饮酒对轴性脊柱关节炎患者临床疗效和结构损伤的影响：系统文献综述与元分析》。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine Pub Date : 2024-10-24 DOI:10.1016/j.jbspin.2024.105794

Evelyne Gendron , Sinead Maguire , Melanie Anderson , Sindhu R. Johnson , Robert D. Inman , Nigil Haroon

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引用次数: 0

摘要

目的系统回顾饮酒（AC）对轴性脊柱关节炎（axSpA）疾病特异性结果的影响：方法：对有关 axSpA 和 AC 的观察性研究进行系统回顾。对多个电子数据库进行了关键词检索。两名研究人员对文章进行了审查，以评估纳入资格。采用乔安娜-布里格斯研究所（Joanna Briggs Institute）的关键评估清单来评估偏倚风险。采用标准化均值差异（SMD）来综合数据，采用 I² 来确定异质性。根据巴斯强直性脊柱炎疾病活动指数（BASDAI）和强直性脊柱炎疾病活动评分（ASDAS）测量脊柱疼痛、疾病活动度，并根据修改后的斯托克斯强直性脊柱炎脊柱评分（mSASSS）测量脊柱放射学进展作为研究结果：搜索策略共发现 703 条记录；对 13 篇文章进行了资格评估。共纳入 5 项研究（n = 3858）。与不饮酒者相比，饮酒的 axSpA 患者的 BASDAI（SMD -0.19，95% CI -0.37~-0.02，I²=72.5%）和脊柱疼痛（SMD -0.17，95% CI -0.24~-0.09，I²=0%）较低。ASDAS没有发现明显差异（SMD -0.19，95% CI -0.39至0.00，I² = 36%）。一项关于脊柱放射学进展的队列研究表明，消费者的放射学进展更大（SMD 0.35，95% CI 0.08 至 0.62）：结论：AC 似乎与较低的疾病活动度和脊柱疼痛有关。结论：AC 似乎与较低的疾病活动度和脊柱疼痛有关，但这些发现可能反映了性别和吸烟的混杂因素。有必要进一步开展纵向队列研究，采用标准化的 AC 测量方法来评估酒精对结构性损伤进展的影响方向。

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The effect of alcohol consumption on clinical outcomes and structural damage in patients with axial spondyloarthritis: A systematic literature review and meta-analysis

Objective

To systematically review the effects of alcohol consumption (AC) on disease-specific outcomes in axial spondyloarthritis (axSpA).

Methods

A systematic review of observational studies on axSpA and AC was conducted. Multiple electronic databases were searched for keywords. Two investigators reviewed articles to assess for inclusion eligibility. The Joanna Briggs Institute Critical Appraisal checklist was employed to evaluate the risk of bias. Standardized mean differences (SMD) were used to synthesize the data and I² was used to ascertain heterogeneity. Spinal pain, disease activity as measured by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS), and spinal radiographic progression based on the modified Stokes Ankylosing Spondylitis Spinal Score (mSASSS) were examined as outcomes.

Results

Search strategy identified 703 records; 13 articles were assessed for eligibility. Five studies (n = 3858) were included. Compared to non-consumers, axSpA patients who consumed alcohol had lower BASDAI (SMD: −0.19, 95% CI: −0.37 to −0.02, I² = 72.5%) and lower spinal pain (SMD: −0.17, 95% CI: −0.24 to −0.09, I² = 0%). No significant difference was found for ASDAS (SMD: −0.19, 95% CI: −0.39 to 0.00, I² = 36%). One cohort study on the spinal radiographic progression indicated greater radiographic progression among consumers (SMD: 0.35, 95% CI: 0.08 to 0.62).

Conclusion

AC appears to be associated with lower disease activity and spinal pain. However, these findings may reflect confounding by sex and smoking. Further longitudinal cohort studies with standardized measures for AC are warranted to assess the direction of alcohol's effect on structural damage progression.

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来源期刊

Joint Bone Spine 医学-风湿病学

CiteScore

4.50

自引率

11.90%

发文量

184

审稿时长

25 days

期刊介绍： Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.