{"title":"乌克兰急诊医院与医疗保健相关的感染和抗菌药物的使用，涉及战争治疗的伤亡：2024年的多中心横断面研究","authors":"Arkadii Vodianyk, Eugene Diomin, Andrii Husakov, Ihnat Havrilov, Artem Horbachevskyi, Jarno Habicht","doi":"10.1016/j.jhin.2025.05.015","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>True burden of healthcare associated infections (HAIs) in Ukraine remains unknown. The pilot point prevalence survey (PPS) of HAIs and antimicrobial use (AMU) was organized in Ukrainian hospitals in 2021 but data were limited and not fully represented changes in HAIs burden associated with full scale invasion of Russian Federation in 2022. PPS on HAI and AMU was conducted in 5 healthcare facilities to understand burden of HAI in Ukraine in 2024.</p><p><strong>Materials and methods: </strong>Our research was designed as multicenter cross-sectional study. Four acute care tertiary level hospitals and one specialized institution participated in the study. Patients of all ages from surgical wards, intensive care units (ICU) and medical wards were included. Data were collected on a single day for every ward, timeframe for the whole study was one month. HAI case definitions and PPS procedure were based on most recent European Center for disease control (ECDC) documents.</p><p><strong>Results: </strong>660 patients were included into the study. 83 patients had 91 HAIs, HAI prevalence was 12.6% pp. 37 (40.7%) of HAIs were present on admission and 54 (59.3%) were obtained during current hospitalization. The most frequent HAI was surgical site infection (50.5%), followed by pneumonia (12.1%), skin and soft tissue (9.9%), urinary tract (6.6%), bloodstream (5.5%) and systemic infections (5.5%). The highest prevalence of HAI (51.9% pp) was observed in ICUs, followed by 12.1% pp in surgical wards. Most common organisms were Acinetobacter (22.4%) and Klebsiella spp. (22.4%). All HAIs pathogens showed very high resistance levels (66-100%) to 3rd generation cephalosporins, glycopeptides and carbapenems. Highest use of antimicrobials was recorded in ICU (88.9% pp).</p><p><strong>Conclusions: </strong>The study discovered significant prevalence of HAI's in Ukrainian hospitals, higher than European average. Antimicrobials use rate was comparable to European, but with disproportionally high use at ICU.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Healthcare-associated infections and antimicrobial use in Ukrainian acute care hospitals, involved into casualties of war treatment: multicenter cross-sectional study in 2024.\",\"authors\":\"Arkadii Vodianyk, Eugene Diomin, Andrii Husakov, Ihnat Havrilov, Artem Horbachevskyi, Jarno Habicht\",\"doi\":\"10.1016/j.jhin.2025.05.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>True burden of healthcare associated infections (HAIs) in Ukraine remains unknown. The pilot point prevalence survey (PPS) of HAIs and antimicrobial use (AMU) was organized in Ukrainian hospitals in 2021 but data were limited and not fully represented changes in HAIs burden associated with full scale invasion of Russian Federation in 2022. PPS on HAI and AMU was conducted in 5 healthcare facilities to understand burden of HAI in Ukraine in 2024.</p><p><strong>Materials and methods: </strong>Our research was designed as multicenter cross-sectional study. Four acute care tertiary level hospitals and one specialized institution participated in the study. Patients of all ages from surgical wards, intensive care units (ICU) and medical wards were included. Data were collected on a single day for every ward, timeframe for the whole study was one month. HAI case definitions and PPS procedure were based on most recent European Center for disease control (ECDC) documents.</p><p><strong>Results: </strong>660 patients were included into the study. 83 patients had 91 HAIs, HAI prevalence was 12.6% pp. 37 (40.7%) of HAIs were present on admission and 54 (59.3%) were obtained during current hospitalization. The most frequent HAI was surgical site infection (50.5%), followed by pneumonia (12.1%), skin and soft tissue (9.9%), urinary tract (6.6%), bloodstream (5.5%) and systemic infections (5.5%). The highest prevalence of HAI (51.9% pp) was observed in ICUs, followed by 12.1% pp in surgical wards. Most common organisms were Acinetobacter (22.4%) and Klebsiella spp. (22.4%). All HAIs pathogens showed very high resistance levels (66-100%) to 3rd generation cephalosporins, glycopeptides and carbapenems. Highest use of antimicrobials was recorded in ICU (88.9% pp).</p><p><strong>Conclusions: </strong>The study discovered significant prevalence of HAI's in Ukrainian hospitals, higher than European average. Antimicrobials use rate was comparable to European, but with disproportionally high use at ICU.</p>\",\"PeriodicalId\":54806,\"journal\":{\"name\":\"Journal of Hospital Infection\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hospital Infection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jhin.2025.05.015\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hospital Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jhin.2025.05.015","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Healthcare-associated infections and antimicrobial use in Ukrainian acute care hospitals, involved into casualties of war treatment: multicenter cross-sectional study in 2024.
Background: True burden of healthcare associated infections (HAIs) in Ukraine remains unknown. The pilot point prevalence survey (PPS) of HAIs and antimicrobial use (AMU) was organized in Ukrainian hospitals in 2021 but data were limited and not fully represented changes in HAIs burden associated with full scale invasion of Russian Federation in 2022. PPS on HAI and AMU was conducted in 5 healthcare facilities to understand burden of HAI in Ukraine in 2024.
Materials and methods: Our research was designed as multicenter cross-sectional study. Four acute care tertiary level hospitals and one specialized institution participated in the study. Patients of all ages from surgical wards, intensive care units (ICU) and medical wards were included. Data were collected on a single day for every ward, timeframe for the whole study was one month. HAI case definitions and PPS procedure were based on most recent European Center for disease control (ECDC) documents.
Results: 660 patients were included into the study. 83 patients had 91 HAIs, HAI prevalence was 12.6% pp. 37 (40.7%) of HAIs were present on admission and 54 (59.3%) were obtained during current hospitalization. The most frequent HAI was surgical site infection (50.5%), followed by pneumonia (12.1%), skin and soft tissue (9.9%), urinary tract (6.6%), bloodstream (5.5%) and systemic infections (5.5%). The highest prevalence of HAI (51.9% pp) was observed in ICUs, followed by 12.1% pp in surgical wards. Most common organisms were Acinetobacter (22.4%) and Klebsiella spp. (22.4%). All HAIs pathogens showed very high resistance levels (66-100%) to 3rd generation cephalosporins, glycopeptides and carbapenems. Highest use of antimicrobials was recorded in ICU (88.9% pp).
Conclusions: The study discovered significant prevalence of HAI's in Ukrainian hospitals, higher than European average. Antimicrobials use rate was comparable to European, but with disproportionally high use at ICU.
期刊介绍：
The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience.
The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that:
provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings;
provide new insight into cleaning, disinfection and decontamination;
provide new insight into the design of healthcare premises;
describe novel aspects of outbreaks of infection;
throw light on techniques for effective antimicrobial stewardship;
describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control;
improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change;
improve understanding of the use of IT systems in infection surveillance and prevention and control.
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