New Microbiologica最新文献_第7页

Multidrug resistance and high genotypic diversity in Campylobacter upsaliensis from household dogs in Metro Manila, Philippines. 菲律宾马尼拉大都会家犬上沙弯曲杆菌的多药耐药性和高基因型多样性。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-09-01

Ma Socorro Edden Palacio Subejano, Gil Mallari Penuliar

引用次数: 0

Thanatomicrobiome in forensic medicine. 法医学中的Thanatomicrobiome。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-09-01

Ahlam Abdoun, Nadir Amir, Mokrane Fatima

引用次数: 0

The investigation of community-acquired and nosocomial respiratory syncytial virus and other viral respiratory tract infections in children. 儿童社区获得性和医院感染呼吸道合胞病毒及其他病毒性呼吸道感染的调查。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-09-01

Serap Özen, Özden Özgür Horoz, Gökhan Öztürk, Huri Sökmen, Tülay Kandemir, Fügen Yarkin

{"title":"The investigation of community-acquired and nosocomial respiratory syncytial virus and other viral respiratory tract infections in children.","authors":"Serap Özen, Özden Özgür Horoz, Gökhan Öztürk, Huri Sökmen, Tülay Kandemir, Fügen Yarkin","doi":"","DOIUrl":"","url":null,"abstract":"Although respiratory viruses are known as the major causes of community-acquired respiratory tract infections all over the world, they can also cause serious nosocomial respiratory infections and hospital outbreaks. The aim of this study is to investigate the incidence of community-acquired and nosocomial RSV and other viral respiratory tract infections in children hospitalized at the Pediatric Intensive Care Unit of Cukurova University Faculty of Medicine. Nasopharyngeal swab samples were taken from 100 children aged 0-16 years with suspected community-acquired (60) and nosocomial (40) respiratory tract infections from September 2018 to June 2021. The Multiplex real-time PCR test was used for the diagnosis of respiratory viruses. Of children with community-acquired respiratory tract infections, 65% (39/60) were positive for at least one virus and the rate of coinfection in this group was 35.9% (14/39). In children with nosocomial respiratory tract infection, positivity was detected to be 62.5% (25/40) and the coinfection rate was 40% (10/25). The most predominant virus in community-acquired respiratory tract infections was influenza A virus (25%), followed by ADV (18.3%), hBoV (15%), RSV (11.7%), and RhV (10%). In nosocomial viral respiratory tract infections, the most common virus was RSV (20%), followed by influenza A virus (12.5%), RhV (12.5%), ADV (12.5%), hMpV (10%), and hBoV (10%). Early diagnosis of respiratory viral infections with real-time PCR test is important in terms of reducing morbidity and mortality, applying control methods to prevent the spread of nosocomial viruses, shortening the hospitalization period, preventing the use of unnecessary antibiotics, and giving appropriate antiviral treatment.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 3","pages":"271-277"},"PeriodicalIF":1.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41179307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of mortality in people with chronic liver diseases hospitalized for Coronavirus disease of 2019 (COVID-19) in a tertiary hospital in Lombardy, Italy. 意大利伦巴第一家三级医院因2019年冠状病毒病（新冠肺炎）住院的慢性肝病患者的死亡风险。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-09-01

Martina Ranzenigo, Daniele Ceccarelli, Laura Galli, Costanza Bertoni, Alessia Siribelli, Emanuela Messina, Hamid Hasson, Riccardo Lolatto, Antonella Castagna, Caterina Uberti-Foppa, Giulia Morsica

