Journal of Hospital Infection最新文献

{"title":"Clinical and microbiological effectiveness of pulsed-xenon ultraviolet light disinfection in a neonatal intensive care unit in Japan","authors":"S. Komamizu ,&nbsp;Y. Yamamoto ,&nbsp;K. Morikane ,&nbsp;Y. Kuwabara ,&nbsp;M. Kondo ,&nbsp;K. Tatebayashi ,&nbsp;T. Koyama ,&nbsp;D. Terazawa","doi":"10.1016/j.jhin.2024.11.015","DOIUrl":"10.1016/j.jhin.2024.11.015","url":null,"abstract":"<div><h3>Background</h3><div>Meticillin-resistant <em>Staphylococcus aureus</em> (MRSA) is a common causative agent of serious healthcare-related infections in neonatal intensive care units (NICUs). In adult ICUs, pulsed-xenon ultraviolet (PX-UV) disinfection of environmental surfaces, along with alcohol-based hand hygiene and terminal cleaning, has been demonstrated to reduce the MRSA acquisition rate.</div></div><div><h3>Aim</h3><div>To explore the impact of PX-UV use in NICUs on reducing MRSA transmission.</div></div><div><h3>Methods</h3><div>The incidence of newly detected MRSA cases was recorded for all patients between January 2021 and December 2022. UV irradiation was used in addition to terminal manual cleaning. During the baseline period, irradiation was performed on areas following the use by patients with MRSA; in the intervention period, irradiation was performed after each patient's use.</div></div><div><h3>Findings</h3><div>Though there was no observed change in the frequency of hand hygiene compliance throughout the study period, the total number of MRSA cases detected per 1000 patient-days decreased significantly.</div></div><div><h3>Conclusion</h3><div>In NICUs, UV irradiation of environmental surfaces, in addition to hand hygiene practices and conventional environmental maintenance, may be effective in reducing MRSA infection.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 13-16"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of postpartum hospital length of stay on infant gut microbiota: a comprehensive analysis of vaginal and caesarean birth","authors":"S. Bashar ,&nbsp;H.M. Tun ,&nbsp;J.Y. Ting ,&nbsp;M. Hicks ,&nbsp;P.J. Mandhane ,&nbsp;T.J. Moraes ,&nbsp;E. Simons ,&nbsp;S.E. Turvey ,&nbsp;P. Subbarao ,&nbsp;J.A. Scott ,&nbsp;A.L. Kozyrskyj","doi":"10.1016/j.jhin.2024.10.012","DOIUrl":"10.1016/j.jhin.2024.10.012","url":null,"abstract":"<div><h3>Background</h3><div>The primary concern with prolonged hospitalization following birth is the risk of acquiring hospital-acquired infections (HAIs) caused by opportunistic bacteria, which can alter the early establishment of gut microbiota.</div></div><div><h3>Objective</h3><div>To assess the association between postpartum hospital length of stay (LOS) and the composition of gut microbiota at 3 and 12 months of age according to birth mode.</div></div><div><h3>Methods</h3><div>In total, 1313 Canadian infants from the CHILD Cohort Study were involved in this study. Prolonged LOS was defined as ≥2 days following vaginal delivery (VD) and ≥3 days following caesarean section (CS). The gut microbiota of infants was characterized by Illumina 16S rRNA sequencing of faecal samples at 3–4 months and 12 months of age.</div></div><div><h3>Findings</h3><div>Following prolonged LOS, VD infants with no exposure to intrapartum antibiotics had a higher abundance of bacteria known to cause HAIs in their gut, including <em>Enterococcus</em> spp. at 3 and 12 months, <em>Citrobacter</em> spp. at 3 months, and <em>Clostridioides difficile</em> at 12 months. Abundance of <em>Enterococcus</em> spp. or <em>Citrobacter</em> spp. at 3 months significantly mediated the association between LOS and low abundance of Bacteroidaceae, or higher Enterococcaeae/Bacteriodaceae or Enterobacterales/Bacteroidaceae abundance ratios at 12 months of age in VD infants without intrapartum antibiotic exposure. HAI-causing Enterobacterales were also more abundant in later infancy in infants with prolonged LOS following CS. In the absence of exclusive breastfeeding at 3 months or any breastfeeding at 12 months, Porphyromonadaceae (of Bacteroidota) were depleted in CS infants with prolonged LOS.</div></div><div><h3>Conclusions</h3><div>Prolonged hospital stay after birth is associated with infant gut dysbiosis.