Joint Bone Spine最新文献

{"title":"Factors associated with severity and mortality of COVID-19 in patients with connective tissue diseases and rheumatoid arthritis: A nation-wide, population-based analysis of the French national medico-administrative SNDS database","authors":"Lou Kawka ,&nbsp;Thibaut Fabacher ,&nbsp;Erik Sauleau ,&nbsp;Fabienne Coury ,&nbsp;Laurent Arnaud ,&nbsp;Société Française de Rhumatologie (SFR)","doi":"10.1016/j.jbspin.2024.105818","DOIUrl":"10.1016/j.jbspin.2024.105818","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the risk and predictors of severity and mortality of COVID-19 infection in patients with Connective Tissue Diseases (CTDs).</div></div><div><h3>Methods</h3><div>Using the French nationwide claims and hospitalization database, we assembled a nation-wide exhaustive cohort of adult CTD patients with rheumatoid arthritis, systemic lupus, Sjögren's disease, inflammatory myopathies, systemic sclerosis. We analyzed the rates of hospitalization, severe inpatient stays (intensive care unit [ICU] admissions or in-hospital mortality), and in-hospital mortality with COVID-19 from January 1st to December 31st, 2020.</div></div><div><h3>Results</h3><div>The study included 329,276 CTD patients (75.5% female, mean age 65.2<!--> <!-->±<!--> <!-->15.3 years). Among these, 3,389 (1.03%) were hospitalized, with COVID-19 infection, 973 (0.29%) required admission to ICU and 713 (0.22%) died. Patients who were hospitalized had severe inpatient stays, or died were predominantly male, older and with comorbidities (<em>P</em> <!-->&lt;<!--> <!-->0.0001 for all). The risk of hospitalization, severe inpatient stay, and death was significantly higher in patients treated with glucocorticoids, leflunomide, sulfasalazine, mycophenolate derivatives, and rituximab (<em>P</em> <!-->&lt;<!--> <!-->0.05 for all). TNF inhibitors were associated with reduced hospitalizations and severe inpatient stays (<em>P</em> <!-->&lt;<!--> <!-->0.05 for all) and methotrexate use was associated with decreased mortality (<em>P</em> <!-->&lt;<!--> <!-->0.01).</div></div><div><h3>Conclusion</h3><div>In CTD patients with COVID-19, use of glucocorticoids, rituximab, and certain immunosuppressants was associated with severity and mortality, while TNF inhibitors and methotrexate were protective. These findings can guide clinical and public health decisions for this highly vulnerable group.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105818"},"PeriodicalIF":3.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifetime clinical presentation of Still's disease in the Afro-descendant population of the French West Indies","authors":"Arthur Felix ,&nbsp;Eleonore de Fritsch ,&nbsp;Frederique Delion ,&nbsp;Aurore Abel ,&nbsp;Fabienne Louis-Sidney ,&nbsp;Moustapha Dramé ,&nbsp;Yves Hatchuel ,&nbsp;Christophe Deligny ,&nbsp;Benoit Suzon","doi":"10.1016/j.jbspin.2024.105821","DOIUrl":"10.1016/j.jbspin.2024.105821","url":null,"abstract":"<div><h3>Introduction</h3><div>The continuum in Still's disease has never been addressed in Afro-descendant (AD) populations. The aim of this study was to compare the features of Still's disease between children and adults in the AD population of French West Indies (FWI).</div></div><div><h3>Methods</h3><div>Retrospective longitudinal study from January 2000–2022. We included children and adults with systemic juvenile idiopathic arthritis and Still's disease. Clinical data were obtained from computerized hospital archives, registries of clinicians and the national registry for rare diseases. The main outcome was similarity in cardinal and non-cardinal symptoms.</div></div><div><h3>Results</h3><div>Fifty-eight patients were included (57% adults). Sex distribution between children and adults was significantly different (Female respectively 36% vs 70.6%, <em>P</em> <!