Journal of Computational Neuroscience最新文献

A solvable neural circuit model revealing the dynamical principle of non-optimal temporal weighting in perceptual decision making. 一个可解的神经回路模型揭示了感知决策中非最优时间加权的动力学原理。

IF 2 4区医学

Journal of Computational Neuroscience Pub Date : 2025-07-29 DOI: 10.1007/s10827-025-00910-9

Xuewen Shen, Fangting Li, Bin Min

{"title":"A solvable neural circuit model revealing the dynamical principle of non-optimal temporal weighting in perceptual decision making.","authors":"Xuewen Shen, Fangting Li, Bin Min","doi":"10.1007/s10827-025-00910-9","DOIUrl":"https://doi.org/10.1007/s10827-025-00910-9","url":null,"abstract":"Understanding the mechanism of accumulating evidence over time in deliberate decision-making is crucial for both humans and animals. While numerous models have been proposed over the past few decades to characterize the temporal weighting of evidence, the dynamical principle governing the neural circuits in decision making remain elusive. In this study, we proposed a solvable rank-1 neural circuit model to address this problem. We first derived an analytical expression for integration kernel, a key quantity describing how sensory evidence at different time points is weighted with respect to the final decision. Based on this expression, we illustrated that how the dynamics introduced in the auxiliary space-namely, a subspace orthogonal to the decision variable-modulates the flow fields of decision variable through a gain modulation mechanism, resulting in a variety of integration kernel types, including not only monotonic ones (recency and primacy) but also non-monotonic ones (convex and concave). Furthermore, we quantitatively validated that integration kernel shapes can be understood from dynamical landscapes and non-monotonic temporal weighting reflects topological transitions in the landscape. Additionally, we showed that training on networks with non-optimal weighting leads to convergence toward optimal weighting. Finally, we demonstrate that rank-1 connectivity induces symmetric competition to generate pitchfork bifurcation. In summary, we present a solvable neural circuit model that unifies diverse types of temporal weighting, providing an intriguing link between non-monotonic integration kernel structure and topological transitions of dynamical landscape.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating computational neuroscience into Africa's academic curriculum: Challenges, opportunities, and strategic implementation. 将计算神经科学纳入非洲学术课程：挑战、机遇和战略实施。

IF 1.5 4区医学

Journal of Computational Neuroscience Pub Date : 2025-07-01 DOI: 10.1007/s10827-025-00906-5

Ibeachu P Chinagorom, Peter Oseghale Ohue

引用次数: 0

Do the receptive fields in the primary visual cortex span a variability over the degree of elongation of the receptive fields? 初级视觉皮层的感受野是否跨越了感受野延伸程度的变异性？

IF 1.5 4区医学

Journal of Computational Neuroscience Pub Date : 2025-06-20 DOI: 10.1007/s10827-025-00907-4

Tony Lindeberg

{"title":"Do the receptive fields in the primary visual cortex span a variability over the degree of elongation of the receptive fields?","authors":"Tony Lindeberg","doi":"10.1007/s10827-025-00907-4","DOIUrl":"10.1007/s10827-025-00907-4","url":null,"abstract":"This paper presents the results of combining (i) theoretical analysis regarding connections between the orientation selectivity and the elongation of receptive fields for the affine Gaussian derivative model with (ii) biological measurements of orientation selectivity in the primary visual cortex to investigate if (iii) the receptive fields can be regarded as spanning a variability in the degree of elongation. From an in-depth theoretical analysis of idealized models for the receptive fields of simple and complex cells in the primary visual cortex, we established that the orientation selectivity becomes more narrow with increasing elongation of the receptive fields. Combined with previously established biological results, concerning broad vs. sharp orientation tuning of visual neurons in the primary visual cortex, as well as previous experimental results concerning distributions of the resultant of the orientation selectivity curves for simple and complex cells, we show that these results are consistent with the receptive fields spanning a variability over the degree of elongation of the receptive fields. We also show that our principled theoretical model for visual receptive fields leads to qualitatively similar types of deviations from a uniform histogram of the resultant descriptor of the orientation selectivity curves for simple cells, as can be observed in the results from biological experiments. To firmly investigate the validity of the underlying working hypothesis, we finally formulate a set of testable predictions for biological experiments, to characterize the predicted systematic variability in the elongation over the orientation maps in higher mammals, and its relations to the pinwheel structure.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling characteristics of neuronal firing in the thalamocortical network of connections in control and parkinsonian primates. 对照和帕金森病灵长类丘脑皮质连接网络神经元放电的建模特征。

IF 1.5 4区医学

Journal of Computational Neuroscience Pub Date : 2025-06-20 DOI: 10.1007/s10827-025-00909-2

