Journal of Genetics and Genomics最新文献

Population genomic analysis reveals genomic variations associated with domestication and key agronomic traits in bitter gourd (Momordica charantia). 群体基因组分析揭示了苦瓜（Momordica charantia）驯化和关键农艺性状相关的基因组变异。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-05-06 DOI: 10.1016/j.jgg.2026.04.017

Yu Niu, Rui Wang, Liang Wang, Aizheng Huang, Xu Han, Renbo Yu, Shijun Chen, Juntao Wang, Jiaowen Cheng, Changming Chen, Chengjie Chen, Yan Yang, Yi Liao, Ming Hu

{"title":"Population genomic analysis reveals genomic variations associated with domestication and key agronomic traits in bitter gourd (Momordica charantia).","authors":"Yu Niu, Rui Wang, Liang Wang, Aizheng Huang, Xu Han, Renbo Yu, Shijun Chen, Juntao Wang, Jiaowen Cheng, Changming Chen, Chengjie Chen, Yan Yang, Yi Liao, Ming Hu","doi":"10.1016/j.jgg.2026.04.017","DOIUrl":"https://doi.org/10.1016/j.jgg.2026.04.017","url":null,"abstract":"Bitter gourd (Momordica charantia) is a widely cultivated vegetable and medicinal crop for its nutritional and pharmaceutical properties. Yet, the genomic basis of its domestication and key agronomic traits remains largely unexplored. Here, we present a high-quality, chromosome-level genome assembly specifically representing a smooth bitter gourd cultivar (Y1745), with a total assembly size of 327.14 Mb, a contig N50 of 11.33 Mb, and a scaffold N50 of 23.47 Mb. Comparative genomics reveals lineage-specific expansions of gene families related to stress responses and secondary metabolism. Population genomic analysis of 192 globally representative accessions identifies three distinct genetic groups (China, Southeast Asia, and South Asia Subcontinent), reflecting complex demographic histories, and uncovers strong signatures of selection associated with domestication and regional adaptation. In the genome-wide association study (GWAS) of 35 traits, we identify 893 significant trait-associated loci. Notably, two candidate genes (McWRKY and McFPF1-like 1) are associated with flowering time regulation, and one candidate gene (McEXLB1) with fruit size determination. Our work provides valuable genomic resources for understanding bitter gourd domestication and offers potential genetic targets for breeding.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

m⁶A hypomethylation assembles a fibrogenic TCF7L2-Smad2/3 complex in pterygium. m6A低甲基化在翼状胬肉中组装纤维性TCF7L2-Smad2/3复合物。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-05-06 DOI: 10.1016/j.jgg.2026.04.026

Xin Zhang, Yue Li, Xiaoyan Zhang, Chuanxi Yang, Yaping Jiang, Li Chen, Ming Xu, Yihui Chen

{"title":"m6A hypomethylation assembles a fibrogenic TCF7L2-Smad2/3 complex in pterygium.","authors":"Xin Zhang, Yue Li, Xiaoyan Zhang, Chuanxi Yang, Yaping Jiang, Li Chen, Ming Xu, Yihui Chen","doi":"10.1016/j.jgg.2026.04.026","DOIUrl":"https://doi.org/10.1016/j.jgg.2026.04.026","url":null,"abstract":"Pterygium progression is driven by conjunctival fibroblast fibrosis, where TGF-β and Wnt signaling pathways promote fibrotic processes. However, the crosstalk between these pathways and the underlying epitranscriptomic mechanisms remains poorly understood. In this study, we identify a TCF7L2-Smad2/3 transcriptional complex that mediates key cellular and pathogenic events in pterygium. UV radiation or inflammatory stimuli suppress METTL3 expression in human conjunctival fibroblasts. METTL3 deficiency reduces N6-methyladenosine (m6A) deposition on TCF7L2, Smad2, and Smad3 transcripts, impairing YTHDF2-mediated recognition and degradation, leading to their abnormal stabilization and subsequent protein accumulation. Elevated TCF7L2 partners with Smad2/3 to form a transcriptional complex that directly binds to the FN1 and COL1A1 promoters, driving their expression and extracellular matrix deposition. Exogenous modulation of METTL3 expression either mimics or reverses the TGF-β1-induced fibrotic phenotypes both in vitro and in vivo. Our findings reveal a mechanism through which environmental factors influence pterygium progression by modulating the formation of fibrotic transcriptional complexes via epitranscriptomic regulation. These insights offer potential avenues for treating fibrosis by targeting the epitranscriptome or specific transcriptional complexes.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZFP560 facilitates KAP1-dependent chromatin repression to regulate exit from totipotency. ZFP560促进kap1依赖性染色质抑制以调节全能性的退出。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-05-06 DOI: 10.1016/j.jgg.2026.04.022

Qingsheng Han, Lichao Wang, Chang Liu, Huaxin Yu, Hao Zhou, Min Wei, Zongjin Li, Na Liu

