Nutrition Research Reviews最新文献_第3页

Exploiting the vulnerability of SARS-CoV-2 with a partnership of mucosal immune function and nutrition: a narrative review. 利用SARS-CoV-2的脆弱性与粘膜免疫功能和营养的伙伴关系：叙述性综述

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-05-21 DOI: 10.1017/S0954422425100061

Richard J Head, Jonathan D Buckley, Jennifer H Martin

{"title":"Exploiting the vulnerability of SARS-CoV-2 with a partnership of mucosal immune function and nutrition: a narrative review.","authors":"Richard J Head, Jonathan D Buckley, Jennifer H Martin","doi":"10.1017/S0954422425100061","DOIUrl":"https://doi.org/10.1017/S0954422425100061","url":null,"abstract":"To achieve infectivity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), the virus responsible for COVID-19, must first traverse the upper respiratory tract mucosal barrier. Once infection is established, the cascading complexities of the pathophysiology of COVID-19 makes intervention extremely difficult. Thus, enhancing the defensive properties of the mucosal linings of the upper respiratory tract may reduce infection by SARS-CoV2 and indeed by other viruses such as influenza, which have been responsible for the two major pandemics of the last century. In this review we summarise potential opportunities for foods and nutrients to promote an adequate mucosal immune preparedness with an aim to assist protection against infection by SARS-CoV-2; to maximise the mucosal vaccination (IgA inducing) response to existing systemic vaccines; and to play a role as adjuvants to intranasal vaccines. We identify opportunities for vitamins A, and D, zinc, probiotics, bovine colostrum and resistant starch to promote mucosal immunity and enhance the mucosal response to systemic vaccines, and for vitamin A to also improve the mucosal response to intranasal vaccination. It is possible that an entirely different virus may in the future, by way of convergent evolution, utilise a similar upper respiratory tract infection pathway. A greater research focus on mucosal lymphoid immune protection in partnership with nutrition would result in greater preparedness for such an event.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-54"},"PeriodicalIF":5.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feeding weanling piglets for optimal health and performance: what can we learn from research on complex diets? 饲喂断奶仔猪以获得最佳健康和生产性能：我们可以从复杂日粮研究中学到什么？

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-05-15 DOI: 10.1017/S095442242510005X

Bruno B Carnino, Bruno Bd Muro, Rafaella F Carnevale, Flávio A Coelho, Caio A da Silva, Ines Andretta, Sam Millet, Cesar Ap Garbossa

引用次数: 0

Navigating the protein transition: why dairy and its matrix matter amid rising plant protein trends. 导航蛋白质转变：为什么乳制品及其基质在植物蛋白上升趋势中很重要。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-04-21 DOI: 10.1017/S0954422425000101

Oliver C Witard, Asli Devrim-Lanpir, Michelle C McKinley, D Ian Givens

{"title":"Navigating the protein transition: why dairy and its matrix matter amid rising plant protein trends.","authors":"Oliver C Witard, Asli Devrim-Lanpir, Michelle C McKinley, D Ian Givens","doi":"10.1017/S0954422425000101","DOIUrl":"10.1017/S0954422425000101","url":null,"abstract":"The concept of the protein transition represents a shift from a diet rich in animal proteins to one richer in plant-based alternatives, largely in response to environmental sustainability concerns. However, a simple swap by replacing dairy protein with plant protein will lead to lower protein quality and a lower intake of key micronutrients that sit naturally within the dairy matrix. Owing to antagonistic effects within the plant food matrix, micronutrients in plant sources exhibit lower bioavailability which is not reflected in food composition data or dietary guidelines. The dairy matrix effect includes moderation of blood lipid levels in which calcium plays a key role. Protein recommendations often take a muscle-centric approach. Hence, strategies to increase the anabolic potential of plant proteins have focused on increasing total protein intake to counter the suboptimal amino acid composition relative to dairy protein or leucine fortification. However, emerging evidence indicates a role for nutrient interactions and non-nutrient components (milk exosomes, bioactive peptides) of the dairy matrix in modulating postprandial muscle protein synthesis rates. To ensure the food system transformation is environmentally sustainable and optimal from a nutrition perspective, consideration needs to be given to complementary benefits of different food matrices and the holistic evaluation of foods in the protein transition. This narrative review critically examines the role of dairy in the protein transition, emphasising the importance of the food matrix in nutrient bioavailability and muscle health. By considering both nutritional and sustainability perspectives, we provide a holistic evaluation of dairy's contribution within evolving dietary patterns.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-13"},"PeriodicalIF":5.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the determinants of malnutrition among adolescent girls in Pakistan: what needs to be done? 了解巴基斯坦少女营养不良的决定因素：需要做些什么？

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-04-21 DOI: 10.1017/S0954422425000095

