Joint Bone Spine最新文献

{"title":"Lipid profile and NT-proBNP changes from pre-clinical to established rheumatoid arthritis: A 12 years follow-up explorative study","authors":"Reinder Raadsen ,&nbsp;Bas Dijkshoorn ,&nbsp;Laurette van Boheemen ,&nbsp;Edwin ten Boekel ,&nbsp;Arno W.R. van Kuijk ,&nbsp;Michael T. Nurmohamed","doi":"10.1016/j.jbspin.2023.105683","DOIUrl":"10.1016/j.jbspin.2023.105683","url":null,"abstract":"<div><h3>Objectives</h3><p>The aim of the current study was to explore the changes in lipid and NT-proBNP levels in rheumatoid arthritis (RA) patients through different phases of the disease: from the pre-clinical stage and RA onset up to the treatment phase with biological disease-modifying anti-rheumatic drugs (bDMARDS).</p></div><div><h3>Methods</h3><p>Thirty-eight consecutive patients, initially with arthralgia and rheumatoid factor and/or anti-citrullinated protein antibodies without arthritis, who later developed RA and eventually started treatment with bDMARDs, were included. Lipid spectrum and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were measured longitudinally from several months before diagnosis through treatment with bDMARDs.</p></div><div><h3>Results</h3><p>From baseline, C-reactive protein (CPR) initially increased sharply, decreasing with the start of biological treatment. Low-density lipoprotein-cholesterol (LDL-c) remained stable, high-density lipoprotein-cholesterol (HDL-c) increased, apolipoprotein A1 (ApoA1 and lipoprotein (a) (Lp(a)), and total cholesterol (TC)/HDL-c ratio and apolipoprotein B (ApoB) decreased during follow-up. NT-proBNP closely followed progression of CRP. TC, LDL-c, TC/HDL-c ratio, ApoA and ApoB inverse correlated with CRP, while Lp(a) positively correlated. HDL-c and triglycerides showed no correlation.</p></div><div><h3>Conclusion</h3><p>Changes in the lipid profile and NT-proBNP in RA patients seem to be related to inflammation, with changes reflecting an increase in CVD risk occurring along with rises in CRP levels. These changes seem to already be present at diagnosis, indicating the need for timely control of inflammation.</p></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1297319X23001628/pdfft?md5=d713e06862741ae60129bcb025f30a84&pid=1-s2.0-S1297319X23001628-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139065597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular B-cell clonality assay in minor salivary glands as a useful tool for the lymphoma risk assessment in Sjögren's syndrome","authors":"Audrey Benyamine ,&nbsp;Antoine Poulet ,&nbsp;Pauline Belenotti ,&nbsp;Hugo Nihous ,&nbsp;Nicoleta Ene ,&nbsp;Pierre André Jarrot ,&nbsp;Laure Swiader ,&nbsp;Julien Mancini ,&nbsp;Nathalie Beaufils ,&nbsp;Arnaud Essaydi ,&nbsp;Jean Gabert ,&nbsp;Pierre Jean Weiller ,&nbsp;Gilles Kaplanski","doi":"10.1016/j.jbspin.2023.105686","DOIUrl":"10.1016/j.jbspin.2023.105686","url":null,"abstract":"<div><h3>Objectives</h3><p>Non-Hodgkin's lymphoma (NHL) risk assessment is crucial in Sjögren's syndrome (SS). We studied the prevalence of clonal immunoglobulin gene rearrangements in minor salivary glands (MSG) and their correlations with lymphoma occurrence and with previously established NHL predictors.</p></div><div><h3>Methods</h3><p>Molecular B-cell expansion was studied in fresh-frozen MSG of 207 patients with either suspected SS or with suspected lymphoma during SS, using a standardised multiplex PCR assay combined with heteroduplex analysis by microcapillary electrophoresis. The assignation of clonal cases was based on EuroClonality consortium guidelines.</p></div><div><h3>Results</h3><p>Among 207 studied patients, 31 (15%) had MSG monoclonal B-cell infiltration. Monoclonality was significantly more frequent in patients with SS (28/123, 22.8%) compared with patients without SS (3/84, 3.6%, <em>P</em> <!-->&lt;<!--> <!-->0.001). Monoclonal B-cell infiltration in MSG of SS patients correlated significantly with ongoing salivary gland NHL, salivary gland swelling, CD4⁺ T-cell lymphopenia, rheumatoid factor (RF) activity, low complement levels and type 2 mixed cryoglobulinemia. The accumulation of biological risk factors was associated with a higher rate of MSG B-cell monoclonality given that patients with only positive RF had no probability of MSG B-cell monoclonality, RF-positive patients with 1 or 2 other risk factors had a 25.0% and 85.7% probability of MSG B-cell monoclonality, respectively.