{"title":"ZFP560 facilitates KAP1-dependent chromatin repression to regulate exit from totipotency.","authors":"Qingsheng Han, Lichao Wang, Chang Liu, Huaxin Yu, Hao Zhou, Min Wei, Zongjin Li, Na Liu","doi":"10.1016/j.jgg.2026.04.022","DOIUrl":"https://doi.org/10.1016/j.jgg.2026.04.022","url":null,"abstract":"KRAB zinc finger proteins (KRAB-ZFPs) are the most abundant transcriptional regulators and epigenetic repressors in mammals and contribute to the silencing of transposable elements (TEs) during embryonic development. However, the early effectors of the KRAB-ZFP family during embryonic development and cell state transition remain largely unexplored. Here, we identify that zinc finger protein 560 (ZFP560) is involved in the regulation of early embryonic development and the transition from totipotency in mice. ZFP560 safeguards heterochromatin structure by recruiting KAP1 to facilitate the exit of totipotency. The deficiency of ZFP560 disrupted heterochromatin formation, significantly halting the transition from totipotency to pluripotency. Similarly, the overexpression of ZFP560 promotes exit from the MERVL-positive state and suppresses expression of 2-cell (2C) transcription factors by recruiting KAP1 via its KRAB domain, thereby reducing chromatin accessibility. Taken together, these findings reveal that ZFP560 is a highly expressed 2C-specific KRAB-ZFP transcription factor and a mediator that facilitates the exit from totipotency, providing insights into the epigenetic regulation of early embryonic development.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cohesin variants associated with human reproductive and developmental disorders. 与人类生殖和发育障碍相关的内聚蛋白变异。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-05-06 DOI: 10.1016/j.jgg.2026.04.024

Yuanyuan Liu, Jun Zhou

引用次数: 0

FAK activation drives non-genetic adaptive survival of ALK-rearranged lung cancer under tyrosine kinase inhibitor treatment. FAK激活在酪氨酸激酶抑制剂治疗下驱动alk重排肺癌的非遗传适应性生存。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-05-06 DOI: 10.1016/j.jgg.2026.04.023

Xinru Chen, Jinhui Xue, Lin Zhang, Jie Huang, Songran Liu, Xinxin Zhang, Fan Wang, Yihua Huang, Jiani Zheng, Zhonghan Zhang, Yunpeng Yang, Hongyun Zhao, Jia-Xing Yue, Li Zhang, Jing Li

引用次数: 0

Haplotype-resolved T2T genome assembly of wild Cannabis provides molecular insights into drought tolerance. 野生大麻的单倍型解决T2T基因组组装提供了耐旱性的分子见解。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-05-05 DOI: 10.1016/j.jgg.2026.04.020

Yuan Zhang, Mengbi Guo, Xuejing Zi, Yanping Xu, Pin Lv, Yuan Li, Qingying Zhang, Ming Yang, Yaolong Zhang, Riaz Muhammad Khan, Xuan Chen

引用次数: 0

Knockout of TpNRAMP5 reduces grain cadmium concentration in Polish wheat. 敲除TpNRAMP5可降低波兰小麦籽粒镉浓度。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-05-04 DOI: 10.1016/j.jgg.2026.04.021

Yiran Cheng, Xing Chen, Hongzhu Zhou, Jian Ma, Rui Wang, Yongjun Dong, Xi Li, Dan Long, Jian Zeng, Xing Fan, Houyang Kang, Dandan Wu, Yonghong Zhou, Ke Wang, Yi Wang

引用次数: 0

Brassinosteroids negatively regulate plant de novo root regeneration. 油菜素内酯对植物新生根再生具有负向调控作用。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-04-30 DOI: 10.1016/j.jgg.2026.04.018

Yuan-Yuan Dong, Yu-Tong Jiang, Yuan-Xin Wang, Jin-Hui Chang, Jing-Ting Yang, Li-Qin Hu, Lu-Han Yang, Min Xu, Yuan-Yuan Zhang, Wu Liu, Wen-Hui Lin

{"title":"Brassinosteroids negatively regulate plant de novo root regeneration.","authors":"Yuan-Yuan Dong, Yu-Tong Jiang, Yuan-Xin Wang, Jin-Hui Chang, Jing-Ting Yang, Li-Qin Hu, Lu-Han Yang, Min Xu, Yuan-Yuan Zhang, Wu Liu, Wen-Hui Lin","doi":"10.1016/j.jgg.2026.04.018","DOIUrl":"https://doi.org/10.1016/j.jgg.2026.04.018","url":null,"abstract":"De novo root regeneration (DNRR) is essential for plant survival under mechanical damage and agricultural productivity, and plant hormones play a pivotal role in this process. While auxin, jasmonate (JA), and ethylene are known to be involved in DNRR, the role of brassinosteroids (BR) remains unreported. This study reveals that the reduced BR signaling promotes DNRR, whereas elevated BR signaling suppresses DNRR. Then we further validate that this mechanism is conserved across diverse plant species, including Brassica napus, Nicotiana benthamiana, and Solanum lycopersicum. Studies on the regulatory mechanism indicate that BR regulates DNRR by modulating auxin-related pathways. BR induces the transcription factor BZR1, which directly represses auxin transporter genes (PIN1, PIN3), thereby reducing auxin levels at the wound sites of leaf explants and inhibiting root primordia formation. Besides, BZR1 also transcriptionally suppresses root meristem initiation-related genes (WOX5 and LBD16) to inhibit DNRR. This study demonstrates BR function in plant DNRR, refines the network of hormonal regulation of DNRR, and provides an important clue for improving plant rooting efficiency in agriculture.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ancient genomic profile of the Shatuo Turkic leader Li Keyong. 沙陀突厥领导人李克勇的古代基因组图谱。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-04-29 DOI: 10.1016/j.jgg.2026.04.015

