Joint Bone Spine最新文献

{"title":"Planetary health and rheumatology","authors":"Dirk Holzinger , Candace H. Feldman","doi":"10.1016/j.jbspin.2025.105875","DOIUrl":"10.1016/j.jbspin.2025.105875","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105875"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of gut microbiota in psoriatic arthritis treated with IL-17 inhibitor revealed by metagenomics","authors":"Wei Liu ,&nbsp;Yan Geng ,&nbsp;Yu Wang ,&nbsp;Juan Zhao ,&nbsp;Yong Fan ,&nbsp;Xiaohui Zhang ,&nbsp;Wenhui Xie ,&nbsp;Liang Zhang ,&nbsp;Zhuoli Zhang","doi":"10.1016/j.jbspin.2025.105868","DOIUrl":"10.1016/j.jbspin.2025.105868","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore the evolution of gut microbiota in taxonomy and function in PsA patients during IL-17i treatment.</div></div><div><h3>Methods</h3><div>Twenty PsA patients treated with secukizumab were included. Fecal samples were collected before treatment (0 mo.), first month (1 mo.) and third month (3 mo.) after treatment, and a total of 60 samples were collected. Shotgun metagenomic sequencing was used to detect all fecal samples.</div></div><div><h3>Results</h3><div>In the 1 mo. and 3 mo. after IL-17i treatment, the disease activity in PsA patients decreased significantly. Compared with 0 mo., α-diversity calculated by Shannon index and Pielou index increased significantly at 1 mo. and 3 mo. after treatment. Microbial genes encoding Carbohydrate-Active enZymes (CAZymes) tended to be upregulated after treatment. After treatment, <em>Bacteroidota</em> phylum expanded, especially the abundance of <em>Phocaeicola</em> genus increased gradually with the treatment time (<em>P</em> <!-->&lt;<!--> <!-->0.05). The abundance of <em>Phocaeicola</em> genus was positively correlated with the α-diversity. The Polysaccharide Lyases and Carbohydrate Esterases in CAZymes were significantly positively correlated with most of species in <em>Phocaeicola</em> genus.</div></div><div><h3>Conclusions</h3><div>Treatment with IL-17i induces gut microbiota evolution in PsA patients. The key features of this evolution include increased α-diversity, expansion of the <em>Phocaeicola</em> genus, and upregulation of CAZymes. Species within the <em>Phocaeicola</em> genus may be the critical bacteria driving this evolution.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105868"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associations of kinesiophobia with patient reported outcomes and mobility measures in axial spondyloarthritis","authors":"David Kiefer ,&nbsp;Juergen Braun ,&nbsp;Uta Kiltz ,&nbsp;Niklas Kolle ,&nbsp;Lucia Schneider ,&nbsp;Ioana Andreica ,&nbsp;Bjoern Buehring ,&nbsp;Philipp Sewerin ,&nbsp;Imke Redeker ,&nbsp;Styliani Tsiami ,&nbsp;Susanne Herbold ,&nbsp;Xenofon Baraliakos","doi":"10.1016/j.jbspin.2025.105873","DOIUrl":"10.1016/j.jbspin.2025.105873","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate prevalence and associations of kinesiophobia on patients with axSpA, and its relation to global functioning and health, disease activity, function, spinal mobility and physical activity in comparison to healthy controls (HC).</div></div><div><h3>Methods</h3><div>Cross-sectional, observational study in which consecutive axSpA patients with axSpA (<em>n</em> <!-->=<!--> <!-->100) and 20 healthy controls (HC) were examined by the Tampa scale of kinesiophobia (TSK), and the Fear avoidance belief questionnaire (FABQ). Patient reported outcomes and objective assessments of disease activity physical function, global health and functioning as well as the BASMI, the AS physical performance index (ASPI), the Short Physical Performance Battery (SPPB) and Epionics SPINE (ES) measurements, including range of motion (RoM) and kinematics (RoK) were collected.</div></div><div><h3>Results</h3><div>AxSpA patients showed higher TSK (25.5<!--> <!-->±<!--> <!-->6.8 vs. 14.0<!--> <!-->±<!--> <!-->5.1) and FABQ scores (40.1<!--> <!-->±<!--> <!-->22 vs. 3.1<!--> <!-->±<!--> <!-->6.9) compared to HC, all <em>P</em> <!-->≤<!--> <!-->0.001. Categorical analyses of kinesiophobia levels revealed that patients with higher levels performed significantly worse in ASPI and SPPB tasks, and they also showed impairments in BASMI and ES measures. TSK and FABQ scores correlated with ASAS HI (<em>r</em> <!-->=<!--> <!-->0.45 and <em>r</em> <!-->=<!--> <!-->0.52) and BASFI (<em>r</em> <!-->=<!--> <!-->0.38 and <em>r</em> <!-->=<!--> <!-->0.44), but not with ASPI, SPPB and RoK. Weak correlations were found for BASMI (<em>r</em> <!-->=<!--> <!-->0.24 and <em>r</em> <!-->=<!--> <!-->0.38) and BASDAI (both <em>r</em> <!-->=<!--> <!-->0.35).</div></div><div><h3>Conclusion</h3><div>Kinesiophobia seems to be a clinically relevant problem of axSpA patients, since the mobility of patients with moderate to high TSK and FABQ scores was much more impaired in this study. Of interest, the level of kinesiophobia showed stronger correlations with physical function, global functioning and health than with mobility and PA.