Human ImmunologyPub Date : 2025-09-01Epub Date: 2025-08-08DOI: 10.1016/j.humimm.2025.111556
Marija Velickovic, Thomas R Turner
{"title":"Novel HLA-A, -B, -C and -DRB1 alleles identified in the Australian New South Wales tissue typing laboratory.","authors":"Marija Velickovic, Thomas R Turner","doi":"10.1016/j.humimm.2025.111556","DOIUrl":"10.1016/j.humimm.2025.111556","url":null,"abstract":"<p><p>HLA compatibility between patients and donors is a determining factor for the success of stem cell and solid organ transplantations. However, finding suitable donors remains challenging due to the highly polymorphic nature of HLA genes. Here we are describing 16 novel HLA-A, -B, -C and -DRB1 alleles identified over the period of 2 years. Fourteen differed from their closest reference allele sequence by single nucleotide substitutions detected in the coding regions and 13 contained polymorphism outside antigen recognition domains (exons 2 and 3 in class I and exon 2 in HLA class II). Two novel alleles, a non-sense substitution and a deletion of 2 bp resulted in two null alleles, while a substitution in a splice site resulted in an allele with questionable expression status. In HLA matching procedures, particularly in donor selection, it is important to determine alternatively expressed HLA alleles. Thirteen additional HLA-A, -B, -C and -DRB1 alleles detected as novel at the time of testing were already reported by other laboratories by the time of submission.</p>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"111556"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111391
A. Liacini, C. Carozza, E. Pimpinella, M. Hagerty, J. Glover, M. Ponisciak, N. Berka
{"title":"Identification of a Rare Haplotype Exhibiting Hemizygosity with Complete Absence of one HLA-B allele","authors":"A. Liacini, C. Carozza, E. Pimpinella, M. Hagerty, J. Glover, M. Ponisciak, N. Berka","doi":"10.1016/j.humimm.2025.111391","DOIUrl":"10.1016/j.humimm.2025.111391","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111391"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111443
P. Kluz , J. Stephany , L.G. Hidalgo
{"title":"Surrogate crossmatches as a tool to define the true incidence of HLA class II de novo DSA","authors":"P. Kluz , J. Stephany , L.G. Hidalgo","doi":"10.1016/j.humimm.2025.111443","DOIUrl":"10.1016/j.humimm.2025.111443","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111443"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111363
H. Pickering , R. Ahn , J. Arakawa-Hoyt , S. Bunnapradist , D. Gjertson , M. Pellegrini , T. Sigdel , D. Diamond , L. Lanier , M. Sarwal , J. Schaenman , E. Reed
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111364
Y. Li , T. Wang , X. Hu , H. Zhang , X. Bao , D. Wu , J. He
{"title":"The protective role of donor-derived KIR expression and HLA-Bw4 ligand recognition in reducing aGvHD after allogeneic transplantation","authors":"Y. Li , T. Wang , X. Hu , H. Zhang , X. Bao , D. Wu , J. He","doi":"10.1016/j.humimm.2025.111364","DOIUrl":"10.1016/j.humimm.2025.111364","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111364"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human ImmunologyPub Date : 2025-09-01DOI: 10.1016/j.humimm.2025.111433
A. Liacini , R. Jago , M. Hagerty , M. Ponisciak , C. Carozza , N. Berka
{"title":"Loss of heterozygosity detected in a short tandem repeat and confirmed by NGS-based chimerism: A case report","authors":"A. Liacini , R. Jago , M. Hagerty , M. Ponisciak , C. Carozza , N. Berka","doi":"10.1016/j.humimm.2025.111433","DOIUrl":"10.1016/j.humimm.2025.111433","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111433"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}