The association between familial Mediterranean fever and incident cirrhosis: A population-based matched cohort study

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine Pub Date : 2025-04-30 DOI:10.1016/j.jbspin.2025.105917

Michal Carmiel-Haggai , Rula Daood , Fadi Fassan , Helana Jeries , Dikla Dror-Zur , Mahmud Omar , Abdulla Watad , Tal Patalon , Mohammad E. Naffaa

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引用次数: 0

Abstract

Objective

The association between FMF and incident liver cirrhosis is not widely studied. In this study, we aimed to examine the association between FMF and incident liver cirrhosis in a population-based cohort.

Methods

Patients with FMF aged ≥ 18 in the Maccabi Healthcare Services (MHS) database were identified according to ICD-9 code 277.31 between January 1st, 2000 and December 31st, 2022. A control group was 1:1 age and gender-matched. Patients with chronic liver disease or cirrhosis were excluded, as well as patients who were treated with methotrexate, amiodarone or tamoxifen and patients with less than 12 months of follow-up. Incident cirrhosis was defined as a new diagnosis of cirrhosis according to ICD-9 code (571.5), newly diagnosed major cirrhotic complications or liver transplantation. The Cox proportional hazards models were used to examine the association between FMF and incident cirrhosis and the Kaplan-Meier curves to study the event-free survival.

Results

Incident cirrhosis was detected among 2.1% and 0.4% in the study and control groups, respectively, P < 0.01. Being in the FMF group was associated with a significantly increased risk of incident cirrhosis (HR = 2.60, 95% CI: 1.54–4.38, P < 0.01). At 7 years, the cirrhosis-free survival rate was 98.2% in the study group and 99.6% in the control group (P < 0.01).

Conclusion

FMF was associated with incident cirrhosis, irrespective of the traditional risk factors for metabolic syndrome, suggesting the contribution of the inflammatory state to the development of cirrhosis.

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家族性地中海热与肝硬化之间的关系：一项基于人群的匹配队列研究。

目的：FMF与肝硬化之间的关系尚未得到广泛的研究。在这项研究中，我们的目的是在以人群为基础的队列中研究FMF与肝硬化事件之间的关系。方法：根据2000年1月1日至2022年12月31日的ICD-9代码277.31，对MHS数据库中年龄≥18岁的FMF患者进行识别。对照组的年龄和性别比例为1:1。排除慢性肝病或肝硬化患者，以及接受甲氨蝶呤、胺碘酮或他莫昔芬治疗的患者和随访时间少于12个月的患者。偶发性肝硬化定义为根据ICD-9编码（571.5）新诊断的肝硬化、新诊断的主要肝硬化并发症或肝移植。采用Cox比例风险模型检验FMF与事件性肝硬化之间的关系，并采用Kaplan-Meier曲线研究无事件生存率。结果：研究组和对照组肝硬化发生率分别为2.1%和0.4%,p< 0.01。FMF组与肝硬化发生风险显著增加相关（HR = 2.60, 95% CI: 1.54-4.38, p < 0.01）。7年时，研究组无肝硬化生存率为98.2%，对照组为99.6% （p < 0.01）。结论：与代谢综合征的传统危险因素无关，FMF与肝硬化的发生有关，提示炎症状态对肝硬化的发展有贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Joint Bone Spine 医学-风湿病学

CiteScore

4.50

自引率

11.90%

发文量

184

审稿时长

25 days

期刊介绍： Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.