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105873"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of the ALDH2 rs671 polymorphism and alcohol intake with early-onset gout in a Chinese male cohort","authors":"Shuhui Hu ,&nbsp;Nicola Dalbeth ,&nbsp;Zhiqiang Li ,&nbsp;Ying Chen ,&nbsp;Bingzi Dong ,&nbsp;Can Wang ,&nbsp;Wenyan Sun ,&nbsp;Changgui Li ,&nbsp;Jie Lu","doi":"10.1016/j.jbspin.2025.105876","DOIUrl":"10.1016/j.jbspin.2025.105876","url":null,"abstract":"<div><h3>Objective</h3><div>Gout in young people is increasingly common across the world, including in China. This study aimed to identify clinical and genetic associations with early-onset gout in Chinese men.</div></div><div><h3>Methods</h3><div>One thousand two hundred and one Chinese men with gout were included. Early-onset gout was defined as the first presentation of gout at &lt;<!--> <!-->30<!--> <!-->years. Twenty single nucleotide polymorphisms (SNPs) identified as gout-risk loci or associated with serum urate (SU) levels in East Asian populations were genotyped. Logistic regression was used to evaluate the association of SNPs and clinical factors with early-onset gout.</div></div><div><h3>Results</h3><div>Four hundred and thirty-three (36.1%) participants were identified as having early-onset gout. These patients had higher SU levels and were more likely to experience gout flares than those with later-onset gout. The <em>ALDH2</em> rs671 GG genotype was associated with a lower risk of early-onset gout. Compared to those with GG genotype who never drank alcohol before gout onset, individuals with AA or AG genotypes who drank alcohol before gout onset had a higher likelihood of early-onset gout. Additionally, alcohol intake significantly increased the likelihood of gout flares in early-onset gout patients. Moreover, body mass index, sugar-sweetened beverage intake, family history of gout and renal urate underexcretion were associated with early-onset gout.</div></div><div><h3>Conclusions</h3><div>The <em>ALDH2</em> rs671 GG genotype was significantly associated with a lower risk of early-onset gout, while individuals with the AA or AG genotype who consumed alcohol were more susceptible. These findings indicate that alcohol intake is a potentially modifiable risk factor for early-onset gout in genetically susceptible individuals.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105876"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease and should now be designated by the same unique name, Still's disease","authors":"Stéphane Mitrovic ,&nbsp;Bruno Fautrel","doi":"10.1016/j.jbspin.2025.105872","DOIUrl":"10.1016/j.jbspin.2025.105872","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105872"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could the anti-modified protein antibody concept help better define seronegative rheumatoid arthritis?","authors":"Pauline Brevet ,&nbsp;Manuel Fréret ,&nbsp;Eric Barat ,&nbsp;Thierry Lequerré ,&nbsp;Olivier Boyer ,&nbsp;Olivier Vittecoq","doi":"10.1016/j.jbspin.2025.105869","DOIUrl":"10.1016/j.jbspin.2025.105869","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105869"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How publication bias overestimates the risk of atypical femoral fracture and osteonecrosis of the jaw associated with bisphosphonate use: A meta-epidemiological study","authors":"Arthur Gougeon ,&nbsp;Maëlys Granal ,&nbsp;Emmanuel Massy ,&nbsp;François Gueyffier ,&nbsp;Jean-Christophe Lega ,&nbsp;Audrey Lajoinie ,&nbsp;Guillaume Grenet","doi":"10.1016/j.jbspin.2025.105871","DOIUrl":"10.1016/j.jbspin.2025.105871","url":null,"abstract":"<div><h3>Objectives</h3><div>Bisphosphonates are widely used to treat osteoporosis, bone cancer, Paget's disease, and hypercalcemia to reduce fracture risk. Observational studies have highlighted rare but serious adverse events (AE). Some meta-analyses have found evidence of publication bias, but rarely examined its impact or addressed it in their conclusions. Clinical guidelines are often based on meta-analyses and published literature, which may potentially bias the risk-benefit balance of bisphosphonates. This study assessed the presence and impact of publication bias in bisphosphonate safety evaluations.</div></div><div><h3>Methods</h3><div>Systematic reviews and meta-analyses of bisphosphonate-related AE were searched. Odds ratios from original clinical studies were collected, and publication bias was assessed using funnel plots, Egger's tests, and robust Bayesian meta-analysis (RoBMA). The effect of bias was quantified by comparing unadjusted and adjusted pooled estimates using trim and fill and RoBMA.</div></div><div><h3>Results</h3><div>The analysis included 42 systematic reviews totalizing 112 clinical studies (58% were observational), providing 148 unique point estimates for 10 AE. Publication bias concerned 2 out of 10 adverse events, high risk of publication bias was detected for atypical femur fractures and osteonecrosis of the jaw. For these, bias inflated effect estimates by 40–45% and 47–67%, respectively, with associations with bisphosphonates use disappearing after adjustment. Publication bias may be due to the observational study design for both, and the non-cancer indication for osteonecrosis of the jaw. No high risk of publication bias was found for eight other AE (atrial fibrillation, myocardial infarction, stroke, kidney dysfunction, oesophageal, breast, gastric, and colorectal cancer). This bias may lead to a distorted assessment of the risk-benefit balance.