Joint Bone Spine最新文献

{"title":"Diseases associated with anti-centromere protein F (anti-CENP-F) antibodies: Insights from a large cohort study","authors":"Alexandre Le Joncour ,&nbsp;Jean-Luc Charuel ,&nbsp;Sylvain Choquet ,&nbsp;Jean-Philippe Spano ,&nbsp;Jean-Christophe Corvol ,&nbsp;Bruno Fautrel ,&nbsp;Dominique Thabut ,&nbsp;David Saadoun ,&nbsp;Zahir Amoura ,&nbsp;Pascale Ghillani-Dalbin ,&nbsp;Patrice Cacoub","doi":"10.1016/j.jbspin.2025.105885","DOIUrl":"10.1016/j.jbspin.2025.105885","url":null,"abstract":"<div><h3>Introduction</h3><div>Antinuclear antibodies (ANA) exhibit diverse specificities and are crucial biomarkers in autoimmune disease assessment. Among ANA, anti-centromere protein-F (CENP-F) antibodies have garnered interest due to their association with malignancies. This study aims to characterize the clinical and biological profiles of a large cohort of anti-CENP-F positive patients and evaluate associated diagnoses.</div></div><div><h3>Methods</h3><div>Over 12 years, approximately 151,000 ANA screening samples were assessed, identifying 110 anti-CENP-F positive patients. Clinical and biological characteristics, including demographics, comorbidities, and antibody titers, were retrospectively analyzed. Follow-up data were collected to ascertain associated diagnoses.</div></div><div><h3>Results</h3><div>The median age was 50.9 years, with a predominance of women (73.6%). Median CENP-F antibody titer was 1:160, with 16.4% of patients with a titer higher than 1:1280. A concomitant specific autoimmune antibody was detected in 29 (26.4%) of cases. After a median follow-up of 3.8 years, autoimmune diseases were the most common associated diagnosis (38.2%), followed by neurological diseases (15.5%), hemopathies (8.3%), and cancer (10.9%). Some patients had concurrent cancer and autoimmune diseases. Twelve patients were diagnosed with cancer, primarily lung and breast cancers. In multivariate analysis, older age and higher anti-CENP-F titers were associated with cancer diagnosis.</div></div><div><h3>Conclusion</h3><div>This study provides comprehensive insights into the clinical significance of anti-CENP-F antibodies. Vigilance is warranted in older patients with elevated antibody titers, as they may indicate an increased risk of cancer.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105885"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic background of selected hyperuricemia causing gout with pediatric onset","authors":"Blanka Stiburkova ,&nbsp;Kimiyoshi Ichida","doi":"10.1016/j.jbspin.2025.105884","DOIUrl":"10.1016/j.jbspin.2025.105884","url":null,"abstract":"<div><div>Elevated serum uric acid levels are the essential pathophysiology of gout. Although gout rarely develops in childhood, chronic persistent hyperuricemia can induce precipitation and deposition of sodium urate crystals, leading to the development of gout. Hyperuricemia is caused by increased uric acid production and/or decreased uric acid excretion capacity of the kidneys and/or intestinal tract. Increased production of uric acid, the final metabolite of purine, is associated with an increase of phosphoribosyl pyrophosphate, the key compound in the purine synthesis pathways, as observed in hypoxanthine-guanine phosphoribosyltransferase deficiency. Another mechanism for increased uric acid production is increased adenosine triphosphate consumption that is found in glycogen storage disease type I. On the other hand, in uromodulin-associated kidney disease, the accumulation of abnormal uromodulin in the kidneys leads to tubulointerstitial damage and fibrosis, and the ability to excrete uric acid is compromised, with reduced secretion and increased reabsorption in the proximal tubules. Decreased uric acid excretion from the kidneys or intestinal tract is also mediated by decreased function of the ATP-binding cassette subfamily G member 2, a urate transporter that acts in the urate secretion. This review summarizes the selected pathophysiological mechanisms underlying the genetic basis of hyperuricemia and gout in children, both in terms of purine metabolism and uric acid excretion.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105884"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between osteoporosis and periodontitis","authors":"Françoise Tilotta ,&nbsp;Marjolaine Gosset ,&nbsp;Julia Herrou ,&nbsp;Karine Briot ,&nbsp;Christian Roux","doi":"10.1016/j.jbspin.2025.105883","DOIUrl":"10.1016/j.jbspin.2025.105883","url":null,"abstract":"<div><div>Both osteoporosis and periodontitis are characterized by bone resorption. Osteoporosis is defined as a generalized disease of the skeleton affecting bone microarchitecture and density and conferring a predisposition to fractures, including fractures of the upper end of the femur. Periodontitis is characterized by gingival inflammation and destruction of the alveolar bone, potentially leading to tooth mobility and loss. Both these diseases are common health concerns associated with a considerable economic and societal burden worldwide. The prevention of these two diseases is therefore a real public health issue. The close association between osteoporosis and periodontitis should lead dental surgeons to refer patients with severe periodontitis to a rheumatologist for an assessment of bone density. Conversely, patients with osteoporosis should undergo regular oral check-ups to prevent tooth loss and maintain good oral health.