Journal of Hospital Infection最新文献

{"title":"Vaccination of healthcare workers against mpox: a call for action.","authors":"Giuseppe Lippi, Brandon M Henry, John G Rizk","doi":"10.1016/j.jhin.2024.10.007","DOIUrl":"https://doi.org/10.1016/j.jhin.2024.10.007","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous tunneling versus conventional insertion of peripherally inserted central catheters in hospitalized patients (TUNNEL-PICC): a multicentre, open-label, randomized, controlled trial.","authors":"Eung Tae Kim, Jae Hwan Lee, Dong Jae Shim, Yohan Kwon, Soo Buem Cho, Ki Jun Kim, Doyoung Kim, Jinoo Kim, Eu Suk Kim, Hoyong Jun, Youn Jeong Kim, Jinyeong Kim, Eun Jin Kim, Chung-Jong Kim, Kang-Il Jun, Myoung Jin Shin, Chang Jin Yoon, Seungjae Lee, Soon-Young Song, Je Hwan Won","doi":"10.1016/j.jhin.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.jhin.2024.10.008","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate whether subcutaneous tunneling in peripherally inserted central catheters (PICC) placement could reduce the occurrence of central-line associated blood stream infection (CLABSI).</p><p><strong>Methods: </strong>We conducted an open-label, multicentre, randomized, controlled trial in five tertiary hospitals. Adult hospitalized patients requiring a PICC were randomized in a one-to-one ratio to conventional (cPICC) or tunneled PICC (tPICC) arms using a centralized web-based computer-generated stratified randomization. CLABSI rates between groups were compared in a modified intention-to-treat population. Safety including the incidence of exit-site infection or hemorrhage-associated catheter removal were also compared. This trial was registered with Clinical Research Information Service of Republic of Korea (KCT0005521).</p><p><strong>Results: </strong>From November 2020 to March 2023, 1,324 participants were enrolled and randomly assigned to tPICC (n=662) and cPICC (n=662). This study was terminated early due to the cohort CLABSI rate being lower than estimated, therefore, the original sample size of 1,694 would render the study underpowered to detect a difference in CLABSI rates. In the tPICC, CLABSI occurred in 13 of 651 participants over 11,071 catheter-days (1.2/1,000 catheter-days), compared with 20 among 650 patients with cPICC over 11,141 catheter-days (1.8/1,000 catheter-days, rate ratio 0.65, 95% CI 0.30-1.38, p=0.30). The incidence of exit-site infection (29 tPICC, 36 cPICC, p=0.5) and hemorrhage-associated catheter removal (11 tPICC, 11 cPICC, p=0.99) was not different between both groups.</p><p><strong>Conclusion: </strong>Due to insufficient sample size, this study could not demonstrate a statistically significant CLABSI risk reduction in the tPICC group compared to the cPICC group. Both groups had similar rates of exit site infection and bleeding.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borderline oxacillin-resistant Staphylococcus aureus: an emerging threat in the hospital environment.","authors":"Gareth Hughes, Susan Wilkinson, Jean Harker, Itisha Gupta, Elisabeth Holden, Mark Garvey","doi":"10.1016/j.jhin.2024.09.029","DOIUrl":"https://doi.org/10.1016/j.jhin.2024.09.029","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the clinic to the wards, the evolution of penicillin allergy testing by non-allergists in a UK hospital.","authors":"Cassandra Watson, Shiv Shah, Fatema Hassan, Tina Suri, Deepa Joseph, Guduru Gopal Rao, Alastair McGregor","doi":"10.1016/j.jhin.2024.09.026","DOIUrl":"https://doi.org/10.1016/j.jhin.2024.09.026","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators for using administrative data for surveillance purpose: A narrative overview.","authors":"Virginie Boulanger, Anne MacLaurin, Caroline Quach","doi":"10.1016/j.jhin.2024.09.027","DOIUrl":"https://doi.org/10.1016/j.jhin.2024.09.027","url":null,"abstract":"<p><p>Although administrative data are not originally intended for surveillance purposes, they are frequently used for monitoring public health and patient safety. This article provides a narrative overview of the barriers and facilitators for the use of administrative data for surveillance, with a focus on healthcare-associated infection (HAI) in Canada. In this case, only articles on administrative data in general or related to HAI were included. Validation study and meta-analyses on administrative data accuracy were excluded. Medline, Embase and Google Scholar were searched as well as references list of all included articles, for a total of 90 articles included. Our analysis identifies 78 barriers at the individual, organizational and systemic levels and outlines 75 facilitators and solutions to improve administrative data utilization and quality. This narrative overview will help to understand barriers, facilitators and offer practical recommendations for optimizing the use of administrative data.