Nutrition Research Reviews最新文献_第4页

Selenium supplementation in chronic kidney disease patients undergoing haemodialysis: a systematic review of the effects on plasma selenium, antioxidant and inflammatory markers, immunological parameters and thyroid hormones. 接受血液透析的慢性肾病患者补硒：对血浆硒、抗氧化和炎症标志物、免疫学参数和甲状腺激素影响的系统综述。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2024-09-25 DOI: 10.1017/S0954422424000222

Pricilla de C Trigueira, Viviane de O Leal, Barbara R Cardoso, Denise Mafra, Marina C Araujo, Milena B Stockler-Pinto

{"title":"Selenium supplementation in chronic kidney disease patients undergoing haemodialysis: a systematic review of the effects on plasma selenium, antioxidant and inflammatory markers, immunological parameters and thyroid hormones.","authors":"Pricilla de C Trigueira, Viviane de O Leal, Barbara R Cardoso, Denise Mafra, Marina C Araujo, Milena B Stockler-Pinto","doi":"10.1017/S0954422424000222","DOIUrl":"https://doi.org/10.1017/S0954422424000222","url":null,"abstract":"Selenium (Se) is a mineral with several biological functions, and studies have shown that its deficiency can be linked to many complications in patients with chronic kidney disease (CKD). This study aims to systematically review the effects of Se supplementation in patients with CKD undergoing haemodialysis (HD). This systematic review was carried out according to the PRISMA statement. Clinical trials were searched in PubMed, Lilacs, Embase, Scopus and Cochrane Library databases from inception to July 2021 and updated in July 2024. The protocol was registered on PROSPERO (CRD42021231444). Two independent reviewers performed the study screening and data extraction, and the risk of bias was evaluated using the Cochrane Collaboration tool. Thirteen studies were included in this review. Only nine studies showed results on Se levels; in all, reduced Se levels were observed before supplementation. A positive effect of supplementation on plasma Se level was demonstrated. Of the ten studies analysed, six demonstrated positive effects on antioxidant and inflammatory markers. Only one study analysed immunological parameters, showing a positive impact. From two studies that analysed thyroid hormones, only one showed positive results. All studies were classified as high risk of bias. The findings suggest that Se supplementation significantly increases plasma Se levels in these patients; however, there are still not enough studies to clarify the effects of Se supplementation on the antioxidant and inflammatory markers, immune system and thyroid hormones. Further studies are needed to elucidate the effects of Se supplementation and to provide a recommendation for patients with CKD undergoing HD.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-12"},"PeriodicalIF":5.1,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of zinc levels on osteoarthritis: A comprehensive review. 锌水平对骨关节炎的影响：综述。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2024-09-23 DOI: 10.1017/S0954422424000234

İbrahim Tekeoğlu, Muhammed Zahid Şahin, Ayhan Kamanlı, Kemal Nas

{"title":"The influence of zinc levels on osteoarthritis: A comprehensive review.","authors":"İbrahim Tekeoğlu, Muhammed Zahid Şahin, Ayhan Kamanlı, Kemal Nas","doi":"10.1017/S0954422424000234","DOIUrl":"https://doi.org/10.1017/S0954422424000234","url":null,"abstract":"Osteoarthritis (OA), a disease with a multifactorial aetiology and an enigmatic root cause, affects the quality of life of many elderly patients. Even though there are certain medications utilised to reduce the symptomatic effects, a reliable treatment method to reverse the disease is yet to be discovered. Zinc is a cofactor of over 3000 proteins and is the only metal found in all six classes of enzymes. We explored zinc’s effect on the immune system and the bones as OA affects both. We also discussed zinc-dependent enzymes, highlighting their significant role in the disease’s pathogenesis. It is important to note that both excessive and deficient zinc levels can negatively affect bone health and immune function, thereby exacerbating OA. The purpose of this review is to offer a better understanding of zinc’s impact on OA pathogenesis and to provide clarity regarding its beneficial and detrimental outcomes. We searched thoroughly systematic reviews, meta-analysis, review articles, research articles and randomised controlled trials to ensure a comprehensive review. In brief, using zinc supplementation in the treatment of OA may act as a doubled-edged sword, offering potential benefits but also posing risks.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-12"},"PeriodicalIF":5.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the dietary intake and nutritional status of defence members: a systematic literature review 国防人员的膳食摄入量和营养状况如何：系统文献综述

