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Beyond CD34: how CD117+ cell sorting unveiled the truth behind post-transplant relapse 超越CD34: CD117+细胞如何分选揭示移植后复发的真相
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111438
G.G. de Lima, L. Bento, N. Bacal, E. Souto, C. Duarte, D. Batista, M. Torres
{"title":"Beyond CD34: how CD117+ cell sorting unveiled the truth behind post-transplant relapse","authors":"G.G. de Lima, L. Bento, N. Bacal, E. Souto, C. Duarte, D. Batista, M. Torres","doi":"10.1016/j.humimm.2025.111438","DOIUrl":"10.1016/j.humimm.2025.111438","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111438"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA editing sites in coding sequences of ABO blood group alleles ABO血型等位基因编码序列中的RNA编辑位点。
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111586
Supriyo Chakraborty , Deepika Sharma , Joydeep Chandra Das , Srinjay Kumar Bharadaj , Stella Bharadaj
{"title":"RNA editing sites in coding sequences of ABO blood group alleles","authors":"Supriyo Chakraborty ,&nbsp;Deepika Sharma ,&nbsp;Joydeep Chandra Das ,&nbsp;Srinjay Kumar Bharadaj ,&nbsp;Stella Bharadaj","doi":"10.1016/j.humimm.2025.111586","DOIUrl":"10.1016/j.humimm.2025.111586","url":null,"abstract":"<div><h3>Purpose</h3><div>The <em>ABO</em> blood group gene, a protein-coding gene on chromosome 9, is essential for identifying a person’s blood group phenotype. A, B, and O are the three primary alleles of the gene. The <em>ABO</em> blood grouping system is crucial for organ transplantation and blood transfusion because it helps to avoid potentially fatal unfavorable immunological reactions. This study looks into the codon structuring pattern, Codon Usage Bias (CUB) as well as RNA alteration sites in the <em>ABO</em> blood group alleles of <em>Homo sapiens</em>.</div></div><div><h3>Results</h3><div>The <em>ABO</em> blood group gene has high GC content and low CUB, which both point to significant variation in synonymous codon use. It was discovered that 18 codons were underrepresented and 13 codons were overrepresented in <em>ABO</em> gene. The research indicates that the evolution of <em>ABO</em> blood group genes is shaped by two primary factors: mutational force as well as natural selection, which plays a more substantial role (53.20%) compared to mutational force (46.80%). Transition sites were more than transversion sites. RNA editing sites analysis identified the greatest substitution of C by T nucleotides in ABO alleles.</div></div><div><h3>Conclusion</h3><div>Overall, the discoveries broaden our understanding of codon utilization mechanisms and the RNA alteration sites in human <em>ABO</em> blood group alleles.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111586"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A noninvasive urine biomarker CXCL10 bead-based detection assay for monitoring renal transplants 一种无创尿液生物标志物CXCL10头部检测方法用于监测肾脏移植
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111400
N. Xu, E. Hasan, A. Karamafrooz, J. Nguyen, R. Pei, D. Lowe
{"title":"A noninvasive urine biomarker CXCL10 bead-based detection assay for monitoring renal transplants","authors":"N. Xu,&nbsp;E. Hasan,&nbsp;A. Karamafrooz,&nbsp;J. Nguyen,&nbsp;R. Pei,&nbsp;D. Lowe","doi":"10.1016/j.humimm.2025.111400","DOIUrl":"10.1016/j.humimm.2025.111400","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111400"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innate alloimmunity: SIRPA mismatches between the donor and recipient are associated with kidney allograft outcome 先天性异体免疫：供体和受体之间的SIRPA不匹配与肾移植的结果有关
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111354
A. Senev , A. Tambur , D. Metes , F. Lakkis , A. Cherukuri
{"title":"Innate alloimmunity: SIRPA mismatches between the donor and recipient are associated with kidney allograft outcome","authors":"A. Senev ,&nbsp;A. Tambur ,&nbsp;D. Metes ,&nbsp;F. Lakkis ,&nbsp;A. Cherukuri","doi":"10.1016/j.humimm.2025.111354","DOIUrl":"10.1016/j.humimm.2025.111354","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111354"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incremental clinical benefit (ICB) and cost effectiveness ratio (ICER) of routine flow cytometric crossmatch (FCXM) prior to kidney transplantation 肾移植前常规流式细胞交叉匹配（FCXM）的增量临床获益（ICB）和成本效益比（ICER）
