Journal of Genetics and Genomics最新文献_第2页

Genomic insights into demographic history, structural variation landscape, and complex traits from 514 Hu sheep genomes. 对514个湖羊基因组的人口历史、结构变异景观和复杂性状的基因组分析。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1016/j.jgg.2024.11.015

Kaiyu Chen, Yuelang Zhang, Yizhe Pan, Xin Xiang, Chen Peng, Jiayi He, Guiqing Huang, Zhengguang Wang, Pengju Zhao

{"title":"Genomic insights into demographic history, structural variation landscape, and complex traits from 514 Hu sheep genomes.","authors":"Kaiyu Chen, Yuelang Zhang, Yizhe Pan, Xin Xiang, Chen Peng, Jiayi He, Guiqing Huang, Zhengguang Wang, Pengju Zhao","doi":"10.1016/j.jgg.2024.11.015","DOIUrl":"10.1016/j.jgg.2024.11.015","url":null,"abstract":"Hu sheep is an indigenous breed from the Taihu Lake Plain in China, known for its high fertility. Although Hu sheep belong to the Mongolian group, their demographic history and genetic architecture remain inconclusive. Here, we analyze 697 sheep genomes from representatives of Mongolian sheep breeds. Our study suggests that the ancestral Hu sheep first separated from the Mongolian group approximately 3000 years ago. As Hu sheep migrated from the north and flourished in the Taihu Lake Plain around 1000 years ago, they developed a unique genetic foundation and phenotypic characteristics, which are evident in the genomic footprints of selective sweeps and structural variation landscape. Genes associated with reproductive traits (BMPR1B and TDRD10) and horn phenotype (RXFP2) exhibit notable selective sweeps in the genome of Hu sheep. A genome-wide association analysis reveals that structural variations at LOC101110773, MAST2, and ZNF385B may significantly impact polledness, teat number, and early growth in Hu sheep, respectively. Our study offers insights into the evolutionary history of Hu sheep and may serve as a valuable genetic resource to enhance the understanding of complex traits in Hu sheep.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"245-257"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OsbZIP27 coordinates with OsHUB1 and OsHUB2 to modulate drought tolerance in rice. OsbZIP27与OsHUB1和OsHUB2协同调节水稻抗旱性。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1016/j.jgg.2024.11.016

Zuntao Xu, Yachun Yang, Fei Zhang, Hao Li, Hui Ma, Wenge Wu, Yong Ding

引用次数: 0

Epigenetic control of plant abiotic stress responses. 植物非生物胁迫反应的表观遗传控制。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-09-23 DOI: 10.1016/j.jgg.2024.09.008

Lijun Ma, Lihe Xing, Zicong Li, Danhua Jiang

引用次数: 0

Activation of γ-globin expression by a common variant disrupting IKAROS-binding motif in β-thalassemia. 在β地中海贫血症中，一个破坏IKAROS结合基序的常见变体激活了γ-球蛋白的表达。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-11-08 DOI: 10.1016/j.jgg.2024.10.015

Hualei Luo, Jueheng Wang, Lang Qin, Xinhua Zhang, Hailiang Liu, Chao Niu, Mengyang Song, Congwen Shao, Peng Xu, Miao Yu, Haokun Zhang, Yuhua Ye, Xiangmin Xu

{"title":"Activation of γ-globin expression by a common variant disrupting IKAROS-binding motif in β-thalassemia.","authors":"Hualei Luo, Jueheng Wang, Lang Qin, Xinhua Zhang, Hailiang Liu, Chao Niu, Mengyang Song, Congwen Shao, Peng Xu, Miao Yu, Haokun Zhang, Yuhua Ye, Xiangmin Xu","doi":"10.1016/j.jgg.2024.10.015","DOIUrl":"10.1016/j.jgg.2024.10.015","url":null,"abstract":"Programmed silencing of γ-globin genes in adult erythropoiesis is mediated by several chromatin remodeling complexes, which determine the stage-specific genome architecture in this region. Identification of cis- or trans-acting mutations contributing to the diverse extent of fetal hemoglobin (Hb F) might illustrate the underlying mechanism of γ-β-globin switching. Here, we recruit a cohort of 1142 β-thalassemia patients and dissect the natural variants in the whole β-globin gene cluster through a targeted next-generation sequencing panel. A previously unreported SNP rs7948668, predicted to disrupt the binding motif of IKAROS as a key component of chromatin remodeling complexes, is identified to be significantly associated with higher levels of Hb F and age at onset. Gene-editing on this SNP leads to the elevation of Hb F in both HUDEP-2 and primary CD34+ cells while the extent of elevation is amplified in the context of β-thalassemia mutations, indicating epistasis effects of the SNP in the regulation of Hb F. Finally, we perform ChIP-qPCR and 4C assays to prove that this variant disrupts the binding motif of IKAROS, leading to enhanced competitiveness of HBG promoters to locus control regions. This study highlights the significance of common regulatory SNPs and provides potential targets for treating β-hemoglobinopathy.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"157-167"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome-wide association analysis reveals regulatory genes for the metabolite synthesis of 2-acetyl-1-pyrroline in aromatic coconut (Cocos nucifera L.). 全基因组关联分析揭示了芳香椰子（Cocos nucifera L.）代谢产物2-乙酰基-1-吡咯啉合成的调控基因。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1016/j.jgg.2024.12.002

