Joint Bone Spine最新文献

{"title":"Time-course of tophus resolution on Dual-energy CT and ultrasound after 24 months of a treat-to-target strategy: Results from GOUT-DECTUS study","authors":"Tristan Pascart ,&nbsp;Pascal Richette ,&nbsp;Valérie Bousson ,&nbsp;Sébastien Ottaviani ,&nbsp;Hang-Korng Ea ,&nbsp;Frédéric Lioté ,&nbsp;Augustin Latourte ,&nbsp;Thomas Bardin ,&nbsp;Jérémy Ora ,&nbsp;Aurore Pacaud ,&nbsp;Marie Vandecandelaere ,&nbsp;Hélène Luraschi ,&nbsp;Charlotte Jauffret ,&nbsp;Victor Laurent ,&nbsp;Mathilde Boissel ,&nbsp;Laurène Norberciak ,&nbsp;Julie Legrand ,&nbsp;Guillaume Lefevre ,&nbsp;Vincent Ducoulombier ,&nbsp;Jean-François Budzik","doi":"10.1016/j.jbspin.2025.105892","DOIUrl":"10.1016/j.jbspin.2025.105892","url":null,"abstract":"<div><h3>Objectives</h3><div>The main objective of the study was to evaluate the kinetics of tophus volume measured with dual-energy CT (DECT) and ultrasound (US) in patients with gout during their first 24<!--> <!-->months of treat-to-target (T2T) urate-lowering therapy.</div></div><div><h3>Methods</h3><div>This was a prospective, multicenter, 24-month longitudinal pilot study including ULT-naïve patients with gout and US tophi. Clinical visits, and DECT and US scans of the knees and feet were performed at baseline, 6, 12 and 24<!--> <!-->months. The largest tophus identified by US was chosen as the index tophus. The primary outcome was the change in the absolute volume and relative change from baseline of the tophus index volume measured with US and with DECT at all timepoints, with their correlation assessed by the Spearman correlation coefficient (ρ).</div></div><div><h3>Results</h3><div>A total of 55 patients (63.1 (12.3) years old, predominantly male (47/55 [85.5%]), with baseline serum urate levels of 8.73 mg/dL [7.93; 9.52] were included. Index tophus volume measured with US changed from median [inter-quartile range] 0.61 cm³ [0.30; 1.20] at baseline to 0.07 cm³ [0; 0.50] at month 24, and with DECT from 0.1 cm³ [0; 0.63] at baseline to 0 cm³ [0; 0] at month 24. Relative changes in index tophus volume measured with US and DECT were respectively −56% [−90; 0] and −96% [−100; −34] at M6, −84% [−100; −13] and −100% [−100; −89] at M12, and −96% [−100; −72] and −100% [−100; −100] at M24. The correlation for relative tophus volume change was weak at month 6 (ρ<!--> <!-->=<!--> <!-->0.39 [0.01; 0.74]) and moderate at months 12 (ρ<!--> <!-->=<!--> <!-->0.43 [−0.14; 0.82]) and 24 (ρ<!--> <!-->=<!--> <!-->0.42 [−0.01; 0.73]).</div></div><div><h3>Conclusion</h3><div>Complete tophus resolution is obtained at 24<!--> <!-->months of T2T in DECT but not in US, which provided a greater variability of volumetric assessments throughout follow-up.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105892"},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of corticosteroid therapy in persistent synovitis following septic arthritis in adults: Report of 12 cases","authors":"Alia Barthel ,&nbsp;Renaud Felten ,&nbsp;Jeannot Gaudias ,&nbsp;Lucas Niglis ,&nbsp;Cyril Boeri ,&nbsp;Cécile Ronde-Oustau ,&nbsp;Philippe Clavert ,&nbsp;Stéphane Klein","doi":"10.1016/j.jbspin.2025.105887","DOIUrl":"10.1016/j.jbspin.2025.105887","url":null,"abstract":"<div><h3>Context</h3><div>Septic arthritis management relies on appropriate antibiotic therapy and joint drainage. Despite quick microbial eradication, recovery is often incomplete, with significant sequelae such as loss of joint mobility affecting over 30% of patients, sometimes requiring surgery. Persistent synovitis after treatment poses clinical challenges, and the use of corticosteroids as a way to reduce this residual inflammation has been poorly studied.</div></div><div><h3>Method</h3><div>This retrospective, uncontrolled series evaluated the clinical efficacy of corticosteroid therapy in 12 adult patients with persistent synovitis following native septic arthritis.</div></div><div><h3>Results</h3><div>Twelve patients were included, most with knee arthritis (10/12, 83.3%). Median antibiotics course before corticosteroids was 14 days (7–30) and all had controlled infections. Route of administration was mostly intra-articular (10/12, 83.3%). Complete (8/12, 66.7%) or partial (3/12, 25.0%) clinical improvement was obtained with a median response time of 2 days. At the end of follow-up, 75% of cases (9/12) met primary endpoint. There were no early infectious complications. Three cases were classified as treatment failures: one patient had no clinical improvement, and two eventually required knee arthroplasty.