Joint Bone Spine最新文献

{"title":"Clinical enthesitis in patient with psoriatic arthritis, a systematic literature review with meta-analysis","authors":"Caroline Pignon ,&nbsp;Noémie Bibas ,&nbsp;Clementina Lopez-Medina ,&nbsp;Bruno Fautrel ,&nbsp;Laure Gossec","doi":"10.1016/j.jbspin.2024.105807","DOIUrl":"10.1016/j.jbspin.2024.105807","url":null,"abstract":"<div><h3>Objectives</h3><div>Enthesitis is considered a hallmark of psoriatic arthritis (PsA). The objective was to assess clinical enthesitis in PsA including its prevalence in different contexts, scores used and consequences of enthesitis.</div></div><div><h3>Methods</h3><div>A systematic literature review with meta-analysis was conducted in PubMed 2010–2023, focusing on manuscripts involving adult PsA patients and reporting information related to enthesitis. Data collected included the prevalence of clinical enthesitis (i.e., number of patients with at least one enthesitis); scores used: Leeds Enthesitis Index (LEI), MASES, SPARCC; and impact of enthesitis on disease activity, patient-reported outcomes and use of analgesics. Univariate random-effects meta-analysis was applied for pooling percentages and means.</div></div><div><h3>Results</h3><div>Overall, 212 studies, i.e., 84,262 PsA patients were analyzed. The pooled prevalence of enthesitis in the overall population was 41.6% [95% confidence interval, 37.4–45.8]; with 67.2% [62.0–72.6] in trials and 27.8% [24.5–31.2] in observational studies. The number of enthesitis varied according to the score used, with the lowest observed for the LEI, which was the most widely-used score (63.7%). Patients with enthesitis had higher disease activity and disease burden in comparison with those without enthesitis.</div></div><div><h3>Conclusion</h3><div>Enthesitis is a frequent manifestation in PsA, concerning close to half the patients, and is more prevalent in trials than in observational studies, reflecting recruitment patterns. The clinical assessment of enthesitis remains challenging, with heterogeneity in the scores used influencing the results: the most used score was the LEI, which also led to the lowest number of enthesitis. Links with patients’ quality of life should be further explored.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105807"},"PeriodicalIF":3.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone sarcoidosis: Extensive hand lesions","authors":"Lilia Nacef ,&nbsp;Johanna Sigaux ,&nbsp;Elodie Rivière ,&nbsp;Luca Semerano ,&nbsp;Hilario Nunes ,&nbsp;Nathalie Saidenberg-Kermanac’h","doi":"10.1016/j.jbspin.2024.105805","DOIUrl":"10.1016/j.jbspin.2024.105805","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105805"},"PeriodicalIF":3.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood-onset versus adult-onset Takayasu arteritis: A study of 239 patients from China","authors":"Fang Kong ,&nbsp;Yingjie Xu ,&nbsp;Xu Huang ,&nbsp;Jianming Lai ,&nbsp;Yi Zhao","doi":"10.1016/j.jbspin.2024.105806","DOIUrl":"10.1016/j.jbspin.2024.105806","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to compare clinical features, vascular involvement, disease activity, and management between Chinese patients with childhood-onset Takayasu arteritis (cTAK) and adult-onset Takayasu arteritis (aTAK).</div></div><div><h3>Methods</h3><div>In total, 239 patients with TAK from the pediatric and adult rheumatology departments of two tertiary care centers were retrospectively evaluated. Data on demographic characteristics, laboratory results, disease activity, vascular involvement, and management regimens were collected and compared between the cTAK and aTAK patients.</div></div><div><h3>Results</h3><div>In total, 85 cTAK and 154 aTAK patients were enrolled. There was a significant difference in the female/male ratio between the cTAK and aTAK groups (2.3:1 vs. 10.8:1, <em>P</em> <!-->&lt;<!--> <!-->0.001). Fever, hypertension, arrhythmia, and heart failure were more frequent in the cTAK group. The median Indian Takayasu Clinical Activity Score-scores were significantly higher in the cTAK group compared to the aTAK group (5 vs. 3, <em>P</em> <!-->=<!--> <!-->0.004). The prevalence of supra-aortic artery involvement was significantly higher in the aTAK group than in the cTAK group (<em>P</em> <!-->&lt;<!--> <!-->0.05). The rate of involvement of coronary and renal arteries was significantly lower in the aTAK group than in the cTAK group (<em>P</em> <!-->&lt;<!--> <!-->0.05). Compared to the aTAK patients, the cTAK patients were more likely to be treated with biological agents (76.5% vs. 9.1%, <em>P</em> <!-->&lt;<!--> <!-->0.001).</div></div><div><h3>Conclusion</h3><div>cTAK patients had more severe disease and inflammation. Coronary and renal artery involvement was more common among cTAK patients, whereas supra-aortic artery involvement was more common in aTAK patients increasing their risk of cerebral infarction. Biologics were used more frequently in cTAK patients.