Journal of Ect最新文献_第2页

Managing Psychomotor Agitation in Autism With Electroconvulsive Therapy Under Severe Thrombocytopenia: A Clinical Challenge. 在严重血小板减少症下用电休克治疗自闭症患者的精神运动性躁动：一个临床挑战。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-18 DOI: 10.1097/YCT.0000000000001263

Rafael Robles de Andrade, Arthur Tolentino, Ana Laura Schumacher, Angelo Samuelson Gomes Silva, Pedro Henrique Melloni Forte, Osmar Henrique Della-Torre, Paulo Dalgalarrondo

引用次数: 0

Efficacy and Tolerability of Low-Field Magnetic Stimulation for Treatment of Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Sham-Controlled Studies. 低场磁刺激治疗抑郁症的疗效和耐受性：随机假对照研究的系统回顾和荟萃分析。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-17 DOI: 10.1097/YCT.0000000000001242

Dhiman R Bharadwaj, Suresh Aaditya, Shailja Singh, Neha Sharma, Jyothirmayi Kotipalli, Arogya Nadhudu Dovari, Swarndeep Singh, Brijesh Sathian, Sai Krishna Tikka

{"title":"Efficacy and Tolerability of Low-Field Magnetic Stimulation for Treatment of Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Sham-Controlled Studies.","authors":"Dhiman R Bharadwaj, Suresh Aaditya, Shailja Singh, Neha Sharma, Jyothirmayi Kotipalli, Arogya Nadhudu Dovari, Swarndeep Singh, Brijesh Sathian, Sai Krishna Tikka","doi":"10.1097/YCT.0000000000001242","DOIUrl":"10.1097/YCT.0000000000001242","url":null,"abstract":"Low-field magnetic stimulation (LFMS) has shown promising results for treating depression in preclinical and clinical studies. No previous meta-analysis has investigated its effects on depression. The aim of this systematic review and meta-analysis is to identify, evaluate, and summarize the current evidence for the efficacy and tolerability of LFMS in patients with depressive disorder. PubMed, Embase, Scopus, and Google Scholar databases were systematically searched to identify eligible studies published until February 15, 2025. Review protocol was prospectively registered with PROSPERO (CRD420250650519). Meta-analyses using a random-effects model was conducted to calculate pooled estimates. Standardized mean difference (SMD) and odds ratio (OR) were calculated for continuous and categorical outcomes, respectively. Nine randomized controlled trials (RCTs) comprising 571 patients were analysed. Five RCTs (55.5%) had 'some concerns', and 2 (22.2%) had a 'high risk' of bias. A moderate treatment effect size (SMD=-0.61; 95% CI: -0.91 to -0.30; P <0.001) favouring LFMS for the treatment of depression compared with sham stimulation was obtained. LFMS was well-tolerated with no significant difference in the frequency of adverse events reported between LFMS and sham groups, except for a significantly higher risk of myalgia associated with LFMS (OR=2.69; 95% CI: 1.14-6.31, P =0.02). Certainty of evidence on GRADE was 'low' for the primary outcome. LFMS may be a safe and effective neuromodulation technique for adjunctive treatment of depression. There is a need to conduct more robust RCTs with larger sample sizes, longer follow-up durations, and standardized LFMS stimulation parameters to better characterize its safety and efficacy.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical Steps: Using Electroconvulsive Therapy in Patients With Neurodevelopmental Disorders and Catatonia. 实用步骤：在神经发育障碍和紧张症患者中使用电休克疗法。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-12 DOI: 10.1097/YCT.0000000000001258

Neera Ghaziuddin, H Yavuz Ince, Hannah Reynard, Alexander Palffy, Daniel F Maixner, Lee E Wachtel

引用次数: 0

Electroconvulsive Therapy for Treatment-Resistant Poststroke Depression Following Flow Diversion-Related In-Stent Thrombosis. 电休克疗法治疗卒中后抑郁后血流转移相关的支架内血栓形成。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-10 DOI: 10.1097/YCT.0000000000001261

Eric A Grin, Jordan Intrator, Hannah Weiss, Patrick Ying, Benjamin Fuchs, Erez Nossek, Brandon Jun

引用次数: 0

Variability in Real-World Electroconvulsive Therapy (ECT) Practice: Is Perfection the Enemy of the Good? 现实世界电痉挛治疗（ECT）实践的可变性：完美是好的敌人吗？

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-06 DOI: 10.1097/YCT.0000000000001260