{"title":"Risk of mortality in people with chronic liver diseases hospitalized for Coronavirus disease of 2019 (COVID-19) in a tertiary hospital in Lombardy, Italy.","authors":"Martina Ranzenigo, Daniele Ceccarelli, Laura Galli, Costanza Bertoni, Alessia Siribelli, Emanuela Messina, Hamid Hasson, Riccardo Lolatto, Antonella Castagna, Caterina Uberti-Foppa, Giulia Morsica","doi":"","DOIUrl":"","url":null,"abstract":"The impact of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection on patients with pre-existing chronic liver diseases (CLD) remains elusive. The aim of this study was to investigate the in-hospital mortality in patients hospitalized for Coronavirus disease of 2019 (COVID-19) with CLD (CLD group) compared to those without CLD (non-CLD group). We performed a retrospective cohort study including patients with confirmed SARS-CoV-2 infection, hospitalized at San Raffaele Hospital (Milan), stratified according to the presence or absence of CLD. A propensity score was estimated and used to match the two groups by age, gender, body mass index, type 2 diabetes mellitus, and hypertension. Predictors of mortality were assessed using univariate and multivariate logistic regression model. Among 1210 patients with COVID-19, 41 (3.4%) were included in the CLD group and 1169 (96.6%) in the non-CLD group. Using a propensity score, we matched 41 patients in the CLD group with 123 in the non-CLD group. At admission, patients in the CLD group had worse liver function, lower platelets count, and lower c-reactive protein levels. By multivariate analysis, the CLD group showed a higher risk of death: OR 4.04 (95% CI 1.29-12.70; p= 0.017). Our study showed that COVID-19 with chronic liver diseases has a higher risk of mortality during hospitalization.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 3","pages":"296-302"},"PeriodicalIF":1.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monkeypox virus transmission in tattoo parlor. 猴痘病毒在纹身店传播。

IF 1.5 4区医学

New Microbiologica Pub Date : 2023-09-01

Carlo Tascini, Francesco Sbrana, Simone Giuliano, Monica Geminiani, Alberto Pagotto

引用次数: 0

Inhibition of S. aureus biofilm formation by linezolid alleviates sepsis-induced lung injury caused by S. aureus infection through direct inhibition of icaA activity. 利奈唑胺对金黄色葡萄球菌生物膜形成的抑制通过直接抑制icaA活性减轻由金黄色葡萄菌感染引起的败血症诱导的肺损伤。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-09-01

Huan Kuang, Hongxia Bi, Xiaoran Li, Xiaojv Lv, Yanbin Liu

{"title":"Inhibition of S. aureus biofilm formation by linezolid alleviates sepsis-induced lung injury caused by S. aureus infection through direct inhibition of icaA activity.","authors":"Huan Kuang, Hongxia Bi, Xiaoran Li, Xiaojv Lv, Yanbin Liu","doi":"","DOIUrl":"","url":null,"abstract":"Antibiotic-resistant S. aureus infections can be life-threatening. Linezolid is known to hinder S. aureus biofilm formation, but the underlying molecular mechanism remains unclear. Molecular docking revealed that linezolid can bind to icaA, and this was confirmed by thermal drift assays. Linezolid demonstrated a dose-dependent inhibition of icaA enzyme activity. Mutating Trp267, a key residue identified through molecular docking, significantly decreased linezolid binding and inhibitory effects on mutant icaA activity. However, the mutant icaA Trp267Ala showed only slight activity reduction compared to icaA. Linezolid had minimal impact on icaB's thermal stability and activity. The 50S ribosomal L3ΔSer145 mutant S. aureus exhibited similar growth and biofilm formation to the wild-type strain. Linezolid effectively suppressed the growth and biofilm formation of wildtype S. aureus. Although linezolid lost its ability to inhibit the growth of the mutant strain, it still effectively hindered its biofilm formation. Linezolid exhibited weaker attenuation of sepsis-induced lung injury caused by 50S ribosomal L3ΔSer145 mutant S. aureus compared to wild-type S. aureus. These findings indicate that linezolid hampers S. aureus biofilm formation by directly inhibiting icaA activity, independently of its impact on bacterial growth.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 3","pages":"285-295"},"PeriodicalIF":1.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers to HCV micro-elimination in a cohort of people living with HIV (PLWH). HIV感染者（PLWH）队列中HCV微消除的障碍。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-09-01

Claudia Bartalucci, Lucia Taramasso, Laura Ambra Nicolini, Laura Magnasco, Laura Labate, Antonio Vena, Sara Mora, Mauro Giacomini, Matteo Bassetti, Antonio Di Biagio

