgia: 1.2 %).</div></div><div><h3>Conclusion</h3><div>These results confirm robust immunogenicity and safety in adults, supporting tailored booster strategies for aging populations with waning immunity.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 6","pages":"Article 111612"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Polymorphism, Methylation, and IL6 gene expression in children with obesity 肥胖儿童的遗传多态性、甲基化和IL6基因表达

IF 2.2 4区医学

Human Immunology Pub Date : 2025-11-01 Epub Date: 2025-10-25 DOI: 10.1016/j.humimm.2025.111604

Julya R.S. Nascimento , Rafael S. Lima , Fabiana M. Kattah , Rafael T. Mattos , Nayara I. Medeiros , Carlos A. Menezes , Fabricio Rios-Santos , Walderez O. Dutra , Juliana A.S. Gomes , Paula R. Moreira

{"title":"Genetic Polymorphism, Methylation, and IL6 gene expression in children with obesity","authors":"Julya R.S. Nascimento , Rafael S. Lima , Fabiana M. Kattah , Rafael T. Mattos , Nayara I. Medeiros , Carlos A. Menezes , Fabricio Rios-Santos , Walderez O. Dutra , Juliana A.S. Gomes , Paula R. Moreira","doi":"10.1016/j.humimm.2025.111604","DOIUrl":"10.1016/j.humimm.2025.111604","url":null,"abstract":"<div><div>IL-6 is a key cytokine involved in the chronic low-grade inflammatory state that characterizes childhood obesity. IL-6 expression and signaling are controlled in various instances, including polymorphisms and methylation of its promoter. Therefore, the present study aims to investigate the expression, polymorphisms and promoter methylation of <em>IL6</em> in childhood obesity. Methodology: The anthropometric and biochemical profiles of 44 children with eutrophy (EU group) and 44 with obesity (OB group) were determined. We also assessed two common <em>IL6</em> polymorphisms (rs1800795 and rs1800797) and the methylation status of its promoter in these groups. Moreover, expression of IL-6 in leukocytes was determined in 9 children of the EU group and 11 of the OB group. Results: Besides the anthropometric and biochemical alterations, the OB group presents higher IL-6 expression and lower total methylation frequency than the EU group. The A+/A- genotypes for rs1800797 and the C+/C- genotypes for rs1800795 are associated with changes in metabolic parameters. We also observed correlations between the IL-6 expression and methylation profiles with anthropometric and biochemical measures. Conclusion: IL-6 is a key molecule regulating the metabolic profile in children. Methylation and polymorphisms in its gene promoter may help understand the regulation of childhood obesity.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 6","pages":"Article 111604"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of machine learning ensemble model for predicting DSA positivity and immunological risk stratification after kidney transplantation 用于预测肾移植后DSA阳性和免疫风险分层的机器学习集成模型的开发

IF 2.2 4区医学

Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111408

D. Park , J. Lee , J. Hwang , H. Kim , B. Choi , T. Ban

引用次数: 0

New data analysis method to detect loss of HLA by One Lambda LABType products 用一Lambda LABType产品检测HLA缺失的新数据分析方法

IF 2.2 4区医学

Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111401

S. Argounova, H. Bennett, B. Valdez, A. Chikova

引用次数: 0

HLA-specific IgM and IgG antibody competition affects mean fluorescence intensity (MFI) signals in the single antigen assay hla特异性IgM和IgG抗体竞争影响单抗原测定中的平均荧光强度（MFI）信号

IF 2.2 4区医学

Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111395

T. Vu, T. Abeywardana, R. Wang, M. Beltran-Lemus, N. Xu, I. Wakefield, R. Pei, D. Lowe

引用次数: 0

The impact of HLA genotype imputation on allele determination, eplet mismatch and alloimmune risk categories in a southeast Asian cohort of kidney transplant recipients HLA基因型植入对东南亚肾移植受者等位基因测定、等位基因错配和同种免疫风险类别的影响

IF 2.2 4区医学

Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111437

E. Wong , H. Sran , M. D’Costa , Z. Chang , A. Ng , A. Lim , W. Koh , A. Vathsala

引用次数: 0