Journal of Hospital Infection最新文献

{"title":"Impact on peripheral catheter failure with the use of an extension set with integrated needless connector compared to a straight hub: a prospective quasi-experimental study.","authors":"Marta Piriz-Marabajan, Alexander Rombauts, Nerea Roch-Villaverde, Ana Pilar Cortes-Palacios, Engracia Fernandez-Piqueras, Susana Serrano-Condal, Marta Taltavull-Menendez, Sara Grillo, Antonella Francesca Simonetti, Pol Duch, Virginia Pomar-Solchaga, Laura Escolà-Vergé, Joaquin Lopez-Contreras","doi":"10.1016/j.jhin.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.09.009","url":null,"abstract":"<p><strong>Background: </strong>Peripheral intravenous catheter (PIVC) failure is a significant clinical issue. Evidence is needed on the impact of different PIVC systems on outcomes.</p><p><strong>Aim: </strong>To analyze the effect of add-on extension sets with integrated connectors on PIVC outcomes in real-world practice.</p><p><strong>Methods: </strong>A prospective, open-label, quasi-experimental study with blinded analyst was conducted at a tertiary hospital in Barcelona, Spain, comparing two PIVC systems. The control system (standard winged PIVC with add-on needleless connector) was evaluated from March 1 to April 6, 2022, and the study system (with add-on extension set and integrated needleless connector) from September 9 to December 14, 2023. The primary endpoint was overall PIVC failure per 1000 catheter-days, analyzed as relative rate.</p><p><strong>Findings: </strong>A total of 1019 PIVCs (607 patients) in the control group and 1028 PIVCs (634 patients) in the study group were followed. Groups had similar hospital stay, dwell times, and mortality. Patients in the study group were more likely to have heart disease, COPD, and be physically restrained. Overall, 795 (39.7%) PIVCs failed, a rate of 86.0 per 1000 catheter-days. The most common reasons for unplanned removal were extravasation (10.6%), occlusion (8.1%), accidental removal (7.7%), phlebitis (7.4%), and discomfort (5.5%). PIVC failure was significantly lower in the study group compared with control (37.2% vs. 42.1%, p = 0.025). Failure per 1000 catheter-days showed a non-significant reduction (RR = 0.89; 95% CI 0.77-1.03).</p><p><strong>Conclusion: </strong>PIVC failure remains high. A PIVC with add-on extension and integrated needleless connector did not show a statistically significant reduction in failure rate.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory-Acquired Infections in the MENA Region: A Systematic Review of Reported Cases and Biosafety Gaps.","authors":"Maha M Ayoub, Faizah D Retnowati, Asma Maliha, Rafia Anjum, Marawan Abu-Madi, Atiyeh M Abdallah","doi":"10.1016/j.jhin.2025.09.010","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.09.010","url":null,"abstract":"<p><strong>Background: </strong>Laboratory-acquired infections (LAIs) are a significant occupational health hazard to laboratory workers. Laboratory personnel can become infected by various pathogens handled as part of their work, including bacteria, fungi, viruses, and parasites. Despite their importance, data on LAI in the Middle East and North Africa (MENA) regions are limited. The aim of this study was to systematically review the reported LAIs in the MENA region to identify gaps in biosafety practices and identify the most common infectious agents contributing to them.</p><p><strong>Methods: </strong>The PubMed, Scopus, LAI, and Belgian Biosafety Server (BBS) databases were searched from conception to October 2024 for any reports and cases of LAIs in the MENA region, following PRISMA guidelines. Using a systematic strategy, inclusion criteria were relevant studies reporting cases involving MENA laboratory workers. Non-laboratory cases or studies with insufficient data were excluded. Quality was assessed using a specific quality assessment tool for case reports and case series. Reported cases were analyzed by infection type, risk factors, and laboratory practices.</p><p><strong>Results: </strong>Of 2,062 studies, 12 articles (24 cases) from Egypt, Saudi Arabia, Turkey, and UAE were considered eligible for inclusion. Twenty-four LAI cases were reported in the MENA region between 1968 and 2016. Brucella melitensis was the most frequently reported pathogen, reported in 66.7% of cases, highlighting a specific occupational risk in microbiology laboratories in the region. The review also identified gaps in data reporting, variability in laboratory biosafety practices, and a tendency towards underreporting.</p><p><strong>Conclusions: </strong>This review highlights the occupational health risks posed by LAIs in the MENA region, with Brucella spp. identified as the predominant pathogens in reported cases, and it also identifies gaps in biosafety practices. Limitations include underreporting and English-only searches. No funding was received.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of spatial distance in SARS-CoV-2 nosocomial transmission.","authors":"C J R Illingworth, G Yahiaoui, M Butler, R C Brock, C Peters, R Thaxter, S Evans, T Gouliouris, A Conway Morris, C B Beggs, E Vanoli, C Crawford, V L Keevil, R J B Goudie","doi":"10.1016/j.jhin.