Risk factors of surgical site infection in liver transplantation recipients: a systematic review and meta-analysis

IF 3.1 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection Pub Date : 2025-08-11 DOI:10.1016/j.jhin.2025.07.013

S. Jin , X. Wei , X. Wang , W. Zhang , C. Wang , Y. Kang , Y. Sun , W. Yang , B. Wang

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引用次数: 0

Abstract

Surgical site infection (SSI) is a common and significant complication following organ transplantation, with liver transplantation (LT) being particularly susceptible to high infection rate. Despite its prevalence, no systematic meta-analysis has integrated evidence across major risk factors associated with post-LT SSI. We performed a systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, and the Cochrane Database. We searched for eligible articles through April 2025. Of 8593 articles screened, 18 were included. R 4.1.3 software was used for this meta-analysis. Eighteen studies, including data from 9874 LT recipients and 1619 reported infection events, were included. Our analysis identified two LT-specific factors associated with elevated SSI risk: Roux-en-Y anastomosis (odds ratio (OR) 2.61, 95% confidence interval (CI) 1.95 to 3.26, I² = 43.37%), graft-to-recipient weight ratio (GRWR) <0.01 (OR 2.19, 95% CI 1.54 to 2.84, I² = 0%). In addition, re-transplantation, preoperative haemodialysis, biliary complications, and prior surgical history constitute significant risk factors. The meta-analysis revealed an overall SSI incidence rate of 21% across the investigated studies. Given the serious implications of SSI, increasing awareness of these risk factors and implementing targeted prevention strategies should be a priority for clinicians to reduce SSI rate after LT.

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肝移植受者手术部位感染的危险因素：系统回顾和荟萃分析。

背景：手术部位感染（Surgical site infection， SSI）是器官移植术后常见且重要的并发症，其中肝移植（liver transplantation， LT）尤其易发生高感染率。尽管它很普遍，但没有系统的荟萃分析整合了与lt后SSI相关的主要危险因素的证据。方法：我们对来自PubMed、Embase、Web of Science和Cochrane数据库的研究进行了系统回顾和荟萃分析。我们搜索了2025年4月之前符合条件的文章。在8593篇被筛选的文章中，有18篇被纳入。采用r4.1.3软件进行meta分析。结果：纳入了18项研究，包括9874例肝移植受者和1619例报告感染事件的数据。我们的分析确定了两个与SSI风险升高相关的lt特异性因素：Roux-en-Y吻合（OR 2.61, 95%CI 1.95至3.26,I2 = 43.37%），移植物与受体体重比(GRWR) < 0.01 （OR 2.19, 95%CI 1.54至2.84,I2 = 0%）。此外，再移植、术前血液透析、胆道并发症和既往手术史也是重要的危险因素。荟萃分析显示，在所调查的研究中，SSI的总发病率为21%。结论：考虑到SSI的严重影响，提高对这些危险因素的认识并实施有针对性的预防策略应该是临床医生降低术后SSI发生率的首要任务。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hospital Infection 医学-传染病学

CiteScore

12.70

自引率

5.80%

发文量

271

审稿时长

19 days

期刊介绍： The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience. The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that: provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings; provide new insight into cleaning, disinfection and decontamination; provide new insight into the design of healthcare premises; describe novel aspects of outbreaks of infection; throw light on techniques for effective antimicrobial stewardship; describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control; improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change; improve understanding of the use of IT systems in infection surveillance and prevention and control.