Saira Zafar, Babar Tasneem Shaikh

{"title":"Understanding the determinants of malnutrition among adolescent girls in Pakistan: what needs to be done?","authors":"Saira Zafar, Babar Tasneem Shaikh","doi":"10.1017/S0954422425000095","DOIUrl":"10.1017/S0954422425000095","url":null,"abstract":"Adolescent girls are vulnerable and deserve the utmost attention to complement their nutrition. This scoping review endeavours to identify the determinants of malnutrition among adolescent girls in Pakistan and to comprehend the interventions to improve their health and nutritional status. This review of the literature was conducted using Google Scholar, PubMed/Medline, Scopus and Web of Science for articles published between 2015 and 2024. MeSH terms used for search were as follows: adolescent, youth, health, malnutrition, nutrition interventions, systems approach. In addition, reports from the WHO, the UN, the World Bank, the Government of Pakistan and other organisations were also critically reviewed. Moreover, this paper has used the Pathways framework, which advocates multi-sectoral approaches for poverty reduction. In most developing countries, the compromised nutritional status of adolescent girls, compounded by poverty, has life-long health and economic consequences, as well as their infants having nutritional deficits. They are expected to grow as stunted children. Abundant evidence has shown that nutrition-sensitive and nutrition-specific interventions can improve their nutritional status and that of subsequent generations. There is a dire need to involve key stakeholders from health, education, nutrition, population, women's development, social welfare and other relevant sectors. It is imperative to design interventions for adolescent girls in each country's context to break the intergenerational cycle of malnutrition and to improve economic productivity. Political commitment and effective governance along with policy coherence are required for their healthy transitions into adulthood.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-6"},"PeriodicalIF":5.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elimination reintroduction diets and oral food challenge in adults with rheumatoid arthritis: a scoping review. 成人类风湿关节炎患者的消除、重新引入饮食和口服食物挑战：一项范围综述。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-04-04 DOI: 10.1017/S0954422425000083

Julianne McNeill, Caryn Zinn, Gael Mearns, Rebecca Grainger

{"title":"Elimination reintroduction diets and oral food challenge in adults with rheumatoid arthritis: a scoping review.","authors":"Julianne McNeill, Caryn Zinn, Gael Mearns, Rebecca Grainger","doi":"10.1017/S0954422425000083","DOIUrl":"10.1017/S0954422425000083","url":null,"abstract":"Many people with rheumatoid arthritis (RA) believe that certain foods may influence disease activity. Elimination reintroduction diets and oral food challenges are dietary strategies used to identify foods that may exacerbate symptoms. This review summarises and appraises the literature on elimination diet interventions that include food reintroductions or oral food challenges in adults with RA. It describes study design, measures used to assess the effects of food exclusion and challenge, foods identified that may affect RA symptoms, and the measures used to assess the outcome of excluding those foods. A search of five databases, two thesis repositories and Open Grey was conducted to identify records published from inception to January 2025, using terms related to RA, elimination diets and food sensitivity. Eligible records were screened independently by two reviewers, and data extraction followed Joanna Briggs Institute guidelines. Data are presented using a narrative synthesis approach with descriptive data analysis. In total, forty-eight records met inclusion criteria comprising twenty intervention studies (sample sizes 4-94) and seventeen case studies, conducted across twelve countries (1949-2024). Interventions included single-food exclusions, few-food diets, low-allergen meal replacements and fasting protocols. Reintroduction methods varied from a single-food challenge to multiple reintroductions, with five studies using blinded challenges. Outcome measures included physician- or participant-observed symptom changes, clinical assessments and laboratory measures, though these were heterogeneous. Findings reveal a lack of standardised protocols, dated methodologies and limited contemporary research. Controlled studies are needed to establish evidence-based protocols, investigate mechanisms, and guide dietary strategies as adjuncts to RA pharmacological treatment.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-18"},"PeriodicalIF":5.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of zinc, iron and vitamin B₁₂ content of edible insects and comparison with dietary reference values. 食用昆虫中锌、铁和维生素B12含量的系统综述及其与膳食参考值的比较。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-03-27 DOI: 10.1017/S0954422425000071

