Journal of Hospital Infection最新文献

{"title":"The role of kitchens/pantries in the spread of multi-drug-resistant organisms","authors":"A. Cobb , C. Molyneux , V. Raviprakash , C. Skull , M. Weinbren","doi":"10.1016/j.jhin.2025.04.022","DOIUrl":"10.1016/j.jhin.2025.04.022","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"163 ","pages":"Pages 112-113"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term within-household sharing of ESBL-producing E. coli carrying blaCTX-M-147 that converted to blaCTX-M-14","authors":"H. Aardema , S. Rosema , M.A. Fliss , L. Gard , A.J.M. Lokate , C.L.E. Hazenberg , A. Voss , E. Bathoorn","doi":"10.1016/j.jhin.2025.03.008","DOIUrl":"10.1016/j.jhin.2025.03.008","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"163 ","pages":"Pages 105-107"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a novel automated pre-cleaning method for endoscopy.","authors":"F Mevel, G Rahmi, A Sornet, A-M Hillion, C Ronceray, C Cellier, I Podglajen, N Kassis-Chikhani","doi":"10.1016/j.jhin.2025.06.011","DOIUrl":"10.1016/j.jhin.2025.06.011","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":"82-86"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand disinfections per patient-day in relation to use of unsterile gloves per patient-day: a comparator for the appropriate use of unsterile gloves in the clinical setting?","authors":"A. Ambrosch","doi":"10.1016/j.jhin.2025.04.014","DOIUrl":"10.1016/j.jhin.2025.04.014","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"163 ","pages":"Pages 110-111"},"PeriodicalIF":3.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying indicators and targets for the new World Health Organization global framework on infection and prevention and control: an e-Delphi study.","authors":"Giovanni Satta, Paul Rogers, Joao Bana E Costa, Ermira Tartari, Ana Flavia Santos, Peter Bischoff, Julie Storr, Landry Cihambanya, Ana Paula Coutinho Rehse, Iman Heweidy, Zhao Li, Pilar Ramon-Pardo, Aparna Singh Shah, Michael Lindsay Grayson, Benedetta Allegranzi","doi":"10.1016/j.jhin.2025.04.039","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.04.039","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organization (WHO) recently developed the global action plan (GAP) and monitoring framework (MF) for Infection Prevention and Control (IPC). An e-Delphi survey was conducted as part of a consultative process to achieve consensus on IPC MF indicators and targets.</p><p><strong>Methods: </strong>The study was conducted as an e-Delphi consensus-seeking exercise, with two rounds of sequential surveys. In round 1 participants were asked to assess each indicator and target using a 5-point Likert scale, and in round 2 to re-assess those that did not reach consensus and to rank all indicators and targets in priority order. \"Consensus\" was defined when >70% of the responses fell within the two positive extreme ranges of the scale and < 5% of the responses fell within the two negative extreme ranges.</p><p><strong>Findings: </strong>86 country representatives along with experts from 63 countries participated in the initial draft IPC MF development. The e-Delphi study invited 394 participants, with response rates of 36% (142/394) in round 1 and 69% (98/142) in round 2. Of the 134 indicators and 27 targets included in round 1, all but one achieved consensus, and 16 showed >5% level of disagreement. In round 2, three indicators were rejected and participants ranked the top ten global targets and top five national targets. The survey showed strong support for improving IPC surveillance, whilst research ranked lower due to other competing priorities.</p><p><strong>Conclusion: </strong>A high level of agreement on the proposed indicators and targets to be monitored by all countries to track progress in IPC was achieved through a strong consensus building process. The WHO IPC GAP and MF was adopted by all countries during the 77^th World Health Assembly in May 2024.