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105883"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Costo-vertebral joint involvement in axial spondyloarthritis","authors":"Noa Nemesh,&nbsp;Shiri Keret,&nbsp;Gleb Slobodin","doi":"10.1016/j.jbspin.2025.105881","DOIUrl":"10.1016/j.jbspin.2025.105881","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105881"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of various inflammatory arthritis incidences during 2015–2020: A nationwide population-based register study in Finland","authors":"Laura Heimola ,&nbsp;Ritva Peltomaa ,&nbsp;Anna Laine ,&nbsp;Hannu Kautiainen ,&nbsp;Kari Puolakka ,&nbsp;Vappu Rantalaiho","doi":"10.1016/j.jbspin.2025.105886","DOIUrl":"10.1016/j.jbspin.2025.105886","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105886"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and safety of anifrolumab for belimumab-experienced and biologic-naïve patients with systemic lupus erythematosus: Results from the Kyushu Collagen Disease Network for Systemic Lupus Erythematosus (KCDN-SLE) registry","authors":"Masahiro Ayano ,&nbsp;Naoyasu Ueda ,&nbsp;Koji Mishima ,&nbsp;Shun-Ichiro Ota ,&nbsp;Kazuo Kushimoto ,&nbsp;Atsushi Tanaka ,&nbsp;Goro Doi ,&nbsp;Tsuyoshi Nakayama ,&nbsp;Makiko Maekawa ,&nbsp;Tomomi Tsuru ,&nbsp;Mitsuteru Akahoshi ,&nbsp;Koichi Akashi ,&nbsp;Takahiko Horiuchi ,&nbsp;Hiroaki Niiro","doi":"10.1016/j.jbspin.2025.105882","DOIUrl":"10.1016/j.jbspin.2025.105882","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105882"},"PeriodicalIF":3.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained remission after bispecific antibody anti-IL-1β/anti-IL-18 therapy in a severe childhood Still's disease with recurrent macrophage activation syndrome","authors":"Jade Cognard ,&nbsp;Jonathan Sormani ,&nbsp;Malo Freppel ,&nbsp;Maurane Lepage ,&nbsp;Marine Fouillet-Desjonquères ,&nbsp;Audrey Laurent ,&nbsp;Maurine Jouret ,&nbsp;Franck Zekre ,&nbsp;Samira Khaldi-Plassart ,&nbsp;Maud Tusseau ,&nbsp;Alexandre Belot","doi":"10.1016/j.jbspin.2025.105874","DOIUrl":"10.1016/j.jbspin.2025.105874","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105874"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and ultrasonographic predictors of disease activity after TNF-α inhibitor spacing in patients with psoriatic arthritis","authors":"Antonio Marchesoni ,&nbsp;Pierluigi Macchioni ,&nbsp;Giovanni Ciancio ,&nbsp;Gilda Sandri ,&nbsp;Alen Zabotti ,&nbsp;Luca Montaguti ,&nbsp;Gentiana Vukatana ,&nbsp;Fabio Mascella ,&nbsp;Donatella Chessa ,&nbsp;Elisa Verduci ,&nbsp;Marcello Govoni ,&nbsp;Amelia Spinella ,&nbsp;Francesca Zuliani ,&nbsp;Marco Bruschi ,&nbsp;Nazzarena Malavolta ,&nbsp;Mariacristina Focherini ,&nbsp;Carlo Salvarani","doi":"10.1016/j.jbspin.2025.105877","DOIUrl":"10.1016/j.jbspin.2025.105877","url":null,"abstract":"<div><h3>Objective</h3><div>Dose reduction of biologic drugs in patients with psoriatic arthritis (PsA) who are in Minimal Disease Activity (MDA) is now considered a feasible option. This study evaluated which baseline clinical and ultrasonographic (US) factors may be predictive of disease activity after anti-TNF-α spacing.</div></div><div><h3>Methods</h3><div>This observational, prospective, multicentre, 12-month study enrolled consecutive adult patients with PsA taking TNF-α inhibitors and in stable MDA who accepted to reduce their dose therapy by doubling the administration interval. Data collection included demographics, personal history, clinical disease characteristics, and joints and entheses US features. Patients maintaining the MDA were compared with those who experienced a disease flare during the 12 months of follow-up. The statistical analysis included the comparison between groups and the search of the factors associated with persistence of MDA.</div></div><div><h3>Results</h3><div>Of the evaluable 72 patients (29 females and 43 males), 55 (76.4%) maintained a state of MDA while 17 (23.6%) experienced a disease relapse. Baseline values of DAPSA<!--> <!-->&lt;<!--> <!-->2 and of BASDAI<!--> <!-->&lt;<!--> <!-->1.5, and lower BASDAI and DAS28 values were significantly associated with maintenance of MDA. The multivariate analysis showed that baseline values of DAPSA<!--> <!-->&lt;<!--> <!-->2 and of BASDAI<!--> <!-->&lt;<!--> <!-->1.5 were predictive of persistence of MDA. Baseline US findings were not associated with the outcome of disease activity.</div></div><div><h3>Conclusions</h3><div>In this study, anti-TNF-α spacing proved to be feasible in most of the PsA patients in a stable MDA. The only factor predictive of persistence of remission was a very low clinical disease activity at baseline.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105877"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The real impact of age at onset in psoriatic arthritis: A Portuguese multicenter study","authors":"Carolina Mazeda ,&nbsp;Carolina Vilafanha ,&nbsp;Pedro Miguel Teixeira ,&nbsp;Catarina Abreu ,&nbsp;Tiago Meirinhos ,&nbsp;Rafaela Nicolau ,&nbsp;Maria Pontes-Ferreira ,&nbsp;João Rovisco ,&nbsp;Daniela Oliveira ,&nbsp;Anabela Barcelos","doi":"10.1016/j.jbspin.2025.105870","DOIUrl":"10.1016/j.jbspin.2025.105870","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105870"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geography, neighborhoods and mortality in rheumatic diseases.","authors":"Jasvinder A Singh","doi":"10.1016/j.jbspin.2025.105878","DOIUrl":"https://doi.org/10.1016/j.jbspin.2025.105878","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"105878"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}