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of Mycobacterium gordonae in heater-cooler units: a five-year prospective surveillance of devices frequently subjected to chloramine-T booster disinfection.","authors":"S Ditommaso, J Garlasco, G Memoli, A Curtoni, A Bondi, A Ceccarelli, M Giacomuzzi","doi":"10.1016/j.jhin.2024.10.006","DOIUrl":"10.1016/j.jhin.2024.10.006","url":null,"abstract":"<p><strong>Background: </strong>Worldwide, the detection of Mycobacterium chimaera in LivaNova heater-cooler units (HCUs) has led to their replacement with other HCUs, although non-tuberculous mycobacteria (NTM) have been reported also for HCUs produced by other manufacturers. In almost all hospitals of our region, LivaNova HCUs have been replaced with Maquet HCU40s, regularly disinfected with chloramine-T.</p><p><strong>Aim: </strong>To report the results of the surveillance over a 63-month operation period of the Maquet devices, and to provide a trend in NTM positivity over time.</p><p><strong>Methods: </strong>Twenty-nine Maquet devices (HCU40 and HU35) were monitored by two culture methods and propidium monoazide polymerase chain reaction (PMA-PCR) method. The trend in NTM positivity rate was evaluated through the Locally Estimated Scatterplot Smoothing regression and then modelled over time through segmented logistic regression.</p><p><strong>Findings: </strong>The data acquired during the study period demonstrate a remarkable increase in the positivity rate, especially after the third year (maximum slope change at 1280 days). Non-tuberculous mycobacteria were isolated in 150 water samples (37.2%); 100% and 62% of HCU40 and HU35 devices, respectively, were colonized with non-tuberculous mycobacteria. The most frequently detected species were Mycobacterium gordonae (73%) followed by Mycobacterium chelonae (41%) and Mycobacterium paragordonae (11%).</p><p><strong>Conclusion: </strong>Preventive strategies by disinfection with chloramine-T did not effectively reduce non-tuberculous mycobacteria colonization of Maquet devices. Although, to date, no cases of postoperative invasive infections linked to Maquet devices have been reported, our microbiological results emphasize the need for (1) designing changes to increase safety of devices and (2) researching and developing new disinfection protocols including alternative molecules.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serratia marcescens outbreak at a neonatal intensive care unit in an acute care tertiary hospital in Singapore.","authors":"Bushra Shaik Ismail, Xian Toh Hui, Hua Seah Jia, Yuen Tan Kwee, Chee Lee Lai, Yann Tay Yih, Chue Khong Kum, Mei Audrey Seet Wai, Katherine Concepcion Tesalona, Hao Alvin Ngeow Jia, Ying Selina Ho Kah, Bing Poon Woei, Mun Deborah Lai Chooi, Ko Karrie Kwan Ki, Lin Ling Moi","doi":"10.1016/j.jhin.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.jhin.2024.10.002","url":null,"abstract":"<p><strong>Objective: </strong>To report the epidemiological, diagnostic, and genetic investigation of an outbreak of neonatal patients infected or colonized with Serratia marcescens (S. marcescens) including the infection control interventions.</p><p><strong>Design: </strong>Outbreak investigation report.</p><p><strong>Setting: </strong>28-bedded neonatal unit in an acute care tertiary hospital in Singapore divided into three areas: two negative-pressure airborne infection isolation rooms with a shared anteroom, 10 neonatal intensive care unit (NICU) beds, and 16 high dependency beds.</p><p><strong>Patients: </strong>A total of five neonates were involved in this outbreak.</p><p><strong>Methods: </strong>Screening of in-flight patients and their immediate environment for S. marcescens to determine probable environmental sources, whole genome sequencing (WGS) analysis of resulting isolates to determine clone-relatedness and possible transmission patterns. Implementation of infection control interventions included prompt isolation of cases, enhanced equipment and environmental disinfection, use of alcohol-based hand rub as the preferred hand hygiene mode, enhanced infection prevention orientation for parents, review of practices, audits, and immediate feedback on non-compliance.</p><p><strong>Results: </strong>Five neonates infected or colonized with S. marcescens were involved in this outbreak. Four were infection cases whilst one identified through contact tracing. Three NICU sinks and the milk preparation room sink were tested positive for S. marcescens. WGS confirmed clonality of strains from two NICU sinks, and milk preparation room sink with that of the five neonates.