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105806"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-onset axial spondyloarthritis: A multicentre nationwide study","authors":"Margarida Lucas Rocha ,&nbsp;Sofia Ramiro ,&nbsp;Rita Pinheiro Torres ,&nbsp;Alice Castro ,&nbsp;Alice Neves ,&nbsp;Ana Martins ,&nbsp;Ana Teodósio Chícharo ,&nbsp;Beatriz Mendes ,&nbsp;Carolina Ochôa Matos ,&nbsp;Catarina Soares ,&nbsp;Cláudia Miguel ,&nbsp;Cláudia Pinto Oliveira ,&nbsp;Hugo Parente ,&nbsp;José Melo Gomes ,&nbsp;Mariana Luís ,&nbsp;Mariana Emília Santos ,&nbsp;Maura Couto ,&nbsp;Miguel Bernardes ,&nbsp;Paula Valente ,&nbsp;Roberto Pereira da Costa ,&nbsp;Alexandre Sepriano","doi":"10.1016/j.jbspin.2024.105804","DOIUrl":"10.1016/j.jbspin.2024.105804","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 1","pages":"Article 105804"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is a periprosthetic fracture a fragility fracture like another?","authors":"Victoria Houel ,&nbsp;Cécile Philippoteaux ,&nbsp;Julien Paccou","doi":"10.1016/j.jbspin.2024.105802","DOIUrl":"10.1016/j.jbspin.2024.105802","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 1","pages":"Article 105802"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can the patient global assessment of disease activity help to discriminate inflammatory and non-inflammatory refractoriness in early rheumatoid arthritis?","authors":"Bernardo D’Onofrio ,&nbsp;Elise van Mulligen ,&nbsp;Serena Bugatti ,&nbsp;Annette van der Helm-van Mil","doi":"10.1016/j.jbspin.2024.105803","DOIUrl":"10.1016/j.jbspin.2024.105803","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105803"},"PeriodicalIF":3.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seronegative rheumatoid arthritis: Neglected in clinical trials, a giant in clinical practice","authors":"Serena Bugatti ,&nbsp;Carlomaurizio Montecucco","doi":"10.1016/j.jbspin.2024.105800","DOIUrl":"10.1016/j.jbspin.2024.105800","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 1","pages":"Article 105800"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxychloroquine and Sjögren's disease: current evidences for its use","authors":"Marlon J. Sandino-Bermúdez,&nbsp;Gabriela Hernández-Molina","doi":"10.1016/j.jbspin.2024.105799","DOIUrl":"10.1016/j.jbspin.2024.105799","url":null,"abstract":"<div><div>About 25–50% of patients with primary Sjögren's disease (SjD) take hydroxychloroquine (HCQ). Although it is widely prescribed, and recommended in international guidelines, its use is mostly based on expert opinion and personal experience. Our aim was to provide a comprehensive overview of the pathogenic mechanisms of HCQ, the current clinical evidence for its use, and its safety in primary SjD. HCQ plays an immunomodulatory and anti-inflammatory role, mainly by regulating some interferon proteins, chemokines, BAFF levels, and by modifying gut microbiota. It decreases immunoglobulins and ESR levels. In a Latin-American cohort, the main indications were arthritis, parotid gland enlargement and sicca-only symptoms. In the clinical setting, most studies showing a positive effect of HQC are open trials or retrospective cohorts. Some of these studies may be biased due to the use of non-validated outcomes, and a placebo response effect. To date, only 3 RCTs have investigated the benefits of HCQ, the JOQUER being the pivotal one. This study failed to improve oral/ocular symptoms or ESSDAI score. However, a re-analysis by symptomatology subgroups detected some differences in the ESSPRI. Recently, promising data from a small phase II RCT of the combination of HCQ/leflunomide was reported, but results should be replicated. Currently, the NECESSITY study is investigating treatment combinations that will provide new insights. In the meantime, HCQ plays a central role in the treatment of SjD due to its excellent benefit-risk profile. Data on damage accrual, quality of life, mortality and prevention of cardiovascular risks are also still lacking.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 1","pages":"Article 105799"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatrics hyperuricemia in clinical practice: A retrospective analysis in 1753 children and adolescents with hyperuricemia","authors":"Blanka Stiburkova ,&nbsp;Marketa Lukesova ,&nbsp;Jiri Zeman","doi":"10.1016/j.jbspin.2024.105796","DOIUrl":"10.1016/j.jbspin.2024.105796","url":null,"abstract":"<div><h3>Objectives</h3><div>Serum levels of uric acid (S-UA) are influenced by the interaction of genetic and environmental factors; detailed studies of hyperuricemia in children are rare. This retrospective study aimed to analyze the causes, risk factors, and therapeutic approaches associated with the development of hyperuricemia in childhood.</div></div><div><h3>Methods</h3><div>In a single-center study, serum uric acid levels were analyzed in 33,900 samples from 13,890 children and adolescents<!--> <!-->&lt;<!