IF 5.7 2区医学

Nutrition Research Reviews Pub Date : 2024-09-16 DOI: 10.1017/s0954422424000143

Jessica Bayes, Emily Burch, Romy Lauche, Jon Wardle

{"title":"What is the dietary intake and nutritional status of defence members: a systematic literature review","authors":"Jessica Bayes, Emily Burch, Romy Lauche, Jon Wardle","doi":"10.1017/s0954422424000143","DOIUrl":"https://doi.org/10.1017/s0954422424000143","url":null,"abstract":"Optimal diet and nutrition is vital for military readiness, performance and recovery. Previous research on military diets has primarily focused on the nutritional composition of field/combat rations and dietary intake during deployment. There is accumulating research exploring the usual free-living dietary intake and nutritional status of defence members in garrison (i.e. military bases on which personnel are stationed). However, no comprehensive review has been conducted to assess the overall dietary quality of defence members internationally. Therefore, this review assessed the diets of military populations against national nutritional guidelines and Military Dietary Reference Intakes (MDRI). A systematic literature review of original research was conducted. CINAHL, Medline (EBSCO), Scopus (Elsevier), PubMed and AMED databases were searched up to the 20/02/2023. A total of thirty-six studies met the inclusion criteria. The overall quality of included studies was high, with a low risk of bias. The diet quality scores indicate poor to fair diet quality among defence members. Defence members display low intakes of fruits, vegetables, wholegrains, seafood, plant protein and nuts and high intakes of added sugars, trans fat and processed meat. Results also indicated suboptimal intake of fibre, essential fatty acids, vitamin A, vitamin E, folate, Mg, Zn and iodine. This may lead to reduced performance, increased risk of chronic diseases and mental health disorders. More research is needed to assess the long-term consequences of poor diet quality in defence members. These results require the attention of policymakers to ensure that military education and food environment is supportive of healthy eating.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"20 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ceramides as the molecular link between impaired lipid metabolism, saturated fatty acid intake and insulin resistance: are all saturated fatty acids to be blamed for ceramide-mediated lipotoxicity? 神经酰胺是脂质代谢受损、饱和脂肪酸摄入量和胰岛素抵抗之间的分子联系：神经酰胺介导的脂肪毒性是否应归咎于所有饱和脂肪酸？

IF 5.7 2区医学

Nutrition Research Reviews Pub Date : 2024-09-12 DOI: 10.1017/s0954422424000179

Domenico Sergi, Enrico Zauli, Claudio Celeghini, Maurizio Previati, Giorgio Zauli

{"title":"Ceramides as the molecular link between impaired lipid metabolism, saturated fatty acid intake and insulin resistance: are all saturated fatty acids to be blamed for ceramide-mediated lipotoxicity?","authors":"Domenico Sergi, Enrico Zauli, Claudio Celeghini, Maurizio Previati, Giorgio Zauli","doi":"10.1017/s0954422424000179","DOIUrl":"https://doi.org/10.1017/s0954422424000179","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has reached epidemic proportions worldwide, posing a huge treat on people’s health and quality of life. From a pathogenetic prospective, T2DM is driven by insulin resistance defined as a blunted response of tissues to insulin which leads to chronic hyperglycaemia. Mechanistically, lipotoxicity and particularly the intracellular accumulation of ceramides in the skeletal muscle and the liver, is a primary metabolic aberration underpinning insulin resistance. Indeed, intracellular ceramide accumulation can hamper insulin signal transduction pathway thereby promoting insulin resistance. This review will provide an updated overview of the metabolic defects underlaying ceramide buildup and the molecular mechanism by which ceramides imping upon insulin signalling. Additionally, the role of specific ceramide subspecies as potential biomarkers for T2DM and the role of both long- and medium-chain saturated fatty acids as a modulator of ceramide metabolism will be discussed.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":"8 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Culinary medicine and healthy ageing: a comprehensive review. 烹饪医学与健康老龄化：全面回顾。

