Joint Bone Spine最新文献

{"title":"The use of bisphosphonates in osteoid osteoma and osteoblastoma of difficult location: A useful and safe medical alternative","authors":"François Robin , Raphael Guillin , Romain Lecigne , Philippe Violas , Florence Burtin , Julien Maximen , Mickael Ropars , Valérie Bousson , Pascal Guggenbuhl","doi":"10.1016/j.jbspin.2025.105911","DOIUrl":"10.1016/j.jbspin.2025.105911","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105911"},"PeriodicalIF":3.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighing in on Obesity and Psoriatic Arthritis - Time to move beyond association to robust randomised trials.","authors":"Stefan Siebert, Naveed Sattar, Lyn D Ferguson","doi":"10.1016/j.jbspin.2025.105915","DOIUrl":"https://doi.org/10.1016/j.jbspin.2025.105915","url":null,"abstract":"<p><p>Almost one in two individuals with psoriatic arthritis (PsA) are now living with obesity. Obesity increases the risk of developing PsA, worsens disease activity, pain and fatigue, impairs treatment response, and amplifies the risk of many cardiometabolic comorbidities already more prevalent in PsA. Despite the increasing evidence for the pathogenic role of obesity in PsA, current treatment focuses on immune mediated therapies, with limited attention to tackling excess adiposity. Residual pain and disease activity in PsA can in turn adversely impact physical activity, leading to a cycle of further weight gain and worse disease activity. Preliminary evidence from dietary interventions in patients with PsA and obesity suggests weight loss of ≥5% body weight can improve disease activity, holding promise for potentially even better improvements with newer pharmacological anti-obesity therapies, such as incretin-based weight loss medicines, which result in average weight losses of 15-20%. In this narrative review, we provide an overview of the adverse impacts of obesity in PsA and discuss weight loss therapies now available to help address this. We highlight the urgent need for robust randomised controlled trials of weight loss therapies in patients with PsA and obesity to determine their clinical and cost effectiveness in PsA management and to inform where these are best implemented in the disease course and treatment pathway.</p>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"105915"},"PeriodicalIF":3.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay between osteoporosis and dementia.","authors":"Véronique Breuil, Marie Charlotte Trojani","doi":"10.1016/j.jbspin.2025.105912","DOIUrl":"10.1016/j.jbspin.2025.105912","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femoral neck shape and trabecular bone microarchitecture association with hip osteoarthritis – Results from the QUALYOR study","authors":"Maxime Auroux ,&nbsp;Jean-Baptiste Pialat ,&nbsp;Alexandre Mercier-Guery ,&nbsp;Anne Piot ,&nbsp;Johann Grapinet ,&nbsp;Paul Henri Himpens ,&nbsp;Blandine Merle ,&nbsp;Elisabeth Fontanges ,&nbsp;Florence Duvert ,&nbsp;Mathilde Proriol ,&nbsp;Pawel Szulc ,&nbsp;Eric Lespessailles ,&nbsp;Roland Chapurlat","doi":"10.1016/j.jbspin.2025.105914","DOIUrl":"10.1016/j.jbspin.2025.105914","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;Hip osteoarthritis (OA) is a major public health concern. The determinants of hip OA, however, are not as well understood as those of other OA sites, such as the knee. In recent years, the role of subchondral bone in the pathogenesis of OA has been emphasized but data are lacking for hip OA. Therefore, we aimed to determine which bone characteristics were associated to hip OA.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We made a cross-sectional analysis of 1537 postmenopausal women included in the QUALYOR prospective cohort. At baseline, we measured areal BMD by DXA at the lumbar spine and the hip, volumetric BMD and geometry by hip quantitative computerized tomography (QCT) using the Bone Investigational Toolkit (BIT) software, as well as microarchitecture at the distal radius and tibia by high-resolution peripheral quantitative tomography (HR-pQCT). We built a hip OA score (CT OA score) with images from the hip QCT, based on the depiction of the four major signs of osteoarthritis: subchondral bone sclerosis, joint space narrowing, osteophytes and subchondral cysts. The severity of each of these four signs was graded as absent, mild, moderate or severe (semi-quantitative score ranging from 0 to 3 for each sign). The absence of hip OA was defined as CT score equal to 0, mild hip OA as CT score between 1 and 4 and moderate to severe hip OA as CT score&lt;!--&gt; &lt;!--&gt;&gt;&lt;!--&gt; &lt;!--&gt;4. Women with and without hip OA were compared using t tests and multivariable modeling.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The mean age was 65.9 (±6.7) years and the mean body mass index was 24.6 (±3.6) kg/m&lt;sup&gt;2&lt;/sup&gt;. Among these 1537 women, 601 had an OA score of 0, 756 between 1 and 4 (mild OA) and 180 greater than 4 (severe OA). Women with hip osteoarthritis had lower trabecular total hip vBMD (125 vs. 129&lt;!--&gt; &lt;!--&gt;mg/cm&lt;sup&gt;3&lt;/sup&gt;, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.01). Cortical hip vBMD did not differ between women with and without hip OA (966.5 vs. 963.5&lt;!--&gt; &lt;!--&gt;mg/cm&lt;sup&gt;3&lt;/sup&gt;, &lt;em&gt;P&lt;/em&gt; n.s). Patients with hip OA also had larger femoral neck volume (11.55 vs. 11.27&lt;!--&gt; &lt;!--&gt;mm&lt;sup&gt;3&lt;/sup&gt;, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001). The BIT analysis showed greater bone resistance to bending (cross-sectional moment of inertia [CSMI] min with 6.03 vs. 5.6&lt;!--&gt; &lt;!