Joint Bone Spine最新文献

{"title":"Transforming myth into reality: a narrative review on the effect of therapies in slowing structural damage progression in axial spondyloarthritis","authors":"Ana Bento da Silva ,&nbsp;Désirée van der Heijde ,&nbsp;Floris van Gaalen ,&nbsp;Sofia Ramiro","doi":"10.1016/j.jbspin.2025.105963","DOIUrl":"10.1016/j.jbspin.2025.105963","url":null,"abstract":"<div><div>Structural damage of the sacroiliac joints and spine is a feared consequence of axial spondyloarthritis (axSpA), leading to impairments in spinal mobility and physical function, thus contributing to the high disease burden and compromising patients’ quality of life. Inhibiting the progression of structural damage is a major treatment goal. Contrasting with the proven clinical efficacy of available therapies (tumour necrosis factor-alpha inhibitors [TNFi], interleukin-17 inhibitors [IL-17i], and Janus kinase inhibitors [JAKi]), their efficacy in slowing damage progression is not clearly demonstrated. For various reasons, including methodological challenges, such an effect could not be demonstrated in randomised clinical trials (RCT). Instruments for assessing structural damage have several limitations, notably their low sensitivity to change, and RCTs with a placebo control group over a long period are not viable for ethical reasons. Based on observational studies, TNFi seem to exert an inhibitory effect compared to conventional treatment, particularly in patients with risk factors for disease progression, mainly pre-existing syndesmophytes, and with longer treatment duration (&gt;<!--> <!-->2 years). Although evidence relating to IL-17i is scarcer, one head-to-head RCT showed no differences between secukinumab (IL-17Ai) and adalimumab (TNFi) in slowing structural damage progression. For JAKi, comparative evidence is lacking. The potential disease-modifying effect appears to be equally promising for TNFi and IL-17Ai, and structural damage inhibition currently does not seem to be a distinguishing feature between drug classes for the treatment of axSpA. The development of more sensitive instruments to capture structural damage appears crucial for conducting comparative studies on the efficacy of current therapies.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105963"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful dual targeted therapy with upadacitinib and risankizumab in psoriatic arthritis, uveitis and alopecia areata","authors":"Núria Adell ,&nbsp;Jaime Notario ,&nbsp;Javier Narváez ,&nbsp;Laura Berbel-Arcobé","doi":"10.1016/j.jbspin.2025.106015","DOIUrl":"10.1016/j.jbspin.2025.106015","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 106015"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of regulatory events on JAK inhibitor prescribing in rheumatoid arthritis: Insights from the French MAJIK Registry","authors":"Marie-Elise Truchetet ,&nbsp;Clément Prati ,&nbsp;Pascale Thevenot ,&nbsp;Christophe Bologna ,&nbsp;Guillermo Carvajal Alegria ,&nbsp;Claire Immediato Daien ,&nbsp;Divi Cornec ,&nbsp;Emmanuelle Dernis ,&nbsp;Bruno Fautrel ,&nbsp;Antoine Pariente ,&nbsp;Christian Roux ,&nbsp;Jean-Hugues Salmon ,&nbsp;Jérémie Sellam ,&nbsp;Emilie Hucteau ,&nbsp;Julien Bezin ,&nbsp;Jérôme Avouac","doi":"10.1016/j.jbspin.2025.106021","DOIUrl":"10.1016/j.jbspin.2025.106021","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 106021"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential targets of air pollutants inducing ankylosing spondylitis: Evidence from eQTL Mendelian randomization and colocalization","authors":"Tiantaixi Tu ,&nbsp;Nuoyan Zhou ,&nbsp;Ye Yang ,&nbsp;Tongtong Zheng ,&nbsp;Qingfeng Xie ,&nbsp;Xinwang Ying","doi":"10.1016/j.jbspin.2025.106018","DOIUrl":"10.1016/j.jbspin.2025.106018","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 106018"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new biochemical score from synovial fluid for diagnosing septic arthritis","authors":"Isabelle Sacco ,&nbsp;Chayma Saadan ,&nbsp;Laura Pina Vegas ,&nbsp;Xavier Chevalier ,&nbsp;Bérénice Souhail ,&nbsp;Raphael Lepeule ,&nbsp;Nadia Oubaya ,&nbsp;Jean-Philippe Bastard ,&nbsp;Soraya Fellahi ,&nbsp;Florent Eymard","doi":"10.1016/j.jbspin.2025.105980","DOIUrl":"10.1016/j.jbspin.2025.105980","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the diagnostic performance of synovial fluid (SF) biochemical markers and assess the value of combining their measurements into a composite score for identifying septic arthritis (SA).