Joint Bone Spine最新文献

{"title":"Platelet-rich plasma and knee osteoarthritis: A critical overview of the multiple biases and methodological complexity","authors":"Hervé Bard ,&nbsp;Paul Ornetti ,&nbsp;Éric Noël ,&nbsp;Florent Eymard","doi":"10.1016/j.jbspin.2025.106014","DOIUrl":"10.1016/j.jbspin.2025.106014","url":null,"abstract":"<div><div>Intra-articular injections of platelet-rich plasma (PRP) are increasingly utilized in the management of knee osteoarthritis (KOA) and various other medical specialties. However, the efficacy of PRP remains a contentious issue; some experts consider it to be a placebo, while others advocate for its therapeutic value. Evidence from controlled clinical trials and meta-analyses has often yielded contradictory results, frequently failing to demonstrate a clear clinical benefit despite favorable outcomes observed in real-world settings. Several factors may contribute to these inconsistencies, with the lack of standardization in PRP preparation and the heterogeneity of KOA phenotypes being the most significant. Phenotyping is more effectively accomplished in specialized clinical environments, which may elucidate the improved outcomes associated with better patient selection. After delineating the specific characteristics of PRP injections and the primary sources of variability, we emphasize the necessity for comprehensive characterization of the injected product and accurate phenotyping of KOA. Additionally, we examine the methodological biases that impede the interpretation of clinical results and propose a treat-to-target approach as a more suitable evaluation strategy. These methodological challenges should not undermine the potential of regenerative medicine, which offers considerable promise. Compared to conventional therapies, regenerative medicine is generally more compatible with human physiology, better tolerated, and potentially less expensive. However, the advancement of this field necessitates strict scientific rigor and objectivity. This involves a meticulous recognition of biases and methodological limitations, as well as a deeper understanding of the underlying mechanisms of action, to refine and optimize therapeutic protocols.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106014"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Health and rheumatology: Research gaps and opportunities for action","authors":"Juan-Manuel Anaya ,&nbsp;Ivan David Lozada-Martinez","doi":"10.1016/j.jbspin.2025.106006","DOIUrl":"10.1016/j.jbspin.2025.106006","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106006"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early upper and lower limbs bone microarchitecture alterations evaluated by HR-PQCT after stroke with hemiplegia","authors":"Adamah Amouzougan ,&nbsp;Myriam Normand ,&nbsp;Hervé Locrelle ,&nbsp;Laure Mathevon ,&nbsp;Elisa Dalix ,&nbsp;Pierre Garnier ,&nbsp;Paul Calmels ,&nbsp;Hubert Marotte ,&nbsp;Thierry Thomas","doi":"10.1016/j.jbspin.2025.106008","DOIUrl":"10.1016/j.jbspin.2025.106008","url":null,"abstract":"<div><h3>Objectives</h3><div>Stroke is the leading cause of acquired physical disability. In recent years, there has been a decline in early mortality due to acute medical care as well as better and earlier prevention of adverse events after stroke, therefore exposing more these patients to fragility fractures. We report very early assessment of bone microarchitecture changes in the first months following stroke-induced hemiplegia in a monocentric prospective study.</div></div><div><h3>Methods</h3><div>Patients had to be included within 15<!--> <!-->days of stroke and 2 follow-up visits were planned at 3 and 6<!--> <!-->months. At each time points, microarchitecture parameters were assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) at the tibia and the radius sites on both paretic and non-paretic sides. <em>P</em>-values were adjusted for multiple comparisons.</div></div><div><h3>Results</h3><div>Ten patients were included. All were all right-handed, hemiplegia occurring on dominant side in 6 of them. Cortical thickness decreased from baseline on paretic side (PS) as early as 3<!--> <!-->months and 6<!--> <!-->months both at radius (<em>P</em> <!-->=<!--> <!-->0.031) and tibia (<em>P</em> <!-->=<!--> <!-->0.005), while it remained stable on non-paretic side (NPS). The radius cortical area also significantly decreased only on PS (<em>P</em> <!-->=<!--> <!-->0.049). There was an increase in Ct.Po on both sides over time, only at the tibia. No early changes in trabecular parameters were observed. As a result, failure load rapidly changed at both radial and tibial locations regardless of side, with numerically greater changes at the tibia PS.