Joint Bone Spine最新文献

{"title":"Back to hormonal replacement therapy","authors":"Florence A. Trémollieres, Anna Gosset","doi":"10.1016/j.jbspin.2025.105898","DOIUrl":"10.1016/j.jbspin.2025.105898","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105898"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging in the assessment of deposits in gout: From research to daily clinical implementation","authors":"Tristan Pascart","doi":"10.1016/j.jbspin.2025.105897","DOIUrl":"10.1016/j.jbspin.2025.105897","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105897"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle in axial spondyloarthritis: Culprit or victim?","authors":"Daniel Wendling, Frank Verhoeven, Clément Prati","doi":"10.1016/j.jbspin.2025.105899","DOIUrl":"10.1016/j.jbspin.2025.105899","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105899"},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral diaphyseal tibial idiopathic hyperostosis: A rare cause of chronic tibial pain","authors":"Mehdi Nassafi , Lokmane Taihi , Frédéric Houssiau","doi":"10.1016/j.jbspin.2025.105894","DOIUrl":"10.1016/j.jbspin.2025.105894","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105894"},"PeriodicalIF":3.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marcel-Francis Kahn (1929–2024)","authors":"Gilles Hayem","doi":"10.1016/j.jbspin.2025.105880","DOIUrl":"10.1016/j.jbspin.2025.105880","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 3","pages":"Article 105880"},"PeriodicalIF":3.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidural pneumorachis","authors":"Wassim Khalil , Alexandre Meynard , Patrick Faure , François Caire , Henri Salle","doi":"10.1016/j.jbspin.2025.105893","DOIUrl":"10.1016/j.jbspin.2025.105893","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105893"},"PeriodicalIF":3.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-course of tophus resolution on Dual-energy CT and ultrasound after 24 months of a treat-to-target strategy: Results from GOUT-DECTUS study","authors":"Tristan Pascart ,&nbsp;Pascal Richette ,&nbsp;Valérie Bousson ,&nbsp;Sébastien Ottaviani ,&nbsp;Hang-Korng Ea ,&nbsp;Frédéric Lioté ,&nbsp;Augustin Latourte ,&nbsp;Thomas Bardin ,&nbsp;Jérémy Ora ,&nbsp;Aurore Pacaud ,&nbsp;Marie Vandecandelaere ,&nbsp;Hélène Luraschi ,&nbsp;Charlotte Jauffret ,&nbsp;Victor Laurent ,&nbsp;Mathilde Boissel ,&nbsp;Laurène Norberciak ,&nbsp;Julie Legrand ,&nbsp;Guillaume Lefevre ,&nbsp;Vincent Ducoulombier ,&nbsp;Jean-François Budzik","doi":"10.1016/j.jbspin.2025.105892","DOIUrl":"10.1016/j.jbspin.2025.105892","url":null,"abstract":"<div><h3>Objectives</h3><div>The main objective of the study was to evaluate the kinetics of tophus volume measured with dual-energy CT (DECT) and ultrasound (US) in patients with gout during their first 24<!--> <!-->months of treat-to-target (T2T) urate-lowering therapy.</div></div><div><h3>Methods</h3><div>This was a prospective, multicenter, 24-month longitudinal pilot study including ULT-naïve patients with gout and US tophi. Clinical visits, and DECT and US scans of the knees and feet were performed at baseline, 6, 12 and 24<!--> <!-->months. The largest tophus identified by US was chosen as the index tophus. The primary outcome was the change in the absolute volume and relative change from baseline of the tophus index volume measured with US and with DECT at all timepoints, with their correlation assessed by the Spearman correlation coefficient (ρ).</div></div><div><h3>Results</h3><div>A total of 55 patients (63.1 (12.3) years old, predominantly male (47/55 [85.5%]), with baseline serum urate levels of 8.73 mg/dL [7.93; 9.52] were included. Index tophus volume measured with US changed from median [inter-quartile range] 0.61 cm³ [0.30; 1.20] at baseline to 0.07 cm³ [0; 0.50] at month 24, and with DECT from 0.1 cm³ [0; 0.63] at baseline to 0 cm³ [0; 0] at month 24. Relative changes in index tophus volume measured with US and DECT were respectively −56% [−90; 0] and −96% [−100; −34] at M6, −84% [−100; −13] and −100% [−100; −89] at M12, and −96% [−100; −72] and −100% [−100; −100] at M24. The correlation for relative tophus volume change was weak at month 6 (ρ<!--> <!-->=<!--> <!-->0.39 [0.01; 0.74]) and moderate at months 12 (ρ<!