Journal of Computational Neuroscience最新文献_第10页

Improving a cortical pyramidal neuron model's classification performance on a real-world ecg dataset by extending inputs. 通过扩展输入改进皮层锥体神经元模型在真实世界心电图数据集上的分类性能。

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-08-01 Epub Date: 2023-05-06 DOI: 10.1007/s10827-023-00851-1

Ilknur Kayikcioglu Bozkir, Zubeyir Ozcan, Cemal Kose, Temel Kayikcioglu, Ahmet Enis Cetin

引用次数: 0

Functional architecture of M1 cells encoding movement direction. M1细胞编码运动方向的功能架构。

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-08-01 Epub Date: 2023-06-07 DOI: 10.1007/s10827-023-00850-2

Caterina Mazzetti, Alessandro Sarti, Giovanna Citti

{"title":"Functional architecture of M1 cells encoding movement direction.","authors":"Caterina Mazzetti, Alessandro Sarti, Giovanna Citti","doi":"10.1007/s10827-023-00850-2","DOIUrl":"10.1007/s10827-023-00850-2","url":null,"abstract":"In this paper we propose a neurogeometrical model of the behaviour of cells of the arm area of the primary motor cortex (M1). We will mathematically express as a fiber bundle the hypercolumnar organization of this cortical area, first modelled by Georgopoulos (Georgopoulos et al., 1982; Georgopoulos, 2015). On this structure, we will consider the selective tuning of M1 neurons of kinematic variables of positions and directions of movement. We will then extend this model to encode the notion of fragments introduced by Hatsopoulos et al. (2007) which describes the selectivity of neurons to movement direction varying in time. This leads to consider a higher dimensional geometrical structure where fragments are represented as integral curves. A comparison with the curves obtained through numerical simulations and experimental data will be presented. Moreover, neural activity shows coherent behaviours represented in terms of movement trajectories pointing to a specific pattern of movement decomposition Kadmon Harpaz et al. (2019). Here, we will recover this pattern through a spectral clustering algorithm in the subriemannian structure we introduced, and compare our results with the neurophysiological one of Kadmon Harpaz et al. (2019).","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":"51 3","pages":"299-327"},"PeriodicalIF":1.2,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10329174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effect of cortical extracellular GABA on motor response 皮层细胞外GABA对运动反应的影响

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-06-13 DOI: 10.1007/s10827-022-00821-z

O. Hoshino, M. Zheng, Y. Fukuoka

引用次数: 0

Numerical simulations of one- and two-dimensional stochastic neural field equations with delay 一维和二维时滞随机神经场方程的数值模拟

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-05-27 DOI: 10.1007/s10827-022-00816-w

Tiago F. Sequeira, P. Lima

引用次数: 3

Dynamics of ramping bursts in a respiratory neuron model. 呼吸神经元模型中斜坡爆发的动力学。

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-05-01 Epub Date: 2021-10-26 DOI: 10.1007/s10827-021-00800-w

Muhammad U Abdulla, Ryan S Phillips, Jonathan E Rubin

{"title":"Dynamics of ramping bursts in a respiratory neuron model.","authors":"Muhammad U Abdulla, Ryan S Phillips, Jonathan E Rubin","doi":"10.1007/s10827-021-00800-w","DOIUrl":"https://doi.org/10.1007/s10827-021-00800-w","url":null,"abstract":"Intensive computational and theoretical work has led to the development of multiple mathematical models for bursting in respiratory neurons in the pre-Bötzinger Complex (pre-BötC) of the mammalian brainstem. Nonetheless, these previous models have not captured the pre-inspiratory ramping aspects of these neurons' activity patterns, in which relatively slow tonic spiking gradually progresses to faster spiking and a full-blown burst, with a corresponding gradual development of an underlying plateau potential. In this work, we show that the incorporation of the dynamics of the extracellular potassium ion concentration into an existing model for pre-BötC neuron bursting, along with some parameter adjustments, suffices to induce this ramping behavior. Using fast-slow decomposition, we show that this activity can be considered as a form of parabolic bursting, but with burst termination at a homoclinic bifurcation rather than as a SNIC bifurcation. We also investigate the parameter-dependence of these solutions and show that the proposed model yields a greater dynamic range of burst frequencies, durations, and duty cycles than those produced by other models in the literature.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":"161-180"},"PeriodicalIF":1.2,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39561469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Emergence of stochastic resonance in a two-compartment hippocampal pyramidal neuron model. 随机共振在双室海马锥体神经元模型中的出现。