Hao Ding, Xiang Lv, Guangzhen Zhou, Xiaomei Liu, Xiwei Sun, Jing Li, Amjad Iqbal, Yaodong Yang

{"title":"Genome-wide association analysis reveals regulatory genes for the metabolite synthesis of 2-acetyl-1-pyrroline in aromatic coconut (Cocos nucifera L.).","authors":"Hao Ding, Xiang Lv, Guangzhen Zhou, Xiaomei Liu, Xiwei Sun, Jing Li, Amjad Iqbal, Yaodong Yang","doi":"10.1016/j.jgg.2024.12.002","DOIUrl":"10.1016/j.jgg.2024.12.002","url":null,"abstract":"Coconut (Cocos nucifera L.) is a key tropical economic tree valued for its fruit flavor, particularly 2-acetyl-1-pyrroline (2AP), a vital aroma metabolite. To enhance high-aromatic coconut breeding efforts, it is essential to deeply understand the hereditary factors governing the production of 2AP. In this study, a genome-wide association analysis identifies 32 loci that exhibit significant associations with 2AP content based on single nucleotide polymorphism (SNP) variations from 168 aromatic coconut germplasm resources. Transcriptome analysis then pinpoints 22 candidate genes near significant loci involved in 2AP metabolism. Proteins encoded by these genes are involved in amino acid metabolism, glycolysis, and secondary metabolism. Among these, Asparagine synthetase coding gene ASN1, Gamma-glutamylcysteine synthetase coding gene GSH1, and UbiA prenyltransferase coding gene UBIA are enriched in the linkage region constructed by significant locus Chr04_61490504. In particular, the SNP mutation of CnASN1 leads to amino acid changes in the functional region of the coding protein, potentially resulting in differences in 2AP content among haplotype populations. Identifying variations in related candidate genes, particularly the gene CnASN1, provides molecular markers closely associated with 2AP synthesis for coconut breeding and offers further insights into the metabolic mechanisms of 2AP.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"179-188"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving regulatory T cell-based therapy: insights into post-translational modification regulation. 改进基于调节性 T 细胞的疗法：深入了解翻译后修饰调控。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-09-30 DOI: 10.1016/j.jgg.2024.09.014

Aiting Wang, Yanwen Wang, Rui Liang, Bin Li, Fan Pan

{"title":"Improving regulatory T cell-based therapy: insights into post-translational modification regulation.","authors":"Aiting Wang, Yanwen Wang, Rui Liang, Bin Li, Fan Pan","doi":"10.1016/j.jgg.2024.09.014","DOIUrl":"10.1016/j.jgg.2024.09.014","url":null,"abstract":"Regulatory T (Treg) cells are pivotal for maintaining immune homeostasis and play essential roles in various diseases, such as autoimmune diseases, graft-versus-host disease (GVHD), tumors, and infectious diseases. Treg cells exert suppressive function via distinct mechanisms, including inhibitory cytokines, granzyme or perforin-mediated cytolysis, metabolic disruption, and suppression of dendritic cells. Forkhead Box P3 (FOXP3), the characteristic transcription factor, is essential for Treg cell function and plasticity. Cumulative evidence has demonstrated that FOXP3 activity and Treg cell function are modulated by a variety of post-translational modifications (PTMs), including ubiquitination, acetylation, phosphorylation, methylation, glycosylation, poly(ADP-ribosyl)ation, and uncharacterized modifications. This review describes Treg cell suppressive mechanisms and summarizes the current evidence on PTM regulation of FOXP3 and Treg cell function. Understanding the regulatory role of PTMs in Treg cell plasticity and function will be helpful in designing therapeutic strategies for autoimmune diseases, GVHD, tumors, and infectious diseases.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"145-156"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish. Wnt2bb信号通过激活斑马鱼体内Yap的表达，促进咽软骨前体的增殖和软骨细胞的成熟。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-11-19 DOI: 10.1016/j.jgg.2024.11.006