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A proof of concept evaluation of dry heat as an aerial disinfection method for hospitals: preliminary data for bactericidal efficacy","authors":"C. Djayet ,&nbsp;A. Iwanoff ,&nbsp;M. Boubaya ,&nbsp;P. Moenne-Locoz ,&nbsp;E. Carbonnelle ,&nbsp;D. Seytre ,&nbsp;M. Laleem ,&nbsp;A. Izri ,&nbsp;J.R. Zahar ,&nbsp;A. Jacolot","doi":"10.1016/j.jhin.2025.08.003","DOIUrl":"10.1016/j.jhin.2025.08.003","url":null,"abstract":"<div><h3>Background</h3><div>In hospitals, the prevention of healthcare-associated infections requires biocleaning of the patient's immediate environment. Micro-organisms can survive for long periods of time – up to several months – on certain environmental surfaces, resulting in their transmission to the patient through direct contact or via the hands of healthcare workers. Dry heat is a long-recognized antimicrobial process. However, its use as an aerial method of disinfection for hospital surfaces is innovative. An evaluation of bactericidal efficacy is required before any real-world application, to ensure that this method satisfies current standards.</div></div><div><h3>Aim</h3><div>In this study, we aimed to investigate the effect of dry heat generated at a temperature of 60 °C for 30 min on the bacterial contamination of horizontal surfaces in a room, comparing this method with disinfection by the direct application of a detergent-disinfectant – the current reference method.</div></div><div><h3>Methods</h3><div>Four supports, made from the materials most commonly found in patient rooms, were inoculated with five different bacterial species representative of hospital ecology and tested. More than 900 bacteriological samples were taken at different times after the disinfection phase.</div></div><div><h3>Findings</h3><div>The bactericidal activity of the dry heat process was demonstrated by a decrease in bacterial levels of more than 5 log₁₀ cfu/mL in 10 min, regardless of bacterial species or substrate. After 30 min, dry heat was significantly more effective than detergent-disinfectant and mechanical action alone.</div></div><div><h3>Conclusion</h3><div>Dry heat (60 °C for 30 min) showed bactericidal activity against non-spore-forming vegetative bacteria under the conditions tested in this study. This method can be automated, meets ecological criteria and is not toxic to humans; it may represent a potential alternative for surface disinfection using quaternary ammonium disinfectants against vegetative bacteria, although further investigation is required to confirm efficacy against other clinically relevant pathogens.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"165 ","pages":"Pages 9-15"},"PeriodicalIF":3.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of carbapenem-resistant Enterobacterales in healthcare and community settings in the UK: a systematic review and meta-analysis","authors":"H. Almadhoon ,&nbsp;I. Ahmad ,&nbsp;W.W.Y. Lee ,&nbsp;A. Matthews ,&nbsp;E.R. Carter ,&nbsp;J.A. Otter ,&nbsp;D.M. Lecky ,&nbsp;A.H. Holmes ,&nbsp;N.J. Zhu","doi":"10.1016/j.jhin.2025.07.030","DOIUrl":"10.1016/j.jhin.2025.07.030","url":null,"abstract":"<div><div>Carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) pose a growing threat in the UK, with increasing prevalence in recent years associated with higher morbidity, mortality and healthcare costs. This review synthesizes evidence in the prevalence of CP-CRE in UK healthcare and community settings. A systematic review was conducted across major five databases and two preprint websites until 14^th February 2024. Eligible records were assessed in Covidence, with metadata extracted and quality evaluated using an adapted Newcastle–Ottawa Scale. Pooled CP-CRE prevalence rates with 95% confidence intervals (CIs) were assessed using chi^<em>2</em> and <em>I</em>^<em>2</em><em>,</em>where the Q statistic followed an X² distribution (with k-1 degrees of freedom). Publication bias was evaluated using Egger's test and funnel plot, with sensitivity analyses performed. Among 1344 screened records, 32 studies were included. The overall pooled prevalence of CRE and carbapenemase-producing Enterobacterales (CPE) in healthcare settings was 1.17% (95%Cl 0.29–2.51%, <em>I</em>^<em>2</em> = 99.70%, <em>N</em> = 171,107) and 1.06% (95%Cl 0.59–1.64%; <em>I</em>^<em>2</em> = 97.60, <em>N</em> = 263,833), respectively. CPE pooled prevalence was