C J R Illingworth, G Yahiaoui, M Butler, R C Brock, C Peters, R Thaxter, S Evans, T Gouliouris, A Conway Morris, C B Beggs, E Vanoli, C Crawford, V L Keevil, R J B Goudie
{"title":"空间距离在SARS-CoV-2医院传播中的作用","authors":"C J R Illingworth, G Yahiaoui, M Butler, R C Brock, C Peters, R Thaxter, S Evans, T Gouliouris, A Conway Morris, C B Beggs, E Vanoli, C Crawford, V L Keevil, R J B Goudie","doi":"10.1016/j.jhin.2025.09.011","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The nosocomial transmission of respiratory viruses causes significant disruption to hospital care, but the spatial dynamics of transmission on hospital wards are poorly understood.</p><p><strong>Methods: </strong>We developed a model integrating computational fluid dynamics (CFD) simulations into an epidemiological reconstruction of virus transmission to quantify the relationship between SARS-CoV-2 transmission and the location of beds in medicine for the elderly wards.</p><p><strong>Findings: </strong>Data from CFD simulations described a pattern in which exposure to an infected host decreased by approximately 40% for each additional metre of distance, with a further four-fold reduction when patients were in separate rooms. However, statistical inference suggested that only 72% (95% C. I. 45% to 96%) of the transmission events identified on wards could be explained by this model. Other cases of transmission occurred at distances too great to be consistent with the simulation model, suggesting that distance-independent mechanisms such as shared facilities or staff-mediated transmission had an important role in nosocomial transmission.</p><p><strong>Interpretation: </strong>Our results suggest that while spatial separation reduces transmission risk, infection prevention and control strategies such as the use of single-bed rooms may be insufficient to prevent outbreaks. Comprehensive approaches to preventing nosocomial transmission, addressing multiple potential viral transmission pathways, are necessary.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of spatial distance in SARS-CoV-2 nosocomial transmission.\",\"authors\":\"C J R Illingworth, G Yahiaoui, M Butler, R C Brock, C Peters, R Thaxter, S Evans, T Gouliouris, A Conway Morris, C B Beggs, E Vanoli, C Crawford, V L Keevil, R J B Goudie\",\"doi\":\"10.1016/j.jhin.2025.09.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The nosocomial transmission of respiratory viruses causes significant disruption to hospital care, but the spatial dynamics of transmission on hospital wards are poorly understood.</p><p><strong>Methods: </strong>We developed a model integrating computational fluid dynamics (CFD) simulations into an epidemiological reconstruction of virus transmission to quantify the relationship between SARS-CoV-2 transmission and the location of beds in medicine for the elderly wards.</p><p><strong>Findings: </strong>Data from CFD simulations described a pattern in which exposure to an infected host decreased by approximately 40% for each additional metre of distance, with a further four-fold reduction when patients were in separate rooms. However, statistical inference suggested that only 72% (95% C. I. 45% to 96%) of the transmission events identified on wards could be explained by this model. Other cases of transmission occurred at distances too great to be consistent with the simulation model, suggesting that distance-independent mechanisms such as shared facilities or staff-mediated transmission had an important role in nosocomial transmission.</p><p><strong>Interpretation: </strong>Our results suggest that while spatial separation reduces transmission risk, infection prevention and control strategies such as the use of single-bed rooms may be insufficient to prevent outbreaks. Comprehensive approaches to preventing nosocomial transmission, addressing multiple potential viral transmission pathways, are necessary.</p>\",\"PeriodicalId\":54806,\"journal\":{\"name\":\"Journal of Hospital Infection\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hospital Infection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jhin.2025.09.011\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hospital Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jhin.2025.09.011","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
The role of spatial distance in SARS-CoV-2 nosocomial transmission.
Background: The nosocomial transmission of respiratory viruses causes significant disruption to hospital care, but the spatial dynamics of transmission on hospital wards are poorly understood.
Methods: We developed a model integrating computational fluid dynamics (CFD) simulations into an epidemiological reconstruction of virus transmission to quantify the relationship between SARS-CoV-2 transmission and the location of beds in medicine for the elderly wards.
Findings: Data from CFD simulations described a pattern in which exposure to an infected host decreased by approximately 40% for each additional metre of distance, with a further four-fold reduction when patients were in separate rooms. However, statistical inference suggested that only 72% (95% C. I. 45% to 96%) of the transmission events identified on wards could be explained by this model. Other cases of transmission occurred at distances too great to be consistent with the simulation model, suggesting that distance-independent mechanisms such as shared facilities or staff-mediated transmission had an important role in nosocomial transmission.
Interpretation: Our results suggest that while spatial separation reduces transmission risk, infection prevention and control strategies such as the use of single-bed rooms may be insufficient to prevent outbreaks. Comprehensive approaches to preventing nosocomial transmission, addressing multiple potential viral transmission pathways, are necessary.
期刊介绍：
The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience.
The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that:
provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings;
provide new insight into cleaning, disinfection and decontamination;
provide new insight into the design of healthcare premises;
describe novel aspects of outbreaks of infection;
throw light on techniques for effective antimicrobial stewardship;
describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control;
improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change;
improve understanding of the use of IT systems in infection surveillance and prevention and control.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