Tom Bbosa, Dorothy Nakimbugwe, Christophe Matthys, Mik Van Der Borght

{"title":"A systematic review of zinc, iron and vitamin B12 content of edible insects and comparison with dietary reference values.","authors":"Tom Bbosa, Dorothy Nakimbugwe, Christophe Matthys, Mik Van Der Borght","doi":"10.1017/S0954422425000071","DOIUrl":"10.1017/S0954422425000071","url":null,"abstract":"Entomophagy (eating edible insects) could potentially address human deficiencies of iron, zinc and vitamin B12. This article aims to summarise available evidence about the iron, zinc and vitamin B12 content of raw and processed edible insects and compare these with the nutritional needs of different human life stages. A systematic literature search using specific keywords (edible insects, iron content, zinc content, vitamin B12 content and nutritional composition) in Web of Science and Scopus databases was performed. Forty-six studies were reviewed. To ensure standardised comparisons, articles with nutrient-enriched edible insects were excluded. The quality of records was assessed using standardised protocols. Results indicate that edible insects are generally either 'sources of' or 'rich in' iron, zinc and vitamin B12 required for optimal nutrition and health of different human life stages. Moreover, iron, zinc and vitamin B12 contents of edible insect species were generally either comparable to or higher than that of (lean) beef, (lean) pork, poultry and kidney beans. Most insect species were oven processed with little/no species-specific data for other processing methods. Variations in micronutrient content existed between processing methods and among oven-processed edible insects. Data inaccuracies, poor data quality control and lack of insect-specific official analytical methods contributed to fairly high variations and made comparisons difficult. Based on available data, edible insects can potentially address human deficiencies of iron, zinc and vitamin B12 despite the observed variations, data gaps and lack of edible insect matrix-specific official methods, in addition to limited human bioavailability and efficacy studies.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-17"},"PeriodicalIF":5.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinc Ion Dyshomeostasis in Autism Spectrum Disorder. 自闭症谱系障碍的锌离子平衡失调。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-03-13 DOI: 10.1017/S095442242500006X

Asma Ahmadani, Monia Kittana, Farah Al-Marzooq, Sandeep Subramanya, Maria Cristina D'Adamo, Amita Attlee, Mauro Pessia

{"title":"Zinc Ion Dyshomeostasis in Autism Spectrum Disorder.","authors":"Asma Ahmadani, Monia Kittana, Farah Al-Marzooq, Sandeep Subramanya, Maria Cristina D'Adamo, Amita Attlee, Mauro Pessia","doi":"10.1017/S095442242500006X","DOIUrl":"https://doi.org/10.1017/S095442242500006X","url":null,"abstract":"Autism spectrum disorder (ASD) is a neurodevelopmental disorder with significant social, communicative, and behavioral challenges, and its prevalence is increasing globally at an alarming rate. Children with ASD often have nutritional imbalances, and multiple micronutrient deficiencies. Among these, zinc (Zn2+) deficiency is prominent and has gained extensive scientific interest over the past few years. Zn2+ supports numerous proteins, including enzymes and transcription factors, and controls neurogenesis and cell differentiation. It modulates synaptic transmission and plasticity by binding to receptors, ion channels, and transporters. These interactions are crucial as changes in these processes may contribute to cognitive and behavioral abnormalities in neurodevelopmental disorders, including ASD. Notably, mutations in genes linked to ASD result in Zn2+ dyshomeostasis, altering pivotal biological processes. Additionally, Zn2+ promotes gut health by maintaining gut wall integrity, preventing inflammation and leaky gut, translocation of gut bacteria and their metabolites into systemic circulation, and supporting cognitive processes via the gut-brain axis. Zn2+ deficiency during pregnancy alters gut microbiota composition, induces pro-inflammatory cytokine production, may affect neuronal functioning, and is associated with ASD etiology in offspring and exacerbation of autistic traits in genetically predisposed children. This review focuses on Zn2+ dyshomeostasis, discussing various Zn2+-dependent dysfunctions underlying distinct autistic phenotypes and describing recent progress in the neurobiology of ASD in human and animal models. Comprehensive research on the physiological processes altered by Zn2+ deficiency is crucial for designing preventive and innovative therapeutic measures for this disorder.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-65"},"PeriodicalIF":5.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional value of organic food in children. 有机食品对儿童的营养价值。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-02-26 DOI: 10.1017/S0954422425000046

Arnaud De Luca, Alain Bocquet, Sandra Brancato-Bouet, Martin Chalumeau, Christophe Dupont, Dominique Darmaun, François Feillet, Marie-Laure Frelut, Dominique Guimber, Alexandre Lapillonne, Agnès Linglart, Sophie Nicklaus, Noël Peretti, Jean-Christophe Rozé, Umberto Simeoni, Jean-Pierre Chouraqui