--> <!-->=<!--> <!-->0.43 [−0.14; 0.82]) and 24 (ρ<!--> <!-->=<!--> <!-->0.42 [−0.01; 0.73]).</div></div><div><h3>Conclusion</h3><div>Complete tophus resolution is obtained at 24<!--> <!-->months of T2T in DECT but not in US, which provided a greater variability of volumetric assessments throughout follow-up.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105892"},"PeriodicalIF":3.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of corticosteroid therapy in persistent synovitis following septic arthritis in adults: Report of 12 cases","authors":"Alia Barthel ,&nbsp;Renaud Felten ,&nbsp;Jeannot Gaudias ,&nbsp;Lucas Niglis ,&nbsp;Cyril Boeri ,&nbsp;Cécile Ronde-Oustau ,&nbsp;Philippe Clavert ,&nbsp;Stéphane Klein","doi":"10.1016/j.jbspin.2025.105887","DOIUrl":"10.1016/j.jbspin.2025.105887","url":null,"abstract":"<div><h3>Context</h3><div>Septic arthritis management relies on appropriate antibiotic therapy and joint drainage. Despite quick microbial eradication, recovery is often incomplete, with significant sequelae such as loss of joint mobility affecting over 30% of patients, sometimes requiring surgery. Persistent synovitis after treatment poses clinical challenges, and the use of corticosteroids as a way to reduce this residual inflammation has been poorly studied.</div></div><div><h3>Method</h3><div>This retrospective, uncontrolled series evaluated the clinical efficacy of corticosteroid therapy in 12 adult patients with persistent synovitis following native septic arthritis.</div></div><div><h3>Results</h3><div>Twelve patients were included, most with knee arthritis (10/12, 83.3%). Median antibiotics course before corticosteroids was 14 days (7–30) and all had controlled infections. Route of administration was mostly intra-articular (10/12, 83.3%). Complete (8/12, 66.7%) or partial (3/12, 25.0%) clinical improvement was obtained with a median response time of 2 days. At the end of follow-up, 75% of cases (9/12) met primary endpoint. There were no early infectious complications. Three cases were classified as treatment failures: one patient had no clinical improvement, and two eventually required knee arthroplasty.</div></div><div><h3>Conclusion</h3><div>Addressing an issue for which there is no data for adult patients, our results suggest that corticosteroids could be an effective option to treat « persistent synovitis » after septic arthritis restoring joint function and preventing long-term disability. This small, retrospective and descriptive study has limitations and larger, randomized studies are needed to confirm these results.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105887"},"PeriodicalIF":3.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addition of allopurinol to traditional Vietnamese medicine shows major improvement of 100 gout patients in a single center one-year prospective study","authors":"Thomas Bardin ,&nbsp;Quang Dinh Nguyen ,&nbsp;Valérie Bausson ,&nbsp;Khoi Tran ,&nbsp;Nicola Dalbeth ,&nbsp;Chuc Tran ,&nbsp;Dai Huynh ,&nbsp;Quang Huy Nguyen ,&nbsp;Minh Do ,&nbsp;Pascal Richette ,&nbsp;Matthieu Resche-Rigon","doi":"10.1016/j.jbspin.2025.105889","DOIUrl":"10.1016/j.jbspin.2025.105889","url":null,"abstract":"<div><h3>Objectives</h3><div>Gout is frequently severe in Vietnam, where urate-lowering drugs (ULDs) are seldom used and many patients are treated only with traditional herbal medicine. We assessed the addition of Western medicine on severe gout in Vietnamese people.</div></div><div><h3>Methods</h3><div>One hundred Vietnamese, ULD-free, crystal-proven gout patients with a GFR<!--> <!-->&gt;<!--> <!-->60<!--> <!-->mL/min, were prospectively followed for 1<!--> <!-->year after allopurinol initiation. The treatment protocol included allopurinol given according to the 2016 EULAR recommendations, flare prophylaxis with colchicine during the first months, and traditional herbal medicine. At each visit, gout flares were counted by a daily diary, digital foot photographs were taken for semi-quantitative tophus scoring, serum urate (SU) was measured. Ultrasound (US) scan was performed at baseline, 6 and 12<!--> <!-->months for double contour (DC) and index tophus measurement. Quality of life (Gout Impact Score [GIS]) and function were recorded at inclusion and after 12<!