</div></div><div><h3>Conclusion</h3><div>Stroke-induced hemiplegia was associated with microarchitectural damages in both tibial and radial cortical envelopes regardless of body side, as early as 3<!--> <!-->months post-event. These results suggest the need for early bone loss prevention including pharmacologic treatments.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106008"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ear involvement in patients affected by juvenile idiopathic arthritis","authors":"Giulia La Barbera ,&nbsp;Francesco Ciodaro ,&nbsp;Giovanni Luppino ,&nbsp;Federica Li Pomi ,&nbsp;Sabrina Loteta ,&nbsp;Giovanni Miceli ,&nbsp;Clelia Cusmano ,&nbsp;Valeria Chirico ,&nbsp;Angela Alibrandi ,&nbsp;Roberto Chimenz ,&nbsp;Carmela Visalli ,&nbsp;Francesco Borgia ,&nbsp;Giovanni Conti","doi":"10.1016/j.jbspin.2025.106002","DOIUrl":"10.1016/j.jbspin.2025.106002","url":null,"abstract":"<div><h3>Objective</h3><div>The incudomalleal and incudostapedial articulations are synovial joints that may be involved in the inflammatory process in patients with juvenile idiophathic arthritis (JIA). The aim of the study was to assess the frequency of hearing impairment and associated risk factors in JIA patients.</div></div><div><h3>Methods</h3><div>We performed a cohort study on 45 patients with three JIA subtype (oligoarticular, polyarticular and psoriatic) aged between 3 and 18<!--> <!-->years. The control group consisted of 30 healthy sex and age-matched children. Subjects underwent audiological exams and clinical-rheumatologic evaluations, including joint count (Juvenile Arthritis Disease Activity Score<!--> <!-->=<!--> <!-->cJADAS10) and inflammatory markers.</div></div><div><h3>Results</h3><div>Audiological impairment was detected in 16/45 (35.5%) patients with JIA. Hypoacusis was found in a significant number of ears in JIA patients (16/90<!--> <!-->=<!--> <!-->17.8%; <em>P</em> <!-->&lt;<!--> <!-->0.05) compared with to control group ears. Hypoacusis was frequently observed in patients with psoriasis (6/16 ears). Abnormal findings in tympanometry were observed in five types of As (with a shallow peak), four with type B (flat pattern), and in two with type C (with a negative pressure). The stapedius reflex was absent in only one patient (3%). JIA patients with hypoacusis had a significantly greater cJADAS10 (<em>P</em> <!-->&lt;<!--> <!-->0.001) and Childhood Health Assessment Questionnaire (CHAQ) (<em>P</em> <!-->&lt;<!--> <!-->0.001), a functional and quality of life assessment tool, than JIA patients with normal audiometry.</div></div><div><h3>Conclusion</h3><div>Hearing impairment and/or abnormal tympanograms suggest ear involvement in patients with JIA. This may be considered a complication of the disease and/or a marker of JIA activity, according cJADAS10, and could represent a valuable criterion to select the best therapeutic strategy. Therefore, JIA patients should perform an Ear, Nose and Throat (ENT) evaluation to allow early detection of auditory system involvement to prevent the impact of hearing loss.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106002"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The changing face of axial spondyloarthritis over the last 25 years","authors":"Daniel Wendling ,&nbsp;Philippe Goupille ,&nbsp;Renaud Felten ,&nbsp;Thao Pham ,&nbsp;Anna Molto ,&nbsp;Frank Verhoeven ,&nbsp;Clément Prati ,&nbsp;French spondyloArthritiS Taskforce (FAST)","doi":"10.1016/j.jbspin.2025.106004","DOIUrl":"10.1016/j.jbspin.2025.106004","url":null,"abstract":"<div><div>Axial spondyloarthritis has undergone major changes since the turn of the century, concerning terminology (from ankylosing spondylitis to radiographic axial spondyloarthritis), classification criteria, introduction of targeted therapies (anti-TNF, anti-IL17, JAK inhibitors), and management strategies. Epidemiological data indicate an increasing incidence and a shorter diagnostic delay. Over the past 25 years, additional modifications have been observed: recognition of non-radiographic forms (up to 50% in recent studies), lower male predominance with a sex ratio tending to parity, reduced frequency of HLA-B27 and uveitis, wider use of targeted treatments, and changes in treatment response profiles. Overall disease severity appears to be reduced according to several indicators, including mortality, hip involvement, structural progression, and amyloidosis. The determinants of these changes remain debated and discussed in this narrative review, in the absence of long-term longitudinal studies and because of limited comparability across different time periods. The impact of environmental factors still needs to be assessed.