-->=<!--> <!-->0.03). Diagnostic criteria overlapped in most cases (80%), regardless of age. The children had significantly more typical skin rashes (100% vs 29.4%, <em>P</em> <!-->&lt;<!--> <!-->0.001), coronary artery dilation (16% vs 0%, <em>P</em> <!-->=<!--> <!-->0.03), and macrophage activation syndrome (52% vs 9%, <em>P</em> <!-->&lt;<!--> <!-->0.001). The adults had significantly more inflammatory polyarthalgia without arthritis (91% vs 32% <em>P</em> <!-->&lt;<!--> <!-->0.001) and pulmonary involvement (51.5% vs 4% <em>P</em> <!-->&lt;<!--> <!-->0.001). The phenotypes were 86% systemic (43% monophasic, 43% polycyclic) and 14% chronic polyarticular. No difference was found in the number of relapses, use of biologics and mortality.</div></div><div><h3>Conclusions</h3><div>There is a rationale for considering Still's disease as a single entity in our AD population, focusing on the cardinal symptoms, but particular attention should be paid to the non-cardinal symptoms depending on the age of onset.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105821"},"PeriodicalIF":3.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleural Irregularities: A new ultrasound marker for lung involvement in primary Sjögren's disease","authors":"Francesco Ferro ,&nbsp;Gaetano La Rocca ,&nbsp;Elena Elefante ,&nbsp;Gianluca Sambataro ,&nbsp;Alessandra Tripoli ,&nbsp;Gianmaria Governato ,&nbsp;Giovanni Fulvio ,&nbsp;Michele Moretti ,&nbsp;Alessandra Bulleri ,&nbsp;Chiara Romei ,&nbsp;Marta Mosca ,&nbsp;Chiara Baldini","doi":"10.1016/j.jbspin.2024.105820","DOIUrl":"10.1016/j.jbspin.2024.105820","url":null,"abstract":"<div><h3>Objectives</h3><div>Lung ultrasound (LUS) has been proposed as a useful tool for the assessment of interstitial lung disease (ILD) in connective tissue diseases. However, there are no studies investigating the significance of pleural irregularities (PI) on LUS in primary Sjögren's disease (SjD) patients. The aim of this study was to explore the role of PI for the assessment of SjD-related lung involvement.</div></div><div><h3>Methods</h3><div>All primary SjD patients who had undergone a chest CT-scan in the lasts 2 months from the start of the study were enrolled, including both SjD patients with known ILD and SjD patients without known lung involvement who underwent a chest CT due to clinical indications other than ILD screening. LUS was performed for all patients and PI total and partial scores were assigned from 0 (normal) to 2 (major changes). Based on CT-scans results SjD patients were divided into 5 groups: normal CT-scan, non SjD-related lung abnormalities, SjD-related non-ILD lung abnormalities, established ILD, newly diagnosed ILD.</div></div><div><h3>Results</h3><div>Nineteen SjD patients with established ILD and 42 without known lung involvement who had undergone a CT-scan were included. Among the latter, CT allowed the diagnosis of 4 new ILD cases. Both total and postero-inferior PI scores were comparable between established ILD and newly diagnosed ILD patients and significantly higher compared to patients with normal CT-scan and SjD related non-ILD lung abnormalities. The AUC for ILD diagnosis was significantly higher for the PI postero-inferior score compared to the PI total score. A cut-off score of 15 for the PI postero-inferior score resulted in a sensitivity of 86.6% and specificity of 84.2% for SjD-ILD diagnosis. Both PI total and postero-inferior scores strongly correlated with HRCT Warrick score (<em>r</em> <!-->=<!--> <!-->0.809 and <em>r</em> <!-->=<!--> <!-->0.854). The correlation between PFT and both total and postero-inferior PI scores was higher than that observed between PFT and the Warrick HRCT score.