--> <!-->months. Foot gout radiographic erosion scores were obtained at baseline, 6 and 12<!--> <!-->months. Outcomes were compared in patients who had reached SU targets at 3<!--> <!-->months and those who did not.</div></div><div><h3>Results</h3><div>Patients’ median age and disease duration were 47 and 8<!--> <!-->years respectively, 91 had clinical tophi and 70 foot gouty erosions. Eighty-four patients were seen at 6<!--> <!-->months and 68 at 12<!--> <!-->months. Allopurinol dosage was progressively increased to a median of 600<!--> <!-->mg/d. Significant improvement of flare rates at M6 and M12, and of GIS and function at M12 were noted and did not associate with SU targets. Tophi (assessed by photograph and US measurements) and DC sign significantly decreased from M6 in association with achievement of<!--> <!-->&lt;<!--> <!-->300<!--> <!-->μmol/L SU target. Foot erosion scores significantly decreased with no association with SU targets. Mild skin rash to allopurinol developed in 7 patients.</div></div><div><h3>Conclusion</h3><div>This one-year open study tested a global gout care delivery model in which treat to uricemia target allopurinol, Western medicine self-treatment of flares, and patient education were added to a background of traditional herbal medicine in a Vietnamese population where gout is traditionally treated with herbal medicine. This shift in practice resulted in dramatic gout improvement.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105889"},"PeriodicalIF":3.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different arthritis patterns in pediatric familial Mediterranean fever: Focus on exon 10 biallelic pathogenic genotypes","authors":"Eray Tunce,&nbsp;Sıla Atamyildiz Uçar,&nbsp;Betül Sözeri","doi":"10.1016/j.jbspin.2025.105888","DOIUrl":"10.1016/j.jbspin.2025.105888","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the prevalence and characteristics of arthritis in pediatric familial Mediterranean fever (FMF) patients with biallelic pathogenic <em>MEFV</em> mutations on exon 10 and to assess the impact of axial joint involvement on disease progression.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 808 pediatric FMF patients with biallelic exon 10 mutations, followed for at least 12<!--> <!-->months. Data on demographics, clinical features, genetic variants, and treatment responses were analyzed. Patients were grouped based on arthritis presence, duration, and axial joint involvement for comparative analysis.</div></div><div><h3>Results</h3><div>Arthritis was observed in 19.2% of patients, with acute and chronic arthritis in 17.9% and 6.4%, respectively. The M694V allele frequency was significantly higher in the arthritis group (82%, <em>P</em> <!-->&lt;<!--> <!-->0.01), with a predominance of the M694V/M694V genotype (70.3%). In contrast, V726A and R761H alleles were less frequent. Chronic arthritis with axial involvement was associated with older age at diagnosis (<em>P</em> <!-->&lt;<!--> <!-->0.01), increased polyarticular involvement (<em>P</em> <!-->&lt;<!--> <!-->0.01), and elevated colchicine resistance (22.6%, <em>P</em> <!-->&lt;<!--> <!-->0.01). The most frequently affected joints included the knee and sacroiliac joints. HLA-B27 positivity was higher in axial arthritis cases, but the need for advanced therapies did not differ significantly.</div></div><div><h3>Conclusions</h3><div>Our study highlights the diverse arthritis presentations in pediatric FMF patients with biallelic pathogenic genotypes. The M694V allele was more prevalent in the arthritis group, suggesting a potential genetic link. Specifically, the reduced frequency of common FMF attack symptoms, such as fever and abdominal pain, in patients with arthritis suggests that this may lead to diagnostic delays. Chronic arthritis with axial involvement was associated with higher colchicine resistance and a greater need for advanced treatments. These findings emphasize the importance of tailored management strategies and long-term follow-up in pediatric FMF patients with arthritis to optimize outcomes.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105888"},"PeriodicalIF":3.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}