Joint Bone Spine最新文献

{"title":"Managing the disease, managing the patient: Towards a comprehensive diagnostic appraoch in psoriatic arthritis and spondyloarthritis","authors":"Rik J. Lories","doi":"10.1016/j.jbspin.2025.105843","DOIUrl":"10.1016/j.jbspin.2025.105843","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 3","pages":"Article 105843"},"PeriodicalIF":3.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining a genetic background for bamboo spine and axial spondyloarthritis","authors":"Şeyma Çolakoğlu Özkaya ,&nbsp;Kerem Abacar ,&nbsp;Yunus Emre Dilek ,&nbsp;Günseli Bayram Akçapınar ,&nbsp;Mehmet Pamir Atagündüz ,&nbsp;Can Erzik","doi":"10.1016/j.jbspin.2025.105842","DOIUrl":"10.1016/j.jbspin.2025.105842","url":null,"abstract":"<div><h3>Objective</h3><div>Bamboo spine is the most severe complication of axial spondyloarthritis (AxSpA). This study aims to address whether haplotypes of endoplasmic reticulum aminopeptidase (<em>ERAP)1</em> and <em>ERAP2</em> single nucleotide polymorphisms (SNPs), previously associated with AxSpA, are associated with the development of bamboo spine in an AxSpA cohort.</div></div><div><h3>Methods</h3><div>The study included 192 patients with AxSpA followed in MARS (MARmara Spondyloarthritis) clinic and fulfilling the modified New York criteria. <em>ERAP1</em> and <em>ERAP2</em> polymorphisms were determined by real-time PCR on genomic DNA using the TaqMan SNP Genotyping Assay for SNPs rs72773968, rs3734016, rs26653, rs26618, rs27895, rs2287987, rs30187, rs10050860, rs17482078, rs27044, rs2549782, rs2248374. The HLA-B genotypes were assessed using the LABTypeTM SSO method.</div></div><div><h3>Results</h3><div>Male gender (<em>P</em> <!-->&lt;<!--> <!-->0.001) and HLA-B27 positivity (<em>P</em> <!-->&lt;<!--> <!-->0.05) were associated with an increased risk of developing a bamboo spine, and peripheral arthritis was significantly less prevalent in AxSpA patients with a bamboo spine (<em>P</em> <!-->&lt;<!--> <!-->0.05). Of the ten ERAP1 haplotypes, haplotype 3 was significantly more prevalent in AxSpA patients with bamboo spine adjusted for HLA-B27 status (<em>P</em> <!-->&lt;<!--> <!-->0.05). Haplotype 3 and -6 were significantly more prevalent exclusively in HLA-B27 (+) patients (<em>P</em> <!-->&lt;<!--> <!-->0.05). Allele frequencies and genotype distributions of single <em>ERAP1</em> SNPs alone were not significantly different between AxSpA patients with and without bamboo spines. There was no association between bamboo spine development and <em>ERAP2</em> SNPs.</div></div><div><h3>Conclusions</h3><div>Our results indicate that HLA-B27 positivity, <em>ERAP1</em> haplotype 3 and -6, and being male confer a significant risk for developing bamboo spine. Whether the association of haplotype 3 and -6 with bamboo spine is confined only to our Turkish patient cohort may deserve attention in other ethnicities.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 3","pages":"Article 105842"},"PeriodicalIF":3.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Is the microRNA-146a (rs2910164) polymorphism associated with rheumatoid arthritis? Association of microRNA-146a (rs2910164) polymorphism and rheumatoid arthritis could depend on gender” [Joint Bone Spine 2015; 82 :166–71]","authors":"Xindie Zhou ,&nbsp;Jinlong Zhu ,&nbsp;Hui Zhang ,&nbsp;Guoxin Zhou ,&nbsp;Yong Huang ,&nbsp;Ruiping Liu","doi":"10.1016/j.jbspin.2024.105808","DOIUrl":"10.1016/j.jbspin.2024.105808","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 1","pages":"Article 105808"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting new erosions in rheumatoid arthritis over one year – Radiography and high-resolution computed tomography of finger joints","authors":"Josephine Therkildsen ,&nbsp;Rasmus Klose-Jensen ,&nbsp;Mathias Hänel ,&nbsp;Bente L. Langdahl ,&nbsp;Jesper S. Thomsen ,&nbsp;Sarah L. Manske ,&nbsp;Kresten K. Keller ,&nbsp;Ellen-Margrethe Hauge","doi":"10.1016/j.jbspin.2024.105812","DOIUrl":"10.1016/j.jbspin.2024.105812","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the number of new erosions in two metacarpophalangeal (MCP) joints over one year assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) and conventional radiography (CR). Furthermore, to estimate the diagnostic accuracy of erosive progression by CR with HR-pQCT as the reference standard.</div></div><div><h3>Methods</h3><div>Paired sets of image data were available from patients with RA (<em>n</em> <!-->=<!--> <!-->310), who underwent HR-pQCT and CR, including the 2nd and 3rd MCP joints only of the dominant hand at baseline and at the one-year follow-up. Erosion number was determined using HR-pQCT and CR. Erosive volume was estimated from segmented HR-pQCT images, and erosion scores were obtained by the Sharp/van der Heijde method from CR. Erosive progression was defined as an increase in total erosion number or a study-specified increase in total erosive volume or total erosion score.