</p><p><strong>Conclusion: </strong>Multiprong strategy was required to contain this outbreak. WGS analysis showed association of biofilms in sinks with the outbreak.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Use of Fourier-Transform Infrared Spectroscopy as a Rapid Screening Tool for Investigating Nosocomial Outbreaks of ST-80 Vancomycin-Resistant Enterococcus faecium.","authors":"River Chun-Wai Wong, Ingrid Yu-Ying Cheung, Christopher Koon-Chi Lai, Man-Ting Yuk, Viola Chi-Ying Chow, Jake Siu-Lun Leung, Nok-Ki Chau, Luis Kohei Konishi, Lam-Kwong Lee, Iain Chi-Fung Ng, Wing-Yin Tam, Jasmine Ho-Ching Tong, Gilman Kit-Hang Siu","doi":"10.1016/j.jhin.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.jhin.2024.10.005","url":null,"abstract":"<p><p>Core genome single-nucleotide polymorphism phylogeny was used to characterise a nosocomial outbreak caused by ST-80 Vancomycin-resistant Enterococcus faecium (VREf). It identified 22 of 25 epidemiologically related isolates as belonging to an outbreak cluster. The use of Fourier-transform infrared (FT-IR) spectroscopy with a cluster-defining cut-off of 0.071 resulted in the correct classification of 21 of 22 phylogenetically related isolates in a single cluster. It successfully distinguished three phylogenetically unrelated isolates from the outbreak cluster, along with five ST-80 unrelated control isolates, and five isolates from a previous outbreak in May 2023, yielding only one mischaracterised environmental isolate. These findings support the potential use of FT-IR spectroscopy as a rapid screening tool to assist outbreak investigations. Notably, this study is the first to focus on the performance of FT-IR spectroscopy in the epidemiological analysis of VREf isolates with the same sequence type.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Kiernan et al - Is detergent-only cleaning paired with chlorine disinfection the best approach for cleaning?","authors":"Catherine Boswell, John Scott, Lisa Ritchie","doi":"10.1016/j.jhin.2024.09.025","DOIUrl":"https://doi.org/10.1016/j.jhin.2024.09.025","url":null,"abstract":"","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative incidence of vancomycin-resistant Enterococcus faecium detection by patient characteristics or possible exposures: prioritization of patients for active screening culture.","authors":"K Furuya, T Yamagishi, K Suzuki, K Sugiyama, M Yamamoto, M Koyama, A Yamada, R Sasaki, J Kurioka, H Kurai, K Tanaka, M Nakagawa, Y Kanazawa, S Onoda, H Inoue, M Koshiko, H Kurosu, T Shimada, T Sunagawa, M Sugai, Y Hakamata","doi":"10.1016/j.jhin.2024.08.013","DOIUrl":"10.1016/j.jhin.2024.08.013","url":null,"abstract":"<p><strong>Background: </strong>The target population for active surveillance culture (ASC) of vancomycin-resistant Enterococcus species (VRE) by stool or rectal swabs has not been fully determined during VRE outbreaks in healthcare settings in non-VRE endemic situation.</p><p><strong>Aim: </strong>To evaluate cumulative incidences of VRE detection during a vancomycin-resistant Enterococcus faecium outbreak to determine reasonable target populations for ASC.</p><p><strong>Methods: </strong>Cases included inpatients whose first VRE-positive sample was obtained at Shizuoka General Hospital between February 2022 and January 2023, during which we conducted admission screening for possible high-risk patients, bi-weekly screening of all inpatients, admission and discharge screening in the high-care unit, and screening of contacts in each ward using stool or rectal samples. We calculated cumulative incidences of VRE detection for those screened by patient characteristics or possible exposure.</p><p><strong>Findings: </strong>Among 60 cases identified, 55 (92%) were by ASC. Cumulative incidence was higher for contacts (6.4%, 15/234) than for those identified by other screening methods (0.5%, 40/8565). Among the patients identified through admission screening, those previously hospitalized in areas of reported VRE outbreaks had the highest cumulative incidence (6.6%, 5/78) followed by patients requiring toilet assistance (3.7%, 6/161). A bundle approach including ASC and prompt contact precautions by the hospital infection control team, local public health centre, and local and national infection control experts helped terminate the outbreak in seven months.</p><p><strong>Conclusion: </strong>Patients with contacts, prior hospitalization in areas with known VRE outbreaks, and who need toilet assistance appear to be high-risk populations for VRE detection and are candidates for ASC.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}