Human Immunology最新文献

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False-positive flow cytometric crossmatch in the presence of therapeutic monoclonal antibodies resolved by FlowDSA-XM assay 在治疗性单克隆抗体存在的情况下,流式细胞术交叉匹配假阳性,通过FlowDSA-XM检测解决
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111394
B. Peton , P. Rao , J.F. Garcia-Gomez , M.Al Malki , K. Gendzekhadze
{"title":"False-positive flow cytometric crossmatch in the presence of therapeutic monoclonal antibodies resolved by FlowDSA-XM assay","authors":"B. Peton , P. Rao , J.F. Garcia-Gomez , M.Al Malki , K. Gendzekhadze","doi":"10.1016/j.humimm.2025.111394","DOIUrl":"10.1016/j.humimm.2025.111394","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111394"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing the donor matching process in solid organ transplantation 实体器官移植中供体匹配过程的优化
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111397
H.T. Phan , K. Karathanou , O. Ani , N.G. Sgourakis , D.S. Monos
{"title":"Optimizing the donor matching process in solid organ transplantation","authors":"H.T. Phan , K. Karathanou , O. Ani , N.G. Sgourakis , D.S. Monos","doi":"10.1016/j.humimm.2025.111397","DOIUrl":"10.1016/j.humimm.2025.111397","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111397"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid capture automation for HLA-typing using digital microfluidics 混合捕获自动化hla分型使用数字微流体
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111407
L. Townsley , C. Lee , E. Cervantes , Y. Athar , H. Lopez , J. Nhan , J. Avelar-Barragan , J. Chen
{"title":"Hybrid capture automation for HLA-typing using digital microfluidics","authors":"L. Townsley , C. Lee , E. Cervantes , Y. Athar , H. Lopez , J. Nhan , J. Avelar-Barragan , J. Chen","doi":"10.1016/j.humimm.2025.111407","DOIUrl":"10.1016/j.humimm.2025.111407","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111407"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel and integrated software solution for providing compatible platelets to HLA-sensitized patients 一种新颖的集成软件解决方案,为hla敏感患者提供兼容的血小板
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111570
Ryan Morlen , Kevin Grieger , Collin Brack , Krystal Bullard , Yan Zheng , Paula Y. Arnold
{"title":"A novel and integrated software solution for providing compatible platelets to HLA-sensitized patients","authors":"Ryan Morlen ,&nbsp;Kevin Grieger ,&nbsp;Collin Brack ,&nbsp;Krystal Bullard ,&nbsp;Yan Zheng ,&nbsp;Paula Y. Arnold","doi":"10.1016/j.humimm.2025.111570","DOIUrl":"10.1016/j.humimm.2025.111570","url":null,"abstract":"<div><div>Transfusion support for sensitized patients is an important function of blood centers and HLA laboratories. However, access to widely available software to facilitate matching patients with compatible donor units is limited. We developed vendor-supported and integrated software that interfaces with the laboratory informatics system, sourcing typing data from our platelet donor registry and retrieving patient HLA typing and unacceptable antibody specificities. The application filters antigen-negative donors and ranks them using an algorithm that incorporates HLA match, donor homozygosity, and cross-reactive group comparison for mismatched antigens, and generates a customizable report of ranked donors for the blood center. Low, moderate, and high antibody reactivities can be filtered to better support highly sensitized patients. Implementing vendor-supported software ensures continued maintenance, support, and the opportunity for updates with evolving platelet matching protocols. This customizable solution reduces transcription errors and streamlines data retrieval, allowing provision of timely and efficient transfusion support for patients.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111570"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical utility of PAK LX HLA class I bead in platelet transfusion PAK LX HLAⅰ类抗原在血小板输注中的临床应用