Carly Ferrell, Qile Jiang, Margaret Olivia Leu, Thomas Wichmann, Michael Caiola

{"title":"Modeling characteristics of neuronal firing in the thalamocortical network of connections in control and parkinsonian primates.","authors":"Carly Ferrell, Qile Jiang, Margaret Olivia Leu, Thomas Wichmann, Michael Caiola","doi":"10.1007/s10827-025-00909-2","DOIUrl":"10.1007/s10827-025-00909-2","url":null,"abstract":"According to current anatomical models, motor cortical areas, the basal ganglia, and the ventral motor thalamus form partially closed (re-entrant) loop structures. The normal patterning of neuronal activity within this network regulates aspects of movement planning and execution, while abnormal firing patterns can contribute to movement impairments, such as those seen in Parkinson's disease. Most previous research on such firing pattern abnormalities has focused on parkinsonism-associated changes in the basal ganglia, demonstrating, among other abnormalities, prominent changes in firing rates, as well as the emergence of synchronized beta-band oscillatory burst patterns. In contrast, abnormalities of neuronal activity in the thalamus and cortex are less explored. However, recent studies have shown both changes in thalamocortical connectivity and anatomical changes in corticothalamic terminals in Parkinson's disease. To explore these changes, we created a computational framework to model the effects of changes in thalamocortical connections as they may occur when an individual transitions from the healthy to the parkinsonian state. A 5-dimensional average neuronal firing rate model was fitted to replicate neuronal firing rate information recorded in healthy and parkinsonian primates. The study focused on the effects of (1) changes in synaptic weights of the reciprocal projections between cortical neurons and thalamic principal neurons, and (2) changes in synaptic weights of the cortical projection to thalamic interneurons. We found that it is possible to force the system to change from a healthy to a parkinsonian state, including the emergent oscillatory activity, by only adjusting these two sets of synaptic weights. Thus, this study demonstrates that small changes in the afferent and efferent connections of thalamic neurons could contribute to the emergence of network-wide firing patterns that are characteristic for the parkinsonian state.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling traveling calcium waves in cellular structures. 细胞结构中的钙离子游波建模

IF 1.5 4区医学

Journal of Computational Neuroscience Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI: 10.1007/s10827-025-00898-2

Patrick A Shoemaker, Bo M B Bekkouche

{"title":"Modeling traveling calcium waves in cellular structures.","authors":"Patrick A Shoemaker, Bo M B Bekkouche","doi":"10.1007/s10827-025-00898-2","DOIUrl":"10.1007/s10827-025-00898-2","url":null,"abstract":"We report a parametric simulation study of traveling calcium waves in two classes of cellular structures: dendrite-like processes and an idealized cell body. It is motivated by the hypothesis that calcium waves may participate in spatiotemporal sensory processing; accordingly, its objective is to elucidate the dependence of traveling wave characteristics (e.g., propagation speed and amplitude) on various anatomical and physiological parameters. The models include representations of inositol trisphosphate and ryanodine receptors (which mediate transient calcium entry into the cytoplasm from the endoplasmic reticulum), as well as other entities involved in calcium transport or reactions. These support traveling cytoplasmic calcium waves, which are fully regenerative for significant ranges of model parameters. We also observe Hopf bifurcations between stable and unstable regimes, the latter being characterized by periodic calcium spikes. Traveling waves are possible in unstable processes during phases with sufficiently high calcium levels in the endoplasmic reticulum. Damped and abortive waves are observed for some parameter values. When both receptor types are present and functional, we find wave speeds on the order of 100 to several hundred micrometers per second and cytosolic calcium transients with amplitudes of tens of micromolar; when ryanodine receptors are absent, these values are on the order of tens of micrometers per second and 1-6 micromolar. Even with significantly downgraded channel conductance, ryanodine receptors can significantly impact wave speeds and amplitudes. Receptor areal densities and the diffusion coefficient for cytoplasmic calcium are the parameters to which wave characteristics are most sensitive.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":"219-245"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical dynamics of neural-connectivity fields. 神经连通性领域的皮质动力学。

IF 1.5 4区医学

Journal of Computational Neuroscience Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI: 10.1007/s10827-025-00903-8

Gerald K Cooray, Vernon Cooray, Karl J Friston

引用次数: 0

Inferring collective synchrony observing spiking of one or several neurons. 推断集体同步性观察一个或几个神经元的尖峰。

IF 1.5 4区医学

Journal of Computational Neuroscience Pub Date : 2025-06-01 Epub Date: 2025-03-22 DOI: 10.1007/s10827-025-00900-x

Arkady Pikovsky, Michael Rosenblum

引用次数: 0

Localist neural plasticity identified by mutual information. 通过互信息识别局部神经可塑性

IF 1.5 4区医学

Journal of Computational Neuroscience Pub Date : 2025-06-01 Epub Date: 2025-03-22 DOI: 10.1007/s10827-025-00901-w

