Joint Bone Spine最新文献

{"title":"Health equity and causes of disparities in rheumatological management","authors":"Mrinalini Dey ,&nbsp;Elena Nikiphorou","doi":"10.1016/j.jbspin.2025.105902","DOIUrl":"10.1016/j.jbspin.2025.105902","url":null,"abstract":"<div><div>Health disparities remain a critical challenge in rheumatological management, contributing to inequities in aspects such as disease outcomes, access to care, and treatment adherence. Evidence suggests that racial and ethnic minorities, as well as individuals from lower socioeconomic backgrounds, experience delayed and reduced access to specialist care, and lower utilisation of advanced therapies. Structural barriers, including limitations in insurance coverage and geographic disparities in rheumatology workforce distribution, further exacerbate these inequities. Additionally, differences in health literacy, treatment adherence, and cultural perceptions of disease significantly impact patient outcomes. Understanding the social determinants of health and integrating patient-centered approaches into rheumatology practice are essential for mitigating disparities and improving outcomes for underserved populations. This review synthesises the current evidence on the multiple aspects of health disparities in rheumatological management, identifies key gaps in research, and proposes strategies to enhance equitable healthcare delivery. Addressing these issues is imperative for achieving better disease control, enhancing quality of life, and reducing the overall burden of rheumatic diseases across diverse populations.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105902"},"PeriodicalIF":3.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of cancer in patients with rheumatoid arthritis under tocilizumab: Data from the French national registry REGATE","authors":"Jacques Morel ,&nbsp;Amélie Wetzman ,&nbsp;Daniel Wendling ,&nbsp;Martin Soubrier ,&nbsp;Sylvie Hoang ,&nbsp;Daniel Briançon ,&nbsp;Olivier Roth ,&nbsp;Philippe Goupille ,&nbsp;Jacques-Eric Gottenberg ,&nbsp;Xavier Mariette ,&nbsp;Cédric Lukas ,&nbsp;On behalf of the French Society of Rheumatology, the investigators participating in REGATE registry","doi":"10.1016/j.jbspin.2025.105900","DOIUrl":"10.1016/j.jbspin.2025.105900","url":null,"abstract":"<div><h3>Objective</h3><div>Our study aimed to estimate the incidence and risk factors of cancer among rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ) and followed for five years in the French registry (REGATE).</div></div><div><h3>Method</h3><div>The REGATE registry is a French prospective cohort study investigating the safety of TCZ in RA (registration n^o: 910346). Data were collected using an e-CRF between 2011 and 2016 and with a questionnaire specifically distributed to participating centers that reported malignancies in REGATE. We mainly focused on solid cancers, hematological malignancies, and non-melanoma skin cancers (NMSC). To identify potential risk factors associated with cancer, we performed a univariate analysis and a multivariate analysis using Cox proportional hazards models.</div></div><div><h3>Results</h3><div>Our study included 1496 patients with RA who were treated with TCZ for a mean duration of 32.0 (±22.0) months and followed for an average of 47 (±15.2) months, resulting in a total exposure of 3990.9 patient-years (PY). Of these patients, 63 (4.2%) were diagnosed with a total of 75 cancers during the follow-up period (35 solid neoplasms, 11 hematological malignancies, 3 melanomas, and 26 NMSC). The overall incidence of cancer excluding NMSC was 7.5/1000 PY (exposure time). Our multivariate analysis revealed that high age (HR<!--> <!-->=<!--> <!-->1.05 [1.02–1.08]), current smoker (HR<!--> <!-->=<!--> <!-->2.65 [1.27–5.53]) and male 2.38 [1,18–4,80]) were independent risk factors for solid cancers. Age and active smoking were associated with higher risk of hematological malignancies.</div></div><div><h3>Conclusion</h3><div>We found no additional risk factors of cancer for RA patients under TCZ, beyond those already known in the general population.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105900"},"PeriodicalIF":3.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute herpes zoster lumbar radiculitis","authors":"Mustafa Kemal Demir ,&nbsp;Zeynep Erdogan Iyigun","doi":"10.1016/j.jbspin.2025.105901","DOIUrl":"10.1016/j.jbspin.2025.105901","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105901"},"PeriodicalIF":3.