Human Immunology最新文献

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Frequency of copy number variation in classical and non-classical HLA genes 经典和非经典HLA基因拷贝数变异的频率
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111371
V. Bravo-Egana , Y. Jilani , T. Grace , T. Lillian , F. Julia
{"title":"Frequency of copy number variation in classical and non-classical HLA genes","authors":"V. Bravo-Egana , Y. Jilani , T. Grace , T. Lillian , F. Julia","doi":"10.1016/j.humimm.2025.111371","DOIUrl":"10.1016/j.humimm.2025.111371","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111371"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual crossmatch compatible, with unexpected fluorescence cytometric crossmatch positive, may be safe to proceed with transplantation under certain circumstances 虚拟交叉配型相容,荧光细胞交叉配型阳性,在某些情况下可以安全进行移植
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111448
E.M. Fore, J. Liu, S. Pandey, T. Harville
{"title":"Virtual crossmatch compatible, with unexpected fluorescence cytometric crossmatch positive, may be safe to proceed with transplantation under certain circumstances","authors":"E.M. Fore, J. Liu, S. Pandey, T. Harville","doi":"10.1016/j.humimm.2025.111448","DOIUrl":"10.1016/j.humimm.2025.111448","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111448"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of 3rd party vessel allograft in kidney transplantation 第三方异体血管移植在肾移植中的影响
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111441
A. Zhang , W. Wu , K. Hensel , J. Puszakowski , K. Zimmerman , M. Libby , D. Thomas , J. Allen , A. Wee
{"title":"The impact of 3rd party vessel allograft in kidney transplantation","authors":"A. Zhang , W. Wu , K. Hensel , J. Puszakowski , K. Zimmerman , M. Libby , D. Thomas , J. Allen , A. Wee","doi":"10.1016/j.humimm.2025.111441","DOIUrl":"10.1016/j.humimm.2025.111441","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111441"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unique case of false positive Pan-A antibody detection in labscreen single-antigen bead assay labscreen单抗原珠试验中Pan-A抗体检测假阳性的独特病例
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111388
J.L. Merschman, L.L. Wakefield, R. Barnes, J. Kreuter, M. Gandhi
{"title":"Unique case of false positive Pan-A antibody detection in labscreen single-antigen bead assay","authors":"J.L. Merschman, L.L. Wakefield, R. Barnes, J. Kreuter, M. Gandhi","doi":"10.1016/j.humimm.2025.111388","DOIUrl":"10.1016/j.humimm.2025.111388","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111388"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triple algorithm-based prediction of de novo donor-specific antibody formation in kidney transplant recipients 基于三重算法的肾移植受者新生供者特异性抗体形成预测
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111356
H. Zhao, D. Zhang, P. Kakodkar, D. Webster, T. Pearce, F. Wu, C. Lewis, A. Mostafa
{"title":"Triple algorithm-based prediction of de novo donor-specific antibody formation in kidney transplant recipients","authors":"H. Zhao, D. Zhang, P. Kakodkar, D. Webster, T. Pearce, F. Wu, C. Lewis, A. Mostafa","doi":"10.1016/j.humimm.2025.111356","DOIUrl":"10.1016/j.humimm.2025.111356","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111356"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving virtual crossmatch (vXM) accuracy: impact of lower DSA thresholds, HLA-C inclusion, and epitope analysis on T-cell flow crossmatch prediction 提高虚拟交叉匹配(vXM)准确性:低DSA阈值、HLA-C包含和表位分析对t细胞流交叉匹配预测的影响
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111383
F. Li , E. Milford , M.Y. Yeung , W. Lane
{"title":"Improving virtual crossmatch (vXM) accuracy: impact of lower DSA thresholds, HLA-C inclusion, and epitope analysis on T-cell flow crossmatch prediction","authors":"F. Li , E. Milford , M.Y. Yeung , W. Lane","doi":"10.1016/j.humimm.2025.111383","DOIUrl":"10.1016/j.humimm.2025.111383","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111383"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying HLA amino acid mismatches that predict kidney graft failure with cross validation using FIBERS 2.0 machine learning binning 使用FIBERS 2.0机器学习交叉验证识别HLA氨基酸错配预测肾移植失败
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111353
R.J. Urbanowicz , H. Bandhey , A.N. Paynter , N. Brown , K. McCullough , L. Gragert , M. Kamoun
{"title":"Identifying HLA amino acid mismatches that predict kidney graft failure with cross validation using FIBERS 2.0 machine learning binning","authors":"R.J. Urbanowicz , H. Bandhey , A.N. Paynter , N. Brown , K. McCullough , L. Gragert , M. Kamoun","doi":"10.1016/j.humimm.2025.111353","DOIUrl":"10.1016/j.humimm.2025.111353","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111353"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nomenclature for factors of the HLA system, update April, May and June 2025 HLA系统因子命名法,2025年4、5、6月更新
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111347
Steven GE. Marsh
{"title":"Nomenclature for factors of the HLA system, update April, May and June 2025","authors":"Steven GE. Marsh","doi":"10.1016/j.humimm.2025.111347","DOIUrl":"10.1016/j.humimm.2025.111347","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111347"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dissection of shared genetic architecture and biological association between psoriasis and cardiovascular disease based on genome-wide association studies. 基于全基因组关联研究的银屑病与心血管疾病的共享遗传结构和生物学关联分析