higher in healthcare carriage samples at 1.23% (95%Cl: 0.68–1.91%; <em>I</em>^<em>2</em> = 98.10%; <em>N</em> = 262,524) than infection samples at 0.03% (95%Cl: 0.00–0.37%; <em>I</em>^<em>2</em> = 0.00%; <em>N</em> = 888). Risk-based admission screening identified a higher CPE proportion of 1.27% (95%Cl: 0.97–1.60%; <em>I</em>^<em>2</em> = <em>67.30%; N</em> = 24,763) compared with universal hospital screening at 0.82% (95%Cl: 0.28–1.65%; <em>I</em>^<em>2</em> = 97.90%; <em>N</em> = 232,033). In the community, only two studies reported CPE prevalence (0.11%; 95%Cl: 0.00–0.79%; <em>I</em>^<em>2</em> = 52.60; <em>N</em> = 2630) from carriage samples using point prevalence surveys, showing low prevalence. This review provides an overview of CP-CRE prevalence across healthcare and community settings in the UK. Our findings support the national surveillance of CP-CRE in the UK, enabling more targeted screening efforts for CP-CRE detection.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"165 ","pages":"Pages 19-31"},"PeriodicalIF":3.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the viable microbiome of the healthcare toilet?","authors":"C. Aumeran ,&nbsp;L. Hamilton ,&nbsp;L. Jamieson ,&nbsp;E. Speake ,&nbsp;S.J. Dancer","doi":"10.1016/j.jhin.2025.07.031","DOIUrl":"10.1016/j.jhin.2025.07.031","url":null,"abstract":"<div><h3>Background</h3><div>Flushing water toilets in hospitals cater for staff and patients, including disabled and unisex facilities. The recent introduction of unisex toilets has highlighted potential microbiological risks between different bathroom facilities.</div></div><div><h3>Aim</h3><div>This project sought to establish the cultivable microbiome in all types of healthcare toilet.</div></div><div><h3>Methods</h3><div>Systematic sampling was performed using quantitative and qualitative microbiology within a multi-site longitudinal study. Hand-touch sites, low sites (floors) and high sites (ceilings) in male/female staff and patient, unisex and disabled facilities were screened in three hospitals. Aerobic colony count (ACC) was determined alongside identification of key pathogens (<em>Staphylococcus aureus</em>, Enterobacterales, enterococci, stenotrophomonas, acinetobacter and fungi). Bacterial pathogens were tested for antimicrobial susceptibilities.</div></div><div><h3>Findings</h3><div>Expected environmental and skin flora were present at all sites. Bioburden was heaviest on floors, closely followed by ceilings. Hand-touch sites were cleanest (&lt;2.5 cfu/cm²) in all toilets (<em>P=</em>0.003), with those in female toilets cleaner than in male toilets (<em>P=</em>0.008). Highest bioburden overall (&gt;12 cfu/cm²) occurred in unisex toilets, followed by male toilets. Flora at high sites was almost identical to that on floors. Bacterial pathogens, including resistant bacteria, were concentrated on patient floors, with 80% isolated alongside ACC&gt;2.5 cfu/cm². Seven of eight <em>Stenotrophomonas maltophilia</em> were recovered from gender-neutral toilets. <em>S. aureus</em> predominated on floors and hand-touch sites in male staff and disabled toilets (<em>P=</em>0.02 and <em>P</em>&lt;0.001, respectively).</div></div><div><h3>Conclusion</h3><div>Cleaning frequencies should be modelled against higher bioburden (unisex) and risk of pathogens (patient toilets). Similar flora on floors and ceilings suggested aerosolization during flushing. The data provides evidence to inform bathroom design, designation and decontamination practices.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"165 ","pages":"Pages 48-56"},"PeriodicalIF":3.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of applications for reprocessing single-use devices: experiences from Taiwan","authors":"C-H. Lee ,&nbsp;M. Saffari ,&nbsp;M.A. Aljaberi ,&nbsp;C-L. Shih ,&nbsp;M.N. Potenza ,&nbsp;C-Y. Lin","doi":"10.1016/j.jhin.2025.08.001","DOIUrl":"10.1016/j.jhin.2025.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Reprocessing single-use medical devices (SUDs) is a common procedure worldwide. However, standardized guidelines are needed to ensure the quality and safety of reprocessed SUDs.