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 50-60"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serratia marcescens outbreak at a neonatal intensive care unit in an acute care tertiary hospital in Singapore","authors":"B. Shaik Ismail ,&nbsp;H.X. Toh ,&nbsp;J.H. Seah ,&nbsp;K.Y. Tan ,&nbsp;L.C. Lee ,&nbsp;Y.Y. Tay ,&nbsp;K.C. Khong ,&nbsp;A.W.M. Seet ,&nbsp;K.C. Tesalona ,&nbsp;A.J.H. Ngeow ,&nbsp;S.K.Y. Ho ,&nbsp;W.B. Poon ,&nbsp;D.C.M. Lai ,&nbsp;K.K.K. Ko ,&nbsp;M.L. Ling","doi":"10.1016/j.jhin.2024.10.002","DOIUrl":"10.1016/j.jhin.2024.10.002","url":null,"abstract":"<div><h3>Background</h3><div><em>Serratia marcescens</em> is an aerobic Gram-negative Enterobacterales bacillus that has emerged as a cause of hospital-associated infections.</div></div><div><h3>Aim</h3><div>To report the epidemiological, diagnostic, and genetic investigation of an outbreak involving five neonatal patients infected or colonized with <em>S. marcescens</em> including the infection control interventions.</div></div><div><h3>Methods</h3><div>The outbreak occurred in a 28-bedded neonatal unit in an acute care tertiary hospital in Singapore divided into three areas: two negative-pressure airborne infection isolation rooms with a shared anteroom, 10 neonatal intensive care unit (NICU) beds, and 16 high-dependency beds. In-flight patients and their immediate environment were screened for <em>S. marcescens</em> to determine probable environmental sources. Whole-genome sequencing (WGS) analysis of resulting isolates was performed to determine clone relatedness and possible transmission patterns. Implementation of infection control interventions included prompt isolation of cases, enhanced equipment and environmental disinfection, use of alcohol-based hand rub as the preferred hand hygiene mode, enhanced infection prevention orientation for parents, review of practices, audits, and immediate feedback on non-compliance.</div></div><div><h3>Findings</h3><div>Five neonates infected or colonized with <em>S. marcescens</em> were involved in this outbreak. Four were infection cases and one was identified through contact tracing. Three NICU sinks and the milk preparation room sink were tested positive for <em>S. marcescens</em>. WGS confirmed clonality of strains from two NICU sinks, and milk preparation room sink with that of the five neonates.</div></div><div><h3>Conclusion</h3><div>A multi-prong strategy was required to contain this outbreak. WGS analysis showed association of biofilms in sinks with the outbreak.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 21-25"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccination of healthcare workers against mpox: a call for action","authors":"G. Lippi ,&nbsp;B.M. Henry ,&nbsp;J.G. Rizk","doi":"10.1016/j.jhin.2024.10.007","DOIUrl":"10.1016/j.jhin.2024.10.007","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 121-122"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-locus sequence typing of Candida tropicalis among Candiduria shows an outbreak in azole-susceptible isolates and clonal cluster enriched in azole-resistant isolates","authors":"L. Zhao ,&nbsp;L.F. Xu ,&nbsp;G.D. Xiang ,&nbsp;Q.C. Zhou ,&nbsp;Y. Wang ,&nbsp;G.Y. Li","doi":"10.1016/j.jhin.2024.11.018","DOIUrl":"10.1016/j.jhin.2024.11.018","url":null,"abstract":"<div><h3>Background</h3><div>The increasing detection rate of <em>C. tropicalis</em> and its azole resistance have made clinical treatment difficult. The presence of candiduria seems to correlate with invasive candida infection, especially for patients admitted to ICUs. However, the prevalence and antifungal resistance of <em>C. tropicalis</em> isolates in urine samples has not been well studied.</div></div><div><h3>Aim</h3><div>To retrospectively investigate the clinical features, antifungal resistance, and genetic relatedness of <em>C. tropicalis</em> isolates from urine samples.</div></div><div><h3>Methods</h3><div>A total of 107 clinical <em>C. tropicalis</em> isolates were retrospectively studied, including phenotypes of isolates and characteristics of patients. The genetic profiles of 107 isolates were genotyped using multi-locus sequence typing (MLST). Phylogenetic analysis was inferred using unweighted pair group method with arithmetic averages. MLST clonal clusters (CCs) were analysed by goeBURST.