IF 3.8 3区 医学 Q1 RHEUMATOLOGY
Marie-Eva Pickering , Jean-Claude Souberbielle , Anne Boutten , Véronique Breuil , Karine Briot , Roland Chapurlat , Patrice Fardellone , Rose-Marie Javier , Eugénie Koumakis , Bernard Cortet , Groupe de Recherche et d’Information sur les Ostéoporoses (GRIO)
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引用次数: 0

摘要

骨质疏松症研究与信息组(GRIO)讨论了间歇性补充维生素 D 与每日补充维生素 D 的利弊,尤其是对患有骨质疏松症或有骨质疏松症风险的成年人而言。文献分析表明,间歇性长期大剂量补充维生素 D(如每月 60,000 IU 或更多)可能会增加某些人群跌倒、骨折和过早死亡的风险,而每日 800-1000 IU 剂量的维生素 D 和钙可减少维生素 D 缺乏症老人跌倒和非椎体骨折的风险。因此,对于骨质疏松症患者或有骨质疏松症风险的患者,我们建议在补充维生素 D 之前测量 25(OH)D 浓度,并补充维生素 D(必要时优化钙摄入量),以获得 30 至 60 纳克/毫升的浓度。我们建议使用初始负荷剂量,尤其是对于那些需要快速补充维生素 D 的人群(骨软化症状和/或 25(OH)D 浓度在 30 至 60 纳克/毫升之间)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO
Advantages and disadvantages of intermittent versus daily vitamin D supplementation especially in adults with or at risk of osteoporosis are discussed by the Osteoporosis Research and Information Group (GRIO). The analysis of the literature suggests that intermittent long-term high doses vitamin D supplementation (such as 60,000 IU/month or more), may increase the risk of falls, fracture and premature death in certain populations, while daily doses of 800–1000 IU with calcium decrease falls and non-vertebral fractures in the elderly with vitamin D deficiency. In patients with or at risk of osteoporosis we hence recommend measuring the 25(OH)D concentration prior to supplementation and to provide vitamin D supplementation (with optimization of calcium intake if needed) to obtain a concentration between 30 and 60 ng/mL. We recommend the use of an initial loading dose, especially in those who need a quick repletion of vitamin D store (symptoms of osteomalacia and/or 25(OH)D concentration < 12 ng/mL, patients eligible for treatment with potent antiresorptive therapy), followed by a maintenance dose. A daily supplementation should be the rule when possible. When daily forms are however not available or not reimbursed, we recommend, like other experts, to continue using intermittent dosing with the smallest available dose (≤ 50,000 IU) and the shortest interval between doses as a stopgap until reimbursement or adequate daily pharmaceutical forms (pills or soft capsules of 1000, 2000 IU) are available.
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来源期刊
Joint Bone Spine
Joint Bone Spine 医学-风湿病学
CiteScore
4.50
自引率
11.90%
发文量
184
审稿时长
25 days
期刊介绍: Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.
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