Yao Yu, Xiaoguang Zhu, Xin Chang, Zixiao Huang, Panxin Du, Xiaoying Ren, Baoshuai Zhang, Ke Wang, Yishan Wu, Sheng Han, Li Jin, Yi Zheng, Hailiang Meng, Shaoqing Wen

{"title":"Ancient genomic profile of the Shatuo Turkic leader Li Keyong.","authors":"Yao Yu, Xiaoguang Zhu, Xin Chang, Zixiao Huang, Panxin Du, Xiaoying Ren, Baoshuai Zhang, Ke Wang, Yishan Wu, Sheng Han, Li Jin, Yi Zheng, Hailiang Meng, Shaoqing Wen","doi":"10.1016/j.jgg.2026.04.015","DOIUrl":"https://doi.org/10.1016/j.jgg.2026.04.015","url":null,"abstract":"The Shatuo Turks played a pivotal role in late Tang and Five Dynasties China. However, similar to other Turkic groups, the genetic history and population origins of the Shatuo remain poorly understood. This study presents a genomic investigation of a Shatuo leader through the analysis of ancient DNA from Li Keyong (856 CE-908 CE), founder of the Later Tang dynasty, providing an opportunity to elucidate the genetic composition and origins of this pivotal group. Through comprehensive population genetic analyses, including PCA, ADMIXTURE analysis, f-statistics, and qpAdm modeling, it has been found that Li Keyong had a nearly balanced admixture, with 53.4% Ancient Northeast Asian and 46.6% Western Steppe ancestry. Additionally, he carried a Western Eurasian paternal lineage (R1a1a1b2∼AM01870) and an Eastern Steppe maternal lineage (C4a1a + 195). This genetic profile contrasts sharply with the predominantly Northeast Asian ancestry observed in the Ashina royal clan, highlighting significant genetic heterogeneity within Turkic confederations. Our results suggest that the Shatuo emerged from complex cross-Eurasian interactions, consistent with the hypothesis of a multi-ethnic origin.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TMEM63B channel is the mechanosensor in alveolar epithelial type II cells. TMEM63B通道是肺泡上皮II型细胞的机械传感器。

IF 7.1 2区生物学

Journal of Genetics and Genomics Pub Date : 2026-04-29 DOI: 10.1016/j.jgg.2026.04.016

Shi-Yu Zhan, Xiao-Yu Teng, Dan Wu, Yunfeng Zhu, Tian-Zi Zhang, Hong-Li Guo, Xiaofeng Tan, Guolin Yang, Gui-Zhou Li, Yue-Ying Wang, Bi-Xian Zhong, Gui-Fang Duan, Feng Chen, Jie Xu, Yun Stone Shi

{"title":"TMEM63B channel is the mechanosensor in alveolar epithelial type II cells.","authors":"Shi-Yu Zhan, Xiao-Yu Teng, Dan Wu, Yunfeng Zhu, Tian-Zi Zhang, Hong-Li Guo, Xiaofeng Tan, Guolin Yang, Gui-Zhou Li, Yue-Ying Wang, Bi-Xian Zhong, Gui-Fang Duan, Feng Chen, Jie Xu, Yun Stone Shi","doi":"10.1016/j.jgg.2026.04.016","DOIUrl":"https://doi.org/10.1016/j.jgg.2026.04.016","url":null,"abstract":"Inspiration-induced mechanical stretching serves as the primary driving force for pulmonary surfactant secretion from alveolar epithelial type II (AT2) cells. However, the mechanism by which AT2 cells sense mechanical stimuli remains elusive. Here, we demonstrate that TMEM63B functions as a critical mechanosensor on the plasma membrane of AT2 cells. We find that stretch induces significant currents in AT2 cells. Using Tmem63bHA-fl/HA-fl mice, we show that TMEM63B is expressed on the plasma membrane of AT2 cells. Deletion of TMEM63B in AT2 cells abolishes the stretch-induced currents and suppresses the secretion of pulmonary surfactant. Activation of TMEM63B causes Ca2+ influx, lamellar body (LB) fusion, and pulmonary surfactant secretion. These processes are markedly impaired upon TMEM63B deletion. In contrast, ATP-induced Ca2+ influx and LB fusion are unaffected by TMEM63B deletion, indicating that TMEM63B plays a specialized role in sensing mechanical stretch in the lungs. Therefore, our study establishes TMEM63B as a key mechanosensor critical for AT2 cell-mediated pulmonary surfactant secretion.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0