Journal of Ect最新文献

Extended High Definition Transcranial Direct Current Stimulus for Improvement in Cognitive Functions as Measured by Sensorimotor Network Alterations in Chronic Schizophrenia: A Resting State fMRI Study. 延长高清晰度经颅直流电刺激对慢性精神分裂症患者认知功能的改善，通过感觉运动网络改变来测量：一项静息状态fMRI研究。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-09 DOI: 10.1097/YCT.0000000000001158

Bhawna Yadav, Nishant Goyal, Chandramouli Roy, Dharani Ramamoorthy

{"title":"Extended High Definition Transcranial Direct Current Stimulus for Improvement in Cognitive Functions as Measured by Sensorimotor Network Alterations in Chronic Schizophrenia: A Resting State fMRI Study.","authors":"Bhawna Yadav, Nishant Goyal, Chandramouli Roy, Dharani Ramamoorthy","doi":"10.1097/YCT.0000000000001158","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001158","url":null,"abstract":"Introduction: Cognitive symptoms form core of schizophrenia affecting interpersonal and socio-occupational functioning. Impaired dorsolateral prefrontal cortex function is implicated in these symptoms. Dysfunction in sensory-motor network (SMN) has been attributed to cognitive dysfunction in schizophrenia. High-definition tDCS (HD-tDCS), an optimized form of tDCS, has the potential for more focalized neuromodulation. Extended HD-tDCS (eHD-tDCS), that is, more than 10 sessions over an extended period of time, may increase the effectiveness of stimulation.Objectives: We aimed to study the effects of eHD-tDCS on SMN alterations for improvement in cognitive functions in chronic schizophrenia.Methods: Fifty-one patients of chronic schizophrenia (>2-year continuous illness) with predominantly cognitive symptoms were enrolled for this sham-controlled trial. Participants received 20 sessions of eHD-tDCS at 2 mA for 20 minutes twice daily over 10 days. Montreal Cognitive Assessment Scale and Clinical Global Impression-Severity Scale and Resting State f MRI (rsfMRI) were used to assess outcome. Clinical assessments were carried out at baseline, 2 weeks, and 6 weeks and rsfMRI at baseline and 2 weeks.Results: Significant improvement was noted in both active and sham groups across all outcome variables over time. However, a statistically significant decrease in cognitive symptoms and illness severity in active group was noted at the end of treatment at 2 weeks, maintained till the end of 6 weeks. After application of eHD-tDCS, a significant improvement in functional connectivity was noted in SMN. The novel extended stimulation protocol was safe and well tolerated.Conclusions: Extended HD-tDCS emerges to have a substantial potential in the treatment of cognitive symptoms and it is safe and well tolerated.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New-Onset Atrial Fibrillation After Electroconvulsive Therapy: A Case Report and Clinical Implications. 电休克治疗后新发心房颤动一例报告及其临床意义。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-09 DOI: 10.1097/YCT.0000000000001169

Maria Miguel Amaral Dos Santos Figueiredo, Pedro Miguel Azevedo Afonso

引用次数: 0

Safe, Repeated Treatment With Electroconvulsive Therapy in Combination With KarXT. 安全，反复治疗电痉挛疗法联合KarXT。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-09 DOI: 10.1097/YCT.0000000000001168

Jason M Andrus, Sohag N Sanghani

引用次数: 0

The Relative Efficacy and Side-Effect Profile of Ultrabrief Pulse and Brief Pulse ECT: A Systematic Review of Recent Literature. 超短脉冲和短脉冲电痉挛的相对疗效和副作用：近期文献的系统综述。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-09 DOI: 10.1097/YCT.0000000000001164