--&gt;cm&lt;sup&gt;4&lt;/sup&gt; and section modulus [Z] polar with 7.98 vs. 7.59&lt;!--&gt; &lt;!--&gt;cm&lt;sup&gt;3&lt;/sup&gt;, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.05) at the femoral neck in patients with mild hip OA and even greater in women with severe hip OA. Patients with hip OA had significantly higher trabecular area measured at the radius by HR-pQCT (205.11 vs. 192.61&lt;!--&gt; &lt;!--&gt;mm&lt;sup&gt;2&lt;/sup&gt;, between group difference 12.50 95% CI [8.15–16.86] &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.01), lower trabecular number at the tibia (1.57/μm vs. 1.63/μm, between group difference −0.06 95% CI [−0.09 to −0.03] &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.001) and higher trabecular spacing at the tibia (0.58 vs. 0.56&lt;!--&gt; &lt;!--&gt;μm, between gro","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105914"},"PeriodicalIF":3.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid arthritis before rheumatoid arthritis: What can we learn from clinical trials?","authors":"Daniel Aletaha,&nbsp;Daniela Sieghart","doi":"10.1016/j.jbspin.2025.105910","DOIUrl":"10.1016/j.jbspin.2025.105910","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 6","pages":"Article 105910"},"PeriodicalIF":3.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune diseases' mortality: secular trends and causes.","authors":"Carine Salliot, Camille Langbour","doi":"10.1016/j.jbspin.2025.105908","DOIUrl":"https://doi.org/10.1016/j.jbspin.2025.105908","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":"105908"},"PeriodicalIF":3.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune diseases' mortality: Secular trends and causes.","authors":"Carine Salliot, Camille Langbour","doi":"10.1016/j.jbspin.2025.105907","DOIUrl":"10.1016/j.jbspin.2025.105907","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighing in on obesity and psoriatic arthritis – Time to move beyond association to robust randomised trials","authors":"Stefan Siebert ,&nbsp;Naveed Sattar ,&nbsp;Lyn D. Ferguson","doi":"10.1016/j.jbspin.2025.105904","DOIUrl":"10.1016/j.jbspin.2025.105904","url":null,"abstract":"<div><div>Almost one in two individuals with psoriatic arthritis (PsA) are now living with obesity. Obesity increases the risk of developing PsA, worsens disease activity, pain and fatigue, impairs treatment response, and amplifies the risk of many cardiometabolic comorbidities already more prevalent in PsA. Despite the increasing evidence for the pathogenic role of obesity in PsA, current treatment focuses on immune mediated therapies, with limited attention to tackling excess adiposity. Residual pain and disease activity in PsA can in turn adversely impact physical activity, leading to a cycle of further weight gain and worse disease activity. Preliminary evidence from dietary interventions in patients with PsA and obesity suggests weight loss of<!--> <!-->≥<!--> <!-->5% body weight can improve disease activity, holding promise for potentially even better improvements with newer pharmacological anti-obesity therapies, such as incretin-based weight loss medicines, which result in average weight losses of 15–20%. In this narrative review, we provide an overview of the adverse impacts of obesity in PsA and discuss weight loss therapies now available to help address this. We highlight the urgent need for robust randomised controlled trials of weight loss therapies in patients with PsA and obesity to determine their clinical and cost effectiveness in PsA management and to inform where these are best implemented in the disease course and treatment pathway.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105904"},"PeriodicalIF":3.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel options to treat psoriatic arthritis and spondyloarthritis – Interleukin-17 gives up its family secrets","authors":"Flavia Sunzini,&nbsp;Danai Vossou,&nbsp;Iain B. McInnes","doi":"10.1016/j.jbspin.2025.105905","DOIUrl":"10.1016/j.jbspin.2025.105905","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 4","pages":"Article 105905"},"PeriodicalIF":3.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of inflammasomes in autoinflammatory diseases","authors":"Cyrielle Hou,&nbsp;Zhuo Wang,&nbsp;Valentin Eichenberger,&nbsp;Fabio Martinon","doi":"10.1016/j.jbspin.2025.105903","DOIUrl":"10.1016/j.jbspin.2025.105903","url":null,"abstract":"<div><div>Inflammasomes are multiprotein complexes that play a crucial role in the innate immune response by detecting cellular stress and initiating inflammatory signaling through the release of cytokines. When inflammation is dysregulated, it can contribute significantly to the development of autoinflammatory diseases, a group of disorders characterized by inappropriate inflammation in the absence of infection or autoimmunity. This review examines the current understanding of inflammasome dysfunction in various autoinflammatory diseases, highlighting recent advances that connect genetic mutations and environmental triggers to the hyperactivation of inflammasomes. We focus on key inflammasomes, including NLRP1, NLRP3, NLRC4, and Pyrin, and their involvement in disorders such as Cryopyrin-Associated Periodic Syndromes and Familial Mediterranean Fever. Furthermore, we discuss the molecular mechanisms that lead to inflammasome dysregulation, such as gain-of-function mutations. We also review therapeutic approaches targeting these pathways, which show promise in alleviating disease symptoms and improving patient outcomes.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"92 5","pages":"Article 105903"},"PeriodicalIF":3.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}