Joint Bone Spine最新文献

{"title":"Modifications of intestinal barrier dysfunction under tofacitinib administration in rat adjuvant arthritis","authors":"Sophie Hecquet , Perle Totoson , Hélène Martin , Jean-Paul Pais-de-Barros , Maude Tournier , Clément Prati , Daniel Wendling , Céline Demougeot , Frank Verhoeven","doi":"10.1016/j.jbspin.2025.105933","DOIUrl":"10.1016/j.jbspin.2025.105933","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105933"},"PeriodicalIF":3.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-6: A new target in crystal-induced arthritides – A narrative review","authors":"Augustin Latourte ,&nbsp;Tristan Pascart ,&nbsp;Pascal Richette","doi":"10.1016/j.jbspin.2025.105935","DOIUrl":"10.1016/j.jbspin.2025.105935","url":null,"abstract":"<div><div>Gout and calcium pyrophosphate deposition disease (CPPD) are two highly prevalent causes of inflammatory arthritis, characterized by the pathological deposition of monosodium urate (MSU) and CPP crystals, respectively, in joint tissues. These crystals can induce an intense inflammatory response, known as crystal-induced inflammation, which involves innate immunity and is highly dependent of the activation of interleukin 1β (IL-1β) following the recruitment of the NLRP3 inflammasome. In patients in whom first-line treatments (colchicine, prednisone, NSAIDs) are either ineffective or inappropriate, IL-1 inhibitors can be used to treat acute crystal-induced arthritis. However, some patients do not respond to these therapies, or experience adverse events. There is therefore a need for other treatments, particularly in CPPD, where the inflammation induced by CPP crystals can be chronic and affect elderly patients, making IL-1 inhibitors a less suitable option. IL-6, which is highly expressed during crystal-induced inflammation, is emerging as a promising therapeutic target in chronic CPP arthritis, with publications reporting the efficacy of tocilizumab in patients with inadequate response to other treatments, including anakinra, the most commonly used IL-1 inhibitor in this indication (off-label). These data require confirmation in randomized controlled trials. Other therapies, such as JAK inhibitors or NLRP3 inhibitors, may also be of interest in crystal-induced arthritis.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105935"},"PeriodicalIF":3.8,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of idiopathic inflammatory myopathies","authors":"Raquel Campanilho-Marques ,&nbsp;João Eurico Fonseca ,&nbsp;Pedro M. Machado","doi":"10.1016/j.jbspin.2025.105932","DOIUrl":"10.1016/j.jbspin.2025.105932","url":null,"abstract":"<div><div>Adult idiopathic inflammatory myopathies (IIMs) are rare autoimmune disorders affecting multiple organs, making diagnosis and treatment challenging. Current management relies on immunosuppressants like corticosteroids, methotrexate, azathioprine, mycophenolate mofetil, rituximab, and intravenous immunoglobulin, though treatment responses vary across patients and subtypes. Despite substantial challenges in clinical research, such as patient recruitment, misdiagnoses from overlapping symptoms with other conditions, and inconsistencies in disease classification, the growing number of myositis-specific clinical trials provides optimism. Progress in targeted therapies has the potential to refine treatment approaches, support the development of more standardized, evidence-based guidelines, and ultimately enhance patient outcomes. In this paper, we aim to provide a review of the current therapeutic options based on IIM subtypes.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105932"},"PeriodicalIF":3.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity and mortality of inflammatory rheumatic diseases: evolution of approaches.","authors":"Chloé Bernardy, Mickaël Dalecky, Sarah Guillaud-Rollin, Tiphaine Dujardin, Romain Gastaldi, Athan Baillet","doi":"10.1016/j.jbspin.2025.105931","DOIUrl":"https://doi.org/10.1016/j.jbspin.2025.105931","url":null,"abstract":"<p><p>Chronic inflammatory rheumatic diseases include rheumatoid arthritis, spondyloarthritis and psoriatic arthritis. These diseases affect mainly joints but also have systemic involvement. Patients with chronic inflammatory rheumatic diseases have an increased risk of comorbidities, both due to disease activity and the use of treatments such as corticosteroids. Thus, a higher mortality rate was shown in these patients, particularly in RA, with a risk of premature death increased by half compared to the general population in epidemiological studies from the early 2000s. However, severe forms of rheumatic diseases, particularly at the radiological level, seem to be decreasing. This review reports the evolution of the incidence, prevalence and mortality in rheumatic diseases rheumatism, including in the context of prescription of targeted treatments.