Joint Bone Spine最新文献

{"title":"Treatment of idiopathic inflammatory myopathies","authors":"Raquel Campanilho-Marques ,&nbsp;João Eurico Fonseca ,&nbsp;Pedro M. Machado","doi":"10.1016/j.jbspin.2025.105932","DOIUrl":"10.1016/j.jbspin.2025.105932","url":null,"abstract":"<div><div>Adult idiopathic inflammatory myopathies (IIMs) are rare autoimmune disorders affecting multiple organs, making diagnosis and treatment challenging. Current management relies on immunosuppressants like corticosteroids, methotrexate, azathioprine, mycophenolate mofetil, rituximab, and intravenous immunoglobulin, though treatment responses vary across patients and subtypes. Despite substantial challenges in clinical research, such as patient recruitment, misdiagnoses from overlapping symptoms with other conditions, and inconsistencies in disease classification, the growing number of myositis-specific clinical trials provides optimism. Progress in targeted therapies has the potential to refine treatment approaches, support the development of more standardized, evidence-based guidelines, and ultimately enhance patient outcomes. In this paper, we aim to provide a review of the current therapeutic options based on IIM subtypes.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105932"},"PeriodicalIF":3.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of SAPHO syndrome with wrist involvement as the first presentation and response to tofacitinib therapy","authors":"Cunhao Shan ,&nbsp;Fanzhang Meng ,&nbsp;Aijie Yuan ,&nbsp;Zhimin Lin ,&nbsp;Fan Bu ,&nbsp;Litao Zhang ,&nbsp;Chen Li","doi":"10.1016/j.jbspin.2025.105960","DOIUrl":"10.1016/j.jbspin.2025.105960","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105960"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity and mortality of inflammatory rheumatic diseases: Evolution of approaches","authors":"Chloé Bernardy ,&nbsp;Mickaël Dalecky ,&nbsp;Sarah Guillaud-Rollin ,&nbsp;Tiphaine Dujardin ,&nbsp;Romain Gastaldi ,&nbsp;Athan Baillet","doi":"10.1016/j.jbspin.2025.105931","DOIUrl":"10.1016/j.jbspin.2025.105931","url":null,"abstract":"<div><div>Chronic inflammatory rheumatic diseases include rheumatoid arthritis, spondyloarthritis and psoriatic arthritis. These diseases affect mainly joints but also have systemic involvement. Patients with chronic inflammatory rheumatic diseases have an increased risk of comorbidities, both due to disease activity and the use of treatments such as corticosteroids. Thus, a higher mortality rate was shown in these patients, particularly in RA, with a risk of premature death increased by half compared to the general population in epidemiological studies from the early 2000s. However, severe forms of rheumatic diseases, particularly at the radiological level, seem to be decreasing. This review reports the evolution of the incidence, prevalence and mortality in rheumatic diseases rheumatism, including in the context of prescription of targeted treatments.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105931"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Naples prognostic score with the risk of all-cause and cardiovascular mortality in individuals with rheumatoid arthritis: A cross-sectional analysis of the NHANES 2001–2018","authors":"Feiyue Zhou,&nbsp;Yuhan Xie,&nbsp;Yiran Zhang,&nbsp;Ping Jiang","doi":"10.1016/j.jbspin.2025.105928","DOIUrl":"10.1016/j.jbspin.2025.105928","url":null,"abstract":"<div><h3>Objectives</h3><div>This study seeks to assess how the Naples Prognostic Score (NPS) correlates with mortality in individuals with RA.</div></div><div><h3>Methods</h3><div>This study assessed the National Health and Nutrition Examination Survey (NHANES) database spanning from 2001 to 2018. NPS was computed utilizing serum albumin (SA), total cholesterol (TC), neutrophil to lymphocyte ratio (NLR), and lymphocyte to monocyte ratio (LMR). A self-administered questionnaire was utilized to gather data from individuals with RA, and the national death index was adopted to determine death rates. Weighted multivariate Cox regression evaluation and Kaplan–Meier survival curve assessment were carried out to explore the correlation of NPS with RA mortality risk, and subgroup analysis and sensitivity analysis were performed to investigate the robustness of the correlation.