</div></div><div><h3>Methods</h3><div>Patients who underwent arthrocentesis with SF biochemical analysis (proteins, glucose, lactate dehydrogenase (LDH), lactate) were included in the initial cohort (IC) (May 2018-May 2021) or the validation cohort (June 2021–March 2023). Using IC data, we compared marker levels in SA vs. non-SA and vs. crystal-related arthritis (C-rA) subgroup. Based on receiver operating characteristic (ROC) curves, we identified two thresholds (one optimizing sensitivity, the other specificity) to assign a score of 0–2 for each biomarker. We developed a composite score by combining the individual scores for discriminative biomarkers and assessed its diagnostic performance.</div></div><div><h3>Results</h3><div>We included 190 SF (170 patients) in the IC; 36 SF (18.9%) were septic. Glucose level was lower in SA than non-SA and C-rA, but lactate and LDH levels were higher (<em>P</em> <!-->&lt;<!--> <!-->0.001). The composite score was developed with a 0–6 scale, with the following thresholds: glucose (≤<!--> <!-->7 and ≤<!--> <!-->1.5<!--> <!-->mmol/L), lactate (≥<!--> <!-->4.5 and ≥<!--> <!-->7.5<!--> <!-->mmol/L), and LDH (≥<!--> <!-->600 and ≥<!--> <!-->1200 UI/L). A composite score ≥<!--> <!-->3 had 100% sensitivity and 73.9% specificity for SA diagnosis in the IC cohort, and a score≥<!--> <!-->5 had 55.5% sensitivity and 97.8% specificity. These findings were consistent in the validation cohort.</div></div><div><h3>Conclusion</h3><div>A combined score based on SF markers including glucose, LDH, and lactate may be an effective method for rapidly ruling out SA. A multicentric study is warranted to confirm these results.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105980"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial spondyloarthritis and polymyalgia rheumatica: When differential diagnosis is not that obvious","authors":"Margarida Lucas Rocha ,&nbsp;Sofia Ramiro ,&nbsp;Alexandre Sepriano","doi":"10.1016/j.jbspin.2025.105977","DOIUrl":"10.1016/j.jbspin.2025.105977","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105977"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission and objective signs of inflammation in axial spondyloarthritis – Mapping the symptom – Inflammation landscape in axial spondyloarthritis","authors":"Mikhail Protopopov,&nbsp;Fabian Proft","doi":"10.1016/j.jbspin.2025.105946","DOIUrl":"10.1016/j.jbspin.2025.105946","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105946"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline characteristics of the TRANSLATE2 cohort: A prospective study on rheumatoid arthritis-associated interstitial lung disease","authors":"Pierre-Antoine Juge ,&nbsp;Marie-Pierre Debray ,&nbsp;Valérie Devauchelle Pensec ,&nbsp;Christophe Richez ,&nbsp;Jérôme Avouac ,&nbsp;Lidwine Wemeau-Stervinou ,&nbsp;René-Marc Flipo ,&nbsp;Hilario Nunes ,&nbsp;Nathalie Saidenberg-Kermanac’h ,&nbsp;Jacques-Eric Gottenberg ,&nbsp;Stéphane Jouneau ,&nbsp;Arnaud Constantin ,&nbsp;Vincent Cottin ,&nbsp;Hubert Marotte ,&nbsp;Martin Soubrier ,&nbsp;Bruno Fautrel ,&nbsp;Gaëtane Nocturne ,&nbsp;Pascal Richette ,&nbsp;Francis Berenbaum ,&nbsp;Hagit Zylberman-Yona ,&nbsp;Philippe Dieudé","doi":"10.1016/j.jbspin.2025.105991","DOIUrl":"10.1016/j.jbspin.2025.105991","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the baseline characteristics of patients enrolled in the TRANSLATE2 cohort (<span><span>NCT04227535</span><svg><path></path></svg></span>), a national, multicenter, prospective case-control study designed to investigate the genetic and non-genetic determinants of interstitial lung disease (ILD) in rheumatoid arthritis (RA).</div></div><div><h3>Methods</h3><div>Cases with RA-ILD and RA controls without ILD were consecutively included in TRANSLATE2 with a 5-year prospective follow-up. All participants fulfilled the ACR/EULAR 2010 classification criteria for RA. ILD presence or absence was confirmed for every participant by chest high-resolution computed tomography (HRCT). Baseline demographic and clinical data were collected. Blood samples were collected at enrollment for centralized biobanking of DNA, RNA, and serum to support future genetic and biomarker studies. For ILD cases, chest HRCT scans were centrally reviewed to determine HRCT pattern. For the current study, associations with ILD were tested using univariable and multivariable logistic regression models.