</div></div><div><h3>Conclusions</h3><div>PI may represent a valid tool for the assessment of lung involvement in SjD, particularly for the screening of ILD. PI assessment limited to postero-inferior lung fields seem to maintain good diagnostic accuracy, allowing to save time in clinical practice.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105820"},"PeriodicalIF":3.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is a severe axial spondyloarthritis?","authors":"Félicie Costantino ,&nbsp;Maxime Breban ,&nbsp;Maria-Antonietta D’Agostino","doi":"10.1016/j.jbspin.2024.105814","DOIUrl":"10.1016/j.jbspin.2024.105814","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105814"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry","authors":"Jurgen Sota ,&nbsp;Gaafar Ragab ,&nbsp;Ibrahim AlMaglouth ,&nbsp;Giuseppe Lopalco ,&nbsp;Abdurrahman Tufan ,&nbsp;Haner Direskeneli ,&nbsp;Andrea Hinojosa-Azaola ,&nbsp;Henrique Ayres Mayrink Giardini ,&nbsp;Silvana Guerriero ,&nbsp;Paola Triggianese ,&nbsp;Petros P. Sfikakis ,&nbsp;Matteo Piga ,&nbsp;Piero Ruscitti ,&nbsp;Marcello Govoni ,&nbsp;Annamaria Iagnocco ,&nbsp;Francesco Carubbi ,&nbsp;José Hernández-Rodríguez ,&nbsp;Ahmed Hatem Laymouna ,&nbsp;Ayman Abdel-Monem Ahmed Mahmoud ,&nbsp;Mahmoud Ghanema ,&nbsp;Luca Cantarini","doi":"10.1016/j.jbspin.2024.105819","DOIUrl":"10.1016/j.jbspin.2024.105819","url":null,"abstract":"<div><h3>Objectives</h3><div>Gender impact on phenotypical expression of Behçet's disease (BD) has been specifically investigated only in a few large-scale studies. The main goal of the study was to examine gender differences in a large cohort of patients affected by BD.</div></div><div><h3>Methods</h3><div>Data were retrieved from the International AIDA Network Registry for BD. We assessed differences between males and females in terms of Behçet's syndrome Overall Damage Index (BODI), differences in the disease manifestations at onset and in the cumulative manifestations throughout disease course, as well as differences in the cardiovascular risk. Finally, predictive factors leading to major organ involvement were investigated.</div></div><div><h3>Results</h3><div>In total, 1024 BD patients (567 males, 457 females) were enrolled in the study, with a male-to-female ratio of 1.24/1. Males displayed a significantly higher mean<!--> <!-->±<!--> <!-->SD BODI (1.92<!--> <!-->±<!--> <!-->2.09) at the last follow-up, compared to female patients (1.25<!--> <!-->±<!--> <!-->1.87) (<em>P</em> <!-->&lt;<!--> <!-->0.0001). Uveitis (<em>P</em> <!-->&lt;<!--> <!-->0.0001) and vascular involvement (<em>P</em> <!-->=<!--> <!-->0.0076) were significantly more frequent among males whereas female patients were significantly over-represented in arthralgia (<em>P</em> <!-->&lt;<!--> <!-->0.0001), arthritis (<em>P</em> <!-->=<!--> <!-->0.00025), isolated headache (<em>P</em> <!-->&lt;<!--> <!-->0.0001), central nervous system (CNS) involvement (<em>P</em> <!-->=<!--> <!-->0.040), and gastrointestinal involvement (<em>P</em> <!-->=<!--> <!-->0.00046). Regarding cardiovascular risk, no differences between the two groups emerged (<em>P</em> <!-->=<!--> <!-->0.617). Four variables were associated with the development of major organ involvement: male gender (OR<!--> <!-->=<!--> <!-->2.104, <em>P</em> <!-->=<!--> <!-->0.001), current treatment with biologic agents (OR<!--> <!-->=<!--> <!-->2.257, <em>P</em> <!-->=<!--> <!-->0.0003), origin from endemic countries (OR<!--> <!-->=<!--> <!-->2.661, <em>P</em> <!-->=<!--> <!-->0.0009), and disease duration (OR<!--> <!-->=<!--> <!-->1.002, <em>P</em> <!-->=<!--> <!-->0.024).