</div></div><div><h3>Results</h3><div>Altogether 1683 individuals with RA were enrolled in this research. In the Kaplan–Meier analysis, notable survival discrepancies were observed among various groups in all-cause and cardiovascular (CV) mortality events (<em>P</em> <!-->&lt;<!--> <!-->0.001). Following adjustment for all confounders, Group 3 (NPS<!--> <!-->=<!--> <!-->3–4) exhibited a markedly heightened likelihood of all-cause mortality by 2.04 times (hazard ratio [HR]<!--> <!-->=<!--> <!-->2.04, 95% confidence interval [CI]: 1.21–3.05, <em>P</em> <!-->&lt;<!--> <!-->0.01) and CV mortality by 3.59 times (HR<!--> <!-->=<!--> <!-->3.59, 95%CI: 1.24–10.4, <em>P</em> <!-->&lt;<!--> <!-->0.05) in comparison to Group 1 (NPS<!--> <!-->=<!--> <!-->0). Subgroup analysis and sensitivity analysis indicated that the results were robust.</div></div><div><h3>Conclusion</h3><div>In the US population, NPS shows a significantly positive correlation with the likelihood of all-cause and CV mortality in individuals with RA. The integration of the NPS into clinical decision-making can offer a more dependable evaluation of the prognosis of individuals with RA.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105928"},"PeriodicalIF":3.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of intra-articular platelet-rich plasma compared with placebo in knee osteoarthritis: A systematic review and meta-analysis","authors":"Maxime Auroux ,&nbsp;Thaïs Debionne ,&nbsp;Sabine Mainbourg ,&nbsp;Roland Chapurlat","doi":"10.1016/j.jbspin.2025.105947","DOIUrl":"10.1016/j.jbspin.2025.105947","url":null,"abstract":"<div><h3>Objectives</h3><div>Our primary aim was to evaluate the efficacy on pain and function of intra-articular platelet-rich plasma (PRP) injection in knee osteoarthritis (KOA) compared with intra-articular saline solution injection.</div></div><div><h3>Methods</h3><div>A search for randomized controlled studies (RCTs) using intra-articular platelet-rich plasma injection compared with intra-articular saline solution injection up to August 2024 (PROSPERO registration number: CRD42022311893) was undertaken in publication databases. Studies that reported pain and function evaluation with visual analogue scale (VAS) and/or WOMAC, size sample, study date and location were included. A meta-analysis was conducted to estimate the efficacy on pain and function of intra-articular platelet-rich plasma injection.</div></div><div><h3>Results</h3><div>We identified 11 RCTs including 1616 patients (849 on PRP, 767 on placebo) conducted in 7 countries, with 56% of patients being women. The mean age was 56.9<!--> <!-->years. VAS analysis at 3 and 6<!--> <!-->months after intervention was in favor of PRP use (respective mean difference [MD] −1.1 [95% CI: −1.8; −0.4] and −2.0 [95% CI: −2.8; −1.2]) but with high heterogeneity, whereas no efficacy was shown at 12<!--> <!-->months. The variation of total WOMAC at 3<!--> <!-->months after intervention was in favor of PRP use (MD −12.9 [95% CI: −20.5; −5.3]), but no efficacy was shown at 6 and 12<!--> <!-->months.</div></div><div><h3>Conclusion</h3><div>We have found a weak efficacy of PRP in knee osteoarthritis, up to 6<!--> <!-->months after intervention, so the clinical relevance of PRP use is debatable.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105947"},"PeriodicalIF":3.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between familial Mediterranean fever and incident cirrhosis: A population-based matched cohort study","authors":"Michal Carmiel-Haggai ,&nbsp;Rula Daood ,&nbsp;Fadi Fassan ,&nbsp;Helana Jeries ,&nbsp;Dikla Dror-Zur ,&nbsp;Mahmud Omar ,&nbsp;Abdulla Watad ,&nbsp;Tal Patalon ,&nbsp;Mohammad E. Naffaa","doi":"10.1016/j.jbspin.2025.105917","DOIUrl":"10.1016/j.jbspin.2025.105917","url":null,"abstract":"<div><h3>Objective</h3><div>The association between FMF and incident liver cirrhosis is not widely studied. In this study, we aimed to examine the association between FMF and incident liver cirrhosis in a population-based cohort.