Whole-genome sequencing provides insights into the evolutionary adaptation and conservation of gibbons.

Abstract

Gibbons are small, arboreal apes that play a critical role in tropical biodiversity and ecosystem ecology. However, nearly all species of gibbons are threatened by habitat loss, illegal trade, hunting, and other human activities. Long-term poor understanding of their genetics and evolution undermines effective conservation efforts. In this study, we analyse comparative population genomic data of four Nomascus species. Our results reveal strong genetic differentiation among these species as well as gene flow among Nomascus species. Additionally, we identify genomic features that are potentially related to natural selection linked to vocalization, fructose metabolism, motor balance, and body size, consistent with the unique phenotype and adaptability of gibbons. Inbreeding coupled with population declines due to climate change and historical human activities leads to reduced genetic diversity and the accumulation of deleterious variation that likely affects cardiovascular disease and the reproductive potential of gibbons and further reduces their fitness, highlighting the urgent need for effective conservation strategies.