</div></div><div><h3>Results</h3><div>At baseline, 250 erosions were identified by CR compared to 1864 erosions by HR-pQCT. After one year, 3 new erosions were detected by CR compared to 66 new erosions by HR-pQCT. Erosive progression was identified in 40 patients using HR-pQCT and in 3 patients using CR. With HR-pQCT as reference, CR had a sensitivity of 2.5% (95% CI: 0.1–13.2%) and a specificity of 99.3% (95% CI: 97.3–99.9%) for detecting erosive progression.</div></div><div><h3>Conclusion</h3><div>HR-pQCT identified more than 20 times the number of new erosions, and more than 10 times as many patients with erosive progression than CR. HR-pQCT is a sensitive tool for monitoring new erosions and erosive progression over one year in RA.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 1","pages":"Article 105812"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ankylosing spondylitis and neurodegenerative diseases: Systematic review and meta-analysis","authors":"Anling Luo ,&nbsp;Qin Yang ,&nbsp;Zhao Zhang,&nbsp;Yujia Yang,&nbsp;Xuzi Li,&nbsp;Yiting Deng,&nbsp;Li He,&nbsp;Muke Zhou","doi":"10.1016/j.jbspin.2024.105793","DOIUrl":"10.1016/j.jbspin.2024.105793","url":null,"abstract":"<div><h3>Background</h3><div>Increasing evidence indicates the mechanism of overlapping immune dysfunction and inflammation disorder shared by ankylosing spondylitis (AS) and neurodegenerative diseases (NDs). However, the exact correlation between the two is still unclear. Different studies have reported inconsistent results about how AS and NDs are related.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the association between AS and risk of NDs.</div></div><div><h3>Methods</h3><div>We searched electronic databases including PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials to identify studies reporting relationship between NDs risk and AS published before April 10th, 2024. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were estimated. All analyses were conducted using Stata V.12.0 software.</div></div><div><h3>Results</h3><div>A total of 15 comparisons out of 10 studies involving 851,936 participants were included. The results showed that the risk of NDs was higher among AS patients than those who were not (OR: 1.36, 95% CI: 1.15–1.60, <em>P</em> <!-->&lt;<!--> <!-->0.001). In addition, subgroup analysis showed that AS was associated with an increased risk of Parkinson's disease (PD) development (OR: 1.55, 95% CI: 1.31–1.83, <em>P</em> <!-->&lt;<!--> <!-->0.001), whereas there is no observed association with Alzheimer's disease (AD) and dementia (OR: 1.22, 95% CI: 0.96–1.55, <em>P</em> <!-->=<!--> <!-->0.098; OR: 1.34, 95% CI: 0.96–1.87, <em>P</em> <!-->=<!--> <!-->0.089, respectively).</div></div><div><h3>Conclusion</h3><div>The current meta-analysis identified AS as a risk factor for the development of NDs. Clinicians should be aware of the potential association between these diseases. Further research is necessary to confirm the causal relationship and underlying mechanisms between AS and NDs.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 1","pages":"Article 105793"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A large-scale multi-omics polygenic risk score analysis identified candidate risk locus associated with rheumatoid arthritis","authors":"Jingni Hui ,&nbsp;Dan He ,&nbsp;Chen Liu,&nbsp;Panxing Shi,&nbsp;Ruixue Zhou,&nbsp;Meijuan Kang,&nbsp;Ye Liu,&nbsp;Yifan Gou,&nbsp;Bingyi Wang,&nbsp;Shiqiang Cheng,&nbsp;Xuena Yang,&nbsp;Chuyu Pan,&nbsp;Wenming Wei,&nbsp;Feng Zhang","doi":"10.1016/j.jbspin.2024.105841","DOIUrl":"10.1016/j.jbspin.2024.105841","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the associations of multi-omics polygenic risk score (PRS) and rheumatoid arthritis (RA) to identify potential genes/proteins and biological pathways.</div></div><div><h3>Methods</h3><div>Based on multi-omics data from 48,813 participants in the INTERVAL cohort, we calculated multi-omics PRS for 13,646 mRNAs (RNASeq), 308 proteins (Olink), 2380 proteins (SomaScan), 726 metabolites (Metabolon), and 141 metabolites (Nightingale). Using the generalized linear model, we first evaluated the associations between multi-omics PRS and RA in 58,813 UK Biobank participants. The Gene Ontology (GO) project and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed to identify the functional pathways in RA. Furthermore, differential gene expression profile datasets were used to validate the identified genes/proteins in our study.</div></div><div><h3>Results</h3><div>We identified 59 transcriptomics PRS and 29 proteomics PRS significantly associated with RA. Both proteomics and transcriptomic PRS identified HLA-DQA2 (RNASeq: OR<!--> <!-->=<!--> <!-->1.19, <em>P</em> <!-->=<!--> <!-->1.18<!--> <!-->×<!--> <!