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Mollusc and crustacean consumption in the first 1000 days: a scoping review. 头 1,000 天的软体动物和甲壳类动物消费:范围审查。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-02-12 DOI: 10.1017/S0954422424000064
Brietta M Oaks, Emmanuel A Gyimah, Eliza Kleban, Kathleen Ragsdale, Lora L Iannotti
{"title":"Mollusc and crustacean consumption in the first 1000 days: a scoping review.","authors":"Brietta M Oaks, Emmanuel A Gyimah, Eliza Kleban, Kathleen Ragsdale, Lora L Iannotti","doi":"10.1017/S0954422424000064","DOIUrl":"10.1017/S0954422424000064","url":null,"abstract":"<p><p>Mollusc and crustacean consumption in the first 1000 d may improve maternal and child health by providing essential nutrients. However, in some contexts, molluscs and crustaceans have been associated with allergies and environmental contamination, potentially leading to adverse health and development outcomes. It is unclear whether the health benefits of consuming molluscs and crustaceans, collectively classified as shellfish in nutrition, are outweighed by the potential risks to pregnant women and children. We conducted a scoping review (PROSPERO: CRD42022320454) in PubMed, Scopus and EBSCO Global Health of articles published between January 2000 and March 2022 that assessed shellfish consumption during pregnancy, lactation or childhood (0-2 years) in relation to maternal health, child health or child development. A total of forty-six articles were included in this review. Overall, shellfish consumption was associated with higher biomarkers of environmental contaminants, with mercury being the most studied and having the strongest evidence base. The limited research on nutritional biomarker status shows an association between shellfish consumption and iodine status. Preterm birth was not associated with shellfish consumption, but newborn anthropometry showed mixed results, with several studies reporting lower birth weight with higher shellfish consumption. The few studies that examined child development and maternal health outcomes reported no significant associations. This review revealed trade-off health risks and benefits with inclusion of molluscs and crustaceans in the dietary patterns of mothers and young children. More research is needed to understand how these aquatic animal-source foods may be safely consumed and leveraged for improving human nutrition.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"181-191"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrition and health effects of pectin: A systematic scoping review of human intervention studies. 果胶对营养和健康的影响:人类干预研究的系统性范围界定审查。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-09-26 DOI: 10.1017/S0954422424000180
Annika M Weber, Nélida Pascale, Fangjie Gu, Elizabeth P Ryan, Frederique Respondek
{"title":"Nutrition and health effects of pectin: A systematic scoping review of human intervention studies.","authors":"Annika M Weber, Nélida Pascale, Fangjie Gu, Elizabeth P Ryan, Frederique Respondek","doi":"10.1017/S0954422424000180","DOIUrl":"10.1017/S0954422424000180","url":null,"abstract":"<p><p>Pectin is composed of a group of complex polysaccharides that are naturally found in various plants and are associated with a range of beneficial health effects. Health outcomes from dietary pectin can vary depending on botanical origin, dietary dose and structure of pectin. The objective of this scoping review is to build a comprehensive overview of the current evidence available on intervention studies conducted in humans and to better understand the possible knowledge gaps in terms of structure-function relationships across the different health-related effects. PubMed and Embase databases were searched using PRISMA-ScR guidelines, yielding 141 references (from the initial 3704), representing 134 intervention studies performed between 1961 and 2022 that met inclusion criteria. Studies were divided into six categories, which included gut health, glycaemic response and appetite, fat metabolism, bioavailability of micronutrients, immune response and other topics. Review of these human intervention studies identified a variety of cohort characteristics and populations (life stage, health status, country), sources/types of pectin (i.e. citrus, sugarbeet, apple, other and non-defined), intervention timeframes (from one single intake to 168 d) and doses (0.1-50 g/d) that were tested for health outcomes in people. Gut health, post-prandial glucose regulation and maintenance of blood cholesterol represented the largest categories of studied outcomes. Further research to strengthen the structure-function relationships for pectin with health properties and associated outcomes is warranted and will benefit from a more precise description of physico-chemical characteristics and molecular compositions, such as degree of esterification, weight, degree of branching, viscosity, gel formation and solubility.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"306-323"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of energy-restricted diets with or without nuts on weight, body composition and glycaemic control in adults: a scoping review. 含或不含坚果的能量限制饮食对成人体重、身体成分和血糖控制的影响:范围综述。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-02-23 DOI: 10.1017/S0954422424000106
Lauren C Mead, Alison M Hill, Sharayah Carter, Alison M Coates
