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HLA-specific IgM and IgG antibody competition affects mean fluorescence intensity (MFI) signals in the single antigen assay hla特异性IgM和IgG抗体竞争影响单抗原测定中的平均荧光强度（MFI）信号
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111395
T. Vu, T. Abeywardana, R. Wang, M. Beltran-Lemus, N. Xu, I. Wakefield, R. Pei, D. Lowe
{"title":"HLA-specific IgM and IgG antibody competition affects mean fluorescence intensity (MFI) signals in the single antigen assay","authors":"T. Vu, T. Abeywardana, R. Wang, M. Beltran-Lemus, N. Xu, I. Wakefield, R. Pei, D. Lowe","doi":"10.1016/j.humimm.2025.111395","DOIUrl":"10.1016/j.humimm.2025.111395","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111395"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of HLA genotype imputation on allele determination, eplet mismatch and alloimmune risk categories in a southeast Asian cohort of kidney transplant recipients HLA基因型植入对东南亚肾移植受者等位基因测定、等位基因错配和同种免疫风险类别的影响
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111437
E. Wong , H. Sran , M. D’Costa , Z. Chang , A. Ng , A. Lim , W. Koh , A. Vathsala
{"title":"The impact of HLA genotype imputation on allele determination, eplet mismatch and alloimmune risk categories in a southeast Asian cohort of kidney transplant recipients","authors":"E. Wong , H. Sran , M. D’Costa , Z. Chang , A. Ng , A. Lim , W. Koh , A. Vathsala","doi":"10.1016/j.humimm.2025.111437","DOIUrl":"10.1016/j.humimm.2025.111437","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111437"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond CD34: how CD117+ cell sorting unveiled the truth behind post-transplant relapse 超越CD34: CD117+细胞如何分选揭示移植后复发的真相
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111438
G.G. de Lima, L. Bento, N. Bacal, E. Souto, C. Duarte, D. Batista, M. Torres
{"title":"Beyond CD34: how CD117+ cell sorting unveiled the truth behind post-transplant relapse","authors":"G.G. de Lima, L. Bento, N. Bacal, E. Souto, C. Duarte, D. Batista, M. Torres","doi":"10.1016/j.humimm.2025.111438","DOIUrl":"10.1016/j.humimm.2025.111438","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111438"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA editing sites in coding sequences of ABO blood group alleles ABO血型等位基因编码序列中的RNA编辑位点。
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111586
Supriyo Chakraborty , Deepika Sharma , Joydeep Chandra Das , Srinjay Kumar Bharadaj , Stella Bharadaj
{"title":"RNA editing sites in coding sequences of ABO blood group alleles","authors":"Supriyo Chakraborty ,&nbsp;Deepika Sharma ,&nbsp;Joydeep Chandra Das ,&nbsp;Srinjay Kumar Bharadaj ,&nbsp;Stella Bharadaj","doi":"10.1016/j.humimm.2025.111586","DOIUrl":"10.1016/j.humimm.2025.111586","url":null,"abstract":"<div><h3>Purpose</h3><div>The <em>ABO</em> blood group gene, a protein-coding gene on chromosome 9, is essential for identifying a person’s blood group phenotype. A, B, and O are the three primary alleles of the gene. The <em>ABO</em> blood grouping system is crucial for organ transplantation and blood transfusion because it helps to avoid potentially fatal unfavorable immunological reactions. This study looks into the codon structuring pattern, Codon Usage Bias (CUB) as well as RNA alteration sites in the <em>ABO</em> blood group alleles of <em>Homo sapiens</em>.</div></div><div><h3>Results</h3><div>The <em>ABO</em> blood group gene has high GC content and low CUB, which both point to significant variation in synonymous codon use. It was discovered that 18 codons were underrepresented and 13 codons were overrepresented in <em>ABO</em> gene. The research indicates that the evolution of <em>ABO</em> blood group genes is shaped by two primary factors: mutational force as well as natural selection, which plays a more substantial role (53.20%) compared to mutational force (46.80%). Transition sites were more than transversion sites. RNA editing sites analysis identified the greatest substitution of C by T nucleotides in ABO alleles.</div></div><div><h3>Conclusion</h3><div>Overall, the discoveries broaden our understanding of codon utilization mechanisms and the RNA alteration sites in human <em>ABO</em> blood group alleles.</div></div>","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 5","pages":"Article 111586"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
