Injury-International Journal of the Care of the Injured最新文献

{"title":"Should we reconsider age classification of ISO ski binding settings for children?","authors":"Gerhard Ruedl, Martin Burtscher","doi":"10.1016/j.injury.2024.112007","DOIUrl":"10.1016/j.injury.2024.112007","url":null,"abstract":"","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 112007"},"PeriodicalIF":2.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperextension tibial plateau fractures: An increasingly recognised injury in need of consensus.","authors":"Daniel W.R. Seng , Peter V. Giannoudis","doi":"10.1016/j.injury.2024.112001","DOIUrl":"10.1016/j.injury.2024.112001","url":null,"abstract":"","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 112001"},"PeriodicalIF":2.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Firearm violence and the 'reopening phenomenon' in Turkey","authors":"Abuzer Özkan ,&nbsp;Enes Ferhatlar ,&nbsp;Abdullah Algin","doi":"10.1016/j.injury.2024.111962","DOIUrl":"10.1016/j.injury.2024.111962","url":null,"abstract":"<div><h3>Aim</h3><div>The COVID-19 pandemic has affected many habits and social reactions. During the lifting of COVID-19 lockdown measures in the USA, there was a notable surge in firearm violence, which became known as “the reopening phenomenon”. This study evaluated the impact of a similarly proposed phenomenon on individuals living in a center of Türkiye.</div></div><div><h3>Method</h3><div>This retrospective observational study involved the evaluation of firearm injuries in three periods of 455 days each surrounding the COVID-19 pandemic: the pre-pandemic period (January 1, 2018-April 1, 2019) the pandemic lockdown period (March 2, 2020-May 31, 2021), and the reopening period (June 4, 2021-September 2, 2022).</div></div><div><h3>Results</h3><div>The incidents analyzed predominantly involved the use of pistols (<em>n</em> = 371, 96 %). Long-barreled pistols caused injury in only 16 (4.1 %) cases. Most injuries (<em>n</em> = 275, 71 %) were located in the lower extremity. The comparison of the pre-pandemic, Pandemic lockdown and Reopening periods did not reveal a significant difference in the rate of firearm violence (<em>p</em> = 0.266, x² goodness of fit)</div></div><div><h3>Conclusion</h3><div>We did not observe the reopening phenomena around the COVID-19 pandemic period in a center of Türkiye. However, firearm violence remains a significant societal issue for both Türkiye and the world.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 111962"},"PeriodicalIF":2.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical effects of different miniplate use on bone and miniplate systems in multiple mandible fracture: A finite element study","authors":"Erdinç Sulukan ,&nbsp;Zeynep Gümrükçü","doi":"10.1016/j.injury.2024.111983","DOIUrl":"10.1016/j.injury.2024.111983","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of this study is to evaluate the biomechanical efficiency of different miniplates in the treatment of multiple mandibula fractures.</div></div><div><h3>Material and Method</h3><div>Mandible, miniplates, and screws were modeled using the Solid Works v2015 (Dassault Systèmes, France) program, Subsequently two fracture lines were created on the right parasymphysis and angulus mandible. Models were divided into two main groups according to the plates used in the anterior fracture line: group A, 2 piece 4-hole-bar-I plate, and group B, ellipse plate. Each group was divided into five subgroups according to the plates used in the posterior fracture line (I, X, G, 3D, E) and 10 study models were created in total. Under three different biting forces (anterior, right, left), maximum von-Mises stresses seen on miniplates/screws, and Pmax/Pmin stresses seen in the cortically/cancellous bone were analyzed using the Ansys 16.2 software (ANSYS, Inc., USA). Data was visualized using a color distribution scale and interpreted.</div></div><div><h3>Results</h3><div>The highest von-Mises stress, seen in plates, was found in the I plate (353.82 MPa) at the angulus region of model A1. The highest Pmax and Pmin stresses, revealed in cortical bone, were found respectively in model A1 (181.63 MPa) and model B2 (115.01 MPa). The ideal results on plates were seen in models B3 and B5, in which E plates were used in the parasymphysis and G/E plates were used in the angulus region.</div></div><div><h3>Conclusion</h3><div>Grid and ellipse plates provide successful results and plate geometry is more critical than number in terms of stress distribution.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 111983"},"PeriodicalIF":2.