</div></div><div><h3>Aim</h3><div>To examine the factors associated with SUD reprocessing in Taiwanese medical settings.</div></div><div><h3>Methods</h3><div>A standardized qualification checklist for reprocessing assessment was developed under the supervision of Taiwan's Ministry of Health and Welfare. A retrospective review of administrative data was used in the present study. Applications for reprocessing SUDs were received and analysed from 26 healthcare settings across different regions. Success rates over 12 checklist items, as well as the total success rate, were computed. Generalized estimating equations were used to identify potential associated factors with the success rates.</div></div><div><h3>Findings</h3><div>The present study results show that five medical centres, 12 regional hospitals, and nine district hospitals participated. Overall, 394 applications for reprocessing of 33 SUDs were received. Approximately 27% of applications could pass all 12 checklist items. Hospital class and location, number of employees, and annual income were associated with the overall success rate.</div></div><div><h3>Conclusion</h3><div>Because only about one-quarter of contributing hospitals could pass all criteria defined for successful evaluation of SUD reprocessing, establishing a stronger monitoring system is suggested to ensure acceptable reprocessing procedures. Further investigation of factors associated with successful evaluation of SUD reprocessing is warranted.</div></div>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":"165 ","pages":"Pages 143-152"},"PeriodicalIF":3.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BURDEN OF CARBAPENEM RESISTANT GRAM-NEGATIVE BACTERIAL INFECTIONS IN VIETNAM - A NATIONAL HOSPITAL SURVEY.","authors":"Mattias Larsson, Truong Le Van Ngoc, Nguyen Thi Dung, Do Thi Ngat, Hoang Thi Bich Ngoc, Nong Minh Vuong, Doan Mai Phuong, Truong Thai Phuong, Pham Hong Nhung, Håkan Hanberger, Le Kien Ngai, Nandini Sreenivasan, Annick Lenglet, Anders Dalsgaard, Do Duy Cuong, Linus Olson","doi":"10.1016/j.jhin.2025.03.019","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.03.019","url":null,"abstract":"<p><strong>Introduction: </strong>The WHO Bacterial Pathogen Priority List 2024 highlights Carbapenem-Resistant Gram-Negative Bacteria (CRGNB), including Enterobacterales (CRE) and Acinetobacter baumannii (CRAB), followed by Pseudomonas aeruginosa (CRPA), as top priorities due to their virulence, resistance, transmission, and limited treatment options.</p><p><strong>Objective: </strong>This national hospital survey aimed to assess the burden of CRGNB infections and evaluate microbiological laboratory capacity across Vietnam.</p><p><strong>Methods: </strong>An online survey was distributed to central hospitals and provincial Departments of Health in Vietnam's 63 provinces, which then forwarded it to district and private hospitals.</p><p><strong>Results: </strong>A total of 324 hospitals participated: 20 central, 190 provincial, 106 district, and 8 private. Half reported microbiological capacity for bacterial culture and susceptibility testing. Among 57,667 reported Gram-negative isolates, 17,417 (30.2%) were CRGNB, including Klebsiella pneumoniae (CRE 37%), Escherichia coli (CRE 11%), Acinetobacter baumannii (CRAB 64%), and Pseudomonas aeruginosa (CRPA 39%). CRE sepsis treatment included cephalosporins, aminoglycosides, carbapenems, fluoroquinolones, and colistin. CRE infections were associated with higher crude mortality (31.7% vs. 20.2%, p<0.001), longer hospital stays (10.4 vs. 8.9 days, p<0.001), and higher costs (1,025vs.1,025vs.773, p<0.001) compared to carbapenem-susceptible Enterobacterales. Reported infection prevention and control (IPC) interventions included CRE surveillance (41%), isolation (36%), point prevalence surveys (15%), and cohort care (7%). IPC funding sources included general health insurance (40%) and hospital funds (32%).</p><p><strong>Conclusion: </strong>CRGNB pose a significant burden in terms of morbidity, mortality, and financial impact. Strengthening microbiological infrastructure, improving CRGNB screening, and enhancing IPC measures are urgently needed.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}