--> <!-->19 years (6760 girls and 7130 boys) obtained between 2013 and 2023. Hyperuricemia was defined as S-UA<!--> <!-->&gt;<!--> <!-->370<!--> <!-->μmol/L (6.22<!--> <!-->mg/dL) in girls and<!--> <!-->&gt;<!--> <!-->420<!--> <!-->μmol/L (7.06<!--> <!-->mg/dL) in boys; mild hyperuricemia was defined as 370–420<!--> <!-->μmol/L in boys<!--> <!-->&lt;<!--> <!-->13 years.</div></div><div><h3>Results</h3><div>In the analyzed group, hyperuricemia was found in 1753 patients (12.6%), including 586 girls and 864 boys; mild hyperuricemia was found in 303 boys<!--> <!-->&lt;<!--> <!-->13 years. The most common associated conditions were obesity with body mass index<!--> <!-->&gt;<!--> <!-->95th percentile (27.8% of girls, 26.3% of boys) and chronic kidney disease (18.6% of boys, 11.4% of girls). Hyperuricemia was also relatively common in children with connective tissue disorders (10.6%) or different inherited metabolic disorders (10.7%). Transitory hyperuricemia was found in 19.1% of girls and 10.1% of boys with acute gastroenteritis. Urate-lowering therapy was used in 73 children and adolescents with severe hyperuricemia (S-UA 556<!--> <!-->±<!--> <!-->107<!--> <!-->μmol/L, fraction excretion of UA 3.27<!--> <!-->±<!--> <!-->1.98%). Eight treated children had chronic kidney disease, nine were extremely obese, one had combined antiepileptic therapy, and 55 had inherited metabolic diseases, including 26 children with disorders of purine metabolism. The initial daily dose of allopurinol (50–100<!--> <!-->mg) normalized the S-UA (350<!--> <!-->±<!--> <!-->80<!--> <!-->μmol/L) in a majority of children, except for extremely obese adolescents (weight 98–149<!--> <!-->kg) where the dose had to be increased to 200–300<!--> <!-->mg.</div></div><div><h3>Conclusions</h3><div>Asymptomatic hyperuricemia is a relatively common biochemical finding in pediatric clinical practice. The etiology of hyperuricemia should be carefully analyzed, and the value of individualized hyperuricemia management and the eventual benefits of urate-lowering therapy in children must be carefully considered.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 1","pages":"Article 105796"},"PeriodicalIF":3.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous neurostimulation parameters for neuropathic radicular pain: Results from a two period crossover randomized trial","authors":"Vincent Ducoulombier ,&nbsp;Hassane Challi ,&nbsp;Pavlos Petit ,&nbsp;Bernard Leroy ,&nbsp;Adeline Versavel ,&nbsp;Hélène Luraschi ,&nbsp;Romain Chiquet ,&nbsp;Kheira Zenati ,&nbsp;Jean-François Budzik ,&nbsp;Jean-François Desrousseaux ,&nbsp;Hichem Khenioui ,&nbsp;Anne Bera-Louville ,&nbsp;Eric Houvenagel ,&nbsp;Laurène Norberciak ,&nbsp;Tristan Pascart","doi":"10.1016/j.jbspin.2024.105797","DOIUrl":"10.1016/j.jbspin.2024.105797","url":null,"abstract":"<div><h3>Objectives</h3><div>Transcutaneous neurostimulation (TENS) is commonly used in the treatment of chronic radicular pain, but without any consensus on the type of current to be delivered. The aim of this study was to compare the conventional high-frequency, low-intensity current called c-TENS with a mixed current called m-TENS, combining c-TENS with a low-frequency, high-intensity current.</div></div><div><h3>Methods</h3><div>This was a single-blind, two-period crossover randomized trial. Included patients had chronic (≥<!--> <!-->3<!--> <!-->months), neuropathic (dn4<!--> <!-->≥<!--> <!-->4) radicular pain of at least moderate intensity (Visual Analogic Scale [VAS]<!--> <!-->≥<!--> <!-->40<!--> <!-->mm [0–100<!--> <!-->mm]). Patients were randomized to receive either c-TENS or m-TENS first, then the other, and both during one month. The primary outcome was the level of radicular pain, measured by VAS at the end of each of the two period.</div></div><div><h3>Results</h3><div>Seventy-four patients were included (mean age: 51.9<!--> <!-->±<!--> <!-->13.5<!--> <!-->years, female proportion: 65.6%). The mean duration of radicular pain was 45.2<!--> <!-->±<!--> <!-->51<!--> <!-->months and the mean radicular intensity was 67<!--> <!-->±<!--> <!-->12.5/100<!--> <!-->mm. After one month of treatment, VAS decreased to 53.9<!--> <!-->±<!--> <!-->20.1<!--> <!-->mm under c-TENS and to 53.9<!--> <!-->±<!--> <!-->21.3 under m-TENS (NS). Thirteen patients (20.3%) had a VAS<!--> <!-->&lt;<!--> <!-->40/100 with either c-TENS or m-TENS (NS). Tolerance was the same for the two modes. Twenty-nine patients (46%) designated c-TENS as the most effective mode, and 34 patients (54%) designated m-TENS.</div></div><div><h3>Conclusion</h3><div>This study shows no difference in terms of efficacy or tolerance between c-TENS and m-TENS. There is no justification for preferring one of these two modes over the other for the treatment of chronic neuropathic radicular pain.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105797"},"PeriodicalIF":3.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}