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Selective bead group missing in HLA single antigen bead assay: Technical error or assay limitation? HLA单抗原珠检测缺少选择性珠组：技术错误还是检测限制？
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111425
A. Liacini , M. Ohashi , P. Sibilia , K. McGee , B. Bentayeb , J. Brissette , N. Yu
{"title":"Selective bead group missing in HLA single antigen bead assay: Technical error or assay limitation?","authors":"A. Liacini , M. Ohashi , P. Sibilia , K. McGee , B. Bentayeb , J. Brissette , N. Yu","doi":"10.1016/j.humimm.2025.111425","DOIUrl":"10.1016/j.humimm.2025.111425","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111425"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genotyping HLA-B in exomes using a combination of SNP and allele calls with HLA-mapper and imputation with a multiethnic reference panel 利用SNP和等位基因呼叫结合HLA-mapper进行外显子组HLA-B基因分型，并利用多种族参考面板进行代入
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111368
R.M. Barbosa , D. Meyer , L. Colli , M. Naslavsky , N. Vince , E.A. Donadi , E. Castelli
{"title":"Genotyping HLA-B in exomes using a combination of SNP and allele calls with HLA-mapper and imputation with a multiethnic reference panel","authors":"R.M. Barbosa , D. Meyer , L. Colli , M. Naslavsky , N. Vince , E.A. Donadi , E. Castelli","doi":"10.1016/j.humimm.2025.111368","DOIUrl":"10.1016/j.humimm.2025.111368","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111368"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of HLA mismatches on survival after unrelated donor hematopoietic cell transplantation with in vivo T-cell depletion for non-malignant disorders varies by patient age and diagnosis HLA错配对非恶性疾病非亲属供体造血细胞移植（体内t细胞耗损）后存活的影响因患者年龄和诊断而异
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111362
A.C. Lima , C. Bonfim , G.F. Rampim , T.B. Mourão , I.H. Noronha , R. de Marco , M. Gerbase-DeLima
{"title":"The impact of HLA mismatches on survival after unrelated donor hematopoietic cell transplantation with in vivo T-cell depletion for non-malignant disorders varies by patient age and diagnosis","authors":"A.C. Lima , C. Bonfim , G.F. Rampim , T.B. Mourão , I.H. Noronha , R. de Marco , M. Gerbase-DeLima","doi":"10.1016/j.humimm.2025.111362","DOIUrl":"10.1016/j.humimm.2025.111362","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111362"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful desensitization of HLA and non-HLA antibody with daratumumab-based immunotherapy: a case report from pediatric cardiac transplantation 以达拉图单抗为基础的免疫治疗成功脱敏HLA和非HLA抗体：儿童心脏移植一例报告
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111430
A. Zhang , S. Amdani , K. Zimmerman , J. Pontious , J. Allen , D. Thomas , M. Libby , G. Boyle , J. Hoover , M. Townsend
{"title":"Successful desensitization of HLA and non-HLA antibody with daratumumab-based immunotherapy: a case report from pediatric cardiac transplantation","authors":"A. Zhang , S. Amdani , K. Zimmerman , J. Pontious , J. Allen , D. Thomas , M. Libby , G. Boyle , J. Hoover , M. Townsend","doi":"10.1016/j.humimm.2025.111430","DOIUrl":"10.1016/j.humimm.2025.111430","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111430"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moving towards a graded proficiency testing survey for ABO genotyping 迈向ABO基因分型分级熟练程度测试调查
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111375
R.Hod Dvorai , C. Murphey , O. Timofeeva
{"title":"Moving towards a graded proficiency testing survey for ABO genotyping","authors":"R.Hod Dvorai , C. Murphey , O. Timofeeva","doi":"10.1016/j.humimm.2025.111375","DOIUrl":"10.1016/j.humimm.2025.111375","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111375"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecules and their human orthologs 分子和它们的人类同源物
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111404
S. Kaabinejadian , H. Yari , W. Berry , S. Cate , M. Mwoyosvi , H. Cavanagh , S. Zhao , W. Hildebrand
