Diseases associated with anti-centromere protein F (anti-CENP-F) antibodies: Insights from a large cohort study

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine Pub Date : 2025-03-14 DOI:10.1016/j.jbspin.2025.105885

Alexandre Le Joncour , Jean-Luc Charuel , Sylvain Choquet , Jean-Philippe Spano , Jean-Christophe Corvol , Bruno Fautrel , Dominique Thabut , David Saadoun , Zahir Amoura , Pascale Ghillani-Dalbin , Patrice Cacoub

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引用次数: 0

Abstract

Introduction

Antinuclear antibodies (ANA) exhibit diverse specificities and are crucial biomarkers in autoimmune disease assessment. Among ANA, anti-centromere protein-F (CENP-F) antibodies have garnered interest due to their association with malignancies. This study aims to characterize the clinical and biological profiles of a large cohort of anti-CENP-F positive patients and evaluate associated diagnoses.

Methods

Over 12 years, approximately 151,000 ANA screening samples were assessed, identifying 110 anti-CENP-F positive patients. Clinical and biological characteristics, including demographics, comorbidities, and antibody titers, were retrospectively analyzed. Follow-up data were collected to ascertain associated diagnoses.

Results

The median age was 50.9 years, with a predominance of women (73.6%). Median CENP-F antibody titer was 1:160, with 16.4% of patients with a titer higher than 1:1280. A concomitant specific autoimmune antibody was detected in 29 (26.4%) of cases. After a median follow-up of 3.8 years, autoimmune diseases were the most common associated diagnosis (38.2%), followed by neurological diseases (15.5%), hemopathies (8.3%), and cancer (10.9%). Some patients had concurrent cancer and autoimmune diseases. Twelve patients were diagnosed with cancer, primarily lung and breast cancers. In multivariate analysis, older age and higher anti-CENP-F titers were associated with cancer diagnosis.

Conclusion

This study provides comprehensive insights into the clinical significance of anti-CENP-F antibodies. Vigilance is warranted in older patients with elevated antibody titers, as they may indicate an increased risk of cancer.

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与抗着丝粒蛋白F（抗cenp -F）抗体相关的疾病：来自大型队列研究的见解

抗核抗体（ANA）具有多种特异性，是自身免疫性疾病评估的重要生物标志物。在ANA中，抗着丝粒蛋白f （CENP-F）抗体由于与恶性肿瘤相关而引起了人们的兴趣。本研究旨在描述一大批抗cenp - f阳性患者的临床和生物学特征，并评估相关诊断。方法：在12年的时间里，对大约15.1万份ANA筛查样本进行了评估，鉴定出110例抗cenp - f阳性患者。回顾性分析临床和生物学特征，包括人口统计学、合并症和抗体滴度。收集随访数据以确定相关诊断。结果：中位年龄50.9岁，以女性居多（73.6%）。中位CENP-F抗体滴度为1:160，其中16.4%的患者滴度高于1:1280。29例（26.4%）患者同时检测到特异性自身免疫抗体。中位随访3.8年后，自身免疫性疾病是最常见的相关诊断（38.2%），其次是神经系统疾病（15.5%）、血液病（8.3%）和癌症（10.9%）。一些患者同时患有癌症和自身免疫性疾病。12名患者被诊断出患有癌症，主要是肺癌和乳腺癌。在多变量分析中，年龄越大和抗cenp - f滴度越高与癌症诊断相关。结论：本研究全面揭示了抗cenp - f抗体的临床意义。抗体滴度升高的老年患者应保持警惕，因为这可能表明癌症风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Joint Bone Spine 医学-风湿病学

CiteScore

4.50

自引率

11.90%

发文量

184

审稿时长

25 days

期刊介绍： Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.