Xiaojuan Guo, Liping Yang, Yujie Wang, Mengna Yuan, Wenqing Zhang, Xinyu He, Qiang Wang

{"title":"Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish.","authors":"Xiaojuan Guo, Liping Yang, Yujie Wang, Mengna Yuan, Wenqing Zhang, Xinyu He, Qiang Wang","doi":"10.1016/j.jgg.2024.11.006","DOIUrl":"10.1016/j.jgg.2024.11.006","url":null,"abstract":"Pharyngeal cartilage morphogenesis is crucial for the formation of craniofacial structures. Cranial neural crest cells are specified at the neural plate border, migrate to pharyngeal arches, and differentiate into pharyngeal chondrocytes, which subsequently flatten, elongate, and stack like coins during maturation. Although the developmental processes prior to chondrocyte maturation have been extensively studied, their subsequent changes in morphology and organization remain largely elusive. Here, we show that wnt2bb is expressed in the pharyngeal ectoderm adjacent to the chondrogenic precursor cells in zebrafish. Inactivation of Wnt2bb leads to a reduction in nuclear β-catenin, which impairs chondrogenic precursor proliferation and disrupts chondrocyte morphogenesis and organization, eventually causing a severe shrinkage of pharyngeal cartilages. Moreover, the decrease of β-catenin in wnt2bb-/- mutants is accompanied by the reduction of Yap expression. Reactivation of Yap can restore the proliferation of chondrocyte progenitors as well as the proper size, shape, and stacking of pharyngeal chondrocytes. Our findings suggest that Wnt/β-catenin signaling promotes Yap expression to regulate pharyngeal cartilage formation in zebrafish.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"220-230"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated analysis reveals that miR-548ab promotes the development of obesity and T2DM. 综合分析发现miR-548ab促进肥胖和T2DM的发展。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-11-27 DOI: 10.1016/j.jgg.2024.11.011

Chongge Pan, Yali Hou, Yanting Hou, Ruizhen Wang, Meiyu Qian, Xue Bai, Maodi Liang, Jingzhou Wang, Jie Liu, Qianqian Wei, Ziyan Pan, Ting Wang, Chenyu Hu, Kun Xiang, Chun Yang, Cuizhe Wang, Hua Chen, Jun Zhang

{"title":"Integrated analysis reveals that miR-548ab promotes the development of obesity and T2DM.","authors":"Chongge Pan, Yali Hou, Yanting Hou, Ruizhen Wang, Meiyu Qian, Xue Bai, Maodi Liang, Jingzhou Wang, Jie Liu, Qianqian Wei, Ziyan Pan, Ting Wang, Chenyu Hu, Kun Xiang, Chun Yang, Cuizhe Wang, Hua Chen, Jun Zhang","doi":"10.1016/j.jgg.2024.11.011","DOIUrl":"10.1016/j.jgg.2024.11.011","url":null,"abstract":"Dysregulation of microRNA (miRNA) expression following the development of obesity is closely linked to the onset of type 2 diabetes mellitus (T2DM). Identifying differentially expressed miRNAs and their roles in regulating glucose metabolism will provide a theoretical foundation for the molecular mechanisms underlying obesity-induced T2DM. Here, we perform a genome-wide association study involving 5 glycolipid metabolism traits in 1783 Kazakh and 1198 Uyghur individuals to identify miRNAs associated with fasting plasma glucose (FPG) levels. A miR-548ab mimic and inhibitor are administered to hepatocytes and adipocytes, as well as obese and diabetic mice, to determine miR-548ab-related downstream signalling pathways. The effects of miR-548ab on glucose metabolism are validated using the glucose tolerance test and insulin tolerance test. Collectively, these results indicate that miR-548ab is significantly associated with FPG levels and obesity-related T2DM in both Kazakh and Uyghur populations. The miR-548ab-GULP1/SLC25A21-GLUT4 network exerts regulatory effects on glucose metabolism, obesity, and T2DM, positioning it as a candidate risk factor, potential diagnostic marker, and therapeutic target for obesity-induced T2DM. Additionally, through evolutionary analysis, the authentic variants or haplotypes of GULP1 and SLC25A21 are categorized according to their genetic susceptibility to T2DM. The miR-548ab inhibitor shows beneficial effects in obese and diabetic mice.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"231-244"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TMEM39A and TMEM131 facilitate bulk transport of ECM proteins through large COPII vesicle formation. TMEM39A 和 TMEM131 可通过大 COPII 囊泡的形成促进 ECM 蛋白质的批量运输。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-11-08 DOI: 10.1016/j.jgg.2024.10.013

