Joint Bone Spine最新文献

{"title":"Late-onset psoriatic arthritis: a separate entity.","authors":"Daniel Wendling, Frank Verhoeven, Clément Prati","doi":"10.1016/j.jbspin.2026.106065","DOIUrl":"https://doi.org/10.1016/j.jbspin.2026.106065","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"106065"},"PeriodicalIF":4.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mega-aortic syndrome in Cogan syndrome.","authors":"Philipp Jud, Rupert Horst Portugaller","doi":"10.1016/j.jbspin.2026.106064","DOIUrl":"https://doi.org/10.1016/j.jbspin.2026.106064","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"106064"},"PeriodicalIF":4.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social and occupational factors are associated with musculoskeletal pain prevalence in the general population: A population-based cohort study","authors":"Florian Bailly ,&nbsp;Benjamin Granger ,&nbsp;Violaine Foltz ,&nbsp;Sofiane Kab ,&nbsp;Audrey Petit ,&nbsp;Florence Tubach ,&nbsp;Bruno Fautrel","doi":"10.1016/j.jbspin.2025.105984","DOIUrl":"10.1016/j.jbspin.2025.105984","url":null,"abstract":"<div><h3>Objective</h3><div>Musculoskeletal pain (MP) is a leading cause of disability worldwide, affecting individual well-being and public health. However, in the literature, the prevalence of MP varies considerably because of methodological inconsistencies, selection biases, and differences in case definitions. This study aimed to estimate the population-based prevalence of MP in France and identify key demographic, socioeconomic, and occupational factors associated with MP.</div></div><div><h3>Methods</h3><div>This cross-sectional study used baseline data for the CONSTANCES cohort study, a large, population-based epidemiological study with participants representative of the French adult population (18–69<!--> <!-->years old). Inverse probability weighting was used to correct for selection bias and to improve the generalizability of prevalence estimates. MP was assessed with the Nordic Musculoskeletal Questionnaire, with significant pain defined as lasting<!--> <!-->&gt;<!--> <!-->30<!--> <!-->days in the past 12<!--> <!-->months. Multivariate logistic regression models were used to identify factors associated with low back pain, estimating odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Among 193,436 participants, 46.2% reported pain in at least one anatomical site. The most affected areas were the low back (26.6% adjusted prevalence), shoulder (21.4%), neck (19.0%), and knee (19.1%). Odds of low back pain was associated with female sex (OR: 1.39 [95% CI: 1.32–1.47]), older age, obesity, depression (1.71 [1.62–1.80]), and comorbidity burden (1.20 [1.15–1.25]). Odds of low back pain was associated with moderate or high occupational physical activity (OR: 1.33 [1.20–1.50] and 1.69 [1.48–1.93]) but was inversely associated with very active leisure-time physical activity (0.82 [0.70–0.96]). Education level but not household income was a significant socioeconomic factor associated with MP.</div></div><div><h3>Conclusion</h3><div>MP imposes a substantial burden on the French population, particularly among individuals with physically demanding jobs and low education levels. These findings highlight the paradox of physical activity associated with MP.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105984"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring gout with ultrasound: Is it useful in daily practice?","authors":"Lene Terslev ,&nbsp;Hilde Berner Hammer","doi":"10.1016/j.jbspin.2025.105965","DOIUrl":"10.1016/j.jbspin.2025.105965","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105965"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccinating patients with autoimmune diseases","authors":"Ai Li Yeo ,&nbsp;Kevin L. Winthrop","doi":"10.1016/j.jbspin.2025.105978","DOIUrl":"10.1016/j.jbspin.2025.105978","url":null,"abstract":"<div><h3>Purpose</h3><div>Vaccine preventable diseases, especially respiratory infections, occur at higher frequency in patients with rheumatic diseases who are immunosuppressed. The focus of this review is to highlight vaccinations that patients with rheumatic diseases should optimally receive, with a focus on efficacy and safety of vaccines.</div></div><div><h3>Main findings</h3><div>In general, vaccines are effective in reducing the burden of infection. However, due to underlying immunosuppression, their efficacy is most likely reduced compared to the general population. This is even true of the novel vaccines, mRNA and subunit vaccines. Emerging evidence, particularly for withholding methotrexate for 1–2 weeks post vaccination can improve immunogenicity without significantly increasing the risk of disease flare. Administration of live vaccines continue to provide clinicians a challenge especially in the setting of recent measles outbreaks. Assessing underlying degree of immunosuppression and following national guidelines can help clinicians vaccinate these patients safely. If this is not possible, then measles immunoglobulin can be administered.