{"title":"Effects of energy-restricted diets with or without nuts on weight, body composition and glycaemic control in adults: a scoping review.","authors":"Lauren C Mead, Alison M Hill, Sharayah Carter, Alison M Coates","doi":"10.1017/S0954422424000106","DOIUrl":"10.1017/S0954422424000106","url":null,"abstract":"<p><p>Energy-restricted (ER) diets promote weight loss and improve body composition and glycaemic control. Nut consumption also improves these parameters. However, less is known about the combined benefit of these two strategies. This scoping review implemented a systematic search of Medline, Embase and Scopus to identify randomised controlled trials evaluating the effect of ER diets with or without nuts on body mass, body composition and glycaemic control in adults. After reviewing titles and abstracts, twenty-nine full-text articles were screened, resulting in seven studies reported in eight papers that met the inclusion criteria. Energy restriction was achieved by prescribing a set energy target or reducing intake by 1000-4200 kJ from daily energy requirements. Interventions ranged from 4 to 52 weeks in duration and contained 42-84 g/d of almonds, peanuts, pistachios or walnuts. While all studies reported that energy restriction resulted in significant weight loss, the addition of nuts to ER diets demonstrated significantly greater weight loss in only approximately half of the included studies (4/7 studies). There was limited evidence to support additional benefits from nuts for body composition measures or glycaemic control. Although improvements in weight loss and glycaemia were not consistent when nuts were included in ER diets, no study revealed an adverse effect of nut consumption on health outcomes. Future studies could explore the effect of consuming different types and amounts of nuts, combined with various levels of energy restriction on weight, body composition and glycaemic control.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"202-218"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of zinc levels on osteoarthritis: A comprehensive review. 锌水平对骨关节炎的影响:综述。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-09-23 DOI: 10.1017/S0954422424000234
İbrahim Tekeoğlu, Muhammed Zahid Şahin, Ayhan Kamanlı, Kemal Nas
{"title":"The influence of zinc levels on osteoarthritis: A comprehensive review.","authors":"İbrahim Tekeoğlu, Muhammed Zahid Şahin, Ayhan Kamanlı, Kemal Nas","doi":"10.1017/S0954422424000234","DOIUrl":"10.1017/S0954422424000234","url":null,"abstract":"<p><p>Osteoarthritis (OA), a disease with a multifactorial aetiology and an enigmatic root cause, affects the quality of life of many elderly patients. Even though there are certain medications utilised to reduce the symptomatic effects, a reliable treatment method to reverse the disease is yet to be discovered. Zinc is a cofactor of over 3000 proteins and is the only metal found in all six classes of enzymes. We explored zinc’s effect on the immune system and the bones as OA affects both. We also discussed zinc-dependent enzymes, highlighting their significant role in the disease’s pathogenesis. It is important to note that both excessive and deficient zinc levels can negatively affect bone health and immune function, thereby exacerbating OA. The purpose of this review is to offer a better understanding of zinc’s impact on OA pathogenesis and to provide clarity regarding its beneficial and detrimental outcomes. We searched thoroughly systematic reviews, meta-analysis, review articles, research articles and randomised controlled trials to ensure a comprehensive review. In brief, using zinc supplementation in the treatment of OA may act as a doubled-edged sword, offering potential benefits but also posing risks.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"282-293"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current perspectives and challenges in the estimation of fruit juice consumption across the lifecycle in Europe. 欧洲果汁生命周期消费估算的现状与挑战。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-02-15 DOI: 10.1017/S095442242400009X
Janette Walton, Laura Kehoe
{"title":"Current perspectives and challenges in the estimation of fruit juice consumption across the lifecycle in Europe.","authors":"Janette Walton, Laura Kehoe","doi":"10.1017/S095442242400009X","DOIUrl":"10.1017/S095442242400009X","url":null,"abstract":"<p><p>Fruit juice (FJ) is typically low in energy, contains natural sugars, important amounts of micronutrients and is not permitted to have added sugars/sweeteners. However, its role in a healthy diet is under scrutiny partly due to the wider adoption of the definition for free sugars in nutrition policy. This review aimed to identify data on FJ consumption from national food consumption surveys across Europe, to examine current intakes, percent consumers and its contribution to intakes of energy, total sugars, free sugars, vitamin C, folate and potassium. Data were extracted on the population mean intake of FJ and its contribution to nutrient intakes across the lifecycle and crude estimates of population mean intakes across countries were reported for the total population and for consumers only. This review highlighted significant gaps/challenges regarding the availability of country-specific national food consumption surveys across Europe and specifically data on FJ consumption (including complexities surrounding categorisations). Nonetheless, using a comparable/homogenous definition, the mean intake of FJ among consumers was approximately 1 × 150 ml glass/day for adults/older adults, with lower intakes among infants (86 g/d), children (108 g/d) and teenagers (112 g/d). FJ made important contributions to intakes of vitamin C while making little contribution to energy intakes but also contributed 2-14 % of free sugars intake (which may be considered modest compared to other sources). The complexity of collating and interpreting data on FJ intake as elucidated in this review raises questions surrounding the categorisation of FJ in research and presents significant challenges for policymakers with respect to dietary guidance for FJ.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"69-80"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing nutritional issues and eating behaviours among university students: a narrative review. 解决大学生的营养问题和饮食行为:叙述性综述。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-02-15 DOI: 10.1017/S0954422424000088
