Journal of Ect最新文献

Modified Electroconvulsive Therapy Normalizes Plasma GNA13 Following Schizophrenic Relapse. 改良电休克疗法可使精神分裂症复发后的血浆 GNA13 恢复正常

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-08-08 DOI: 10.1097/YCT.0000000000001050

Hongli Zhang, Hui Li, Mei Yu, Minglan Yu, Shuangshuang Feng, Wang Tingting, Yang Yu, Jin Zhang, Kezhi Liu, Youguo Tan, Bo Xiang

{"title":"Modified Electroconvulsive Therapy Normalizes Plasma GNA13 Following Schizophrenic Relapse.","authors":"Hongli Zhang, Hui Li, Mei Yu, Minglan Yu, Shuangshuang Feng, Wang Tingting, Yang Yu, Jin Zhang, Kezhi Liu, Youguo Tan, Bo Xiang","doi":"10.1097/YCT.0000000000001050","DOIUrl":"10.1097/YCT.0000000000001050","url":null,"abstract":"Objective: GNA13 is an important member of the G protein family, and its coding gene GNA13 has been identified as one of the risk genes for schizophrenia (SCZ). This study aimed to investigate the relationship between GNA13 levels and the clinical symptoms of SCZ following treatment with modified electroconvulsive therapy (MECT).Methods: This study recruited 82 SCZ patients and 86 healthy controls (HCs). Each SCZ patient received 6 sessions of MECT. The Positive and Negative Syndrome Scale (PANSS) was used to assess SCZ symptom severity. Plasma levels of GNA13 were measured by enzyme-linked immunosorbent assay.Results: Pretreatment, SCZ patients had a higher GNA13 level than HC ( t = 8.199, P < 0.001). MECT reduced the GNA13 level significantly ( t = 11.13, P < 0.001) and normalized the difference between SCZ and HC ( t = 0.219, P = 0.827). After treatment, the downregulation of GNA13 (ΔGNA13) was negatively correlated with the positive symptoms score reduction rate (ΔP) ( r = -0.379, P = 0.027) and positively correlated with the negative score reduction rate (ΔN) ( r = 0.480, P = 0.004) in females. In both males and females, the receiver operating characteristic curve revealed that the pretreatment GNA13 level could help differentiate SCZ from HC (male: area under the curve = 0.792, P < 0.001; female: area under the curve = 0.814, P < 0.001).Conclusion: The reduced expression of GNA13 after MECT may be related to the exhibition of both negative and positive symptoms of SCZ in female patients.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"286-292"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between ECT Quality Measures and Likelihood to Transition From Acute to Continuation and Maintenance ECT. 电痉挛疗法质量衡量标准与从急性期向持续和维持性电痉挛疗法过渡的可能性之间的相关性。

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-06-20 DOI: 10.1097/YCT.0000000000001028

Haley Schuster, Ryan W Walters, Jacob Mathy, Sriram Ramaswamy, Imad Alsakaf

{"title":"Correlation Between ECT Quality Measures and Likelihood to Transition From Acute to Continuation and Maintenance ECT.","authors":"Haley Schuster, Ryan W Walters, Jacob Mathy, Sriram Ramaswamy, Imad Alsakaf","doi":"10.1097/YCT.0000000000001028","DOIUrl":"10.1097/YCT.0000000000001028","url":null,"abstract":"Objectives: To evaluate the association between 3 ECT quality measures (seizure duration, Postictal Suppression Index [PSI], and heart rate response) and therapeutic compliance as indicated by transitioning from acute to continuation to maintenance phases of ECT.Methods: This was a retrospective chart review of patients who received ECT between July 2016 and July 2019. ECT quality measures were lagged by 1 ECT session to examine the effect of the prior session's quality measure on progressing to a higher ECT phase at the subsequent ECT session. Associations with therapeutic compliance were analyzed using mixed-effects ordinal regression and mixed-effects partial proportional odds models.Results: Seizure duration was associated with 8% higher adjusted odds of progressing to out of the acute phase (95% confidence interval [CI]: 2% to 15%, P = 0.007) and 18% higher adjusted odds of progressing to the maintenance phase (95% CI: 10% to 28%, P < 0.001); PSI was associated with 9% higher adjusted odds of progressing out of the acute phase (95% CI: 3% to 16%, P = 0.005), whereas heart rate response was not statistically associated with therapeutic compliance. Greater therapeutic compliance was also associated with bilateral electrode placement and older age.Conclusions: Longer seizure duration was associated with greater therapeutic compliance across all ECT phases, PSI was associated with progressing out of the acute phase, and heart rate response was not associated with therapeutic compliance. Our findings assist ECT psychiatrists in optimizing ECT quality measures to promote better compliance with ECT.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"268-276"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine Learning in Electroconvulsive Therapy: A Systematic Review. 电休克疗法中的机器学习：系统回顾。