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111422
A. Liacini , H. Enten , D. Janes , R. Stedem , L. Gaule , N. Berka
{"title":"Clinical utility of PAK LX HLA class I bead in platelet transfusion","authors":"A. Liacini ,&nbsp;H. Enten ,&nbsp;D. Janes ,&nbsp;R. Stedem ,&nbsp;L. Gaule ,&nbsp;N. Berka","doi":"10.1016/j.humimm.2025.111422","DOIUrl":"10.1016/j.humimm.2025.111422","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111422"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HLA-DPB1 allele frequencies across four donor populations HLA-DPB1等位基因在四个供体人群中的频率
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111413
L. Santiago , S.A. Stinnett , J.J. Chew , N.A. Lemp , S. Dionne
{"title":"HLA-DPB1 allele frequencies across four donor populations","authors":"L. Santiago ,&nbsp;S.A. Stinnett ,&nbsp;J.J. Chew ,&nbsp;N.A. Lemp ,&nbsp;S. Dionne","doi":"10.1016/j.humimm.2025.111413","DOIUrl":"10.1016/j.humimm.2025.111413","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111413"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of amino acid variants suggests that HLA-C confers risk for type 1 diabetes differently than other classical HLA antigens 氨基酸变异分析表明,HLA- c与其他经典HLA抗原相比,具有不同的1型糖尿病风险
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111370
J.A. Noble , S.J. Mack
{"title":"Analysis of amino acid variants suggests that HLA-C confers risk for type 1 diabetes differently than other classical HLA antigens","authors":"J.A. Noble ,&nbsp;S.J. Mack","doi":"10.1016/j.humimm.2025.111370","DOIUrl":"10.1016/j.humimm.2025.111370","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111370"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DRB5 presented peptides bind to HLA-DP molecules using inverted binding mode DRB5所提出的肽以反向结合模式与HLA-DP分子结合
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111398
S. Kaabinejadian , H. Yari , M. Nielsen , W. Hildebrand
{"title":"DRB5 presented peptides bind to HLA-DP molecules using inverted binding mode","authors":"S. Kaabinejadian ,&nbsp;H. Yari ,&nbsp;M. Nielsen ,&nbsp;W. Hildebrand","doi":"10.1016/j.humimm.2025.111398","DOIUrl":"10.1016/j.humimm.2025.111398","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111398"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unexpected increase in calculated panel reactive antibody & positive retrospective crossmatch in a heart transplant recipient induced by intra-aortic balloon pump 在主动脉内球囊泵诱导的心脏移植受者中计算的面板反应性抗体和阳性回顾性交叉配型的意外增加
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111390
R. Siegel , P. Sarkis , M.A. Bieda , K. Hacke , T. Kinard , J. Adamski , B. Hardaway , F.X. Downey III , A. Jaramillo
{"title":"Unexpected increase in calculated panel reactive antibody & positive retrospective crossmatch in a heart transplant recipient induced by intra-aortic balloon pump","authors":"R. Siegel ,&nbsp;P. Sarkis ,&nbsp;M.A. Bieda ,&nbsp;K. Hacke ,&nbsp;T. Kinard ,&nbsp;J. Adamski ,&nbsp;B. Hardaway ,&nbsp;F.X. Downey III ,&nbsp;A. Jaramillo","doi":"10.1016/j.humimm.2025.111390","DOIUrl":"10.1016/j.humimm.2025.111390","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111390"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TLR4 or Itgb4 regulates HLA I mediated cell proliferation and monocyte capture to endotehlial cells via different pathways TLR4或Itgb4通过不同途径调节HLA I介导的细胞增殖和单核细胞捕获内皮细胞
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111369
Y. Jin , J.A. Nevarez-Mejia , E. Rozengurt , E. Reed
{"title":"TLR4 or Itgb4 regulates HLA I mediated cell proliferation and monocyte capture to endotehlial cells via different pathways","authors":"Y. Jin ,&nbsp;J.A. Nevarez-Mejia ,&nbsp;E. Rozengurt ,&nbsp;E. Reed","doi":"10.1016/j.humimm.2025.111369","DOIUrl":"10.1016/j.humimm.2025.111369","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111369"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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