</p></div><div><h3>Conclusion</h3><p>The detection of MSG monoclonal B-cell expansion by this easy-to-perform molecular assay is useful, both at the time of diagnosis and during the course of SS. Monoclonal B-cell expansion is associated with a subset of SS patients presenting either ongoing lymphoma or other established lymphoma predictive factors.</p></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139065649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fibrodysplasia ossificans progressiva patient with a rare missense mutation in ACVR1 detected on 18F-FDG PET/CT","authors":"Haopeng Ni,&nbsp;Songhan Tang,&nbsp;Ying Zhang","doi":"10.1016/j.jbspin.2023.105682","DOIUrl":"10.1016/j.jbspin.2023.105682","url":null,"abstract":"<div><p>Fibrodysplasia ossificans progressiva (FOP) is an exceedingly rare human genetic disorder characterized by the progressive and incapacitating formation of ectopic bone outside the skeleton. We report a case of FOP patient with mutations within the <em>ACVR1</em> gene (c.982G<!--> <!-->&gt;<!--> <!-->A; p.G328R). ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT) was carried out for disease assessment. Previous studies have shown increased FDG uptake in regions of heterotopic ossification (HO) in FOP. However, in our study, the PET/CT features demonstrate that active ossificans exhibit increased ¹⁸F-FDG uptake, whereas end-stage ossifications do not. Collectively, ¹⁸F-FDG PET/CT emerges as a prospective approach to evaluate medication efficacy in the early stages, directing early intervention and pharmacological management of FOP before ossifications formation.</p></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139071912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"J-shaped association of serum uric acid concentrations with all-cause mortality in individuals with osteoarthritis: A prospective cohort study","authors":"Jinlong Zhao ,&nbsp;Bangxin Sha ,&nbsp;Lingfeng Zeng ,&nbsp;Yaoxing Dou ,&nbsp;Hetao Huang ,&nbsp;Guihong Liang ,&nbsp;Jianke Pan ,&nbsp;Kunhao Hong ,&nbsp;Guanghui Zhou ,&nbsp;Weiyi Yang ,&nbsp;Jun Liu","doi":"10.1016/j.jbspin.2023.105679","DOIUrl":"10.1016/j.jbspin.2023.105679","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this study was to explore the relationship between serum uric acid (SUA) concentrations and all-cause mortality in individuals with osteoarthritis (OA).</p></div><div><h3>Methods</h3><p>All participant data were retrieved from the National Health and Nutrition Examination Survey database. A total of 4671 participants (age range: 20 to 85 years old), including 2988 females and 1683 males, were included in this study. The determination of death outcome was based on the National Death Index (up to December 31, 2019). We explored the nonlinear relationship between SUA concentrations and all-cause mortality in OA patients by establishing a Cox proportional risk model and a two-segment Cox proportional risk model and ran an interaction test to identify the high-risk population for all-cause mortality.</p></div><div><h3>Results</h3><p>During 30,645 person-years of follow-up, the number of all-cause deaths for females and males was 736 and 516, respectively. After multivariate adjustment, we found a nonlinear relationship between SUA concentrations and all-cause mortality in both females and males with OA. In addition, we found a J-shaped relationship between SUA concentrations and all-cause mortality. The SUA concentration thresholds for all-cause mortality of females and males were stable at 5.6<!--> <!-->mg/dl and 6.2<!--> <!-->mg/dl, respectively. Compared with SUA concentrations below the inflection point, the all-cause mortality risk at higher SUA concentrations in females and males with OA increased by 20% (hazard ratio [HR]: 1.2, 95% confidence interval [CI]: 1.1 to 1.2) and 25% (HR: 1.2, 95% CI: 1.12 to 1.39), respectively.</p></div><div><h3>Conclusions</h3><p>There is a nonlinear relationship between SUA concentrations and all-cause mortality in the American OA population (J-shaped association). The all-cause mortality thresholds for SUA concentrations in females and males are 5.6<!--> <!-->mg/dl and 6.2<!