</div></div><div><h3>Conclusion</h3><div>BD displays a more severe course among males. This subgroup develops more irreversible damage and presents more frequently ocular and vascular involvement during disease course. On the other hand, female patients are prone to experience articular involvement, headache, CNS and gastrointestinal involvement. These data suggest the existence of a gender-driven disease expression.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105819"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive tophaceous gout with subcutaneous deposits in the buttocks","authors":"Chen Li ,&nbsp;Fanzhang Meng ,&nbsp;Bohan Hu ,&nbsp;Zixuan Shu ,&nbsp;Zhimin Lin ,&nbsp;Shengguang Li","doi":"10.1016/j.jbspin.2024.105816","DOIUrl":"10.1016/j.jbspin.2024.105816","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105816"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal barrier biomarkers in adult patients with juvenile idiopathic arthritis in transition","authors":"Sophie Hecquet ,&nbsp;Marion Thomas ,&nbsp;Eleonore Parisel ,&nbsp;Alice Combier ,&nbsp;Julien Wipff ,&nbsp;Anne Cauvet ,&nbsp;Gertrude Touanga Ngoti ,&nbsp;Frank Verhoeven ,&nbsp;Céline Demougeot ,&nbsp;Pierre Quartier ,&nbsp;Jérôme Avouac ,&nbsp;Yannick Allanore","doi":"10.1016/j.jbspin.2024.105817","DOIUrl":"10.1016/j.jbspin.2024.105817","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105817"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate osteopathy","authors":"Daniel Wendling,&nbsp;Mickael Chouk,&nbsp;Olivier Fakih,&nbsp;Frank Verhoeven,&nbsp;Clément Prati","doi":"10.1016/j.jbspin.2024.105813","DOIUrl":"10.1016/j.jbspin.2024.105813","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105813"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From a better knowledge of periodontal disease to Porphyromonas gingivalis target for rheumatoid arthritis disease activity","authors":"Elisa Dalix ,&nbsp;Hubert Marotte","doi":"10.1016/j.jbspin.2024.105822","DOIUrl":"10.1016/j.jbspin.2024.105822","url":null,"abstract":"<div><div>Periodontal disease (PD) and rheumatoid arthritis (RA) are both inflammatory diseases affecting the tooth and joint, with local inflammation associated with bone loss. Bacterial infections by oral bacteria are involved in periodontal inflammation, and the best known to be associated with PD is <em>Porphyromonas gingivalis</em> (<em>Pg</em>). A large body of recent data suggests a strong involvement of this specific bacteria, <em>Pg</em>, in PD outcomes, but also in RA. The aim of this review is to discuss the association between PD and <em>Pg</em>, RA and its mechanisms, and to determine whether targeting <em>Pg</em> bacteria could improve RA. Numerous epidemiological studies have already confirmed the association between PD and <em>Pg</em>, as well as between PD and RA, which is mainly associated with a common genetic background, the shared epitope. The involvement of <em>Pg</em> in pathogenesis of RA is supported by the induction of gingival citrullinated proteins and therefore of anti-citrullinated proteins antibodies, which constitute the most specific biomarker of RA. The prevalence of <em>Pg</em> in RA is still controversial, but studies should include patients with preclinical and early RA. Finally, recent data confirmed that targeting <em>Pg</em> is highly effective in improving RA.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105822"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shoulder calcifications associated with a fracture","authors":"Victoire Roblot ,&nbsp;Jules Descamps ,&nbsp;Alan Gauffenic","doi":"10.1016/j.jbspin.2024.105815","DOIUrl":"10.1016/j.jbspin.2024.105815","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105815"},"PeriodicalIF":3.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}