</div></div><div><h3>Principle conclusions</h3><div>Vaccination is an important part of infection reduction strategies for the rheumatologist to consider during a consultation as the number of vaccines available for infective conditions increases. High dose prednisolone, B cell depleting therapies, and methotrexate have the most evidence for reduced vaccine responses and where feasible, attempts should be made to vaccinate when immunosuppression is thought to be lower.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105978"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for denosumab discontinuation in postmenopausal osteoporosis","authors":"Yannick Degboé ,&nbsp;Guillaume Couture","doi":"10.1016/j.jbspin.2025.105954","DOIUrl":"10.1016/j.jbspin.2025.105954","url":null,"abstract":"<div><div>Discontinuation of denosumab in postmenopausal osteoporosis causes a rebound phenomenon with a rapid increase in bone turnover markers and accelerated bone loss, often within 6–12 months. Without an appropriate relay therapy, up-to 10% of the patients experience multiple vertebral fractures. This phenomenon is linked to a multifactorial dysregulation of bone remodelling. In 2021, the European Calcified Tissue Society (ECTS) proposed guidelines for discontinuing denosumab in patients with postmenopausal osteoporosis. Our review covers the latest research on risk stratification for rebound phenomenon, the various relay treatment options based on risk levels, and the recommended follow-up for these patients. Post-denosumab treatment is important. Bisphosphonates therapy and regular monitoring of serum CTX (crosslaps) represent the cornerstone of the management of rebound phenomenon following denosumab discontinuation in postmenopausal osteoporosis.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105954"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporomandibular joint tophus","authors":"Shio-Yi Liao ,&nbsp;Ching-Lan Wu ,&nbsp;Chien-Chih Lai","doi":"10.1016/j.jbspin.2025.106019","DOIUrl":"10.1016/j.jbspin.2025.106019","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 106019"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual JAK and IL-23 blockade: A mechanistically supported strategy in refractory psoriatic arthritis. A case report.","authors":"Paul Gervaise ,&nbsp;Simon Glatigny ,&nbsp;Maxime Breban ,&nbsp;Félicie Costantino","doi":"10.1016/j.jbspin.2025.106017","DOIUrl":"10.1016/j.jbspin.2025.106017","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 106017"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden nidus on MRI, revealed on CT: Lumbar lamina osteoid osteoma","authors":"Mustafa Kemal Demir ,&nbsp;Onder Ertem ,&nbsp;Deniz Konya","doi":"10.1016/j.jbspin.2025.105998","DOIUrl":"10.1016/j.jbspin.2025.105998","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105998"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FGF23: A player not only in bone diseases","authors":"Amélie Cifuentes ,&nbsp;Zacharie Laskar-Marchesseau ,&nbsp;Guillaume Courbon","doi":"10.1016/j.jbspin.2025.105988","DOIUrl":"10.1016/j.jbspin.2025.105988","url":null,"abstract":"<div><div>The skeleton is able to secrete hormones and mediate endocrine functions. Particularly, the fibroblast growth factor 23 (FGF23) has received considerable attention for its unique phosphaturic properties, raising the bone to the status of an essential endocrine regulator. Excess in circulating levels of FGF23, not so surprisingly, then associated to mineral imbalance, in hereditary/acquired mineral and skeletal disorders. A key player, FGF23 excess precedes mineral and skeletal disturbances. However, unexpected effects have been described in the recent years. Various demonstrations have been made that FGF23 is directly regulated by non-mineral stress, including: inflammation, iron deficiency, and glycolysis. In turn, an emerging body of research shows association and causality between FGF23 and the cardiovascular system at large, from the iron metabolism to erythropoiesis, and to the cardiac muscle. This review summarizes canonical and novel effects of FGF23. FGF23 cleavage generates C-terminal peptides that also mediate biological functions. In aggregate, FGF23 measurements should be considered for larger application, as its excess can precede hypophosphatemia, explain hypophosphatemia or resistance to phosphate loading, and possibly predict cardiovascular progression in a wide range of uremic and non-uremic conditions.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105988"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}