--> <!-->mg/dl, respectively.</p></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1297319X23001586/pdfft?md5=f5bd39fa79cb04adaa112795843fa9b4&pid=1-s2.0-S1297319X23001586-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"J-shaped association of serum uric acid concentrations with all-cause mortality in individuals with osteoarthritis: A prospective cohort study","authors":"Jinlong Zhao, Bangxin Sha, Lingfeng Zeng, Yaoxing Dou, Hetao Huang, Guihong Liang, Jianke Pan, Kunhao Hong, Guanghui Zhou, Weiyi Yang, Jun Liu","doi":"10.1016/j.jbspin.2023.105679","DOIUrl":"https://doi.org/10.1016/j.jbspin.2023.105679","url":null,"abstract":"<p>Objective: The purpose of this study was to explore the relationship between serum uric acid (SUA) concentrations and all-cause mortality in individuals with osteoarthritis (OA).</p><p>Methods: All participant data were retrieved from the National Health and Nutrition Examination Survey database. A total of 4671 participants (age range: 20 to 85 years old), including 2988 females and 1683 males, were included in this study. The determination of death outcome was based on the National Death Index (up to December 31, 2019). We explored the nonlinear relationship between SUA concentrations and all-cause mortality in OA patients by establishing a Cox proportional risk model and a two-segment Cox proportional risk model and ran an interaction test to identify the high-risk population for all-cause mortality.</p><p>Results: During 30,645 person-years of follow-up, the number of all-cause deaths for females and males was 736 and 516, respectively. After multivariate adjustment, we found a nonlinear relationship between SUA concentrations and all-cause mortality in both females and males with OA. In addition, we found a J-shaped relationship between SUA concentrations and all-cause mortality. The SUA concentration thresholds for all-cause mortality of females and males were stable at 5.6 mg/dl and 6.2 mg/dl, respectively. Compared with SUA concentrations below the inflection point, the all-cause mortality risk at higher SUA concentrations in females and males with OA increased by 20% (hazard ratio [HR]: 1.2, 95% confidence interval [CI]: 1.1 to 1.2) and 25% (HR: 1.2, 95% CI: 1.12 to 1.39), respectively.</p><p>Conclusions: There is a nonlinear relationship between SUA concentrations and all-cause mortality in the American OA population (J-shaped association). The all-cause mortality thresholds for SUA concentrations in females and males are 5.6 mg/dl and 6.2 mg/dl, respectively.</p>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139020426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucocorticoid treatment and clinical outcomes in patients with polymyalgia rheumatica: A cohort study using routinely collected health data","authors":"Yoshiya Tanaka ,&nbsp;Shinichi Tanaka ,&nbsp;Toshiki Fukasawa ,&nbsp;Shoichiro Inokuchi ,&nbsp;Hidetoshi Uenaka ,&nbsp;Takeshi Kimura ,&nbsp;Toshiya Takahashi ,&nbsp;Naoto Kato","doi":"10.1016/j.jbspin.2023.105680","DOIUrl":"10.1016/j.jbspin.2023.105680","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to describe the following in patients with polymyalgia rheumatica (PMR): (1) real-world glucocorticoid (GC) therapy, (2) improvement in inflammatory parameters associated with disease activity (C-reactive protein [CRP] level and erythrocyte sedimentation rate [ESR]), and (3) incidence of GC-related adverse events (AEs).</p></div><div><h3>Methods</h3><p>A cohort study was conducted using a Japanese electronic medical records database. We included newly diagnosed PMR patients aged<!--> <!-->≥<!--> <!-->50<!--> <!-->years with baseline CRP levels<!--> <!-->≥<!--> <!-->10<!--> <!-->mg/L and/or ESR<!--> <!-->&gt;<!--> <!-->30<!--> <!-->mm/h and an initial GC dose of<!--> <!-->≥<!--> <!-->5<!--> <!-->mg/day. The outcomes were GC dose, inflammatory parameters, and GC-related AEs.</p></div><div><h3>Results</h3><p>A total of 373 PMR patients (mean age, 77.3 years) were analyzed. The median initial GC dose was 15.0<!--> <!-->mg/day, which gradually decreased to 3.5<!--> <!-->mg/day by week 52. The median cumulative GC dose at week 52 was 2455.0<!--> <!-->mg. The median CRP level on day 0 was 64.3<!--> <!-->mg/L, which decreased during weeks 4–52 (1.4–3.2<!--> <!