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142555046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schatzker IV tibial plateau fractures involving the posterolateral column: Higher incidence of lateral meniscus and anterior cruciate ligament injuries with suboptimal postoperative outcomes","authors":"Jian Peng ,&nbsp;Weizhi Ren ,&nbsp;Bin Feng,&nbsp;Zhenghui Hu,&nbsp;Wei Xu","doi":"10.1016/j.injury.2024.111921","DOIUrl":"10.1016/j.injury.2024.111921","url":null,"abstract":"<div><h3>Background</h3><div>Current literature offers scant insights into Schatzker IV tibial plateau fractures (TPFs) that affect the posterolateral (PL) column. This study seeks to elucidate the prevalence of meniscal and ligamentous injuries in the knee, as well as the clinical outcomes, in Schatzker IV TPF cases, both with and without PL column involvement.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of clinical and imaging data from patients with Schatzker IV TPFs who received surgical treatment at our institution between January 2018 and January 2022. Patient demographics and surgical details were meticulously documented. The study participants were categorized into two groups based on the involvement of the PL column in the Schatzker IV TPF. Group A comprised patients without PL column fractures, whereas Group B included those with such fractures. We compared soft tissue injuries affecting knee stability, namely meniscal and ligamentous injuries, between two groups using Magnetic Resonance Imaging (MRI) and surgical records. Further, Group B was divided into subgroups based on the presence or absence of knee subluxation. Within Group B, we measured the lateral plateau depression (LPD) and lateral plateau widening (LPW). Additionally, we investigated the frequency of meniscus entrapment in patients with PL column fractures. Clinical outcomes were assessed using The American Hospital for Special Surgery (HSS) and Rasmussen scores.</div></div><div><h3>Results</h3><div>The study comprised 66 patients with Schatzker IV TPFs. Of these, 12 patients had no PL column fracture, while 54 had a PL column fracture. Group B demonstrated a 57.4 % and 64.8 % incidence of lateral meniscus (LM) and anterior cruciate ligament (ACL) injuries, respectively, significantly higher than that in Group A (25 %, 8.3 %) (<em>p</em> = 0.044, <em>p</em> &lt; 0.001). Within Group B, those with knee subluxation showed a marked increase in LPD (14.5 ± 5.3 mm) and LPW (9.3 ± 4.9 mm), correlating with a higher rate of meniscus entrapment (76.0 %) (<em>p</em> &lt; 0.001). Patients in Group B had lower HSS and Rasmussen scores compared to Group A (<em>p</em> = 0.048, <em>p</em> = 0.006).</div></div><div><h3>Conclusion</h3><div>This investigation reveals that Schatzker IV TPFs involving the PL column are highly associated with increased rates of LM and ACL injuries. Additionally, these fractures correlate with a greater likelihood of knee subluxation and meniscus entrapment, ultimately leading to poorer prognostic outcomes.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 111921"},"PeriodicalIF":2.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of post-traumatic antifibrinolysis in the perioperative blood management of elderly patients with intertrochanteric fractures treated with PFNA: A randomised controlled trial","authors":"Gang Luo,&nbsp;Jiacheng Liu,&nbsp;Weidong Ni,&nbsp;Wei Huang","doi":"10.1016/j.injury.2024.111877","DOIUrl":"10.1016/j.injury.2024.111877","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to evaluate the efficacy and safety of posttraumatic antifibrinolytic therapy with repeated doses of intravenous tranexamic acid (IV-TXA) in reducing perioperative hidden blood loss (HBL) in elderly intertrochanteric femur fracture (IFF) patients.</div></div><div><h3>Method</h3><div>112 elderly IFF patients who were admitted to our department from March 2020 to May 2021 were randomized to receive 100 ml of normal saline (Control group) or 1.5 g of TXA (TXA group) intravenously q12 h from postadmission day 1 (PAD1) to PAD3. Hemoglobin (Hb), hematocrit (Hct), fibrinogen degradation product (FDP), D-dimer (D-D), and coagulation parameters were recorded from PAD1 to postoperative day 3 (POD3). HBL was calculated using the gross formula and recorded as the primary outcome.</div></div><div><h3>Result</h3><div>The patients in TXA group had lower preoperative hidden blood loss(HBL), decline of hemoglobin(ΔHb), FDP (on PAD3), and D-D (on PAD3) compared with control group, while no difference was found in postoperative HBL, postoperative ΔHb and allogeneic blood transfusion (ABT) rate. In subgroup analyses, it was observed that patients who received the intervention within 24 h of injury and between 24 and 72 h of injury exhibited significantly lower preoperative HBL and ΔHb in the TXA group compared with the control group. Furthermore, the reduction in HBL and ΔHb was more pronounced in the former group. While for patients who received the intervention beyond 72 h after injury, no significant differences were observed in preoperative HBL and ΔHb between the two groups. Similarly, no significant differences were noted in postoperative HBL and ΔHb between the TXA and control groups across all subgroups. Additionally, no significant differences were identified in the incidence of venous thromboembolism (VTE) and mortality within one year between the two groups.