immunogenetr: A comprehensive toolkit for clinical HLA informatics 免疫基因：临床HLA信息学的综合工具包
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111361
B. Coskun, N. Brown
{"title":"immunogenetr: A comprehensive toolkit for clinical HLA informatics","authors":"B. Coskun,&nbsp;N. Brown","doi":"10.1016/j.humimm.2025.111361","DOIUrl":"10.1016/j.humimm.2025.111361","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111361"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical efficacy and safety of protein a immunoadsorption in desensitization therapy for highly sensitized renal transplant recipients: a prospective cohort study 蛋白a免疫吸附在高致敏肾移植受者脱敏治疗中的临床疗效和安全性：一项前瞻性队列研究
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111385
B. Yu , L. Song , L. Tan , J. Guang , X. Xie , Y. Zou
{"title":"Clinical efficacy and safety of protein a immunoadsorption in desensitization therapy for highly sensitized renal transplant recipients: a prospective cohort study","authors":"B. Yu ,&nbsp;L. Song ,&nbsp;L. Tan ,&nbsp;J. Guang ,&nbsp;X. Xie ,&nbsp;Y. Zou","doi":"10.1016/j.humimm.2025.111385","DOIUrl":"10.1016/j.humimm.2025.111385","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111385"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking down Pan-Cw using One Lambda™ MagSort™ 使用One Lambda™MagSort™分解Pan-Cw
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111393
I. Wakefield, T. Vu, S. Carey, R. Pei, D. Lowe
{"title":"Breaking down Pan-Cw using One Lambda™ MagSort™","authors":"I. Wakefield,&nbsp;T. Vu,&nbsp;S. Carey,&nbsp;R. Pei,&nbsp;D. Lowe","doi":"10.1016/j.humimm.2025.111393","DOIUrl":"10.1016/j.humimm.2025.111393","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111393"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grading proficiency: when “right” is “wrong” 评分熟练度：当“对”是“错”时
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111442
A. Snaza, R. Maas, R. Bray, H.M. Gebel
{"title":"Grading proficiency: when “right” is “wrong”","authors":"A. Snaza,&nbsp;R. Maas,&nbsp;R. Bray,&nbsp;H.M. Gebel","doi":"10.1016/j.humimm.2025.111442","DOIUrl":"10.1016/j.humimm.2025.111442","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111442"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune mediated rejection in living donor kidney transplant: A retrospective perspective to gain perspective 活体肾移植中免疫介导的排斥反应：回顾性分析
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111436
I. Skaljic, M. Prod, M. Oppermann, S. Piggott, E. Christian, J. Allberts, D. Bolanowski, A. Shetty, N. Sela, R. Bray, H. Gebel
{"title":"Immune mediated rejection in living donor kidney transplant: A retrospective perspective to gain perspective","authors":"I. Skaljic,&nbsp;M. Prod,&nbsp;M. Oppermann,&nbsp;S. Piggott,&nbsp;E. Christian,&nbsp;J. Allberts,&nbsp;D. Bolanowski,&nbsp;A. Shetty,&nbsp;N. Sela,&nbsp;R. Bray,&nbsp;H. Gebel","doi":"10.1016/j.humimm.2025.111436","DOIUrl":"10.1016/j.humimm.2025.111436","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111436"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specific HLA-DQ G1/G2 mismatches affect myeloid malignancy relapse incidence in haploidentical HCT 特异性HLA-DQ G1/G2错配影响单倍体HCT中髓系恶性肿瘤复发率
IF 2.2 4区 医学
Human Immunology Pub Date : 2025-09-01 DOI: 10.1016/j.humimm.2025.111418
M. Carter , P. Rao , M. Al Malki , K. Gendzekhadze
{"title":"Specific HLA-DQ G1/G2 mismatches affect myeloid malignancy relapse incidence in haploidentical HCT","authors":"M. Carter ,&nbsp;P. Rao ,&nbsp;M. Al Malki ,&nbsp;K. Gendzekhadze","doi":"10.1016/j.humimm.2025.111418","DOIUrl":"10.1016/j.humimm.2025.111418","url":null,"abstract":"","PeriodicalId":55047,"journal":{"name":"Human Immunology","volume":"86 ","pages":"Article 111418"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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