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.09.011","url":null,"abstract":"<p><strong>Background: </strong>The nosocomial transmission of respiratory viruses causes significant disruption to hospital care, but the spatial dynamics of transmission on hospital wards are poorly understood.</p><p><strong>Methods: </strong>We developed a model integrating computational fluid dynamics (CFD) simulations into an epidemiological reconstruction of virus transmission to quantify the relationship between SARS-CoV-2 transmission and the location of beds in medicine for the elderly wards.</p><p><strong>Findings: </strong>Data from CFD simulations described a pattern in which exposure to an infected host decreased by approximately 40% for each additional metre of distance, with a further four-fold reduction when patients were in separate rooms. However, statistical inference suggested that only 72% (95% C. I. 45% to 96%) of the transmission events identified on wards could be explained by this model. Other cases of transmission occurred at distances too great to be consistent with the simulation model, suggesting that distance-independent mechanisms such as shared facilities or staff-mediated transmission had an important role in nosocomial transmission.</p><p><strong>Interpretation: </strong>Our results suggest that while spatial separation reduces transmission risk, infection prevention and control strategies such as the use of single-bed rooms may be insufficient to prevent outbreaks. Comprehensive approaches to preventing nosocomial transmission, addressing multiple potential viral transmission pathways, are necessary.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance and the invisible casualties of conflict.","authors":"Jennifer Broom, Alex Broom","doi":"10.1016/j.jhin.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.09.003","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Delhi Metallo-beta-lactamase-NDM-producing Pseudomonas aeruginosa: a legacy of the pandemic.","authors":"Monica de Souza Ferreira de Mattos, Sheila Alexandra Belini Nishiyama, Fabrícia Gimenes, Mariana de Oliveira Ripol, Hilton Vizzi Martinez, Cecília Saori Mitsugui, Heloisa Moreira Dias Pereira, Maria Cristina Bronharo Tognim","doi":"10.1016/j.jhin.2025.09.016","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.09.016","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection prevention and control in burns services: Starting the conversation for a unique patient group.","authors":"P A Jumaa, M A Mugglestone","doi":"10.1016/j.jhin.2025.08.015","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.08.015","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing healthcare workers as potential stool donors for faecal microbiota transplantation: a cross-sectional study of antimicrobial-resistant gut bacteria and enteropathogenic microorganisms.","authors":"María Bonilla-Moreno, Catalina Medina-Gómez, Daiana Guevara-Núñez, Lucía Saiz-Escobedo, Sara Martí, M Ángeles Domínguez, Anna Carrera-Salinas, Graciela Rodríguez-Sevilla","doi":"10.1016/j.jhin.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.09.004","url":null,"abstract":"<p><strong>Background: </strong>Faecal Microbiota Transplantation (FMT) is a procedure designed to modulate the gut microbiome, but identifying reliable stool donors remains challenging. We conducted a study at Bellvitge University Hospital to assess the prevalence of enteropathogenic microorganisms (EPs) and antimicrobial-resistant (AMR) gut bacteria among healthcare workers (HCWs) and evaluate their potential as stool donors.</p><p><strong>Methods: </strong>From November 2022 to April 2023, 106 HCWs were enrolled. Stool samples were tested for a range of EPs using real-time PCR and conventional methods, while AMR gut bacteria were screened using selective culture media. 16SrRNA sequencing was performed, and alpha-diversity was assessed using the Shannon index.</p><p><strong>Findings: </strong>EPs were found in 48.1% of samples (51/106), with protozoa being the most prevalent (37.7%, 40/106), followed by bacteria (10.4%, 11/106) and viruses (4.7%, 5/106). Blastocystis hominis (33%, 35/106) and Dientamoeba fragilis (18.8%, 20/106) were the most common protozoa, while Enteropathogenic Escherichia coli was the most frequent bacterial pathogen (3.8%, 4/106). Extended spectrum β-lactamase-producing E. coli was found in 2.8% of samples (3/106). Carbapenemase-producing bacteria, vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus or Clostridioides difficile were not present in any sample. HCWs with B. hominis had significantly higher Shannon alpha-diversity than those without (p < 0.01).</p><p><strong>Conclusion: </strong>The prevalence of EPs and AMR gut bacteria among HCWs supports the inclusion of HCWs as potential stool donors for FMT, provided they meet health and screening criteria. This approach could help address the shortage of suitable stool donors for FMT programs.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and implementation of an electronic admission-screening tool for Candidozyma auris (formerly Candida auris) at a large healthcare system in Miami, FL.","authors":"Adriana Jimenez, Rossana Rosa, Nathalie Jean, Ashley Flanagan, Kelley Manzanillo Mshia, Gemma Rosello, Lilian M Abbo","doi":"10.1016/j.jhin.2025.08.012","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.08.012","url":null,"abstract":"<p><strong>Objectives: </strong>Candidozyma auris is an urgent public health threat pathogen worldwide. We describe using and implementing an electronic questionnaire to screen all patients for risk factors associated with C. auris upon admission to all facilities within a large healthcare system in Miami, Florida.