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-05-01 Epub Date: 2022-01-13 DOI: 10.1007/s10827-021-00808-2

Muhammad Bilal Ghori, Yanmei Kang, Yaqian Chen

{"title":"Emergence of stochastic resonance in a two-compartment hippocampal pyramidal neuron model.","authors":"Muhammad Bilal Ghori, Yanmei Kang, Yaqian Chen","doi":"10.1007/s10827-021-00808-2","DOIUrl":"https://doi.org/10.1007/s10827-021-00808-2","url":null,"abstract":"In vitro studies have shown that hippocampal pyramidal neurons employ a mechanism similar to stochastic resonance (SR) to enhance the detection and transmission of weak stimuli generated at distal synapses. To support the experimental findings from the perspective of multicompartment model analysis, this paper aimed to elucidate the phenomenon of SR in a noisy two-compartment hippocampal pyramidal neuron model, which was a variant of the Pinsky-Rinzel neuron model with smooth activation functions and a hyperpolarization-activated cation current. With a bifurcation analysis of the model, we demonstrated the underlying dynamical structure responsible for the occurrence of SR. Furthermore, using a stochastically generated biphasic pulse train and broadband noise generated by the Orenstein-Uhlenbeck process as noise perturbation, both SR and suprathreshold SR were observed and quantified. Spectral analysis revealed that the distribution of spectral power under noise perturbations, in addition to inherent neurodynamics, is the main factor affecting SR behavior. The research results suggested that noise enhances the transmission of weak stimuli associated with elongated dendritic structures of hippocampal pyramidal neurons, thereby providing support for related laboratory findings.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":"217-240"},"PeriodicalIF":1.2,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39677556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

High-frequency stimulation induces axonal conduction block without generating initial action potentials. 高频刺激引起轴突传导阻滞，但不产生初始动作电位。

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-05-01 DOI: 10.1007/s10827-021-00806-4

Yihua Zhong, Jicheng Wang, Jonathan Beckel, William C de Groat, Changfeng Tai

{"title":"High-frequency stimulation induces axonal conduction block without generating initial action potentials.","authors":"Yihua Zhong, Jicheng Wang, Jonathan Beckel, William C de Groat, Changfeng Tai","doi":"10.1007/s10827-021-00806-4","DOIUrl":"https://doi.org/10.1007/s10827-021-00806-4","url":null,"abstract":"The purpose of this modeling study is to develop a novel method to block nerve conduction by high frequency biphasic stimulation (HFBS) without generating initial action potentials. An axonal conduction model including both ion concentrations and membrane ion pumps is used to analyze the axonal response to 1 kHz HFBS. The intensity of HFBS is increased in multiple steps while maintaining the intensity at a sub-threshold level to avoid generating an action potential. Axonal conduction block by HFBS is defined as the failure of action potential propagation at the site of HFBS. The simulation analysis shows that step-increases in sub-threshold intensity during HFBS can successfully block axonal conduction without generating an initial response because the excitation threshold of the axon can be gradually increased by the sub-threshold HFBS. The mechanisms underlying the increase in excitation threshold involve changes in intracellular and extracellular sodium and potassium concentration, change in the resting potential, partial inactivation of the sodium channel and partial activation of the potassium channel by HFBS. When the excitation threshold reaches a sufficient level, an acute block occurs first and after additional sub-threshold HFBS it is followed by a post-stimulation block. This study indicates that step-increases in sub-threshold HFBS intensity induces a gradual increase in axonal excitation threshold that may allow HFBS to block nerve conduction without generating an initial response. If this finding is proven to be true in human, it will significantly impact clinical applications of HFBS to treat chronic pain.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":"50 2","pages":"203-215"},"PeriodicalIF":1.2,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035068/pdf/nihms-1785530.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9378087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A model of lateral interactions as the origin of multiwhisker receptive fields in rat barrel cortex. 作为大鼠筒状皮层多须感受野起源的横向相互作用模型。