Rishi Gonuguntla, Sam Dunham, Isaac Benmaman, Neha Gonuguntla, Kevin Ha

{"title":"The Relative Efficacy and Side-Effect Profile of Ultrabrief Pulse and Brief Pulse ECT: A Systematic Review of Recent Literature.","authors":"Rishi Gonuguntla, Sam Dunham, Isaac Benmaman, Neha Gonuguntla, Kevin Ha","doi":"10.1097/YCT.0000000000001164","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001164","url":null,"abstract":"Objective: Electroconvulsive therapy (ECT) is an interventional psychiatric technique used primarily to address treatment resistant psychiatric disorders. There are many different stimulus electrode placements and pulse widths utilized in the administration of this therapy, but it is presently unclear which is optimal. The aim of this study is to assess the relative efficacy and side-effect profile of ultrabrief pulse width ECT (UBP ECT) and brief-pulse width ECT (BP ECT) in the treatment of major depressive disorders.Method: A systematic review of the literature was performed. Studies were identified from PubMed, MEDLINE and PsycINFO between January 2013 to October 2023. The final search terms included ECT, depression, brief pulse, and ultrabrief pulse.Results: The search initially included 64 studies. Forty-three of these studies were not duplicates, after applying exclusion criteria 11 studies were included. UBP ECT was found to have fewer cognitive side effects than BP ECT. Additionally, patients undergoing BP ECT were found to discontinue treatment more frequently due to inability to tolerate side effects. Despite this, BP ECT may have higher rates of symptom remission than UBP ECT. Further studies should be done to clarify the outcomes of each technique.Conclusions: The current evidence slightly favors UBP ECT due to its beneficial side effect profile compared to BP ECT while it has a similar efficacy. However, there is insubstantial evidence in the current body of literature. Additional studies are required to determine which of these techniques is safer and more efficacious in the treatment of major depressive disorders.Study design: Systematic review.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Dose Flumazenil and Caffeine to Facilitate Electroconvulsive Therapy in Malignant Catatonia. 大剂量氟马西尼和咖啡因促进恶性紧张症电休克治疗。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-04 DOI: 10.1097/YCT.0000000000001165

Mark Volpe, Dallas Hamlin, Emma Batchelder, Charles Mormando, Andrew Francis

引用次数: 0

Repeated Electroconvulsive Shock Transiently Affects Cognition and Neurometabolism in Mice. 反复电休克对小鼠认知和神经代谢的短暂影响。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-03 DOI: 10.1097/YCT.0000000000001166

Ajay Sarawagi, Sanjana Sinha, Anant Bahadur Patel

{"title":"Repeated Electroconvulsive Shock Transiently Affects Cognition and Neurometabolism in Mice.","authors":"Ajay Sarawagi, Sanjana Sinha, Anant Bahadur Patel","doi":"10.1097/YCT.0000000000001166","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001166","url":null,"abstract":"Objective: Electroconvulsive therapy (ECT) is an effective intervention for drug-resistant depression. Despite clinical relevance, ECT is underutilized due to hypothetical adverse effects on cognitive functions. This study aims to investigate the short-term and long-term effects of repeated electroconvulsive shock (ECS) on cognition and cerebral glucose metabolism in a mouse model.Methods: Two-month-old C57BL/6NCrl male mice were subjected to 7 sessions of ECS under isoflurane anesthesia in a sham-controlled manner. The spatial working memory was assessed using the Y-maze test after 24 hours and 3 months of the last ECS session. The neurometabolic activity was evaluated via intravenous administration of [1,6-13C2]glucose in awake mice, followed by measurement of 13C labeling of brain metabolites by ex vivo 1H-[13C]-NMR spectroscopy.Results: Repeated ECS led to impaired spatial working memory (ECS: 59.4 ± 6.0%, sham: 68.9 ± 6.7%; P = 0.042; t = 2.3, df = 10) together with perturbed neurometabolite homeostasis such as increased taurine (9.6 ± 0.1 vs 8.9 ± 0.2 μmol/g; Padj < 0.001; t = 7.1, df = 10), and glycerophosphocholine (1.17 ± 0.05 vs 1.06 ± 0.02 μmol/g; Padj = 0.010), and decreased choline (0.12 ± 0.00 vs 0.13 ± 0.01 μmol/g; Padj = 0.019) and phosphocholine (0.50 ± 0.02 vs 0.55 ± 0.02 μmol/g; Padj = 0.011) levels in the cerebral cortex after 24 hours. ECS mice exhibited a transient reduction in the rate of glucose oxidation in glutamatergic neurons (0.352 ± 0.023 vs 0.397 ± 0.024 μmol/g/min; Padj = 0.027; t = 2.6, df = 10) in the cerebral cortex. Interestingly, ECS-induced acute cognitive and neurometabolic deficiencies disappeared after 3 months.Conclusions: Repeated ECS led to transient impairment in cognition and neurometabolism, and cognitive deficits correlated with reduced cerebral glucose metabolism. These findings might be helpful to clinicians in addressing concerns about electroconvulsive therapy.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dire Need and Disproportionate Access: ECT In Youth With Autism Spectrum Disorders and Other Neurodevelopmental Disorders. 迫切需要和不成比例的获取：青少年自闭症谱系障碍和其他神经发育障碍的ECT治疗。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-02 DOI: 10.1097/YCT.0000000000001159

