Joint Bone Spine最新文献

Dysregulation of inflammasomes in autoinflammatory diseases 自身炎性疾病中炎性小体的失调。

IF 3.8 3区医学

Joint Bone Spine Pub Date : 2025-04-05 DOI: 10.1016/j.jbspin.2025.105903

Cyrielle Hou, Zhuo Wang, Valentin Eichenberger, Fabio Martinon

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引用次数: 0

Health equity and causes of disparities in rheumatological management 风湿病管理的卫生公平和差异的原因。

IF 3.8 3区医学

Joint Bone Spine Pub Date : 2025-04-05 DOI: 10.1016/j.jbspin.2025.105902

Mrinalini Dey , Elena Nikiphorou

{"title":"Health equity and causes of disparities in rheumatological management","authors":"Mrinalini Dey , Elena Nikiphorou","doi":"10.1016/j.jbspin.2025.105902","DOIUrl":"10.1016/j.jbspin.2025.105902","url":null,"abstract":"<div><div>Health disparities remain a critical challenge in rheumatological management, contributing to inequities in aspects such as disease outcomes, access to care, and treatment adherence. Evidence suggests that racial and ethnic minorities, as well as individuals from lower socioeconomic backgrounds, experience delayed and reduced access to specialist care, and lower utilisation of advanced therapies. Structural barriers, including limitations in insurance coverage and geographic disparities in rheumatology workforce distribution, further exacerbate these inequities. Additionally, differences in health literacy, treatment adherence, and cultural perceptions of disease significantly impact patient outcomes. Understanding the social determinants of health and integrating patient-centered approaches into rheumatology practice are essential for mitigating disparities and improving outcomes for underserved populations. This review synthesises the current evidence on the multiple aspects of health disparities in rheumatological management, identifies key gaps in research, and proposes strategies to enhance equitable healthcare delivery. Addressing these issues is imperative for achieving better disease control, enhancing quality of life, and reducing the overall burden of rheumatic diseases across diverse populations.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105902"},"PeriodicalIF":3.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of cancer in patients with rheumatoid arthritis under tocilizumab: Data from the French national registry REGATE tocilizumab治疗类风湿性关节炎患者的癌症风险：来自法国国家注册REGATE的数据

IF 3.8 3区医学

Joint Bone Spine Pub Date : 2025-04-04 DOI: 10.1016/j.jbspin.2025.105900

Jacques Morel , Amélie Wetzman , Daniel Wendling , Martin Soubrier , Sylvie Hoang , Daniel Briançon , Olivier Roth , Philippe Goupille , Jacques-Eric Gottenberg , Xavier Mariette , Cédric Lukas , On behalf of the French Society of Rheumatology, the investigators participating in REGATE registry

{"title":"Risk of cancer in patients with rheumatoid arthritis under tocilizumab: Data from the French national registry REGATE","authors":"Jacques Morel , Amélie Wetzman , Daniel Wendling , Martin Soubrier , Sylvie Hoang , Daniel Briançon , Olivier Roth , Philippe Goupille , Jacques-Eric Gottenberg , Xavier Mariette , Cédric Lukas , On behalf of the French Society of Rheumatology, the investigators participating in REGATE registry","doi":"10.1016/j.jbspin.2025.105900","DOIUrl":"10.1016/j.jbspin.2025.105900","url":null,"abstract":"<div><h3>Objective</h3><div>Our study aimed to estimate the incidence and risk factors of cancer among rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ) and followed for five years in the French registry (REGATE).</div></div><div><h3>Method</h3><div>The REGATE registry is a French prospective cohort study investigating the safety of TCZ in RA (registration n<sup>o</sup>: 910346). Data were collected using an e-CRF between 2011 and 2016 and with a questionnaire specifically distributed to participating centers that reported malignancies in REGATE. We mainly focused on solid cancers, hematological malignancies, and non-melanoma skin cancers (NMSC). To identify potential risk factors associated with cancer, we performed a univariate analysis and a multivariate analysis using Cox proportional hazards models.</div></div><div><h3>Results</h3><div>Our study included 1496 patients with RA who were treated with TCZ for a mean duration of 32.0 (±22.0) months and followed for an average of 47 (±15.2) months, resulting in a total exposure of 3990.9 patient-years (PY). Of these patients, 63 (4.2%) were diagnosed with a total of 75 cancers during the follow-up period (35 solid neoplasms, 11 hematological malignancies, 3 melanomas, and 26 NMSC). The overall incidence of cancer excluding NMSC was 7.5/1000 PY (exposure time). Our multivariate analysis revealed that high age (HR=1.05 [1.02–1.08]), current smoker (HR=2.65 [1.27–5.53]) and male 2.38 [1,18–4,80]) were independent risk factors for solid cancers. Age and active smoking were associated with higher risk of hematological malignancies.</div></div><div><h3>Conclusion</h3><div>We found no additional risk factors of cancer for RA patients under TCZ, beyond those already known in the general population.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105900"},"PeriodicalIF":3.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute herpes zoster lumbar radiculitis 急性带状疱疹腰根炎。

IF 3.8 3区医学

Joint Bone Spine Pub Date : 2025-04-04 DOI: 10.1016/j.jbspin.2025.105901

Mustafa Kemal Demir , Zeynep Erdogan Iyigun

引用次数: 0

Back to hormonal replacement therapy. 回到激素替代疗法。

IF 3.8 3区医学

Joint Bone Spine Pub Date : 2025-04-02 DOI: 10.1016/j.jbspin.2025.105898

Florence A Trémollieres, Anna Gosset

引用次数: 0

Imaging in the assessment of deposits in gout: From research to daily clinical implementation 影像学评估痛风沉积物：从研究到日常临床实施。