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105871"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty during polymyalgia rheumatica, giant cell arteritis and other inflammatory rheumatic diseases","authors":"Anne Tournadre","doi":"10.1016/j.jbspin.2025.105864","DOIUrl":"10.1016/j.jbspin.2025.105864","url":null,"abstract":"<div><div>Recent data suggest a pathophysiological role of aging and immunosenescence during polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), by definition rheumatic disease of the elderly. During aging, there is a decline in major physiological functions (immune system, muscle, cognitive, endocrine, cardiovascular, respiratory and renal functions), which combined with multimorbidity, environmental factors and polypharmacy can lead to frailty. Frailty is a clinical syndrome and dynamic concept including a pre-frailty stage; it reflects a reduction in physiological reserve capacities which alters the mechanisms of adaptation to stress. It results in the inability of a vulnerable subject to return to baseline homoeostasis after minor stress, increasing the risk of hospitalization, loss of autonomy and death. To date, there are no consensual criteria for frailty and its assessment in clinical practice remains difficult, based either on physical criteria including weight loss, fatigue, reduction in muscular strength and walking, inactivity or on a multidimensional geriatric assessment. The impact on morbidity and mortality and quality of life, the possibility of detecting reversible stages of pre-frailty and of implementing preventive measures justify interest in rheumatology as the number of patients aged 65 years and older with inflammatory rheumatic diseases is increasing. If there are no specific recommendations for the management of frailty or pre-frailty, recommendations for exercises, physical activity and nutrition to limit sarcopenia and comorbidities can be applied. The association with multimorbidity and its additive effect reinforces the need for screening, prevention and specific management of comorbidities, particularly infections, osteoporosis, cardiovascular diseases, during chronic inflammatory rheumatic diseases, PMR and GCA.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105864"},"PeriodicalIF":3.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant cell arteritis: Role of surgery in the management of vascular complications","authors":"Hélène Greigert ,&nbsp;Camil-Cassien Bamdé ,&nbsp;André Ramon ,&nbsp;Eric Steinmetz ,&nbsp;Yannick Béjot ,&nbsp;Olivier Bouchot ,&nbsp;Bernard Bonnotte ,&nbsp;Maxime Samson","doi":"10.1016/j.jbspin.2025.105862","DOIUrl":"10.1016/j.jbspin.2025.105862","url":null,"abstract":"<div><div>Apart from life-threatening and/or functional emergencies, treatment of vascular lesions in giant cell arteritis (GCA) is medical. Revascularization may be considered if the lesion remains symptomatic or progressive despite optimal medical treatment, provided that there is no disease-related inflammation, and always managed by a team of trained experts. The main risk associated with aortic involvement (aortitis) is the development of an aneurysm, most often in the thoracic aorta, after several years of progression. Indications and surgical techniques used to manage these aneurysms follow the recommendations for the general population. In peripheral artery disease, lesions are characterized by parietal thickening, stenosis and sometimes occlusion, which can lead to exertional claudication or chronic permanent ischemia. Open or endovascular surgical management of these stenotic lesions is frequently complicated by restenosis. The role of endovascular techniques in the management of inflammatory lesions is debated, but there is a preference for open surgery, particularly in the lower limbs. Cervical and cerebral arteries also present a risk of stenosis leading to stroke. Balloon dilation and/or stenting of cervical or cerebral arteries during GCA carries a high-risk of rupture and restenosis, and remains a rescue treatment limited to certain specific cases of stroke where there are concerns about patient prognosis in the absence of intervention.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105862"},"PeriodicalIF":3.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of senescence in polymyalgia rheumatica and giant cell arteritis","authors":"Guillermo Carvajal Alegria","doi":"10.1016/j.jbspin.2025.105860","DOIUrl":"10.1016/j.jbspin.2025.105860","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105860"},"PeriodicalIF":3.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}