</div></div><div><h3>Conclusion</h3><div>Addressing an issue for which there is no data for adult patients, our results suggest that corticosteroids could be an effective option to treat « persistent synovitis » after septic arthritis restoring joint function and preventing long-term disability. This small, retrospective and descriptive study has limitations and larger, randomized studies are needed to confirm these results.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105887"},"PeriodicalIF":3.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addition of allopurinol to traditional Vietnamese medicine shows major improvement of 100 gout patients in a single center one-year prospective study","authors":"Thomas Bardin ,&nbsp;Quang Dinh Nguyen ,&nbsp;Valérie Bausson ,&nbsp;Khoi Tran ,&nbsp;Nicola Dalbeth ,&nbsp;Chuc Tran ,&nbsp;Dai Huynh ,&nbsp;Quang Huy Nguyen ,&nbsp;Minh Do ,&nbsp;Pascal Richette ,&nbsp;Matthieu Resche-Rigon","doi":"10.1016/j.jbspin.2025.105889","DOIUrl":"10.1016/j.jbspin.2025.105889","url":null,"abstract":"<div><h3>Objectives</h3><div>Gout is frequently severe in Vietnam, where urate-lowering drugs (ULDs) are seldom used and many patients are treated only with traditional herbal medicine. We assessed the addition of Western medicine on severe gout in Vietnamese people.</div></div><div><h3>Methods</h3><div>One hundred Vietnamese, ULD-free, crystal-proven gout patients with a GFR<!--> <!-->&gt;<!--> <!-->60<!--> <!-->mL/min, were prospectively followed for 1<!--> <!-->year after allopurinol initiation. The treatment protocol included allopurinol given according to the 2016 EULAR recommendations, flare prophylaxis with colchicine during the first months, and traditional herbal medicine. At each visit, gout flares were counted by a daily diary, digital foot photographs were taken for semi-quantitative tophus scoring, serum urate (SU) was measured. Ultrasound (US) scan was performed at baseline, 6 and 12<!--> <!-->months for double contour (DC) and index tophus measurement. Quality of life (Gout Impact Score [GIS]) and function were recorded at inclusion and after 12<!--> <!-->months. Foot gout radiographic erosion scores were obtained at baseline, 6 and 12<!--> <!-->months. Outcomes were compared in patients who had reached SU targets at 3<!--> <!-->months and those who did not.</div></div><div><h3>Results</h3><div>Patients’ median age and disease duration were 47 and 8<!--> <!-->years respectively, 91 had clinical tophi and 70 foot gouty erosions. Eighty-four patients were seen at 6<!--> <!-->months and 68 at 12<!--> <!-->months. Allopurinol dosage was progressively increased to a median of 600<!--> <!-->mg/d. Significant improvement of flare rates at M6 and M12, and of GIS and function at M12 were noted and did not associate with SU targets. Tophi (assessed by photograph and US measurements) and DC sign significantly decreased from M6 in association with achievement of<!--> <!-->&lt;<!--> <!-->300<!--> <!-->μmol/L SU target. Foot erosion scores significantly decreased with no association with SU targets. Mild skin rash to allopurinol developed in 7 patients.</div></div><div><h3>Conclusion</h3><div>This one-year open study tested a global gout care delivery model in which treat to uricemia target allopurinol, Western medicine self-treatment of flares, and patient education were added to a background of traditional herbal medicine in a Vietnamese population where gout is traditionally treated with herbal medicine. This shift in practice resulted in dramatic gout improvement.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105889"},"PeriodicalIF":3.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different arthritis patterns in pediatric familial Mediterranean fever: Focus on exon 10 biallelic pathogenic genotypes","authors":"Eray Tunce,&nbsp;Sıla Atamyildiz Uçar,&nbsp;Betül Sözeri","doi":"10.1016/j.jbspin.2025.105888","DOIUrl":"10.1016/j.jbspin.2025.105888","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the prevalence and characteristics of arthritis in pediatric familial Mediterranean fever (FMF) patients with biallelic pathogenic <em>MEFV</em> mutations on exon 10 and to assess the impact of axial joint involvement on disease progression.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 808 pediatric FMF patients with biallelic exon 10 mutations, followed for at least 12<!--> <!