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-06-10 DOI: 10.1097/YCT.0000000000001009

Robert M Lundin, Veronica Podence Falcao, Savani Kannangara, Charles W Eakin, Moloud Abdar, John O'Neill, Abbas Khosravi, Harris Eyre, Saeid Nahavandi, Colleen Loo, Michael Berk

{"title":"Machine Learning in Electroconvulsive Therapy: A Systematic Review.","authors":"Robert M Lundin, Veronica Podence Falcao, Savani Kannangara, Charles W Eakin, Moloud Abdar, John O'Neill, Abbas Khosravi, Harris Eyre, Saeid Nahavandi, Colleen Loo, Michael Berk","doi":"10.1097/YCT.0000000000001009","DOIUrl":"10.1097/YCT.0000000000001009","url":null,"abstract":"Abstract: Despite years of research, we are still not able to reliably predict who might benefit from electroconvulsive therapy (ECT) treatment. As we exhaust what is possible using traditional statistical analysis, ECT remains a good candidate for machine learning approaches due to the large data sets with data captured through electroencephalography (EEG) and other objective measures. A systematic review of 6 databases led to the full-text examination of 26 articles using machine learning approaches in examining data predicting response to ECT treatment. The identified articles used a wide variety of data types covering structural and functional imaging data (n = 15), clinical data (n = 5), a combination of clinical and imaging data (n = 2), EEG (n = 3), and social media posts (n = 1). The clinical indications in which response prediction was assessed were depression (n = 21) and psychosis (n = 4). Changes in multiple anatomical regions in the brain were identified as holding a predictive value for response to ECT. These primarily centered on the limbic system and associated networks. Clinical features predicting good response to ECT in depression included shorter duration, lower severity, higher medication dose, psychotic features, low cortisol levels, and positive family history. It has also been possible to predict the likelihood of relapse of readmission with psychosis after ECT treatment, including a better response if higher transfer entropy was calculated from EEG signals. A transdisciplinary approach with an international consortium collecting a wide range of retrospective and prospective data may help to refine and extend these outcomes and translate them into clinical practice.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"245-253"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flurothyl Inhalation Therapy: Resurrecting an Alternative to Electricity Induced Seizures. 氟乙烷吸入疗法：复活电击诱发癫痫的替代疗法。

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-06-28 DOI: 10.1097/YCT.0000000000001033

Max Fink

引用次数: 0

A Randomized Controlled Trial of Ultrabrief Right Unilateral ECT With Frontoparietal Versus Temporoparietal Electrode Placement for Severe Depression-The RAFT ECT Trial. 前顶叶与颞顶叶电极放置治疗严重抑郁症的超短右单侧电痉挛随机对照试验--RAFT ECT 试验。

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-07-05 DOI: 10.1097/YCT.0000000000001018

Colleen Loo, Ana Rita Barreiros, Donel Martin, Vanessa Dong, Mark S George, William V McCall, Shanthi Sarma, Malcolm Hopwood, Alan Weiss, Michael Bull, Clara M Tuneu, Angelo Alonzo, Dusan Hadzi-Pavlovic, Anthony Rodgers, Gregory L Sahlem, Anna J Harvey, Kate Haldane, Louise Brettell, Paul B Fitzgerald, Socrates Dokos, Harold Sackeim

引用次数: 0

Refractory Pediatric Catatonia Following Treatment for an Intracranial Mass: Safe and Effective Use of Electroconvulsive Therapy. 颅内肿块治疗后的难治性儿童紧张症：安全有效地使用电休克疗法。

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-08-23 DOI: 10.1097/YCT.0000000000001066

Joshua Moss, Nadav Kastle, Lee Wolfrum, Pamela Bokat, Elizabeth Perry, Roslyn Gerwin

引用次数: 0

Accelerated Continuous Theta Burst Stimulation in the Treatment of Trichotillomania: A Comprehensive Case Study From Acute Intervention to Maintenance Phase. 加速连续θ脉冲刺激治疗毛手毛脚症：从急性干预到维持阶段的综合案例研究》。

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-03-21 DOI: 10.1097/YCT.0000000000001010

Priyanshi Chaudhary, Sujita Kumar Kar

引用次数: 0

Effectiveness and Safety of Flumazenil Augmentation During Electroconvulsive Therapy. 电休克治疗期间氟马西尼增强剂的有效性和安全性。

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-02-12 DOI: 10.1097/YCT.0000000000001003

Lennart Gistelinck, Nele Van de Velde, Hannelore Tandt, Pieter Verslype, Gilbert Lemmens