Charles H Kellner

引用次数: 0

Rethinking Seizure Termination: A Possible Paradigm Shift in Understanding a Primary Mechanism of ECT. 重新思考癫痫终止：理解电痉挛主要机制的一种可能的范式转变。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-04 DOI: 10.1097/YCT.0000000000001208

Moritz Spangemacher, Jonathan Reinwald, Sebastian Karl, Alexander Sartorius

引用次数: 0

Electroconvulsive Therapy as an Adjunctive Treatment for Clozapine-Resistant Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 电痉挛疗法作为氯氮平抵抗性精神分裂症的辅助治疗：随机对照试验的系统回顾和荟萃分析。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-03 DOI: 10.1097/YCT.0000000000001237

Felipe Mendonça Rocha Barros, Arthur Tolentino, Liliane Smaniotto, Pedro Gabriel Lorencetti, Lais Soares Ker Marques, Marina Guitti de Souza, Rodolfo Francisco Marques, Lucas Mendonça de Araújo Bellesi, Pedro Vieira Prado da Silva, Paulo Dalgalarrondo, Ary Gadelha, Renata Cruz Soares de Azevedo

{"title":"Electroconvulsive Therapy as an Adjunctive Treatment for Clozapine-Resistant Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Felipe Mendonça Rocha Barros, Arthur Tolentino, Liliane Smaniotto, Pedro Gabriel Lorencetti, Lais Soares Ker Marques, Marina Guitti de Souza, Rodolfo Francisco Marques, Lucas Mendonça de Araújo Bellesi, Pedro Vieira Prado da Silva, Paulo Dalgalarrondo, Ary Gadelha, Renata Cruz Soares de Azevedo","doi":"10.1097/YCT.0000000000001237","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001237","url":null,"abstract":"Clozapine-resistant schizophrenia (CRS) is a severe condition with limited therapeutic options. Electroconvulsive therapy (ECT) has been proposed as augmentation, but its efficacy remains uncertain due to methodological limitations and inconsistent findings. This meta-analysis assessed the efficacy and safety of ECT as an adjunctive treatment in CRS. A systematic review and meta-analysis of RCTs was conducted following PRISMA guidelines. Databases were searched up to March 2025. The primary outcome was clinical response, defined in each RCT as a ≥40% to 50% reduction in positive psychotic symptoms. Secondary outcomes included response at ≥20% reduction, changes in negative/general symptoms, adverse effects, and dropouts. Three RCTs (102 participants) were included, two with sham-ECT controls. ECT significantly increased response compared with control for the primary outcome (RR = 5.63; 95% CI: 1.00 to 31.57; P = 0.04; I² = 0%), but showed no difference at the ≥20% threshold (RR = 1.96; 95% CI: 0.45 to 8.44; P = 0.36; I² = 55%). Other secondary outcomes were not pooled due to heterogeneity. ECT was generally well tolerated, with a low dropout rate. The primary outcome was driven by one large-effect study without sham-ECT and using clozapine monotherapy as control, while sham-controlled studies showed no significant benefit. The absence of differences at the ≥20% response threshold likely reflects the sham-ECT effects. Although underpowered, this outcome was reported to discuss active placebo effects. Given CRS severity and limited options, ECT may still be considered in selected cases, but further high-quality sham-controlled RCTs with standardized protocols are required.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Adjunctive High-Definition Transcranial Direct Current Stimulation (HD-tDCS) to Oral Naltrexone on Craving, Brain Glutamate-Glutamine (Glx) at Left Dorsolateral Prefrontal Cortex (DLPFC) in Alcohol Use Disorder: A Randomized Sham-Controlled HD-tDCS-fMRS Study. 口服纳曲酮辅助高分辨率经颅直流电刺激（HD-tDCS）对酒精使用障碍患者左背外侧前额叶皮层（DLPFC）渴望、谷氨酸-谷氨酰胺（Glx）的影响：一项随机假对照HD-tDCS- fmrs研究。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-02 DOI: 10.1097/YCT.0000000000001257