</div></div><div><h3>Conclusion</h3><div>Post-traumatic antifibrinolytic therapy with repeated doses of intravenous TXA is effective and safe in reducing perioperative HBL for elderly IFF patients, especially for patients injured within 24 h.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 111877"},"PeriodicalIF":2.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of elevated exosomal miR-21 levels with nonunion in clavicular fractures post-ORIF: A prospective analysis","authors":"Xiao Hou ,&nbsp;Guoqing Peng ,&nbsp;Wei Zhao ,&nbsp;Xuemei Cheng ,&nbsp;Qianqian Wang ,&nbsp;Tian Gan ,&nbsp;Qian Yang ,&nbsp;Jian Zhang","doi":"10.1016/j.injury.2024.111963","DOIUrl":"10.1016/j.injury.2024.111963","url":null,"abstract":"<div><h3>Background</h3><div>This study investigates the relationship between plasma exosomal miRNAs and nonunion risk following open reduction and internal fixation (ORIF) of clavicle fractures, aiming to identify predictive molecule to enhance patient management and personalized orthopedic care.</div></div><div><h3>Methods</h3><div>Conducted as a prospective cohort study at Taian City Central Hospital, participants included individuals with unilateral, closed clavicle fractures who underwent ORIF (n = 763, 546 males and 217 females). Plasma samples were collected preoperatively for exosome isolation and miRNA extraction, specifically analyzing miR-100, miR-124, miR-125b, and miR-21 using quantitative polymerase chain reaction (qPCR). Patients were classified into union and nonunion groups based on follow-up outcomes at a minimum of three months post-surgery.</div></div><div><h3>Results</h3><div>Out of 763 patients, 720 achieved union while 43 developed nonunion. Notably, the nonunion group exhibited significantly elevated exosomal miR-21 expression levels. Univariate analysis demonstrated a significant association between high miR-21 expression and nonunion occurrence (Relative Risk [RR] = 1.82, P = 0.0004). Multivariate logistic regression analysis corroborated this association (RR &gt; 1.8, P &lt; 0.05), adjusting for covariates. High miR-21 levels (3.12 to 7.89) were robustly associated with nonunion outcomes (RR &gt; 4), independent of other factors. Receiver operating characteristic (ROC) curve analysis indicated certain clinical diagnostic value of miR-21 for predicting nonunion (Area Under the Curve [AUC] = 0.7885).</div></div><div><h3>Conclusions</h3><div>The elevated preoperative levels of exosomal miR-21 were significantly associated with an increased risk of bone nonunion at three months ORIF in patients with clavicle fractures, indicating that miR-21 holds potential as a non-specific predictive molecule.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 111963"},"PeriodicalIF":2.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manipulation of signaling pathways in bone tissue engineering and regenerative medicine: Current knowledge, novel strategies, and future directions","authors":"Ahmad Oryan ,&nbsp;Seyed Ali Afzali ,&nbsp;Nicola Maffulli","doi":"10.1016/j.injury.2024.111976","DOIUrl":"10.1016/j.injury.2024.111976","url":null,"abstract":"<div><div>During osteogenesis, a large number of bioactive molecules, macromolecules, cells, and cellular signals are activated to induce bone growth and development. The activation of molecular pathways leads to the occurrence of cellular events, ultimately resulting in observable changes. Therefore, in the studies of bone tissue engineering and regenerative medicine, it is essential to target fundamental events to exploit the mechanisms involved in osteogenesis. In this context, signaling pathways are activated during osteogenesis and trigger the activation of numerous other processes involved in osteogenesis. Direct influence of signaling pathways should allow to manipulate the signaling pathways themselves and impact osteogenesis. A combination of sequential cascades takes place to drive the progression of osteogenesis. Also, the occurrence of these processes and, more generally, cellular and molecular processes related to osteogenesis necessitate the presence of transcription factors and their activity. The present review focuses on outlining several signaling pathways and transcription factors influencing the development of osteogenesis, and describes various methods of their manipulation to induce and enhance bone formation.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 111976"},"PeriodicalIF":2.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shock wave damage from the ventral side in primary blast injury: An experimental study in pigs","authors":"Nobuaki Kiriu ,&nbsp;Daizoh Saitoh ,&nbsp;Yasumasa Sekine ,&nbsp;Koji Yamamura ,&nbsp;Ruka Sasa ,&nbsp;Masanori Fujita ,&nbsp;Hitoshi Tsuda ,&nbsp;Satoshi Tomura ,&nbsp;Tetsuro Kiyozumi","doi":"10.1016/j.injury.2024.111982","DOIUrl":"10.1016/j.injury.2024.111982","url":null,"abstract":"<div><h3>Aim/Purpose</h3><div>This study aimed to apply a shock wave from the ventral side of a pig and examine its effect to use the results for new body armor production for humans.