</div></div><div><h3>Findings</h3><div>Of the 107 isolates, 27.1% were resistant to fluconazole, and there was a notable increasing trend of fluconazole resistance from 16.1% in 2019 to 40.0% in 2021. Forty-seven diploid sequence types (DSTs) were assigned to ten major CCs. CC1 was the predominant fluconazole-susceptible group; 24 isolates from CC1 belonged to DST333, an outbreak clone in NICU ward. The azole-resistant CC4 contained 19 isolates, accounting for 65.5% of the azole-resistant isolates in this study. CC4 belongs to a prevalent FNS CC1 globally, of which the putative founder genotype was DST225.</div></div><div><h3>Conclusion</h3><div>This study revealed an outbreak of azole-susceptible <em>C. tropicalis</em> isolates in urine specimens and a high azole resistance rate of <em>C</em>. <em>tropicalis</em> in candiduria, and the MLST type showed clonal aggregation in azole-resistant isolates from urine samples.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 96-105"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a polyhexanide-based antiseptic skin solution on Candida auris colonization and invasive fungaemia","authors":"K. Charisi ,&nbsp;I. Galanis ,&nbsp;C. Zarras ,&nbsp;G. Totikidis ,&nbsp;D. Kouroupis ,&nbsp;E. Massa ,&nbsp;C. Michailidou ,&nbsp;S. Goumperi ,&nbsp;E. Kosmidou ,&nbsp;C. Alektoridou ,&nbsp;D. Vlachakis ,&nbsp;E. Mouloudi ,&nbsp;P. Pateinakis ,&nbsp;A. Pyrpasopoulou ,&nbsp;C. Antachopoulos","doi":"10.1016/j.jhin.2024.11.004","DOIUrl":"10.1016/j.jhin.2024.11.004","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 61-63"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for latent tuberculosis infection among healthcare workers at recruitment in a country with a low incidence of tuberculosis: a retrospective study","authors":"C. Vieira Gomes ,&nbsp;S. Rusca ,&nbsp;A. Dumoulin ,&nbsp;P-O. Bridevaux ,&nbsp;L. Arlettaz ,&nbsp;S. Emonet ,&nbsp;G. Catho","doi":"10.1016/j.jhin.2024.11.007","DOIUrl":"10.1016/j.jhin.2024.11.007","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 128-130"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What doesn’t kill biofilm, makes them stronger: critical methodological considerations for endoscope reprocessing","authors":"R. Kanaujia ,&nbsp;A. Sharma ,&nbsp;M. Biswal ,&nbsp;V. Singh","doi":"10.1016/j.jhin.2024.06.024","DOIUrl":"10.1016/j.jhin.2024.06.024","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 135-136"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Dr Dancer","authors":"M.A. Kiernan ,&nbsp;M. Garvey ,&nbsp;P. Norville ,&nbsp;J.A. Otter ,&nbsp;D.J. Weber","doi":"10.1016/j.jhin.2024.11.002","DOIUrl":"10.1016/j.jhin.2024.11.002","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 131-132"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of multidrug-resistant Staphylococcus haemolyticus ST29 in a French neonatal unit","authors":"E. Pouly ,&nbsp;A. Biguenet ,&nbsp;P. Cholley ,&nbsp;D. Hocquet ,&nbsp;X. Bertrand","doi":"10.1016/j.jhin.2024.11.017","DOIUrl":"10.1016/j.jhin.2024.11.017","url":null,"abstract":"<div><h3>Background</h3><div><em>Staphylococcus haemolyticus</em> is a clinically relevant coagulase-negative staphylococcus frequently responsible for hospital-acquired infections, especially in premature newborns.</div></div><div><h3>Aim</h3><div>To describe an outbreak of multidrug-resistant <em>S</em>. <em>haemolyticus</em> in a neonatal department.</div></div><div><h3>Methods</h3><div>The outbreak was investigated using classical methods, including screening of the patients, genotyping of the isolates and environmental survey. Numerous infection control measures were implemented.</div></div><div><h3>Findings</h3><div>In 2022 and 2023, a clonal outbreak of multidrug-resistant <em>S. haemolyticus</em> ST29 (40 infections and 71 carriages) occurred in the neonatology department of a University Hospital in France. The infection control measures implemented only partially controlled the outbreak. Although our investigation did not clearly identify the source and mode of transmission, a reservoir constituted by patients and transmission by healthcare workers are the most likely. This episode occurred in a context of countrywide outbreaks of <em>S. haemolyticus</em> ST29 in several French neonatology departments.</div></div><div><h3>Conclusion</h3><div>This prolonged outbreak of <em>S. haemolyticus</em> ST29 accounted for the increase in the incidence of <em>S. haemolyticus</em>-related infections in French neonatology departments. Implementation of proactive measures is crucial to limit the spread of such pathogens in neonatal ICUs.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"156 ","pages":"Pages 17-20"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}