</p><p><strong>Methods: </strong>We implemented a screening questionnaire within the electronic medical record (EMR) applied at the point-of-entry to all inpatient admissions. The tool asked about risk factors for C. auris colonization and included: previous history of C. auris, overnight hospital stay outside the United States in the last 12 months, tracheostomy or mechanical ventilation present on admission, transfer from a healthcare facility with high risk for C. auris, or history of carbapenemase-producing organism. The questionnaire triggered C. auris colonization testing using polymerase chain reaction (PCR) and initiation of contact precautions for those with identified risk(s).</p><p><strong>Results: </strong>During a 12-month period, the questionnaire was applied to 83,046 admissions. Of those, 4,401 (5.3%) had at least one risk factor for C. auris colonization. Of those tested, 166 (6.1%) were positive by PCR. The overall prevalence was 0.20%. The question with highest positivity was \"arriving from another healthcare facility\" (4.5%), and having a previous history of MDRO was the factor with the highest percent positivity on PCR (16%).</p><p><strong>Conclusion: </strong>Screening questionnaires incorporated in EMR are effective means to detect patients at risk for C. auris colonization, thus facilitating the early implementation of infection prevention and control measures aimed at avoiding the horizontal spread of highly transmissible organisms in healthcare facilities.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inclusion of Emergency Department attendance on classification of Clostridioides difficile infections onset status: A revised definition.","authors":"Antoine Salzmann, Akaninyene Otu, Olisaeloka Nsonwu, Christopher R Bell, Colin S Brown, Dakshika Jeyaratnam, Russell Hope, Dimple Chudasama","doi":"10.1016/j.jhin.2025.08.013","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.08.013","url":null,"abstract":"<p><p>Algorithms used to classify Clostridioides difficile infection (CDI) as hospital- or community-onset have commonly relied on the duration between patient hospital admission and specimen date for classification. This however fails to account for patient stays in emergency departments prior to inpatient hospital admission. The UK Health Security Agency (UKHSA) addresses this concern in a revised definition, implemented as of April 2024. In England, from April 2020 to March 2024, conventional definitions led to 6.7% of hospital-onset CDI cases being misclassified as community-onset. These findings reinforce the rationale for updating England's CDI onset definition, ensuring more accurate and standardized CDI categorisation.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability of Andes virus and its inactivation by WHO-recommended hand rub formulations and surface disinfectants.","authors":"Benjamin Erik Nilsson-Payant, Ranya Fatima Dafi, Selina Krüger, Maria Rosenthal, Daniel Todt, Marylyn Martina Addo, Eike Steinmann, Toni Luise Meister","doi":"10.1016/j.jhin.2025.08.010","DOIUrl":"https://doi.org/10.1016/j.jhin.2025.08.010","url":null,"abstract":"<p><strong>Introduction: </strong>Hantaviruses are responsible for thousands of infections globally. In the absence of vaccines or targeted treatments for severe diseases such as haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), medical care focuses solely on managing symptoms. As a result, preventive hygiene measures, such as disinfection, are essential to reduce transmission and minimize the virus's impact on human health.</p><p><strong>Methodology: </strong>Thus, the virucidal activity of hand antiseptics against ANDV was assessed using a quantitative suspension test in accordance with the European guideline EN14476. Surface disinfection efficacy was evaluated according to EN16777 and virus stability was assessed on stainless steel.</p><p><strong>Results: </strong>In this study, we found that the WHO-recommended hand rub formulations I and II effectively inactivate Andes virus (ANDV) - a prototypic highly pathogenic New World hantavirus - at concentrations of 30% and 20%, respectively. Although ANDV exhibited relatively low stability on stainless steel discs, infectious virus could still be detected days post-contamination. However, disinfection of these surfaces using a variety of alcohol-, aldehyde-, and hydrogen peroxide-based disinfectants completely eliminated viral infectivity.</p><p><strong>Conclusion: </strong>These findings indicate that ANDV has lower environmental stability compared to other enveloped viruses and can be effectively inactivated by all disinfectants tested. This data can inform risk assessments, especially in areas where hantavirus outbreaks are common, and guide cleaning protocols for both healthcare environments and high-risk public spaces.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}