</p>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"105931"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Answer to Annweiler et al.","authors":"Marie-Eva Pickering ,&nbsp;Jean-Claude Souberbielle ,&nbsp;Bernard Cortet","doi":"10.1016/j.jbspin.2025.105925","DOIUrl":"10.1016/j.jbspin.2025.105925","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105925"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early peripheral psoriatic arthritis: Baseline features of the first 186 patients in the French Nationwide APACHE Cohort","authors":"Pascal Claudepierre ,&nbsp;Cecile Gaujoux-Viala ,&nbsp;Arnaud Constantin ,&nbsp;Francis Berenbaum ,&nbsp;Bernard Combe ,&nbsp;Valerie Devauchelle ,&nbsp;Philippe Goupille ,&nbsp;Pascal Richette ,&nbsp;Daniel Wendling ,&nbsp;Gael Mouterde ,&nbsp;Tristan Pascart ,&nbsp;Benedicte Razat ,&nbsp;Etienne Audureau ,&nbsp;Sandrine Jousse-Joulin ,&nbsp;Laure Gossec","doi":"10.1016/j.jbspin.2025.105930","DOIUrl":"10.1016/j.jbspin.2025.105930","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the design and methodology of APACHE, a cohort of patients with early peripheral psoriatic arthritis (pPsA), and to assess the main baseline clinical characteristics of the first included patients.</div></div><div><h3>Methods</h3><div>APACHE is an ongoing prospective multicentre national cohort (<span><span>NCT03768271</span><svg><path></path></svg></span>) with a planned follow-up of 10<!--> <!-->years. Included patients have recent-onset (&lt;<!--> <!-->12<!--> <!-->months) peripheral arthritis, a personal and/or family history of psoriasis, pPsA diagnosed by a rheumatologist, and no history of targeted disease-modifying antirheumatic drug therapy. At inclusion, demographic data, disease activity, comorbidities, and imaging results (not reported here) are collected. A descriptive analysis of these data was performed.</div></div><div><h3>Results</h3><div>The first 186 study patients had a mean age of 44<!--> <!-->±<!--> <!-->11<!--> <!-->years and mean arthritis duration of 6<!--> <!-->±<!--> <!-->4<!--> <!-->months; 84 (45%) were women; 169 (91%) had a history of psoriasis (mean duration, 14<!--> <!-->years) and 71 (38%) were receiving methotrexate. Disease activity was moderate with a mean DAPSA score of 19<!--> <!-->±<!--> <!-->14 and mean swollen and tender joint counts of 2.1<!--> <!-->±<!--> <!-->3.2 and 6.0<!--> <!-->±<!--> <!-->8.0, respectively. The initially involved joints were mainly the hands (40%) and knees (28%). Entheseal pain (39%) was more prevalent than dactylitis (27%). Comorbidities were common, with obesity in 27% and at least one cardiovascular risk factor or disease in 49% of patients.</div></div><div><h3>Conclusion</h3><div>Patients with early peripheral PsA had moderate disease activity, a predominant oligoarticular profile, and a high prevalence of entheseal pain.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105930"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral metatarsal stress fractures mimicking a flare in an obese patient with rheumatoid arthritis","authors":"Nur Kakilli ,&nbsp;Doğukan Erkal ,&nbsp;Mert Çiftdemir ,&nbsp;Nurettin Taştekin","doi":"10.1016/j.jbspin.2025.105926","DOIUrl":"10.1016/j.jbspin.2025.105926","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105926"},"PeriodicalIF":3.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Naples prognostic score with the risk of all-cause and cardiovascular mortality in individuals with rheumatoid arthritis: A cross-sectional analysis of the NHANES 2001–2018","authors":"Feiyue Zhou,&nbsp;Yuhan Xie,&nbsp;Yiran Zhang,&nbsp;Ping Jiang","doi":"10.1016/j.jbspin.2025.105928","DOIUrl":"10.1016/j.jbspin.2025.105928","url":null,"abstract":"<div><h3>Objectives</h3><div>This study seeks to assess how the Naples Prognostic Score (NPS) correlates with mortality in individuals with RA.