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back to hormonal replacement therapy","authors":"Florence A. Trémollieres,&nbsp;Anna Gosset","doi":"10.1016/j.jbspin.2025.105898","DOIUrl":"10.1016/j.jbspin.2025.105898","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105898"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging in the assessment of deposits in gout: From research to daily clinical implementation","authors":"Tristan Pascart","doi":"10.1016/j.jbspin.2025.105897","DOIUrl":"10.1016/j.jbspin.2025.105897","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105897"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle in axial spondyloarthritis: Culprit or victim?","authors":"Daniel Wendling,&nbsp;Frank Verhoeven,&nbsp;Clément Prati","doi":"10.1016/j.jbspin.2025.105899","DOIUrl":"10.1016/j.jbspin.2025.105899","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105899"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral diaphyseal tibial idiopathic hyperostosis: A rare cause of chronic tibial pain","authors":"Mehdi Nassafi ,&nbsp;Lokmane Taihi ,&nbsp;Frédéric Houssiau","doi":"10.1016/j.jbspin.2025.105894","DOIUrl":"10.1016/j.jbspin.2025.105894","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105894"},"PeriodicalIF":3.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marcel-Francis Kahn (1929–2024)","authors":"Gilles Hayem","doi":"10.1016/j.jbspin.2025.105880","DOIUrl":"10.1016/j.jbspin.2025.105880","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 3","pages":"Article 105880"},"PeriodicalIF":3.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidural pneumorachis","authors":"Wassim Khalil ,&nbsp;Alexandre Meynard ,&nbsp;Patrick Faure ,&nbsp;François Caire ,&nbsp;Henri Salle","doi":"10.1016/j.jbspin.2025.105893","DOIUrl":"10.1016/j.jbspin.2025.105893","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105893"},"PeriodicalIF":3.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-course of tophus resolution on Dual-energy CT and ultrasound after 24 months of a treat-to-target strategy: Results from GOUT-DECTUS study","authors":"Tristan Pascart ,&nbsp;Pascal Richette ,&nbsp;Valérie Bousson ,&nbsp;Sébastien Ottaviani ,&nbsp;Hang-Korng Ea ,&nbsp;Frédéric Lioté ,&nbsp;Augustin Latourte ,&nbsp;Thomas Bardin ,&nbsp;Jérémy Ora ,&nbsp;Aurore Pacaud ,&nbsp;Marie Vandecandelaere ,&nbsp;Hélène Luraschi ,&nbsp;Charlotte Jauffret ,&nbsp;Victor Laurent ,&nbsp;Mathilde Boissel ,&nbsp;Laurène Norberciak ,&nbsp;Julie Legrand ,&nbsp;Guillaume Lefevre ,&nbsp;Vincent Ducoulombier ,&nbsp;Jean-François Budzik","doi":"10.1016/j.jbspin.2025.105892","DOIUrl":"10.1016/j.jbspin.2025.105892","url":null,"abstract":"<div><h3>Objectives</h3><div>The main objective of the study was to evaluate the kinetics of tophus volume measured with dual-energy CT (DECT) and ultrasound (US) in patients with gout during their first 24<!--> <!-->months of treat-to-target (T2T) urate-lowering therapy.</div></div><div><h3>Methods</h3><div>This was a prospective, multicenter, 24-month longitudinal pilot study including ULT-naïve patients with gout and US tophi. Clinical visits, and DECT and US scans of the knees and feet were performed at baseline, 6, 12 and 24<!--> <!-->months. The largest tophus identified by US was chosen as the index tophus. The primary outcome was the change in the absolute volume and relative change from baseline of the tophus index volume measured with US and with DECT at all timepoints, with their correlation assessed by the Spearman correlation coefficient (ρ).</div></div><div><h3>Results</h3><div>A total of 55 patients (63.1 (12.3) years old, predominantly male (47/55 [85.5%]), with baseline serum urate levels of 8.73 mg/dL [7.93; 9.52] were included. Index tophus volume measured with US changed from median [inter-quartile range] 0.61 cm³ [0.30; 1.20] at baseline to 0.07 cm³ [0; 0.50] at month 24, and with DECT from 0.1 cm³ [0; 0.63] at baseline to 0 cm³ [0; 0] at month 24. Relative changes in index tophus volume measured with US and DECT were respectively −56% [−90; 0] and −96% [−100; −34] at M6, −84% [−100; −13] and −100% [−100; −89] at M12, and −96% [−100; −72] and −100% [−100; −100] at M24. The correlation for relative tophus volume change was weak at month 6 (ρ<!--> <!-->=<!--> <!-->0.39 [0.01; 0.74]) and moderate at months 12 (ρ<!--> <!-->=<!--> <!-->0.43 [−0.14; 0.82]) and 24 (ρ<!--> <!-->=<!--> <!-->0.42 [−0.01; 0.73]).</div></div><div><h3>Conclusion</h3><div>Complete tophus resolution is obtained at 24<!--> <!-->months of T2T in DECT but not in US, which provided a greater variability of volumetric assessments throughout follow-up.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105892"},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}