Noha M Almoraie, Noor M Alothmani, Wajd D Alomari, Amal H Al-Amoudi
{"title":"Addressing nutritional issues and eating behaviours among university students: a narrative review.","authors":"Noha M Almoraie, Noor M Alothmani, Wajd D Alomari, Amal H Al-Amoudi","doi":"10.1017/S0954422424000088","DOIUrl":"10.1017/S0954422424000088","url":null,"abstract":"<p><p>University life is a critical period for establishing healthy eating habits and attitudes. However, university students are at risk of developing poor eating habits due to various factors, including economic conditions, academic stress and lack of information about nutritional concepts. Poor diet quality leads to malnutrition or overnutrition, increasing the risk of preventable diseases. Food environments on university campuses also play a significant role in shaping the dietary habits of students, with the availability of and accessibility to healthy food options being important factors influencing food choices and overall diet quality. Disordered eating habits and body dissatisfaction are prevalent among university students and can lead to eating disorders. Income and living arrangements also influence dietary habits, with low household income and living alone being associated with unhealthy eating habits. This study is a narrative review that aimed to address nutritional issues and eating behaviours, specifically among university students. We investigated the eating behaviours of university students, including their dietary patterns, food choices and food environments. The objective of this review was to provide insights into the nutritional issues and eating behaviours of university students, with the aim of identifying target areas for intervention to improve the overall health and wellbeing among college students. University food environments need to be restructured to promote healthy eating, including the availability, accessibility, affordability and labelling of healthy foods, and policies to limit the availability of unhealthy foods and drinks on campus.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"53-68"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Programmes to manage food selectivity in individuals with autism spectrum disorder. 管理自闭症谱系障碍患者食物选择性的计划。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-02-22 DOI: 10.1017/S0954422424000052
Chiara Breda, Sara Santero, Maria Vittoria Conti, Hellas Cena
{"title":"Programmes to manage food selectivity in individuals with autism spectrum disorder.","authors":"Chiara Breda, Sara Santero, Maria Vittoria Conti, Hellas Cena","doi":"10.1017/S0954422424000052","DOIUrl":"10.1017/S0954422424000052","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a complex group of neurodevelopmental disorders characterised by impaired social communication and restricted interests/repetitive behaviours. In this regard, sensory processing difficulties and delayed oral motor skills often predispose individuals with ASD to food selectivity (FS). It is usually associated with repetitive eating patterns that can lead to multiple malnutrition conditions. The objective of this narrative review is to present an overview about the existing nutritional interventions aiming at promoting a healthy eating pattern and addressing food selectivity among individuals with ASD. Regarding the interventions targeting nutrition education, the majority of the analysed studies failed to demonstrate their effectiveness. On the other hand, many educational interventions involving taste or cooking sessions, as well as behavioural interventions for FS, demonstrated effective results. Moreover, multidisciplinary in tailoring such programmes, including psychology speech therapy and nutritional skills, is acknowledged as a key approach.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"112-125"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of vegetable consumption on risk of gastric cancer: a systematic review and multi-level meta-analysis of prospective studies. 蔬菜摄入对胃癌风险的影响:前瞻性研究的系统回顾和多层次元分析》。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-02-20 DOI: 10.1017/S0954422424000040
Xiaomin Wu, Guoqiang Qin, Rui Zhang, Yunning Liu, Liling Chen, Jingyang Su, Chao Kong, Zhongze Fang, Jing Wu
{"title":"Effect of vegetable consumption on risk of gastric cancer: a systematic review and multi-level meta-analysis of prospective studies.","authors":"Xiaomin Wu, Guoqiang Qin, Rui Zhang, Yunning Liu, Liling Chen, Jingyang Su, Chao Kong, Zhongze Fang, Jing Wu","doi":"10.1017/S0954422424000040","DOIUrl":"10.1017/S0954422424000040","url":null,"abstract":"<p><p>Vegetables are known to be beneficial to human health, but the association between vegetable consumption and gastric cancer remains uncertain. To synthesise knowledge about the relationship between vegetable group consumption and gastric cancer risk, update present meta-analyses and estimate associations between vegetable consumption and gastric cancer risk based solely on prospective studies, we perform a PRISMA-compliant three-level meta-analysis. Systematic search identified thirteen prospective studies with fifty-two effect sizes that met all inclusion criteria and no exclusion criteria for our meta-analysis. Pooled risk ratios (RRs) showed a positive association between high vegetable consumption and low gastric cancer risk (pooled RR 0·93, 95% confidence interval 0·90-0·97, <i>P</i> = 0·06). In moderator analyses for indicators of gender, region and quantity of vegetable intake, there was no significant difference between subgroups. However, the effect became significant in populations with lower than the minimum risk exposure level (TMREL) of vegetable consumption (<i>P</i> < 0·05). Higher vegetable intake is associated with a decreased risk of gastric cancer. This effect may be limited to specific populations, such as ones with lower vegetable consumption. Evidence from our study has important public health implications for dietary recommendations.