{"title":"Barriers to HCV micro-elimination in a cohort of people living with HIV (PLWH).","authors":"Claudia Bartalucci, Lucia Taramasso, Laura Ambra Nicolini, Laura Magnasco, Laura Labate, Antonio Vena, Sara Mora, Mauro Giacomini, Matteo Bassetti, Antonio Di Biagio","doi":"","DOIUrl":"","url":null,"abstract":"To achieve the World Health Organization goal of hepatitis C virus (HCV) eradication, barriers to treatment should be investigated and overcome. The aim of this study was to identify those barriers and describe the strategies adopted to achieve HCV micro-elimination in a cohort of coinfected people living with HIV (PLWH-HCV). Adult PLWH-HCV followed at our hospital with detectable serum HCV-RNA in 2018 were enrolled. After a three-year follow-up, barriers to HCV treatment were investigated and strategies to overcome them were described. Of 492 PLWH-HCV seen in 2018, 29 (5.9%) had detectable serum HCV-RNA. Eight out of 29 (27.6%) were excluded because they were already under treatment, while 2 others were excluded because they moved to other outpatient clinics. Among the remaining 19 study participants, the most common barriers to treatment were poor adherence to therapies and follow-up visits (n=9, 47%), recent HCV diagnosis awaiting proper staging (n=3, 16%) and treatment hesitancy (n=2, 10%). During the following three years, direct-acting antivirals (DAAs) treatment was completed in 11/19 (58%) cases, with achievement of sustained virological response in 100% of cases. For the remaining cases, 2/19 (10.5%) were lost to follow-up, 2/19 (10.5%) died before treatment initiation and 4/19 (21.0%) are still awaiting treatment. Despite 3 years of effort, HCV micro-elimination has not been achieved at our center. We observed that poor adherence and treatment hesitancy were the main barriers to treatment. Strategies addressing these issues need to be implemented.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 3","pages":"246-251"},"PeriodicalIF":1.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41106913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of hepatitis C virus viremia and genotype distribution in Turkish citizens and immigrants from 2018 to 2022. 2018年至2022年土耳其公民和移民丙型肝炎病毒血症和基因型分布的测定。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-09-01

Murat Yaman, Salih Hazar, Ayfer Bakir

{"title":"Determination of hepatitis C virus viremia and genotype distribution in Turkish citizens and immigrants from 2018 to 2022.","authors":"Murat Yaman, Salih Hazar, Ayfer Bakir","doi":"","DOIUrl":"","url":null,"abstract":"Hepatitis C virus (HCV) infection is an important public health problem with potential risk for Turkey. In order to contribute to the epidemiological data, we aimed to investigate the changes in seroprevalence, viremia rates, and genotypes in the last five years in HCV patients in the southern region of Turkey, which has received heavy migration in recent years, according to demographic criteria. In our study, we analyzed the results retrospectively with demographic data. Conducted at a single center, the study involved 259,875 anti-HCV antibody tests administered between January 2018 and July 2022. The study revealed a prevalence of 0.5% for HCV antibody positivity and a viremia prevalence of 0.1%. Among Turkish nationals, the most common genotypes were GT1 (65.1%), while foreign nationals, mainly of Syrian and Ukrainian origin, showed GT4 (52.3%) as the predominant genotype (p<0.001 for both). Although GT2 (7.4% vs. 4.5%) and GT3 (23.3% vs. 13.6%) were relatively higher in Turkish nationals compared to foreign nationals, the difference was not statistically significant (p=0.750 and p=0.154, respectively). This highlights the importance of continuous monitoring and public health efforts to address the potential impact of these demographic shifts on HCV epidemiology in the region.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"46 3","pages":"252-257"},"PeriodicalIF":1.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular epidemiology typing of blaOXA-48 and blaNDM-1 producing Klebsiella pneumoniae causing nosocomial infection. 引起医院感染的blaOXA-48和blaNDM-1产生的肺炎克雷伯菌的分子流行病学分型。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-09-01

Pegah Shakib, Rashid Ramazanzadeh

引用次数: 0

Seroprevalence of herpes simplex virus type 1 and type 2 - data from a hospital-based study in Varna, northeastern Bulgaria, 2019-2021. 2019-2021年保加利亚东北部瓦尔纳一项医院研究的单纯疱疹病毒1型和2型的血清流行率数据。

IF 1.8 4区医学

New Microbiologica Pub Date : 2023-09-01

Gabriela Tsankova, Tatina Todorova, Neli Ermenlieva, Gergana Nedelcheva, Zhivka Stoykova, Tsvetelina Kostadinova

引用次数: 0