{"title":"Molecules and their human orthologs","authors":"S. Kaabinejadian , H. Yari , W. Berry , S. Cate , M. Mwoyosvi , H. Cavanagh , S. Zhao , W. Hildebrand","doi":"10.1016/j.humimm.2025.111404","DOIUrl":"10.1016/j.humimm.2025.111404","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111404"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of HLA loss of heterozygosity HLA杂合性缺失的表征
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111449
S. Cheung, W. Tong, P. Chu, J. Kwok
{"title":"Characterization of HLA loss of heterozygosity","authors":"S. Cheung, W. Tong, P. Chu, J. Kwok","doi":"10.1016/j.humimm.2025.111449","DOIUrl":"10.1016/j.humimm.2025.111449","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111449"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First use of imlifidase desensitization in a highly sensitized heart and liver transplant candidate: A case report 在高度敏感的心脏和肝脏移植候选人中首次使用氨酰酶脱敏：一例报告
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111584
Eszter Lázár-Molnár , Crystal M Truax , Morgan M Eiting , Dharmendra Jain , Denise Hurst , Kelsea Zukauckas , Arielle Pearce , Sara Bergam , Stephanie Gardner , Frederic Clayton , Roberta Florido , Josef Stehlik , Kevin S Shah
{"title":"First use of imlifidase desensitization in a highly sensitized heart and liver transplant candidate: A case report","authors":"Eszter Lázár-Molnár ,&nbsp;Crystal M Truax ,&nbsp;Morgan M Eiting ,&nbsp;Dharmendra Jain ,&nbsp;Denise Hurst ,&nbsp;Kelsea Zukauckas ,&nbsp;Arielle Pearce ,&nbsp;Sara Bergam ,&nbsp;Stephanie Gardner ,&nbsp;Frederic Clayton ,&nbsp;Roberta Florido ,&nbsp;Josef Stehlik ,&nbsp;Kevin S Shah","doi":"10.1016/j.humimm.2025.111584","DOIUrl":"10.1016/j.humimm.2025.111584","url":null,"abstract":"<div><div>Heart transplant candidates that are highly sensitized against human leukocyte antigens (HLA) face ongoing challenge in finding immunologically compatible donors. Desensitization strategies aimed at reducing HLA antibody titers have variable success rates. Imlifidase, a novel immunoglobulin G-degrading enzyme derived from <em>Streptococcus pyogenes</em> has been successfully used to eliminate pre-formed antibodies in sensitized kidney transplant recipients. We present the first case of imlifidase use for depleting antibodies in a highly and broadly sensitized heart/liver transplant candidate allowing for transplantation to proceed. Overall, our case demonstrates the feasibility of imlifidase use for the purpose of opening a donor-specific antibody-free window to transplantation in patients who are otherwise not transplantable, due strong sensitization refractory to conventional desensitization approaches.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111584"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing HLA-DQ expression in transplanted kidneys with phenocycler spatial imaging 应用phenocycle空间显像技术表征移植肾中HLA-DQ的表达
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111384
K. Kaneta , R.M. Lestz , V. Lam , J. Menteer , L. Baxter-Lowe
{"title":"Characterizing HLA-DQ expression in transplanted kidneys with phenocycler spatial imaging","authors":"K. Kaneta ,&nbsp;R.M. Lestz ,&nbsp;V. Lam ,&nbsp;J. Menteer ,&nbsp;L. Baxter-Lowe","doi":"10.1016/j.humimm.2025.111384","DOIUrl":"10.1016/j.humimm.2025.111384","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111384"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Matched sibling donor versus 8/8 matched unrelated donor in hematopoietic cell transplantation for nonmalignant disorders: a propensity score-matched analysis 在非恶性疾病的造血细胞移植中，匹配的兄弟姐妹供体与8/8匹配的非亲属供体：倾向评分匹配分析
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111367
A.C. Lima , C. Bonfim , G.F. Rampim , T.B. Mourão , I.H. Noronha , R. de Marco , M. Gerbase-DeLima
{"title":"Matched sibling donor versus 8/8 matched unrelated donor in hematopoietic cell transplantation for nonmalignant disorders: a propensity score-matched analysis","authors":"A.C. Lima ,&nbsp;C. Bonfim ,&nbsp;G.F. Rampim ,&nbsp;T.B. Mourão ,&nbsp;I.H. Noronha ,&nbsp;R. de Marco ,&nbsp;M. Gerbase-DeLima","doi":"10.1016/j.humimm.2025.111367","DOIUrl":"10.1016/j.humimm.2025.111367","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111367"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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