-->mg/L). At week 52, 39.0% of patients had a CRP level<!--> <!-->&gt;<!--> <!-->3.0<!--> <!-->mg/L. The cumulative incidence of GC-related AEs at week 52 was 49.0% for osteoporosis, 30.2% for diabetes, 14.9% for hypertension, 12.2% for peptic ulcer, 11.3% for dyslipidemia, 2.9% for glaucoma, and 4.3% for serious infection. The incidence of osteoporosis and diabetes increased with the GC dose.</p></div><div><h3>Conclusion</h3><p>The incidence of GC-related AEs was associated with the GC dose in PMR patients. Further research is required to identify treatment strategies that can effectively control PMR disease activity while minimizing GC use.</p></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1297319X23001598/pdfft?md5=a8e69bc31ac4c2c1389618a81c760ec5&pid=1-s2.0-S1297319X23001598-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139020378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating social and economic status in rheumatoid arthritis exposure studies","authors":"Johanna Sigaux ,&nbsp;Luca Semerano ,&nbsp;Marie-Christophe Boissier","doi":"10.1016/j.jbspin.2023.105677","DOIUrl":"10.1016/j.jbspin.2023.105677","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138886565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac conduction disorders in ankylosing spondylitis: A systematic literature review and meta-analyses of controlled studies","authors":"Mickaël Dalecky ,&nbsp;Tiphaine Dujardin ,&nbsp;Arnaud Pflimlin ,&nbsp;Athan Baillet ,&nbsp;Xavier Romand","doi":"10.1016/j.jbspin.2023.105676","DOIUrl":"10.1016/j.jbspin.2023.105676","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138683827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thalassemia skull","authors":"Parag Vijaysingh Patil","doi":"10.1016/j.jbspin.2023.105675","DOIUrl":"10.1016/j.jbspin.2023.105675","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138683828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facet joint involvement in the inflammatory rheumatic disease","authors":"Arsen Shpigelman ,&nbsp;Aniela Shouval ,&nbsp;Ilai Koder ,&nbsp;Shiri Keret ,&nbsp;Gleb Slobodin","doi":"10.1016/j.jbspin.2023.105674","DOIUrl":"10.1016/j.jbspin.2023.105674","url":null,"abstract":"<div><h3>Background</h3><p>The involvement of facet joints (FJ) in patients with inflammatory rheumatic disorders remains underexplored. This review aims to look at FJ disease from a rheumatologist's perspective, with the emphasis given to the clinical presentations and patterns of FJ engagement in axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), rheumatoid arthritis (RA), and crystal-related arthropathies, and discussion of challenges in studying FJ in rheumatic disease.</p></div><div><h3>Methods</h3><p>A systematic PubMed search using the pertinent keywords was performed, relevant articles extracted, and the acquired data critically assessed, interpreted, and organized according to the authors’ experience and judgment.</p></div><div><h3>Results</h3><p>FJ involvement is common in patients with radiographic axSpA, occurs throughout the spine, but is more frequently seen in the thoracic segment. The existing data suggests that the FJ are primarily affected by the disease process, while altered spine biomechanics due to the presence of syndesmophytes at the same vertebral level contributes to the FJ fusion. Predominant involvement of FJ of the cervical spinal segment has been suggested in PsA; however, prevalence and clinical significance of FJ involvement in PsA is still markedly underexplored. RA-related FJ disease of the cervical spine in patients with poorly controlled RA is not uncommon and can be related to significant morbidity, while the burden of FJ involvement in the thoracic and lumbar spinal segments in RA is also underexplored. FJ disease is possible in the course of crystal-related arthropathies, but the high level of suspicion is a prerequisite for the timely diagnosis.</p></div><div><h3>Conclusions</h3><p>The involvement of FJ in the course of inflammatory rheumatic disease is not uncommon. Prospective studies are needed to understand the epidemiology and significance of FJ disease in inflammatory rheumatic conditions.</p></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138684497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}