HLA typing of HLA-A, −B, −C, −DPB1, −DQB1 and −DRB1 loci of 226 individuals from three metropolitan areas in South Africa

IF 2.1 4区医学 Q3 IMMUNOLOGY

Human Immunology Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI:10.1016/j.humimm.2026.111677

Akiko Suzuki , Richard Baguma , Shobna Sawry , Katherine Gill , Jean Le Roux , Anusha Nana , Faeezah Patel , Nigel Garrett , Alex Sigal , Penny L. Moore , Lee Fairlie , Catherine Riou , Wendy A. Burgers , Ziyaad Valley-Omar

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引用次数: 0

Abstract

The aim of this study was to characterize HLA diversity in individuals from clinical research sites in order to better understand T cell responses to COVID-19 vaccines in relation to their HLA profiles. Next-generation sequence-based typing of the HLA-A, −B, −C, −DPB1, −DQB1 and −DRB1 loci is reported for 226 individuals from three metropolitan areas in South Africa. Overall, the frequencies of both class I and class II HLA alleles in this study were comparable to those identified in other South African studies. While a more uniform allele frequency prevalence was noted for HLA class I and HLA-DRB1 genes, an allele bias was noted within our population for HLA-DPB1 and −DQB1 alleles, where three most prevalent alleles accounted for allele frequencies of between 12.3 and 29.8%. Our HLA genotyping data will contribute to an expanding catalogue of HLA data from Africa, which are available in the Allele Frequencies Net Database under identifiers 3826, 3827 and 3828.

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南非三个大都市地区226人HLA- a、-B、-C、-DPB1、-DQB1和-DRB1位点的分型分析

本研究的目的是表征来自临床研究地点的个体的HLA多样性，以便更好地了解T细胞对COVID-19疫苗的反应与其HLA谱的关系。新一代HLA-A， -B, -C, -DPB1， -DQB1和-DRB1基因座的序列分型报告了来自南非三个大都市地区的226个人。总体而言，本研究中I类和II类HLA等位基因的频率与南非其他研究中发现的频率相当。虽然HLA I类和HLA- drb1基因的等位基因频率更为均匀，但在我们的人群中，HLA- dpb1和-DQB1等位基因存在等位基因偏倚，其中三个最普遍的等位基因占等位基因频率在12.3至29.8%之间。我们的HLA基因分型数据将有助于扩大来自非洲的HLA数据目录，这些数据可在等位基因频率网络数据库中以标识符3826、3827和3828获取。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Immunology 医学-免疫学

CiteScore

5.40

自引率

7.40%

发文量

107

审稿时长

12 days

期刊介绍： The journal''s scope includes understanding the genetic and functional mechanisms that distinguish human individuals in their immune responses to allografts, pregnancy, infections or vaccines as well as the immune responses that lead to autoimmunity, allergy or drug hypersensitivity. It also includes examining the distribution of the genes controlling these responses in populations. Research areas include: Studies of the genetics, genomics, polymorphism, evolution, and population distribution of immune-related genes Studies of the expression, structure and function of the products of immune-related genes Immunogenetics of susceptibility to infectious and autoimmune disease, and allergy The role of the immune-related genes in hematopoietic stem cell, solid organ, and vascularized composite allograft transplant Histocompatibility studies including alloantibodies, epitope definition, and T cell alloreactivity Studies of immunologic tolerance and pregnancy T cell, B cell, NK and regulatory cell functions, particularly related to subjects within the journal''s scope Pharmacogenomics and vaccine development in the context of immune-related genes Human Immunology considers immune-related genes to include those encoding classical and non-classical HLA, KIR, MIC, minor histocompatibility antigens (mHAg), immunoglobulins, TCR, BCR, proteins involved in antigen processing and presentation, complement, Fc receptors, chemokines and cytokines. Other immune-related genes may be considered. Human Immunology is also interested in bioinformatics of immune-related genes and organizational topics impacting laboratory processes, organ allocation, clinical strategies, and registries related to autoimmunity and transplantation.