Dopamine modulation of basolateral amygdala activity and function.

Abstract

The basolateral amygdala (BLA) is central to emotional processing, fear learning, and memory. Dopamine (DA) significantly influences BLA function, yet its precise effects are not clear. We present a mathematical model exploring how DA modulation of BLA activity depends on the network's current state. Specifically, we model the firing rates of interconnected neural groups in the BLA and their responses to external stimuli and DA modulation. BLA projection neurons are separated into two groups according to their responses-fear and safety. These groups are connected by mutual inhibition though interneurons. We contrast 'differentiated' BLA states, where fear and safety projection neurons exhibit distinct activity levels, with 'non-differentiated' states. We posit that differentiated states support selective responses and short-term emotional memory. On the other hand, non-differentiated states represent either the case in which BLA is disengaged, or the activation of the fear and safety neurons is at a similar moderate or high level. We show that, while DA further disengages BLA in the low activity state, it destabilizes the moderate activity non-differentiated BLA state. We show that in the latter non-differentiated state the BLA is hypersensitive, and the polarity of its responses (fear or safety) to salient stimuli is highly random. We hypothesize that this non-differentiated state is related to anxiety and Post-Traumatic Stress Disorder (PTSD).