{"title":"Nutritional value of organic food in children.","authors":"Arnaud De Luca, Alain Bocquet, Sandra Brancato-Bouet, Martin Chalumeau, Christophe Dupont, Dominique Darmaun, François Feillet, Marie-Laure Frelut, Dominique Guimber, Alexandre Lapillonne, Agnès Linglart, Sophie Nicklaus, Noël Peretti, Jean-Christophe Rozé, Umberto Simeoni, Jean-Pierre Chouraqui","doi":"10.1017/S0954422425000046","DOIUrl":"10.1017/S0954422425000046","url":null,"abstract":"In Europe, organic food must comply with specific regulations which do not include nutritional criteria. The ability of organic food to meet the nutritional needs of children is not assessed. This narrative review discusses the nutritional composition (macronutrients, micronutrients) of organic food compared with conventional products and its clinical relevance with a paediatric focus, as well as the health impact of these differences and of contaminants which interfere with metabolism. Other potential differences, particularly regarding the direct/indirect exposure to other contaminants in conventional food, are not addressed in this review. The composition of some organic food may differ from conventional food. Protein content was lower in cereals and eggs. A lower n-6:n-3 polyunsaturated fat (PUFA) ratio was observed in milk, meat and eggs. Long-chain PUFA and vitamin E may be higher in milk, meat and fish, as well as some minerals and antioxidants (phenolic compounds, vitamin C) in fruits, vegetables and starchy food and carotenoids in fruits and vegetables. Epidemiological studies suggest an association between organic diets and lower prevalence of childhood obesity, type 2 diabetes and metabolic syndrome, whereas the protective effect on allergy and cancer is controversial. Some organic food may be of greater nutritional interest for children's diet than conventional food. Standardised studies comparing food composition and diet in children are needed. Considering the lower toxicologic risk and the sustainability of organic food, the Committee on Nutrition encourages the use of organic food, provided that such food is affordable, alongside specific baby food which is subject to strict specific European Union regulations.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-19"},"PeriodicalIF":5.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A narrative review. 猴头菌：预防和延缓阿尔茨海默病进展的一种可能的未来治疗方法？-叙述评论。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-02-24 DOI: 10.1017/S0954422425000058

Nisha Cornford, Margaret Charnley

{"title":"Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A narrative review.","authors":"Nisha Cornford, Margaret Charnley","doi":"10.1017/S0954422425000058","DOIUrl":"10.1017/S0954422425000058","url":null,"abstract":"At present, the treatment of Alzheimer's disease involves only symptomatic medications which have continually demonstrated little efficacy, primarily due to the presence of biological barriers. Despite efforts, researchers have yet to discover a therapeutic treatment that delays neurodegenerative progression or restores associated Alzheimer neuropathological processes. For centuries, Hericium erinaceus (HE) has been used predominantly in Asian countries for its culinary and medicinal purposes; however, this mushroom has not yet been utilised in western pharmacology. This review systematically investigates evidence pertaining to the use of HE as a potential future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease, by highlighting any fundamental neurotrophic and neuroprotective properties. In total, three human clinical trials and thirteen animal-model studies were included in review. The use of HE demonstrated positive significant differences in results obtained from behavioural, histological and biochemical assessments from both human clinical trials and animal model studies accentuating its utility for the improvement of cognitive function. In addition, erinacine-A-enriched HE appears to demonstrate the highest bioactive potency of all HE extracted compounds, providing the greatest effects while also showing transportability ease across biological barriers. In conclusion, evidence suggests that intake of HE may be an appropriate and relevant future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease; however, continued research is necessary to provide further significant evidence of this relationship, through an increased quantity of human clinical trials.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-15"},"PeriodicalIF":5.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron status and risk of iron disorders in neonates: A narrative review of recent studies in animal models. 新生儿铁状态和铁紊乱风险：动物模型近期研究述评

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2025-02-24 DOI: 10.1017/S0954422425000034

Xiuying Wang, Paweł Lipiński, Magdalena Ogłuszka, Rafał Radosław Starzyński

{"title":"Iron status and risk of iron disorders in neonates: A narrative review of recent studies in animal models.","authors":"Xiuying Wang, Paweł Lipiński, Magdalena Ogłuszka, Rafał Radosław Starzyński","doi":"10.1017/S0954422425000034","DOIUrl":"10.1017/S0954422425000034","url":null,"abstract":"The iron regulation mechanisms are not exactly the same between adulthood and the early postnatal period. Also, neonatal iron status is different in full-term versus preterm infants because the prenatal/gestational period, when hepatic iron accumulates, is shortened. Newborns, especially premature infants, are at high risk of iron deficiency due to inadequate iron stores, which constitute the primary source of iron to satisfy the neonate's increasing iron requirements. In addition, frequent blood transfusions and congenital haemochromatosis may induce iron overload in the affected neonate. To understand the cause of neonatal iron deficiency/overload and to promote the development of effective therapeutic interventions in humans, different animal models have been generated by genetic engineering, low-/high-iron diets, phlebotomy/transfusion and surgical manipulation. These models use various laboratory and domestic animals to study iron imbalance. They serve as surrogate models for experiments that are ethically or practically unfeasible to conduct on human neonates. Although an animal model for studying neonatal iron disorders may not fully replicate the complexities of human diseases, it is designed to model specific aspects of these conditions. Combined data from multiple models can help to offset the limitations inherent in each individual model. In this review, we outline approaches to induce neonatal iron disorders, current animal models of full-term and preterm neonates, and recommendations for diagnosis.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-14"},"PeriodicalIF":5.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0