Lee Elizabeth Wachtel, Neera Ghaziuddin

引用次数: 0

A Survey of ECT Anesthesia Practice Variation in Finland. 芬兰电痉挛麻醉实践差异调查。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-01 Epub Date: 2024-07-18 DOI: 10.1097/YCT.0000000000001042

Saara H Huoponen, Katrin Sisa, Markku Taittonen, Tom Saari, Ulla Ahlmén-Laiho

{"title":"A Survey of ECT Anesthesia Practice Variation in Finland.","authors":"Saara H Huoponen, Katrin Sisa, Markku Taittonen, Tom Saari, Ulla Ahlmén-Laiho","doi":"10.1097/YCT.0000000000001042","DOIUrl":"10.1097/YCT.0000000000001042","url":null,"abstract":"Objective: This study examines the extent of variation in anesthesia practices among Finnish neuromodulation units providing electroconvulsive therapy (ECT) and investigates recent changes within individual units.Methods: An electronic survey was carried out among Finnish neuromodulation units exploring staff demographics, anesthesia practices (including agents and adjuvants), patient physiology monitoring, observed adverse effects, patient follow-up times, and recent anesthesia protocol changes.Results: Finland has 26 neuromodulation units providing ECT, of which 18 (69%) responded to our study. The research uncovered significant differences in anesthesia practices, including induction agent choice, convulsion motor component monitoring, staff educational backgrounds, and reported adverse effects. Propofol was the most commonly used anesthetic in 14 units (78%). Three units (17%) reported using methohexital in 80%-100% of their patients, whereas in contrast, methohexital was not used at all in 10 units (56%). Electromyography seizure activity was quantitatively measured in 6 units (33%), whereas 10 units (56%) did not measure electromyography seizure activity at all. The remaining 2 units assessed seizure activity through visual observation. Headache requiring medication was the most commonly reported adverse effect, and it was reported as a frequent problem in 3 units (18%).Conclusions: Based on the variation in anesthesia practices identified in the study, we suggest there may be benefits to developing a national guideline for standardizing treatment.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"84-88"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141725117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous Ketamine to Facilitate Transport of Agitated Patients to the ECT Clinic. 静脉注射氯胺酮以方便将躁动不安的患者送往电痉挛治疗诊所。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-01 Epub Date: 2024-11-26 DOI: 10.1097/YCT.0000000000001090

Olivia Dean, Anthony Byford-Brooks, Kara Hannigan, Danielle Saunders, William Gamble, George Kirov

{"title":"Intravenous Ketamine to Facilitate Transport of Agitated Patients to the ECT Clinic.","authors":"Olivia Dean, Anthony Byford-Brooks, Kara Hannigan, Danielle Saunders, William Gamble, George Kirov","doi":"10.1097/YCT.0000000000001090","DOIUrl":"10.1097/YCT.0000000000001090","url":null,"abstract":"Objectives: Electroconvulsive therapy (ECT) can be effective for a variety of psychiatric conditions, including for some patients who are very psychotic or agitated. Transferring such patients from the psychiatric ward to the ECT clinic can pose significant challenges for treating teams, as they try to minimize the use of restraint.Methods: We developed a protocol for safe transfer of such patients using sedation with ketamine. An intravenous cannula is inserted on the ward in a low stimulus environment with gentle supportive holds. Intravenous ketamine is given in a bolus at 0.5-2.0 mg/kg. The patient is transported on a transfer bed to the ECT clinic within a few minutes, and usual ECT process is immediately followed.Results: We describe 6 patients who were given between 1 and 11 ECT treatments using this method. All of them finished ECT courses without the need for ketamine sedation. Five of them regained capacity, provided informed consent for further ECTs, and eventually reached remission.Conclusions: Ketamine can be used to manage risk and transfer agitated patients to an ECT clinic for treatment.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"e15-e17"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive Transcranial Magnetic Stimulation in Patient Receiving Stellate Ganglion Blocks for PTSD. 重复经颅磁刺激在接受星状神经节阻滞治疗PTSD患者中的应用。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-06-01 DOI: 10.1097/YCT.0000000000001099

Lizbeth Leapo, Scott Polick, Leah Fryml

引用次数: 0