</div></div><div><h3>Methods</h3><div>Patients with FMF aged<!--> <!-->≥<!--> <!-->18 in the Maccabi Healthcare Services (MHS) database were identified according to ICD-9 code 277.31 between January 1st, 2000 and December 31st, 2022. A control group was 1:1 age and gender-matched. Patients with chronic liver disease or cirrhosis were excluded, as well as patients who were treated with methotrexate, amiodarone or tamoxifen and patients with less than 12 months of follow-up. Incident cirrhosis was defined as a new diagnosis of cirrhosis according to ICD-9 code (571.5), newly diagnosed major cirrhotic complications or liver transplantation. The Cox proportional hazards models were used to examine the association between FMF and incident cirrhosis and the Kaplan-Meier curves to study the event-free survival.</div></div><div><h3>Results</h3><div>Incident cirrhosis was detected among 2.1% and 0.4% in the study and control groups, respectively, <em>P</em> <!-->&lt;<!--> <!-->0.01. Being in the FMF group was associated with a significantly increased risk of incident cirrhosis (HR<!--> <!-->=<!--> <!-->2.60, 95% CI: 1.54–4.38, <em>P</em> <!-->&lt;<!--> <!-->0.01). At 7 years, the cirrhosis-free survival rate was 98.2% in the study group and 99.6% in the control group (<em>P</em> <!-->&lt;<!--> <!-->0.01).</div></div><div><h3>Conclusion</h3><div>FMF was associated with incident cirrhosis, irrespective of the traditional risk factors for metabolic syndrome, suggesting the contribution of the inflammatory state to the development of cirrhosis.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105917"},"PeriodicalIF":3.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active hand inflammation. Differing clinical and ultrasound patterns in patients with rheumatoid arthritis and psoriatic arthritis – A cross-sectional, multicenter study","authors":"Julio Ramírez ,&nbsp;Vicenç Torrente-Segarra ,&nbsp;Andrea Cuervo ,&nbsp;Mireia Moreno ,&nbsp;Ana Belén Azuaga ,&nbsp;Lourdes Mateo ,&nbsp;Beatriz Frade-Sosa ,&nbsp;Andrea Zacarías ,&nbsp;Noemí Busquets-Pérez ,&nbsp;Susana Holgado ,&nbsp;Paula Estrada ,&nbsp;Oscar Camacho ,&nbsp;Juan José De Agustín ,&nbsp;Carme Moragues ,&nbsp;María Bonet ,&nbsp;Sandra Farietta ,&nbsp;Patricia Corzo ,&nbsp;Andrés Ponce ,&nbsp;Virginia Ruiz-Esquide ,&nbsp;Lucía Alascio ,&nbsp;Juan D. Cañete","doi":"10.1016/j.jbspin.2025.105916","DOIUrl":"10.1016/j.jbspin.2025.105916","url":null,"abstract":"<div><h3>Objectives</h3><div>To define ultrasound (US) characteristics in patients with Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) exhibiting active hand inflammation.</div></div><div><h3>Methods</h3><div>This cross-sectional, multicenter study collected epidemiological and clinical data from RA and PsA patients with active hand inflammation. US examinations of wrists and metacarpophalangeal joints were performed, focusing on extensor and flexor tendons.</div></div><div><h3>Results</h3><div>A total of 292 patients were included: 192 (61.7%) were women, with a mean age of 56.1 years and mean disease duration of 105.4 months. Ninety-one patients (31.1%) had seropositive RA, 79 (27%) had seronegative RA, and 122 (41.7%) had PsA. Overall, 125 patients (42.8%) exhibited erosive disease, with 103 (35.2%) receiving targeted therapies. All patients had active disease (mean SDAI: 29.5; mean DAPSA: 22.3). Among the cohort, 144 patients (49.3%) showed synovial hypertrophy (SH)<!--> <!-->≥<!--> <!-->2<!--> <!-->+<!--> <!-->Power Doppler (PD). This was more common in seropositive (72.5%) than in seronegative RA (43%) or PsA (36%) (<em>P</em> <!-->≤<!--> <!-->0.001). Erosive disease (OR 8.4 [3.9–18], <em>P</em> <!-->≤<!--> <!