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"192-201"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of the facilitators and barriers to adoption of biofortified foods and food products. 审查采用生物强化食品和食品的促进因素和障碍。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-10-08 DOI: 10.1017/S0954422424000258
Samantha L Huey, Saiful Islam, Neel H Mehta, Elsa M Konieczynski, Valerie M Friesen, Jesse T Krisher, Mduduzi N N Mbuya, Eva C Monterrosa, Annette M Nyangaresi, Saurabh Mehta
{"title":"Review of the facilitators and barriers to adoption of biofortified foods and food products.","authors":"Samantha L Huey, Saiful Islam, Neel H Mehta, Elsa M Konieczynski, Valerie M Friesen, Jesse T Krisher, Mduduzi N N Mbuya, Eva C Monterrosa, Annette M Nyangaresi, Saurabh Mehta","doi":"10.1017/S0954422424000258","DOIUrl":"10.1017/S0954422424000258","url":null,"abstract":"<p><p>Biofortification - the process of increasing the concentrations of essential nutrients in staple crops - is a means of addressing the burden of micronutrient deficiencies at a population level via existing food systems, such as smallholder farms. To realise its potential for global impact, we need to understand the factors that are associated with decisions to adopt biofortified crops and food products. We searched the literature to identify adoption determinants, i.e. barriers to (factors negatively associated) or facilitators of (factors positively associated) adoption, of biofortified crops and food products. We found 41 studies reporting facilitator(s) and/or barrier(s) of adoption. We categorised the factors using the Consolidated Framework of Implementation Research 2.0, resulting in a set of factors that enable or constrain adoption of biofortified foods across twenty-four constructs and five domains of this meta-theoretical determinant framework from implementation science. Facilitators of orange sweet potato adoption included knowledge about importance, relative advantage, efficient production and management practices; barriers included lacking timely access to quality vines and market remoteness (28 studies total). Facilitators of vitamin A cassava adoption included awareness of its benefits and access to information; barriers included poor road networks and scarcity of improved technology including inadequate processing/storage facilities (8). Facilitators of high-iron bean adoption included farmers' networking and high farming experience; barriers included low knowledge of bean biofortification (8). Barriers to vitamin A maize adoption included low awareness and concerns regarding yield, texture and aflatoxin contamination (1). These barriers and facilitators may be a starting point for researchers to move towards testing implementation strategies and/or for policymakers to consider before planning scale-up and continuous optimisation of ongoing projects promoting adoption of biofortified crops and food products.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"371-392"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological properties of vitamin B12. 维生素 B12 的生物特性。
IF 5.1 2区 医学
Nutrition Research Reviews Pub Date : 2025-06-01 Epub Date: 2024-10-08 DOI: 10.1017/S0954422424000210
Monika Moravcová, Tomáš Siatka, Lenka Kujovská Krčmová, Kateřina Matoušová, Přemysl Mladěnka
{"title":"Biological properties of vitamin B<sub>12</sub>.","authors":"Monika Moravcová, Tomáš Siatka, Lenka Kujovská Krčmová, Kateřina Matoušová, Přemysl Mladěnka","doi":"10.1017/S0954422424000210","DOIUrl":"10.1017/S0954422424000210","url":null,"abstract":"<p><p>Vitamin B<sub>12</sub>, cobalamin, is indispensable for humans owing to its participation in two biochemical reactions: the conversion of l-methylmalonyl coenzyme A to succinyl coenzyme A, and the formation of methionine by methylation of homocysteine. Eukaryotes, encompassing plants, fungi, animals and humans, do not synthesise vitamin B<sub>12</sub>, in contrast to prokaryotes. Humans must consume it in their diet. The most important sources include meat, milk and dairy products, fish, shellfish and eggs. Due to this, vegetarians are at risk to develop a vitamin B<sub>12</sub> deficiency and it is recommended that they consume fortified food. Vitamin B<sub>12</sub> behaves differently to most vitamins of the B complex in several aspects, e.g. it is more stable, has a very specific mechanism of absorption and is stored in large amounts in the organism. This review summarises all its biological aspects (including its structure and natural sources as well as its stability in food, pharmacokinetics and physiological function) as well as causes, symptoms, diagnosis (with a summary of analytical methods for its measurement), prevention and treatment of its deficiency, and its pharmacological use and potential toxicity.</p>","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"338-370"},"PeriodicalIF":5.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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