{"title":"Effectiveness and Safety of Flumazenil Augmentation During Electroconvulsive Therapy.","authors":"Lennart Gistelinck, Nele Van de Velde, Hannelore Tandt, Pieter Verslype, Gilbert Lemmens","doi":"10.1097/YCT.0000000000001003","DOIUrl":"10.1097/YCT.0000000000001003","url":null,"abstract":"Introduction: Benzodiazepines are considered to negatively affect seizure quality and duration during electroconvulsive therapy (ECT). Several researchers have advocated the use of flumazenil, a competitive benzodiazepine receptor antagonist, for patients treated with benzodiazepines during ECT. However, clinical evidence regarding flumazenil use in ECT remains sparse. The aim of this study is to investigate the effects of flumazenil on seizure duration and adverse effects.Methods: All patients with depressive disorders, treated with flumazenil during a course of ECT in 2019 in a tertiary hospital, were identified through a retrospective chart review. Seizure duration was recorded before and after flumazenil administration. Effectiveness of ECT was assessed using the Inventory of Depressive Symptomatology and the Bush-Francis Catatonia Rating Scale. Postictal agitation was ascertained by identifying patients who received additional sedatives immediately after ECT or who needed physical restraint.Results: Twenty-six patients were included, receiving a total of 363 treatments, of which 263 were augmented with flumazenil. Flumazenil administration increased electroencephalogram seizure duration on average with 10.5 seconds comparing ECT with or without flumazenil ( P = 0.003). In 21.8% of the cases, no increase in seizure duration was observed. Postictal agitation occurred at least once in 34.6% of the patients receiving flumazenil during their course of ECT.Conclusion: Our results show that flumazenil increases seizure duration, albeit with limited clinical implications. Noteworthy, the prevalence of postictal agitation is high. When confronted with short seizures, clinicians should therefore deploy other available techniques to lower seizure threshold before considering flumazenil.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"e49-e51"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroconvulsive Therapy Changes Immunological Markers in Patients With Major Depressive Disorder: A Scoping Review. 电休克疗法会改变重度抑郁症患者的免疫标记物：范围综述。

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-06-20 DOI: 10.1097/YCT.0000000000001021

Jonathan R Young, Mariah K Evans, Julie Hwang, Michael D Kritzer, Charles H Kellner, Richard D Weiner

{"title":"Electroconvulsive Therapy Changes Immunological Markers in Patients With Major Depressive Disorder: A Scoping Review.","authors":"Jonathan R Young, Mariah K Evans, Julie Hwang, Michael D Kritzer, Charles H Kellner, Richard D Weiner","doi":"10.1097/YCT.0000000000001021","DOIUrl":"10.1097/YCT.0000000000001021","url":null,"abstract":"Abstract: Major depressive disorder (MDD) is a highly prevalent and disabling condition. As such, understanding the causes of and treatment options for MDD is critical. Electroconvulsive therapy (ECT) remains the gold standard depression treatment, but the molecular mechanisms that underlie its effects are still largely unknown. One such explanation hinges on the immuno-inflammatory correlates of ECT treatment, given mounting evidence supporting the inflammatory hypothesis of depression. This review aims to provide an overview of the suggested immunomodulatory effects of ECT and the predictive value of immune biomarkers in relation to treatment outcomes and side effects. We conducted a preregistered, systematic literature search utilizing MEDLINE (PubMed), Embase (Elsevier), and PsycINFO (EBSCO) databases. We employed keywords related to MDD, ECT, gut microbiome, and the immune system. We only included human subjects research published between 1985 and January 13, 2021. Twenty-six unique studies were included in our analyses. Findings indicate a proinflammatory profile associated with MDD, with immune biomarkers exhibiting acute and chronic changes following ECT. Consistently, lower baseline interleukin 6 levels and higher C-reactive protein levels are correlated with a greater reduction in depressive symptoms following ECT. Furthermore, included studies emphasize the predictive value of peripheral immune changes, specifically interleukin 6 and tumor necrosis factor α, on cognitive outcomes following ECT. Given these results, further exploration of the potential roles of immunomodulatory effects on ECT treatment outcomes, as well as adverse cognitive side effects, is indicated.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"232-239"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcranial Random Noise Stimulation in the Management of Cognitive and Behavioral Symptoms in a Suicidal Hanging Survivor: A Case Study. 经颅随机噪声刺激治疗一名有上吊自杀倾向的幸存者的认知和行为症状：案例研究。

IF 1.8 4区医学

Journal of Ect Pub Date : 2024-12-01 Epub Date: 2024-03-21 DOI: 10.1097/YCT.0000000000001011

Sujita Kumar Kar, Rahul Prajapati, Vikas Bharti, Sanjana Bhasin, Priyanshi Chaudhary, Devika Raje

引用次数: 0