-->0.001) and US global score (OR 1.1 [1–1.1], <em>P</em> <!-->≤<!--> <!-->0.001) were associated with SH<!--> <!-->≥<!--> <!-->2<!--> <!-->+<!--> <!-->PD. Extensor paratenonitis was more frequent in PsA (27%) compared to seropositive (9.8%) and seronegative RA (18.9%) (<em>P</em> <!-->≤<!--> <!-->0.01). The number of swollen joints (OR 1.1 [1–1.2], <em>P</em> <!-->≤<!--> <!-->0.001) and joint ankylosis (OR 4.3 [1.1–16.9], <em>P</em> <!-->≤<!--> <!-->0.05) were positively associated with paratenonitis.</div></div><div><h3>Conclusions</h3><div>Synovial pannus was characteristic of RA, while paratenonitis was more common in PsA. SH<!--> <!-->≥<!--> <!-->2<!--> <!-->+<!--> <!-->PD correlated with erosive disease, highlighting the need for prospective studies to validate US as a decision-making tool in arthritis.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105916"},"PeriodicalIF":3.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of older age on the relation between chronic musculoskeletal pain and health-related quality of life: The Maastricht Study","authors":"Saskia P.M. Truijen ,&nbsp;Annelies Boonen ,&nbsp;Carla J.H. van der Kallen ,&nbsp;Annemarie Koster ,&nbsp;Hans Bosma ,&nbsp;Marloes van Onna","doi":"10.1016/j.jbspin.2025.105955","DOIUrl":"10.1016/j.jbspin.2025.105955","url":null,"abstract":"<div><h3>Objective</h3><div>To test the hypothesis that older age negatively impacts the association between chronic musculoskeletal pain (MSP) and health-related quality of life (HRQoL).</div></div><div><h3>Methods</h3><div>Cross-sectional data of 8618 participants aged 40–75 years from the population-based Maastricht Study cohort was used. Chronic MSP presence was self-reported. Pain intensity was measured on a 0–10 scale (10: unbearable pain). Age (seven groups) and chronic MSP (intensity) were regressed in multivariable analyses on (components of) HRQoL: the mental (MCS) and physical component score (PCS) of the 36-item Short Form Survey (SF-36), the EuroQol-VAS measuring overall HRQoL, and (un)paid work days lost in the past six months. Interactions between age groups and chronic MSP were examined.</div></div><div><h3>Results</h3><div>Chronic MSP was reported by 2513/8618 (29%) participants and was associated with worse PCS (β<!--> <!-->=<!--> <!-->−7.4, 95%CI: −7.8 to −7.1), MCS (β<!--> <!-->=<!--> <!-->−1.8, 95%CI: −2.2 to −1.5), EuroQol-VAS (β<!--> <!-->=<!--> <!-->−7.9, 95%CI: −8.9 to −7.0), and a higher likelihood of unproductive days (OR<!--> <!-->=<!--> <!-->2.1, 95%CI:1.9–2.4). An interaction between age group and MSP was only observed for mental health: The negative impact of MSP on mental health was lower in individuals aged 70–75 years (β<!--> <!-->=<!--> <!-->−0.4, 95%CI: −1.3 to 0.6) compared to those aged 40–44 years (β<!--> <!-->=<!--> <!-->−3.1, 95%CI: −5.0 to −1.2) (<em>p</em>_interaction <!-->&lt;<!--> <!-->0.05). Age<!--> <!-->&gt;<!--> <!-->60 years was associated with fewer unproductive days, independent of MSP (OR_range age groups: 0.6 to 0.3; all <em>P</em> <!-->&lt;<!--> <!-->0.01).</div></div><div><h3>Conclusion</h3><div>Although chronic MSP negatively affects physical and mental health as well as work productivity, our findings suggest an unexpected resilience in mental HRQoL among older adults.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105955"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back to hormonal replacement therapy","authors":"Florence A. Trémollieres,&nbsp;Anna Gosset","doi":"10.1016/j.jbspin.2025.105898","DOIUrl":"10.1016/j.jbspin.2025.105898","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105898"},"PeriodicalIF":3.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid arthritis before rheumatoid arthritis: What can we learn from clinical trials?","authors":"Daniel Aletaha,&nbsp;Daniela Sieghart","doi":"10.1016/j.jbspin.2025.105910","DOIUrl":"10.1016/j.jbspin.2025.105910","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105910"},"PeriodicalIF":3.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}