Gabriele Scheler, Martin L Schumann, Johann Schumann

{"title":"Localist neural plasticity identified by mutual information.","authors":"Gabriele Scheler, Martin L Schumann, Johann Schumann","doi":"10.1007/s10827-025-00901-w","DOIUrl":"10.1007/s10827-025-00901-w","url":null,"abstract":"We present a model of pattern memory and retrieval with novel, technically useful and biologically realistic properties. Specifically, we enter n variations of k pattern classes (n*k patterns) onto a cortex-like balanced inhibitory-excitatory network with heterogeneous neurons, and let the pattern spread within the recurrent network. We show that we can identify high mutual-information (MI) neurons as major information-bearing elements within each pattern representation. We employ a simple one-shot adaptive (learning) process focusing on high MI neurons and inhibition. Such 'localist plasticity' has high efficiency, because it requires only few adaptations for each pattern. Specifically, we store k=10 patterns of size s=400 in a 1000/1200 neuron network. We stimulate high MI neurons and in this way recall patterns, such that the whole network represents this pattern. We assess the quality of the representation (a) before learning, when entering the pattern into a naive network, (b) after learning, on the adapted network, and (c) after recall by stimulation. The recalled patterns could be easily recognized by a trained classifier. The recalled pattern 'unfolds' over the recurrent network with high similarity to the original input pattern. We discuss the distribution of neuron properties in the network, and find that an initial Gaussian distribution changes into a more heavy-tailed, lognormal distribution during the adaptation process. The remarkable result is that we are able to achieve reliable pattern recall by stimulating only high information neurons. This work provides a biologically-inspired model of cortical memory and may have interesting technical applications.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":"321-331"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dopamine modulation of basolateral amygdala activity and function. 多巴胺对基底外侧杏仁核活动和功能的调节。

IF 1.5 4区医学

Journal of Computational Neuroscience Pub Date : 2025-06-01 Epub Date: 2025-03-19 DOI: 10.1007/s10827-025-00897-3

Alexey Kuznetsov

{"title":"Dopamine modulation of basolateral amygdala activity and function.","authors":"Alexey Kuznetsov","doi":"10.1007/s10827-025-00897-3","DOIUrl":"10.1007/s10827-025-00897-3","url":null,"abstract":"The basolateral amygdala (BLA) is central to emotional processing, fear learning, and memory. Dopamine (DA) significantly influences BLA function, yet its precise effects are not clear. We present a mathematical model exploring how DA modulation of BLA activity depends on the network's current state. Specifically, we model the firing rates of interconnected neural groups in the BLA and their responses to external stimuli and DA modulation. BLA projection neurons are separated into two groups according to their responses-fear and safety. These groups are connected by mutual inhibition though interneurons. We contrast 'differentiated' BLA states, where fear and safety projection neurons exhibit distinct activity levels, with 'non-differentiated' states. We posit that differentiated states support selective responses and short-term emotional memory. On the other hand, non-differentiated states represent either the case in which BLA is disengaged, or the activation of the fear and safety neurons is at a similar moderate or high level. We show that, while DA further disengages BLA in the low activity state, it destabilizes the moderate activity non-differentiated BLA state. We show that in the latter non-differentiated state the BLA is hypersensitive, and the polarity of its responses (fear or safety) to salient stimuli is highly random. We hypothesize that this non-differentiated state is related to anxiety and Post-Traumatic Stress Disorder (PTSD).","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":"359-372"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants. 听觉剥夺引起的轴突初始段可塑性降低了耳蜗植入神经反应模型的时差敏感性。

IF 1.5 4区医学

Journal of Computational Neuroscience Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.1007/s10827-025-00902-9

Anna Jing, Sylvia Xi, Ivan Fransazov, Joshua H Goldwyn

{"title":"Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.","authors":"Anna Jing, Sylvia Xi, Ivan Fransazov, Joshua H Goldwyn","doi":"10.1007/s10827-025-00902-9","DOIUrl":"10.1007/s10827-025-00902-9","url":null,"abstract":"Synaptic and neural properties can change during periods of auditory deprivation. These changes may disrupt the computations that neurons perform. In the brainstem of chickens, auditory deprivation can lead to changes in the size and biophysics of the axon initial segment (AIS) of neurons in the sound source localization circuit. This is the phenomenon of axon initial segment (AIS) plasticity. Individuals who use cochlear implants (CIs) experience periods of hearing loss, and so we ask whether AIS plasticity in neurons of the medial superior olive (MSO), a key stage of sound location processing, would impact time difference sensitivity in the scenario of hearing with cochlear implants. The biophysical changes that we implement in our model of AIS plasticity include enlargement of the AIS and replacement of low-threshold potassium conductance with the more slowly-activated M-type potassium conductance. AIS plasticity has been observed to have a homeostatic effect with respect to excitability. In our model, AIS plasticity has the additional effect of converting MSO neurons from phasic firing type to tonic firing type. Phasic firing is known to have greater temporal sensitivity to coincident inputs. Consistent with this, we find AIS plasticity degrades time difference sensitivity in the auditory deprived MSO neuron model across a range of stimulus parameters. Our study illustrates a possible mechanism of cellular plasticity in a non-peripheral stage of neural processing that could impose barriers to sound source localization by bilateral cochlear implant users.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":"267-288"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0