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-05-01 Epub Date: 2021-12-01 DOI: 10.1007/s10827-021-00804-6

Linda Ma, Mainak Patel

{"title":"A model of lateral interactions as the origin of multiwhisker receptive fields in rat barrel cortex.","authors":"Linda Ma, Mainak Patel","doi":"10.1007/s10827-021-00804-6","DOIUrl":"https://doi.org/10.1007/s10827-021-00804-6","url":null,"abstract":"While cells within barrel cortex respond primarily to deflections of their principal whisker (PW), they also exhibit responses to non-principal, or adjacent, whiskers (AWs), albeit responses with diminished amplitudes and longer latencies. The origin of multiwhisker receptive fields of barrel cells remains a point of controversy within the experimental literature, with three contending possibilities: (i) barrel cells inherit their AW responses from the AW responses of thalamocortical (TC) cells within their aligned barreloid; (ii) the axons of TC cells within a barreloid ramify to innervate multiple barrels, rather than only terminating within their aligned barrel; (iii) lateral intracortical transmission between barrels conveys AW responsivity to barrel cells. In this work, we develop a detailed, biologically plausible model of multiple barrels in order to examine possibility (iii); in order to isolate the dynamics that possibility (iii) entails, we incorporate lateral connections between barrels while assuming that TC cells respond only to their PW and that TC cell axons are confined to their home barrel. We show that our model is capable of capturing a broad swath of experimental observations on multiwhisker receptive field dynamics within barrels, and we compare and contrast the dynamics of this model with model dynamics from prior work in which employ a similar general modeling strategy to examine possibility (i).","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":"181-201"},"PeriodicalIF":1.2,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39684740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast-slow analysis as a technique for understanding the neuronal response to current ramps. 快慢分析作为一种理解神经元对电流斜坡反应的技术。

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-05-01 Epub Date: 2021-10-19 DOI: 10.1007/s10827-021-00799-0

Kelsey Gasior, Kirill Korshunov, Paul Q Trombley, Richard Bertram

{"title":"Fast-slow analysis as a technique for understanding the neuronal response to current ramps.","authors":"Kelsey Gasior, Kirill Korshunov, Paul Q Trombley, Richard Bertram","doi":"10.1007/s10827-021-00799-0","DOIUrl":"https://doi.org/10.1007/s10827-021-00799-0","url":null,"abstract":"The standard protocol for studying the spiking properties of single neurons is the application of current steps while monitoring the voltage response. Although this is informative, the jump in applied current is artificial. A more physiological input is where the applied current is ramped up, reflecting chemosensory input. Unsurprisingly, neurons can respond differently to the two protocols, since ion channel activation and inactivation are affected differently. Understanding the effects of current ramps, and changes in their slopes, is facilitated by mathematical models. However, techniques for analyzing current ramps are under-developed. In this article, we demonstrate how current ramps can be analyzed in single neuron models. The primary issue is the presence of gating variables that activate on slow time scales and are therefore far from equilibrium throughout the ramp. The use of an appropriate fast-slow analysis technique allows one to fully understand the neural response to ramps of different slopes. This study is motivated by data from olfactory bulb dopamine neurons, where both fast ramp (tens of milliseconds) and slow ramp (tens of seconds) protocols are used to understand the spiking profiles of the cells. The slow ramps generate experimental bifurcation diagrams with the applied current as a bifurcation parameter, thereby establishing asymptotic spiking activity patterns. The faster ramps elicit purely transient behavior that is of relevance to most physiological inputs, which are short in duration. The two protocols together provide a broader understanding of the neuron's spiking profile and the role that slowly activating ion channels can play.","PeriodicalId":54857,"journal":{"name":"Journal of Computational Neuroscience","volume":" ","pages":"145-159"},"PeriodicalIF":1.2,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016091/pdf/nihms-1763371.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39530278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Interneuronal dynamics facilitate the initiation of spike block in cortical microcircuits 神经元间动力学促进皮层微回路中尖峰阻滞的发生

IF 1.2 4区医学

Journal of Computational Neuroscience Pub Date : 2022-04-19 DOI: 10.1007/s10827-022-00815-x

W. Stein, A. Harris

引用次数: 0