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.humimm.2025.111565
Ping Zhou, Xin Jiang, Wanchun Wang, Dan Wang
{"title":"Dissection of shared genetic architecture and biological association between psoriasis and cardiovascular disease based on genome-wide association studies.","authors":"Ping Zhou, Xin Jiang, Wanchun Wang, Dan Wang","doi":"10.1016/j.humimm.2025.111565","DOIUrl":"10.1016/j.humimm.2025.111565","url":null,"abstract":"<p><strong>Background: </strong>The clinical link between psoriasis (PsO) and cardiovascular diseases (CVDs) is well-established, yet the genetic underpinnings of their comorbidity remain unclear. This study aimed to systematically map the shared genetic architecture between PsO and CVDs to identify key risk loci, effector genes, and biological pathways.</p><p><strong>Methods: </strong>We analyzed large-scale genome-wide association study data for PsO and 11 CVDs to assess their genetic correlation. We then identified pleiotropic loci-variants associated with both PsO and CVDs-and applied colocalization analysis to test whether a single causal variant at each locus could explain the shared association. To interpret these findings, we performed functional annotation to map variants to genes and conducted heritability enrichment analysis to identify critical tissues. Finally, we performed an immune-specific colocalization analysis to investigate the role of distinct immune cell types in driving the shared disease risk.</p><p><strong>Results: </strong>The findings revealed significant shared genetic risk between PsO and seven major CVDs (e.g., hypertension, myocardial infarction, and coronary artery disease). We identified 58 pleiotropic loci at the level of genome-wide significance (P < 5 × 10<sup>-8</sup>). Of these, 11 loci passed causal colocalization tests, indicating a high probability of a shared causal variant. Gene-level analysis pinpointed 97 candidate genes, and through multi-evidence integration, we prioritized four (SLC22A5, LMAN2, HSD3B7, and ZNF668) as high-confidence therapeutic targets. Enrichment analyses showed these shared genes are highly expressed in blood and immune-related tissues and are involved in key pathways such as immune activation and cytokine signaling. Furthermore, our findings suggest that T-cell-mediated immune dysregulation is a key mechanism underlying the comorbidity of PsO and at least five of the studied CVDs.</p><p><strong>Conclusion: </strong>Our systematic genetic analysis identifies shared loci and candidate genes for psoriasis and several cardiovascular diseases. The findings point toward immune-mediated pathways as potential links between these conditions and provide a prioritized list of targets warranting future functional study and therapeutic evaluation.</p>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"111565"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proinflammatory phenotype can be critical in defining and modulating the genetic risk of non-syndromic hearing loss 促炎表型在确定和调节非综合征性听力损失的遗传风险方面至关重要
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111582
K.P. Sindura , M. Sebastian , P. Davis , L. Srinivas , S. Sathyan , A. Anaswara , M. Padmaja , Moinak Banerjee
{"title":"Proinflammatory phenotype can be critical in defining and modulating the genetic risk of non-syndromic hearing loss","authors":"K.P. Sindura ,&nbsp;M. Sebastian ,&nbsp;P. Davis ,&nbsp;L. Srinivas ,&nbsp;S. Sathyan ,&nbsp;A. Anaswara ,&nbsp;M. Padmaja ,&nbsp;Moinak Banerjee","doi":"10.1016/j.humimm.2025.111582","DOIUrl":"10.1016/j.humimm.2025.111582","url":null,"abstract":"<div><div>Non-syndromic hearing loss (NSHL) is a common sensory disorder with a multifactorial origin, involving both genetic and environmental components. Its genetic basis shows significant variability and incomplete penetrance across populations. Environmental factors, especially TORCH infections and sterile inflammation, may contribute to NSHL by triggering inflammatory cascades. Cytokines, secreted proteins crucial in immune regulation, play a central role in mediating these inflammatory responses. This study investigates whether genetic variants in cytokine genes contribute to NSHL susceptibility. A case-control genetic association study was conducted in the Malayalam-speaking Dravidian population, focusing on both pro- and anti-inflammatory cytokine gene variants. The findings reveal, for the first time, a strong association between NSHL and variants in pro-inflammatory cytokines <em>IL1A, IFNG, IL3,</em> and <em>IL12B</em>, along with the anti-inflammatory cytokine <em>IL4</em>. These risk variants were associated with increased pro-inflammatory activity and reduced anti-inflammatory responses. Interactome analysis showed interactions among cytokine genes <em>IL6, IL1B,</em> and <em>TNF</em> with key candidate genes such as <em>GSDME, DIABLO,</em> and <em>GJA1</em>. The results suggest an alternative NSHL pathogenesis mechanism, where environmental influences may act through cytokine gene variants to affect gene expression, possibly via a “Goldilocks effect.” This study underscores the complex interplay of genetic and environmental factors in NSHL development.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111582"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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