</div></div><div><h3>Methods</h3><div>Seven male hybrid pigs were used. Each pig was placed under general anesthesia on the experimental table in a blast tube in the left lateral position to expose the front chest area, and shock waves generated by compressed air at 3.0 MPa were applied. We examined changes in vital signs and arterial blood gas in the hyper-acute phase and computed tomography (CT) images, and autopsies were performed for organ damage after 3 h of observation. Pathological examination was performed for lung damage, which is considered a characteristic of shock wave injury.</div></div><div><h3>Results</h3><div>All seven pigs survived. Respiratory arrest occurred in two pigs; however, spontaneous breathing resumed promptly afterward. Hypotension occurred at a frequency of 4. No bradycardia or cardiac arrest was observed in any pig. In the arterial blood gas analysis before and immediately after shock wave exposure and 1 h later, PaO2 decreased immediately but tended to improve thereafter. CT revealed pulmonary contusions and multiple bulla-like lesions on the surface of the lungs. An autopsy showed lung injury in all pigs, particularly in five cases with bulla-like lesions of various sizes on the lung surface across all lobes. Pathological findings showed visceral pleural detachment with elastic fibers from the lung parenchyma, and the cavity lesion on the lung surface comprised bullae. The degree of intra-abdominal hemorrhage varied; however, all but one case showed splenic injury.</div></div><div><h3>Conclusion</h3><div>None of the pigs exposed to shock waves from the ventral side died; however, most showed multiple bullae on the lung surface with lung contusion and splenic injury, which may have been greater than those exposed from the dorsal side. This may be due to the direct impact of the shock wave proceeding from the epigastrium and subcostal region, which are not protected by the skeletal structure of the thorax. These characteristics should be considered when producing new body armor for humans to protect the body from shock waves.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 111982"},"PeriodicalIF":2.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical comparison of Gofried positive support reduction of Pauwels type III femoral neck fractures: A finite elements analysis","authors":"Ming Ding ,&nbsp;Zhihao Su ,&nbsp;Daoyu Wang ,&nbsp;Lan Mo ,&nbsp;Jiong Mei ,&nbsp;Wanju Sun ,&nbsp;Shuang Li ,&nbsp;Ming Ni","doi":"10.1016/j.injury.2024.111979","DOIUrl":"10.1016/j.injury.2024.111979","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate the biomechanical characteristics of non-anatomical reduction and different screw positions on the stability of Pauwels type III femoral neck fractures.</div></div><div><h3>Methods</h3><div>Three-dimensional finite element models of femoral neck fractures were constructed using CT images. Four types of internal fixation methods were simulated, including biplane double-supported screw fixation (BDSF), three inverted triangular parallel cannulated screws (3CS), new parallel cannulated screws with posterior screws moving down (New 3CS), and two parallel cannulated screws (2CS). von Mises stress and total displacement were compared between the fracture models after the femoral head was subjected to an axial load of 2100 N. Stress and displacement data for the implants and the femur were recorded for each fixation method and compared.</div></div><div><h3>Results</h3><div>The results demonstrated that positive reduction of a Pauwels type III femoral neck fracture provided greater stability than neutral or negative reduction. Specifically, the BDSF group showed the lowest maximum von Mises stress in the femur (17.66 MPa) in positive reduction, compared to 3CS (21.08 MPa), New 3CS (22.14 MPa), and 2CS (36.57 MPa). The total displacement of positive reduction in the BDSF group was 0.3143 mm, which was lower than in the 3CS (0.3498 mm), New 3CS (0.3343 mm), and 2CS (0.4533 mm) groups. The stress distribution in the positive support reduction group was lower than that of the other groups, indicating better load distribution. Among the three-screw fixation methods, the New 3CS system exhibited the highest stress in the screws (with a peak of 28.62 MPa), while the 2CS group displayed the highest stresses overall, both in the femur and the screws.</div></div><div><h3>Conclusion</h3><div>For Pauwels type III femoral neck fractures, a positive support reduction with BDSF fixation exhibited superior biomechanical performance than negative reduction. Based on the finite element analysis conducted in this study, the positive support reduction with BDSF fixation can enhance fixation stability, suggesting that non-anatomical reduction is recommended.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"55 12","pages":"Article 111979"},"PeriodicalIF":2.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}