Human Immunology最新文献

{"title":"Corrigendum to “Novel HLA-A, -B, -C and -DRB1 alleles identified in the Australian New South Wales tissue typing laboratory” [Hum. Immunol. 86 (3) (2025) 111275]","authors":"Marija Velickovic , Thomas Turner","doi":"10.1016/j.humimm.2025.111555","DOIUrl":"10.1016/j.humimm.2025.111555","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111555"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotyping HLA-B in exomes using a combination of SNP and allele calls with HLA-mapper and imputation with a multiethnic reference panel","authors":"R.M. Barbosa , D. Meyer , L. Colli , M. Naslavsky , N. Vince , E.A. Donadi , E. Castelli","doi":"10.1016/j.humimm.2025.111368","DOIUrl":"10.1016/j.humimm.2025.111368","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111368"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of HLA mismatches on survival after unrelated donor hematopoietic cell transplantation with in vivo T-cell depletion for non-malignant disorders varies by patient age and diagnosis","authors":"A.C. Lima , C. Bonfim , G.F. Rampim , T.B. Mourão , I.H. Noronha , R. de Marco , M. Gerbase-DeLima","doi":"10.1016/j.humimm.2025.111362","DOIUrl":"10.1016/j.humimm.2025.111362","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111362"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful desensitization of HLA and non-HLA antibody with daratumumab-based immunotherapy: a case report from pediatric cardiac transplantation","authors":"A. Zhang , S. Amdani , K. Zimmerman , J. Pontious , J. Allen , D. Thomas , M. Libby , G. Boyle , J. Hoover , M. Townsend","doi":"10.1016/j.humimm.2025.111430","DOIUrl":"10.1016/j.humimm.2025.111430","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111430"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving towards a graded proficiency testing survey for ABO genotyping","authors":"R.Hod Dvorai , C. Murphey , O. Timofeeva","doi":"10.1016/j.humimm.2025.111375","DOIUrl":"10.1016/j.humimm.2025.111375","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111375"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecules and their human orthologs","authors":"S. Kaabinejadian , H. Yari , W. Berry , S. Cate , M. Mwoyosvi , H. Cavanagh , S. Zhao , W. Hildebrand","doi":"10.1016/j.humimm.2025.111404","DOIUrl":"10.1016/j.humimm.2025.111404","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111404"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of HLA loss of heterozygosity","authors":"S. Cheung, W. Tong, P. Chu, J. Kwok","doi":"10.1016/j.humimm.2025.111449","DOIUrl":"10.1016/j.humimm.2025.111449","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111449"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in-silico design of a multi-epitope vaccine candidate against Human metapneumovirus (HMPV) through prediction of B- and T-cell epitopes and molecular dynamics simlation","authors":"Farhan Ullah ,&nbsp;Shaukat Ullah ,&nbsp;Memona Amin ,&nbsp;Waqas Ullah ,&nbsp;Shahid Ullah ,&nbsp;Sheng Wang","doi":"10.1016/j.humimm.2025.111557","DOIUrl":"10.1016/j.humimm.2025.111557","url":null,"abstract":"<div><div>Human metapneumovirus (HMPV) is a leading cause of acute respiratory tract infections, particularly in pediatric, elderly, and immunocompromised populations. Despite its clinical significance, no licensed vaccine is currently available for HMPV. This study employed an in silico immunoinformatics-based approach to design a multi-epitope subunit vaccine candidate targeting key structural proteins of HMPV, including Matrix2-2, Matrix2-1, Matrix, and Phosphoprotein. B-cell and T-cell epitopes were systematically predicted and screened based on their immunogenicity, antigenicity, non-toxicity, and non-allergenicity. The most promising epitopes were assembled into a single construct using appropriate peptide linkers and immunostimulatory adjuvants to enhance host immune activation. Molecular docking and molecular dynamics (MD) simulations were performed to evaluate the structural stability and binding affinity of the vaccine construct with toll-like receptors TLR4, supporting its potential to trigger innate immune pathways. Additional computational analyses, including immune simulation and in silico cloning, were conducted to further assess the vaccine’s immunogenic profile and expression feasibility. These findings suggest that the proposed multi-epitope vaccine candidate may offer a viable strategy for HMPV prevention and warrants further experimental validation and preclinical evaluation.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111557"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective bead group missing in HLA single antigen bead assay: Technical error or assay limitation?","authors":"A. Liacini ,&nbsp;M. Ohashi ,&nbsp;P. Sibilia ,&nbsp;K. McGee ,&nbsp;B. Bentayeb ,&nbsp;J. Brissette ,&nbsp;N. Yu","doi":"10.1016/j.humimm.2025.111425","DOIUrl":"10.1016/j.humimm.2025.111425","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111425"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissection of shared genetic architecture and biological association between psoriasis and cardiovascular disease based on genome-wide association studies.","authors":"Ping Zhou, Xin Jiang, Wanchun Wang, Dan Wang","doi":"10.1016/j.humimm.2025.111565","DOIUrl":"10.1016/j.humimm.2025.111565","url":null,"abstract":"<p><strong>Background: </strong>The clinical link between psoriasis (PsO) and cardiovascular diseases (CVDs) is well-established, yet the genetic underpinnings of their comorbidity remain unclear. This study aimed to systematically map the shared genetic architecture between PsO and CVDs to identify key risk loci, effector genes, and biological pathways.</p><p><strong>Methods: </strong>We analyzed large-scale genome-wide association study data for PsO and 11 CVDs to assess their genetic correlation. We then identified pleiotropic loci-variants associated with both PsO and CVDs-and applied colocalization analysis to test whether a single causal variant at each locus could explain the shared association. To interpret these findings, we performed functional annotation to map variants to genes and conducted heritability enrichment analysis to identify critical tissues. Finally, we performed an immune-specific colocalization analysis to investigate the role of distinct immune cell types in driving the shared disease risk.</p><p><strong>Results: </strong>The findings revealed significant shared genetic risk between PsO and seven major CVDs (e.g., hypertension, myocardial infarction, and coronary artery disease). We identified 58 pleiotropic loci at the level of genome-wide significance (P < 5 × 10^-8). Of these, 11 loci passed causal colocalization tests, indicating a high probability of a shared causal variant. Gene-level analysis pinpointed 97 candidate genes, and through multi-evidence integration, we prioritized four (SLC22A5, LMAN2, HSD3B7, and ZNF668) as high-confidence therapeutic targets. Enrichment analyses showed these shared genes are highly expressed in blood and immune-related tissues and are involved in key pathways such as immune activation and cytokine signaling. Furthermore, our findings suggest that T-cell-mediated immune dysregulation is a key mechanism underlying the comorbidity of PsO and at least five of the studied CVDs.</p><p><strong>Conclusion: </strong>Our systematic genetic analysis identifies shared loci and candidate genes for psoriasis and several cardiovascular diseases. The findings point toward immune-mediated pathways as potential links between these conditions and provide a prioritized list of targets warranting future functional study and therapeutic evaluation.</p>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"111565"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}