-->months. Data on demographics, clinical features, genetic variants, and treatment responses were analyzed. Patients were grouped based on arthritis presence, duration, and axial joint involvement for comparative analysis.</div></div><div><h3>Results</h3><div>Arthritis was observed in 19.2% of patients, with acute and chronic arthritis in 17.9% and 6.4%, respectively. The M694V allele frequency was significantly higher in the arthritis group (82%, <em>P</em> <!-->&lt;<!--> <!-->0.01), with a predominance of the M694V/M694V genotype (70.3%). In contrast, V726A and R761H alleles were less frequent. Chronic arthritis with axial involvement was associated with older age at diagnosis (<em>P</em> <!-->&lt;<!--> <!-->0.01), increased polyarticular involvement (<em>P</em> <!-->&lt;<!--> <!-->0.01), and elevated colchicine resistance (22.6%, <em>P</em> <!-->&lt;<!--> <!-->0.01). The most frequently affected joints included the knee and sacroiliac joints. HLA-B27 positivity was higher in axial arthritis cases, but the need for advanced therapies did not differ significantly.</div></div><div><h3>Conclusions</h3><div>Our study highlights the diverse arthritis presentations in pediatric FMF patients with biallelic pathogenic genotypes. The M694V allele was more prevalent in the arthritis group, suggesting a potential genetic link. Specifically, the reduced frequency of common FMF attack symptoms, such as fever and abdominal pain, in patients with arthritis suggests that this may lead to diagnostic delays. Chronic arthritis with axial involvement was associated with higher colchicine resistance and a greater need for advanced treatments. These findings emphasize the importance of tailored management strategies and long-term follow-up in pediatric FMF patients with arthritis to optimize outcomes.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105888"},"PeriodicalIF":3.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic background of selected hyperuricemia causing gout with pediatric onset","authors":"Blanka Stiburkova ,&nbsp;Kimiyoshi Ichida","doi":"10.1016/j.jbspin.2025.105884","DOIUrl":"10.1016/j.jbspin.2025.105884","url":null,"abstract":"<div><div>Elevated serum uric acid levels are the essential pathophysiology of gout. Although gout rarely develops in childhood, chronic persistent hyperuricemia can induce precipitation and deposition of sodium urate crystals, leading to the development of gout. Hyperuricemia is caused by increased uric acid production and/or decreased uric acid excretion capacity of the kidneys and/or intestinal tract. Increased production of uric acid, the final metabolite of purine, is associated with an increase of phosphoribosyl pyrophosphate, the key compound in the purine synthesis pathways, as observed in hypoxanthine-guanine phosphoribosyltransferase deficiency. Another mechanism for increased uric acid production is increased adenosine triphosphate consumption that is found in glycogen storage disease type I. On the other hand, in uromodulin-associated kidney disease, the accumulation of abnormal uromodulin in the kidneys leads to tubulointerstitial damage and fibrosis, and the ability to excrete uric acid is compromised, with reduced secretion and increased reabsorption in the proximal tubules. Decreased uric acid excretion from the kidneys or intestinal tract is also mediated by decreased function of the ATP-binding cassette subfamily G member 2, a urate transporter that acts in the urate secretion. This review summarizes the selected pathophysiological mechanisms underlying the genetic basis of hyperuricemia and gout in children, both in terms of purine metabolism and uric acid excretion.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105884"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diseases associated with anti-centromere protein F (anti-CENP-F) antibodies: Insights from a large cohort study","authors":"Alexandre Le Joncour ,&nbsp;Jean-Luc Charuel ,&nbsp;Sylvain Choquet ,&nbsp;Jean-Philippe Spano ,&nbsp;Jean-Christophe Corvol ,&nbsp;Bruno Fautrel ,&nbsp;Dominique Thabut ,&nbsp;David Saadoun ,&nbsp;Zahir Amoura ,&nbsp;Pascale Ghillani-Dalbin ,&nbsp;Patrice Cacoub","doi":"10.1016/j.jbspin.2025.105885","DOIUrl":"10.1016/j.jbspin.2025.105885","url":null,"abstract":"<div><h3>Introduction</h3><div>Antinuclear antibodies (ANA) exhibit diverse specificities and are crucial biomarkers in autoimmune disease assessment. Among ANA, anti-centromere protein-F (CENP-F) antibodies have garnered interest due to their association with malignancies. This study aims to characterize the clinical and biological profiles of a large cohort of anti-CENP-F positive patients and evaluate associated diagnoses.