Healthcare-associated infections and antimicrobial use in Ukrainian acute care hospitals, involved into casualties of war treatment: multicenter cross-sectional study in 2024.

IF 3.9 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection Pub Date : 2025-06-06 DOI:10.1016/j.jhin.2025.05.015

Arkadii Vodianyk, Eugene Diomin, Andrii Husakov, Ihnat Havrilov, Artem Horbachevskyi, Jarno Habicht

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引用次数: 0

Abstract

Background: True burden of healthcare associated infections (HAIs) in Ukraine remains unknown. The pilot point prevalence survey (PPS) of HAIs and antimicrobial use (AMU) was organized in Ukrainian hospitals in 2021 but data were limited and not fully represented changes in HAIs burden associated with full scale invasion of Russian Federation in 2022. PPS on HAI and AMU was conducted in 5 healthcare facilities to understand burden of HAI in Ukraine in 2024.

Materials and methods: Our research was designed as multicenter cross-sectional study. Four acute care tertiary level hospitals and one specialized institution participated in the study. Patients of all ages from surgical wards, intensive care units (ICU) and medical wards were included. Data were collected on a single day for every ward, timeframe for the whole study was one month. HAI case definitions and PPS procedure were based on most recent European Center for disease control (ECDC) documents.

Results: 660 patients were included into the study. 83 patients had 91 HAIs, HAI prevalence was 12.6% pp. 37 (40.7%) of HAIs were present on admission and 54 (59.3%) were obtained during current hospitalization. The most frequent HAI was surgical site infection (50.5%), followed by pneumonia (12.1%), skin and soft tissue (9.9%), urinary tract (6.6%), bloodstream (5.5%) and systemic infections (5.5%). The highest prevalence of HAI (51.9% pp) was observed in ICUs, followed by 12.1% pp in surgical wards. Most common organisms were Acinetobacter (22.4%) and Klebsiella spp. (22.4%). All HAIs pathogens showed very high resistance levels (66-100%) to 3rd generation cephalosporins, glycopeptides and carbapenems. Highest use of antimicrobials was recorded in ICU (88.9% pp).

Conclusions: The study discovered significant prevalence of HAI's in Ukrainian hospitals, higher than European average. Antimicrobials use rate was comparable to European, but with disproportionally high use at ICU.

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乌克兰急诊医院与医疗保健相关的感染和抗菌药物的使用，涉及战争治疗的伤亡：2024年的多中心横断面研究

背景：乌克兰卫生保健相关感染（HAIs）的真正负担仍然未知。2021年在乌克兰各医院组织了HAIs和抗菌素使用（AMU）的试点流行率调查（PPS），但数据有限，不能完全反映与2022年俄罗斯联邦全面入侵相关的HAIs负担的变化。在乌克兰5个卫生保健机构中进行了关于HAI和AMU的PPS，以了解2024年乌克兰HAI的负担。材料与方法：本研究采用多中心横断面研究。4家三级急症医院和1家专科医院参与了研究。包括来自外科病房、重症监护病房（ICU）和内科病房的所有年龄的患者。每个病房在一天内收集数据，整个研究的时间框架为一个月。HAI病例定义和PPS程序基于最新的欧洲疾病控制中心（ECDC）文件。结果：660例患者纳入研究。83例患者有91例HAI，患病率为12.6%。37例HAI（40.7%）在入院时出现，54例HAI（59.3%）在本次住院期间出现。最常见的HAI是手术部位感染（50.5%），其次是肺炎（12.1%）、皮肤和软组织（9.9%）、尿路（6.6%）、血液（5.5%）和全身感染（5.5%）。icu病房的HAI发生率最高（51.9%），其次是外科病房（12.1%）。最常见的微生物是不动杆菌（22.4%）和克雷伯氏菌（22.4%）。所有HAIs病原菌对第三代头孢菌素、糖肽类和碳青霉烯类均表现出很高的耐药水平（66% -100%）。ICU的抗菌药物使用率最高（88.9%）。结论：该研究发现乌克兰医院的HAI患病率显著高于欧洲平均水平。抗菌药物使用率与欧洲相当，但ICU使用率高得不成比例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hospital Infection 医学-传染病学

CiteScore

12.70

自引率

5.80%

发文量

271

审稿时长

19 days

期刊介绍： The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience. The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that: provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings; provide new insight into cleaning, disinfection and decontamination; provide new insight into the design of healthcare premises; describe novel aspects of outbreaks of infection; throw light on techniques for effective antimicrobial stewardship; describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control; improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change; improve understanding of the use of IT systems in infection surveillance and prevention and control.