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111446
F. Fenninger , B. Baillie , K. Sherwood , J. Tran , S. Ghanbarian , S. Bryan , R. Sapir-Pichhadze , J. Lan , P. Keown
{"title":"Incremental clinical benefit (ICB) and cost effectiveness ratio (ICER) of routine flow cytometric crossmatch (FCXM) prior to kidney transplantation","authors":"F. Fenninger ,&nbsp;B. Baillie ,&nbsp;K. Sherwood ,&nbsp;J. Tran ,&nbsp;S. Ghanbarian ,&nbsp;S. Bryan ,&nbsp;R. Sapir-Pichhadze ,&nbsp;J. Lan ,&nbsp;P. Keown","doi":"10.1016/j.humimm.2025.111446","DOIUrl":"10.1016/j.humimm.2025.111446","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111446"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grading proficiency: when “right” is “wrong” 评分熟练度：当“对”是“错”时
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111442
A. Snaza, R. Maas, R. Bray, H.M. Gebel
{"title":"Grading proficiency: when “right” is “wrong”","authors":"A. Snaza,&nbsp;R. Maas,&nbsp;R. Bray,&nbsp;H.M. Gebel","doi":"10.1016/j.humimm.2025.111442","DOIUrl":"10.1016/j.humimm.2025.111442","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111442"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking down Pan-Cw using One Lambda™ MagSort™ 使用One Lambda™MagSort™分解Pan-Cw
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111393
I. Wakefield, T. Vu, S. Carey, R. Pei, D. Lowe
{"title":"Breaking down Pan-Cw using One Lambda™ MagSort™","authors":"I. Wakefield,&nbsp;T. Vu,&nbsp;S. Carey,&nbsp;R. Pei,&nbsp;D. Lowe","doi":"10.1016/j.humimm.2025.111393","DOIUrl":"10.1016/j.humimm.2025.111393","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111393"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune mediated rejection in living donor kidney transplant: A retrospective perspective to gain perspective 活体肾移植中免疫介导的排斥反应：回顾性分析
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111436
I. Skaljic, M. Prod, M. Oppermann, S. Piggott, E. Christian, J. Allberts, D. Bolanowski, A. Shetty, N. Sela, R. Bray, H. Gebel
{"title":"Immune mediated rejection in living donor kidney transplant: A retrospective perspective to gain perspective","authors":"I. Skaljic,&nbsp;M. Prod,&nbsp;M. Oppermann,&nbsp;S. Piggott,&nbsp;E. Christian,&nbsp;J. Allberts,&nbsp;D. Bolanowski,&nbsp;A. Shetty,&nbsp;N. Sela,&nbsp;R. Bray,&nbsp;H. Gebel","doi":"10.1016/j.humimm.2025.111436","DOIUrl":"10.1016/j.humimm.2025.111436","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111436"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
immunogenetr: A comprehensive toolkit for clinical HLA informatics 免疫基因：临床HLA信息学的综合工具包
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111361
B. Coskun, N. Brown
{"title":"immunogenetr: A comprehensive toolkit for clinical HLA informatics","authors":"B. Coskun,&nbsp;N. Brown","doi":"10.1016/j.humimm.2025.111361","DOIUrl":"10.1016/j.humimm.2025.111361","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111361"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical efficacy and safety of protein a immunoadsorption in desensitization therapy for highly sensitized renal transplant recipients: a prospective cohort study 蛋白a免疫吸附在高致敏肾移植受者脱敏治疗中的临床疗效和安全性：一项前瞻性队列研究
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-09-18 DOI: 10.1016/j.humimm.2025.111385
B. Yu , L. Song , L. Tan , J. Guang , X. Xie , Y. Zou
{"title":"Clinical efficacy and safety of protein a immunoadsorption in desensitization therapy for highly sensitized renal transplant recipients: a prospective cohort study","authors":"B. Yu ,&nbsp;L. Song ,&nbsp;L. Tan ,&nbsp;J. Guang ,&nbsp;X. Xie ,&nbsp;Y. Zou","doi":"10.1016/j.humimm.2025.111385","DOIUrl":"10.1016/j.humimm.2025.111385","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111385"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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