Suparna Kumar, Sourav Khanra, Chandramouli Roy, Sanjay Kumar Munda

{"title":"Effect of Adjunctive High-Definition Transcranial Direct Current Stimulation (HD-tDCS) to Oral Naltrexone on Craving, Brain Glutamate-Glutamine (Glx) at Left Dorsolateral Prefrontal Cortex (DLPFC) in Alcohol Use Disorder: A Randomized Sham-Controlled HD-tDCS-fMRS Study.","authors":"Suparna Kumar, Sourav Khanra, Chandramouli Roy, Sanjay Kumar Munda","doi":"10.1097/YCT.0000000000001257","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001257","url":null,"abstract":"Background: Alcohol use disorder (AUD) is a chronic relapsing condition requiring long-term pharmacotherapy. Because of their variable efficacy and poor adherence, newer neuromodulation approaches are being examined. Our study aimed to investigate the effect of adjunctive high-definition transcranial direct current stimulation (HD-tDCS) on craving, brain glutamate-glutamine (Glx) at the left dorsolateral prefrontal cortex (DLPFC) in AUD.Methods: A total of 50 individuals with AUD, randomized into 25 each to active and sham HD-tDCS groups were enrolled on the study. After detoxification, HD-tDCS was administered twice daily over 5 days for a total of 10 sessions. Each participant was started on oral naltrexone 50 mg/day. Alcohol craving questionnaire-NOW (ACQ-NOW), obsessive compulsive drinking scale (OCDS), and brain Glx were measured at baseline and end of 10 sessions of high-definition transcranial direct current stimulation.Results: The active HD-tDCS group showed significantly lower brain Glx at the left DLPFC at the end of 10 sessions from baseline compared with the sham HD-tDCS group. Craving did not show any significant between-group × time effects.Conclusions: Our study showed that the HD-tDCS could significantly change brain Glx at the left DLPFC in AUD. Change in craving did not correlate with change in Glx. Future studies should include a larger sample size, multivoxel assessment and a greater number of HD-tDCS sessions.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Brain Derived Neurotrophic Factor Polymorphism in Transcranial Magnetic Stimulation Response for Major Depressive Disorder. 脑源性神经营养因子多态性在重度抑郁症经颅磁刺激反应中的作用。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-01 Epub Date: 2025-03-04 DOI: 10.1097/YCT.0000000000001123

Megan M Vigne, Jamie Kweon, Andrew M Fukuda, Joshua C Brown, Linda L Carpenter

{"title":"The Role of Brain Derived Neurotrophic Factor Polymorphism in Transcranial Magnetic Stimulation Response for Major Depressive Disorder.","authors":"Megan M Vigne, Jamie Kweon, Andrew M Fukuda, Joshua C Brown, Linda L Carpenter","doi":"10.1097/YCT.0000000000001123","DOIUrl":"10.1097/YCT.0000000000001123","url":null,"abstract":"Objectives: Repetitive transcranial magnetic stimulation (rTMS) is a safe and effective therapy for treatment-resistant depression (TRD). A crucial next step in improving rTMS therapy is to identify response predictors to inform patient selection criteria. Brain-derived neurotrophic factor (BDNF) exerts influence over TRD treatment modalities. BDNF polymorphism, Val66Met, has shown altered cortical plasticity after single-session rTMS in healthy subjects and clinical response in noninvasive brain stimulation methods in major depressive disorder, stroke, Alzheimer's, and cerebral palsy. We sought to evaluate the effect of this BDNF polymorphism on clinical response in a standard course of rTMS therapy for TRD.Methods: In this naturalistic study, 75 patients with TRD completed a standard course of rTMS with weekly clinical assessments via the Inventory of Depressive Symptomatology Self-Report (IDS-SR). BDNF polymorphisms were retrospectively compared in respect to treatment response and remission, baseline and final scores, percent change scores, and scores across the 6-week treatment course.Results: As expected, rTMS significantly decreased depressive symptoms as measured by IDS-SR scores. No difference was found in baseline, final, or percent change IDS-SR scores between polymorphism types. There was no difference between polymorphisms in IDS-SR scores across the treatment course. Response and remission rates did not differ between genotypes.Conclusions: In contrast to previous research highlighting differential response between BDNF polymorphisms to motor plasticity and clinical rTMS outcomes, our data suggest that BDNF polymorphism status may not influence the response to a standard course of 10-Hz rTMS for major depressive disorder. Differences in TMS protocol, target, or BDNF serum levels may underlie our results.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"24-30"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergency Treatment of Neuroleptic Malignant Syndrome By a Remote Mobile Electroconvulsive Therapy (ECT) Team. 远程移动电休克治疗小组对抗精神病药恶性综合征的紧急治疗。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-03-01 Epub Date: 2025-08-27 DOI: 10.1097/YCT.0000000000001179

Clément Guillet, Francky T Endomba, Mehdi Benkhadra

引用次数: 0