Jee Young Sung, Ga-Eun Lim, Jarim Goo, Kyung Jin Jung, Jeong Min Chung, Hyun Suk Jung, Yong-Nyun Kim, Jaegal Shim

{"title":"TMEM39A and TMEM131 facilitate bulk transport of ECM proteins through large COPII vesicle formation.","authors":"Jee Young Sung, Ga-Eun Lim, Jarim Goo, Kyung Jin Jung, Jeong Min Chung, Hyun Suk Jung, Yong-Nyun Kim, Jaegal Shim","doi":"10.1016/j.jgg.2024.10.013","DOIUrl":"10.1016/j.jgg.2024.10.013","url":null,"abstract":"The growth of Caenorhabditis elegans involves multiple molting processes, during which old cuticles are shed and new cuticles are rapidly formed. This process requires the regulated bulk secretion of cuticle components. The transmembrane protein-39 (TMEM-39) mutant exhibits distinct dumpy and ruptured phenotypes characterized by notably thin cuticles. TMEM-39 primarily co-localizes with the coat protein II complex (COPII) in large vesicles rather than small COPII vesicles. These TMEM-39-associated large vesicles (TMEM-39-LVs) form robustly during the molting period and co-localize with various extracellular matrix components, including BLI-1 collagen, BLI-3 dual oxidase, and carboxypeptidases. Through immunoprecipitation using TMEM39A-FLAG and proteomics analysis in human sarcoma cells, we identify TMEM39A-associated proteins, including TMEM131. Knockdown of TMEM131 results in reduced TMEM39A-LV formation and collagen secretion in both C. elegans and human sarcoma cells, indicating a cooperative role between TMEM39A and TMEM131 in the secretion of extracellular components through the formation of large COPII vesicles. Given the conservation of TMEM39A and its associated proteins between C. elegans and humans, TMEM39A-LVs may represent a fundamental machinery for rapid and extensive secretion across metazoans.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"189-203"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated analysis and systematic characterization of the regulatory network for human germline development. 人类生殖系发育调控网络的综合分析和系统特征描述。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2025-02-01 Epub Date: 2024-11-19 DOI: 10.1016/j.jgg.2024.11.005

Yashi Gu, Jiayao Chen, Ziqi Wang, Qizhe Shao, Zhekai Li, Yaxuan Ye, Xia Xiao, Yitian Xiao, Wenyang Liu, Sisi Xie, Lingling Tong, Jin Jiang, Xiaoying Xiao, Ya Yu, Min Jin, Yanxing Wei, Robert S Young, Lei Hou, Di Chen

{"title":"Integrated analysis and systematic characterization of the regulatory network for human germline development.","authors":"Yashi Gu, Jiayao Chen, Ziqi Wang, Qizhe Shao, Zhekai Li, Yaxuan Ye, Xia Xiao, Yitian Xiao, Wenyang Liu, Sisi Xie, Lingling Tong, Jin Jiang, Xiaoying Xiao, Ya Yu, Min Jin, Yanxing Wei, Robert S Young, Lei Hou, Di Chen","doi":"10.1016/j.jgg.2024.11.005","DOIUrl":"10.1016/j.jgg.2024.11.005","url":null,"abstract":"Primordial germ cells (PGCs) are the precursors of germline that are specified at the embryonic stage. Recent studies reveal that humans employ different mechanisms for PGC specification compared with model organisms such as mice. Moreover, the specific regulatory machinery remains largely unexplored, mainly due to the inaccessible nature of this complex biological process in humans. Here, we curate and integrate multi-omics data, including 581 RNA-seq, 54 ATAC-seq, 45 ChIP-seq, and 69 single-cell RNA-seq samples from different stages of human PGC development to recapitulate the precisely controlled and stepwise process, presenting an atlas in the human PGC database (hPGCdb). With these uniformly processed data and integrated analyses, we characterize the potential key transcription factors and regulatory networks governing human germ cell fate. We validate the important roles of some of the key factors in germ cell development by CRISPRi knockdown. We also identify the soma-germline interaction network and discover the involvement of SDC2 and LAMA4 for PGC development, as well as soma-derived NOTCH2 signaling for germ cell differentiation. Taken together, we have built a database for human PGCs (http://43.131.248.15:6882) and demonstrate that hPGCdb enables the identification of the missing pieces of mechanisms governing germline development, including both intrinsic and extrinsic regulatory programs.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"204-219"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0