</div></div><div><h3>Methods</h3><div>Over 12 years, approximately 151,000 ANA screening samples were assessed, identifying 110 anti-CENP-F positive patients. Clinical and biological characteristics, including demographics, comorbidities, and antibody titers, were retrospectively analyzed. Follow-up data were collected to ascertain associated diagnoses.</div></div><div><h3>Results</h3><div>The median age was 50.9 years, with a predominance of women (73.6%). Median CENP-F antibody titer was 1:160, with 16.4% of patients with a titer higher than 1:1280. A concomitant specific autoimmune antibody was detected in 29 (26.4%) of cases. After a median follow-up of 3.8 years, autoimmune diseases were the most common associated diagnosis (38.2%), followed by neurological diseases (15.5%), hemopathies (8.3%), and cancer (10.9%). Some patients had concurrent cancer and autoimmune diseases. Twelve patients were diagnosed with cancer, primarily lung and breast cancers. In multivariate analysis, older age and higher anti-CENP-F titers were associated with cancer diagnosis.</div></div><div><h3>Conclusion</h3><div>This study provides comprehensive insights into the clinical significance of anti-CENP-F antibodies. Vigilance is warranted in older patients with elevated antibody titers, as they may indicate an increased risk of cancer.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105885"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between osteoporosis and periodontitis","authors":"Françoise Tilotta ,&nbsp;Marjolaine Gosset ,&nbsp;Julia Herrou ,&nbsp;Karine Briot ,&nbsp;Christian Roux","doi":"10.1016/j.jbspin.2025.105883","DOIUrl":"10.1016/j.jbspin.2025.105883","url":null,"abstract":"<div><div>Both osteoporosis and periodontitis are characterized by bone resorption. Osteoporosis is defined as a generalized disease of the skeleton affecting bone microarchitecture and density and conferring a predisposition to fractures, including fractures of the upper end of the femur. Periodontitis is characterized by gingival inflammation and destruction of the alveolar bone, potentially leading to tooth mobility and loss. Both these diseases are common health concerns associated with a considerable economic and societal burden worldwide. The prevention of these two diseases is therefore a real public health issue. The close association between osteoporosis and periodontitis should lead dental surgeons to refer patients with severe periodontitis to a rheumatologist for an assessment of bone density. Conversely, patients with osteoporosis should undergo regular oral check-ups to prevent tooth loss and maintain good oral health.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105883"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Costo-vertebral joint involvement in axial spondyloarthritis","authors":"Noa Nemesh,&nbsp;Shiri Keret,&nbsp;Gleb Slobodin","doi":"10.1016/j.jbspin.2025.105881","DOIUrl":"10.1016/j.jbspin.2025.105881","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105881"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of various inflammatory arthritis incidences during 2015–2020: A nationwide population-based register study in Finland","authors":"Laura Heimola ,&nbsp;Ritva Peltomaa ,&nbsp;Anna Laine ,&nbsp;Hannu Kautiainen ,&nbsp;Kari Puolakka ,&nbsp;Vappu Rantalaiho","doi":"10.1016/j.jbspin.2025.105886","DOIUrl":"10.1016/j.jbspin.2025.105886","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105886"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and safety of anifrolumab for belimumab-experienced and biologic-naïve patients with systemic lupus erythematosus: Results from the Kyushu Collagen Disease Network for Systemic Lupus Erythematosus (KCDN-SLE) registry","authors":"Masahiro Ayano ,&nbsp;Naoyasu Ueda ,&nbsp;Koji Mishima ,&nbsp;Shun-Ichiro Ota ,&nbsp;Kazuo Kushimoto ,&nbsp;Atsushi Tanaka ,&nbsp;Goro Doi ,&nbsp;Tsuyoshi Nakayama ,&nbsp;Makiko Maekawa ,&nbsp;Tomomi Tsuru ,&nbsp;Mitsuteru Akahoshi ,&nbsp;Koichi Akashi ,&nbsp;Takahiko Horiuchi ,&nbsp;Hiroaki Niiro","doi":"10.1016/j.jbspin.2025.105882","DOIUrl":"10.1016/j.jbspin.2025.105882","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105882"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}