</div></div><div><h3>Methods</h3><div>This study assessed the National Health and Nutrition Examination Survey (NHANES) database spanning from 2001 to 2018. NPS was computed utilizing serum albumin (SA), total cholesterol (TC), neutrophil to lymphocyte ratio (NLR), and lymphocyte to monocyte ratio (LMR). A self-administered questionnaire was utilized to gather data from individuals with RA, and the national death index was adopted to determine death rates. Weighted multivariate Cox regression evaluation and Kaplan–Meier survival curve assessment were carried out to explore the correlation of NPS with RA mortality risk, and subgroup analysis and sensitivity analysis were performed to investigate the robustness of the correlation.</div></div><div><h3>Results</h3><div>Altogether 1683 individuals with RA were enrolled in this research. In the Kaplan–Meier analysis, notable survival discrepancies were observed among various groups in all-cause and cardiovascular (CV) mortality events (<em>P</em> <!-->&lt;<!--> <!-->0.001). Following adjustment for all confounders, Group 3 (NPS<!--> <!-->=<!--> <!-->3–4) exhibited a markedly heightened likelihood of all-cause mortality by 2.04 times (hazard ratio [HR]<!--> <!-->=<!--> <!-->2.04, 95% confidence interval [CI]: 1.21–3.05, <em>P</em> <!-->&lt;<!--> <!-->0.01) and CV mortality by 3.59 times (HR<!--> <!-->=<!--> <!-->3.59, 95%CI: 1.24–10.4, <em>P</em> <!-->&lt;<!--> <!-->0.05) in comparison to Group 1 (NPS<!--> <!-->=<!--> <!-->0). Subgroup analysis and sensitivity analysis indicated that the results were robust.</div></div><div><h3>Conclusion</h3><div>In the US population, NPS shows a significantly positive correlation with the likelihood of all-cause and CV mortality in individuals with RA. The integration of the NPS into clinical decision-making can offer a more dependable evaluation of the prognosis of individuals with RA.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105928"},"PeriodicalIF":3.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing efficacy and adherence: Importance of patient-centered approach to vitamin D supplementation. Comment on: “Pickering ME, Souberbielle JC, Boutten A, et al. Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO” by Pickering et al. Joint Bone Spine 2025;92:105858","authors":"Cédric Annweiler ,&nbsp;Mathieu Corvaisier","doi":"10.1016/j.jbspin.2025.105927","DOIUrl":"10.1016/j.jbspin.2025.105927","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105927"},"PeriodicalIF":3.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of gout in people aged 15–39 years from 1990 to 2021: Trends, cross-country inequalities and forecast to 2035","authors":"Yinglun Zhang ,&nbsp;Zhibin Jin ,&nbsp;Jing Yao ,&nbsp;Dandan Wang ,&nbsp;Yunxian Yu ,&nbsp;Weijing Zhang","doi":"10.1016/j.jbspin.2025.105929","DOIUrl":"10.1016/j.jbspin.2025.105929","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the trends and cross-country inequalities of gout burden in people aged 15–39 years from 1990 to 2021, with projections to 2035.</div></div><div><h3>Methods</h3><div>The study employed estimates from Global Burden of Diseases (GBD) 2021 to assess prevalence, incidence, and years lived with disability (YLDs) of gout across global, demographic, GBD regional, national, sociodemographic index (SDI) regional, and risk factor levels. Temporal trends in the age-standardized rates (ASRs) of prevalence, incidence and YLDs were assessed by Joinpoint regression, while associations between SDI and ASRs were examined through Spearman correlation. Health inequalities were measured using the slope index of inequality and the concentration index. Future trends were forecast by a Bayesian age-period-cohort model.</div></div><div><h3>Results</h3><div>The burden of gout increased in global, demographic, GBD regional, and SDI level from 1990 to 2021. Males, the 35–39 years subgroup, and High-SDI regions experienced the highest burden. High-income North America owned the highest ASRs while East Asia reported the largest numbers. A moderate positive correlation was observed between gout burden and SDI for nations. Both absolute and relative inequalities increased. Males had higher YLDs due to high body mass index (BMI), females due to kidney dysfunction. Although ASRs were predicted to decrease from 2020 to 2035, numbers were predicted to rise.</div></div><div><h3>Conclusions</h3><div>The gout burden gout in people aged 15–39 years increased with notable inequalities. Despite projected ASRs decreases, overall numbers were likely to increase, highlighting the urgent need for targeted interventions and public health strategies.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105929"},"PeriodicalIF":3.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}