-->10^–24; SomaScan: OR<!--> <!-->=<!--> <!-->1.24, <em>P</em> <!-->=<!--> <!-->4.43<!--> <!-->×<!--> <!-->10^–27) and AGER (RNASeq: OR<!--> <!-->=<!--> <!-->0.91, <em>P</em> <!-->=<!--> <!-->4.18<!--> <!-->×<!--> <!-->10^–4; SomaScan: OR<!--> <!-->=<!--> <!-->0.93, <em>P</em> <!-->=<!--> <!-->3.97<!--> <!-->×<!--> <!-->10^–3) were significantly associated with RA. Proteomic PRS from different profiling platforms (SomaScan and Olink) identified a consistent association between TFF3 (SomaScan: OR<!--> <!-->=<!--> <!-->0.90, <em>P</em> <!-->=<!--> <!-->4.08<!--> <!-->×<!--> <!-->10^–6; Olink: OR<!--> <!-->=<!--> <!-->0.93, <em>P</em> <!-->=<!--> <!-->4.87<!--> <!-->×<!--> <!-->10^–3) and RA. The identified gene/proteins were mainly enriched in the NF-kappa B signaling pathway (hsa04064, <em>P</em> <!-->=<!--> <!-->5.06<!--> <!-->×<!--> <!-->10^–5) and Cytokine-cytokine receptor interaction (hsa04060, <em>P</em> <!-->=<!--> <!-->2.49<!--> <!-->×<!--> <!-->10^–4). In addition, a total of 12 candidate genes in our study were verified in two independent GEO datasets, such as FLOT1 and ABCF1.</div></div><div><h3>Conclusion</h3><div>Our findings provide novel insights into the involvement of identified genes/proteins and pathways in the pathogenesis of RA from multi-omics levels.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 3","pages":"Article 105841"},"PeriodicalIF":3.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and cross-cultural adaptation of the Coping with Rheumatic Stressors (CORS) into French language","authors":"Clementina López-Medina ,&nbsp;Sofia Ramiro ,&nbsp;Caroline van Durme ,&nbsp;Zineb Ez-Zaitouni ,&nbsp;Adrien Nzeusseu Toukap ,&nbsp;Olivier Fogel ,&nbsp;Anna Moltó","doi":"10.1016/j.jbspin.2024.105839","DOIUrl":"10.1016/j.jbspin.2024.105839","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 3","pages":"Article 105839"},"PeriodicalIF":3.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of return to work after multidisciplinary rehabilitation program for patients with chronic low back pain","authors":"Stéphane Le Cam ,&nbsp;Violaine Foltz ,&nbsp;Bruno Fautrel ,&nbsp;Florian Bailly","doi":"10.1016/j.jbspin.2024.105840","DOIUrl":"10.1016/j.jbspin.2024.105840","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with chronic low back pain face functional, psychological, social and professional difficulties. Multidisciplinary rehabilitation programs (MRP) can be an effective treatment to help these patients to improve their condition and return to work.</div></div><div><h3>Objective</h3><div>To determine baseline predictors for return to work after an MRP for patients with chronic low back pain struggling to maintain their job.</div></div><div><h3>Methods</h3><div>A monocentric cohort study was conducted. Patients who had followed a MRP between January 2015 and December 2020 were included. The program consisted of physical activities and different workshops inspired by behavioural therapy, at full time during one month. Pain, lifestyle, history of the disease, function, psychosocial characteristics were evaluated at baseline. Return to work at different possible time point after the MRP was collected. A bivariate and a multivariate analysis were performed to evaluate which factors were associated with return to work.</div></div><div><h3>Results</h3><div>Overall, 251 patients were included. Professional status, duration off work, intensity of low back pain, self-perceived disability, fear-avoidance beliefs at work were associated with return to work after the MRP on bivariate analysis. Having worked in the past 6<!--> <!-->months and the absence of high fear-avoidance beliefs at work at baseline were associated with return to work on multivariate analysis.</div></div><div><h3>Discussion</h3><div>This study suggests that patients with chronic low back pain and professional difficulties need to be included quickly in a MRP, with specific attention to beliefs about pain.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 3","pages":"Article 105840"},"PeriodicalIF":3.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient migratory osteoporosis of epiphyseal lower limbs during FLOT chemotherapy for gastric cancer","authors":"Arthur Bouchut ,&nbsp;Gilles Grimon ,&nbsp;Xavier Mariette ,&nbsp;Gaetane Nocturne","doi":"10.1016/j.jbspin.2024.105829","DOIUrl":"10.1016/j.jbspin.2024.105829","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 3","pages":"Article 105829"},"PeriodicalIF":3.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and depressive mood","authors":"Cédric Lemogne ,&nbsp;Charles Ouazana Vedrines ,&nbsp;Lucile Capuron ,&nbsp;Nicolas Hoertel","doi":"10.1016/j.jbspin.2024.105832","DOIUrl":"10.1016/j.jbspin.2024.105832","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 2","pages":"Article 105832"},"PeriodicalIF":3.8,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}