</div></div><div><h3>Results</h3><div>Among the 506 patients included (275 RA-ILD, 231 RA-noILD), RA-ILD cases were more frequently male (48.4% vs. 29.9%), older at enrollment (66.6 [9.9] vs. 58.5 [13.2] years) and older at RA onset (52.2 [14.7] vs. 45.8 [14.3] years). ILD was independently associated with male sex (OR 1.82; 95% CI 1.06, 3.14) and older age at RA onset (OR per 10 years 1.28; 95% CI 1.10,1.50). For ILD cases, the most frequent HRCT patterns were definite for usual interstitial pneumonia (39.3%) and non-specific interstitial pneumonia (17.8%). At enrollment, respiratory symptoms were observed in 67.3% with a mean forced vital capacity % predicted of 87.6% (21.7) and a mean diffusing capacity of the lung for carbon monoxide % predicted of 58.4% (18.8).</div></div><div><h3>Conclusion</h3><div>The TRANSLATE2 cohort provides a comprehensive and deeply phenotyped dataset that offers a unique opportunity to investigate the genetic architecture, risk factors, and natural history of RA-ILD.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105991"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The failure of IL-23 targeted therapies in axial spondyloarthritis: an unexpected observation","authors":"Nicolas Rosine ,&nbsp;Corinne Miceli-Richard","doi":"10.1016/j.jbspin.2025.105967","DOIUrl":"10.1016/j.jbspin.2025.105967","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105967"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal evolution of publication bias in drug safety assessment: A case study on association between osteonecrosis of the jaw and bisphosphonates","authors":"Nimetullah Aksoy ,&nbsp;Guillaume Grenet ,&nbsp;Maëlys Granal ,&nbsp;Marine Auffret ,&nbsp;François Gueyffier ,&nbsp;Audrey Lajoinie ,&nbsp;Jean-Christophe Lega ,&nbsp;Emmanuel Massy ,&nbsp;Arthur Gougeon","doi":"10.1016/j.jbspin.2025.105970","DOIUrl":"10.1016/j.jbspin.2025.105970","url":null,"abstract":"<div><h3>Objectives</h3><div>The association between bisphosphonates (BP) and osteonecrosis of the jaw (ONJ) has been studied since 2006. However, meta-analyses conducted in 2014 and 2024 detected publication bias. Although it is often assumed that such bias diminishes over time, possibly due to the delayed publication of non-significant results, this trend has not been empirically confirmed in medicine. The aim of this study was to assess how publication bias has evolved in this safety context over time.</div></div><div><h3>Methods</h3><div>A systematic review was conducted on studies assessing the association between BP and ONJ. A cumulative, meta-analysis was performed to estimate the crude odds ratio (OR) year by year. Publication bias was assessed using a visual inspection of funnel plots and Egger's test. When publication bias was detected, the trim-and-fill method was applied to obtain an adjusted OR. The impact of publication bias was quantified using the ratio of odds ratios (ROR) (OR_adjusted/OR_crude).</div></div><div><h3>Results</h3><div>Forty-four studies published between 2006 and 2025 were included. Publication bias was detected from 2008 to 2025. The ROR increased from 0.42 in 2008 to 0.66 in 2025, indicating overestimation of 58% and 34%, respectively. The greatest impact was observed between 2013 and 2020. Subgroup analyses showed stronger residual bias in non-cancer indications.</div></div><div><h3>Conclusions</h3><div>Although publication bias decreased over time, its impact persisted for 17<!--> <!-->years. Consequently, risk perception may remain distorted for an extended period. This observation mirrors the dynamics of pharmacovigilance alerts, which often rely on initial publications. When publication bias is identified in previous meta-analyses, future updates should carefully reassess its presence, even many years later.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105970"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}