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106004"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-rich plasma versus corticosteroids in facet joint syndrome: A controlled, randomized, double-blind study","authors":"Marion Geoffroy ,&nbsp;Myriam Beissat ,&nbsp;L. Kanagaratnam ,&nbsp;Stanley Ackah Miezan ,&nbsp;Jean Hugues Salmon","doi":"10.1016/j.jbspin.2025.106001","DOIUrl":"10.1016/j.jbspin.2025.106001","url":null,"abstract":"<div><h3>Objectives</h3><div>The primary objective of the study was to demonstrate the superiority of platelet-rich plasma injections in treating facet joint syndrome, compared to corticosteroid injections. Secondary objectives were to assess the efficacy of PRP compared to CTC on pain, functional impact, tolerance, and healthcare utilization following the initial infiltrative management.</div></div><div><h3>Methods</h3><div>Patients were randomized (1:1) to receive intra-articular injections into the painful facet joints with either PRP or CTC under radiographic guidance. The primary outcome measure was a 50% improvement in the NRS (from 0 to 10) for spontaneous lumbar pain at 6<!--> <!-->months. Study design: Superiority, controlled, randomized (1:1), prospective, double-blind study.</div></div><div><h3>Results</h3><div>A total of 76 patients were included, at 6<!--> <!-->months, 6 patients in the PRP group and 5 in the CTC group showed a 50% improvement in spontaneous NRS. No statistically significant differences were found in pain at 3, 6, or 12<!--> <!-->months. Regarding functional evaluation, a statistically significant difference was observed in the PRP group at 3<!--> <!-->months according to the ODI. No significant differences were found between groups in terms of satisfaction. Four patients experienced transient adverse effects, only 1 in the PRP group.</div></div><div><h3>Conclusion</h3><div>In patients with facet joint syndrome, PRP injections did not demonstrate superiority over CTC injections in terms of pain relief or clinically significant functional improvement at 6<!--> <!-->months. These results do not support the use of PRP injections for facet joint syndrome.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106001"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the difficult-to-manage concept applicable to osteoporosis?","authors":"Cécile Philippoteaux ,&nbsp;Elena Tsourdi ,&nbsp;Julien Paccou","doi":"10.1016/j.jbspin.2025.105996","DOIUrl":"10.1016/j.jbspin.2025.105996","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 105996"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low back pain in the elderly: abdominal aortic aneurysm as a diagnostic pitfall.","authors":"Maroua Slouma, Sonia Khalbous, Mounir Lmaloum","doi":"10.1016/j.jbspin.2026.106070","DOIUrl":"https://doi.org/10.1016/j.jbspin.2026.106070","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"106070"},"PeriodicalIF":4.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image in Rheumatology. Primary Hyperoxaluria.","authors":"Cristina Calomarde-Gómez, Damian Garcia Perdomo, Laia Gifre","doi":"10.1016/j.jbspin.2026.106069","DOIUrl":"https://doi.org/10.1016/j.jbspin.2026.106069","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"106069"},"PeriodicalIF":4.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescription of Targeted Therapies in patient with a history of cancer.","authors":"Eden Sebbag, Jacques-Eric Gottenberg","doi":"10.1016/j.jbspin.2026.106068","DOIUrl":"https://doi.org/10.1016/j.jbspin.2026.106068","url":null,"abstract":"<p><p>Targeted therapies (TTs), including biologic and targeted synthetic DMARDs, have transformed the management of inflammatory arthritis (IA). However, their use in patients with a history of cancer raises concerns due to the role of immunity in tumor surveillance and the lack of randomized controlled trial data in this population. Recent observational studies and systematic reviews, including over 15,000 patient-years of follow-up, show no increased risk of new or recurrent malignancy with TNF inhibitors compared with csDMARDs. Rituximab appears safe in patients with prior lymphoma, while caution remains warranted for JAK inhibitors and abatacept given potential safety signals observed in other contexts. Importantly, TNF inhibitors initiated within five years of a cancer diagnosis were not associated with higher recurrence risk. The 2024 EULAR Points to Consider provide updated guidance, recommending individualized therapeutic strategies based on cancer type, remission status, and comorbidities, with close collaboration between rheumatologists and oncologists. While current evidence is reassuring for TNF inhibitors, data on other TTs remain limited. Future research should focus on long-term safety, inclusion of broader IA subtypes, and development of personalized cancer risk stratification tools.</p>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"106068"},"PeriodicalIF":4.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}