IF 5.7 2区医学

Nutrition Research Reviews Pub Date : 2024-06-01 Epub Date: 2023-08-22 DOI: 10.1017/S0954422423000148

Jara Domper, Lucía Gayoso, Leticia Goni, Victor de la O, Usune Etxeberria, Miguel Ruiz-Canela

{"title":"Culinary medicine and healthy ageing: a comprehensive review.","authors":"Jara Domper, Lucía Gayoso, Leticia Goni, Victor de la O, Usune Etxeberria, Miguel Ruiz-Canela","doi":"10.1017/S0954422423000148","DOIUrl":"10.1017/S0954422423000148","url":null,"abstract":"Culinary medicine (CM) represents a novel strategy to promote healthy ageing, as it improves adherence to healthy dietary patterns by providing nutritional education and training in cooking skills. We conducted a comprehensive review of the current scientific literature (2011-2022) concerning CM programmes implemented among participants over the age of 40. This review includes fourteen culinary-nutritional interventions. Each CM programme was analysed according to seven variables: health goal, study design, theoretical basis of the intervention, intervention duration, main outcomes, culinary intervention and the effectiveness of intervention. Although CM programmes showed low effectiveness in achieving positive results on psychosocial outcomes, they were successful in improving dietary intake and health-related outcomes. The interventions lasting for at least 5 months and employing study designs with two or more groups seemed to be important factors associated with achieving significant results. Significant results were observed regardless of the prevention phase defined as the health objective of the CM programme. The use of theoretical frameworks as an educational resource did not influence the effectiveness of the interventions. Other variables such as the inclusion of culinary outcomes, the optimisation of the culinary curriculum taught to the participants and the participation of a chef in the intervention are factors that should be taken into account. In addition, several educational components (cooking classes, hands-on cooking, free food delivery, individualized counselling) were promising for achieving health outcomes in ageing people. Our review has shown that CM programmes can be a powerful tool to improve the health status of ageing people.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"179-193"},"PeriodicalIF":5.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10335293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scientific evidence of foods that improve the lifespan and healthspan of different organisms. 有科学证据表明，食物能改善不同生物的寿命和健康状况。

IF 5.7 2区医学

Nutrition Research Reviews Pub Date : 2024-06-01 Epub Date: 2023-07-20 DOI: 10.1017/S0954422423000136

So-Hyun Park, Da-Hye Lee, Dae-Hee Lee, Chang Hwa Jung

引用次数: 0

The use of sentiment and emotion analysis and data science to assess the language of nutrition-, food- and cooking-related content on social media: a systematic scoping review. 使用情感和情绪分析以及数据科学评估社交媒体上与营养、食品和烹饪相关的内容语言：系统性范围审查。

IF 5.1 2区医学

Nutrition Research Reviews Pub Date : 2024-06-01 Epub Date: 2023-03-30 DOI: 10.1017/S0954422423000069

Annika Molenaar, Eva L Jenkins, Linda Brennan, Dickson Lukose, Tracy A McCaffrey

{"title":"The use of sentiment and emotion analysis and data science to assess the language of nutrition-, food- and cooking-related content on social media: a systematic scoping review.","authors":"Annika Molenaar, Eva L Jenkins, Linda Brennan, Dickson Lukose, Tracy A McCaffrey","doi":"10.1017/S0954422423000069","DOIUrl":"10.1017/S0954422423000069","url":null,"abstract":"Social media data are rapidly evolving and accessible, which presents opportunities for research. Data science techniques, such as sentiment or emotion analysis which analyse textual emotion, provide an opportunity to gather insight from social media. This paper describes a systematic scoping review of interdisciplinary evidence to explore how sentiment or emotion analysis methods alongside other data science methods have been used to examine nutrition, food and cooking social media content. A PRISMA search strategy was used to search nine electronic databases in November 2020 and January 2022. Of 7325 studies identified, thirty-six studies were selected from seventeen countries, and content was analysed thematically and summarised in an evidence table. Studies were published between 2014 and 2022 and used data from seven different social media platforms (Twitter, YouTube, Instagram, Reddit, Pinterest, Sina Weibo and mixed platforms). Five themes of research were identified: dietary patterns, cooking and recipes, diet and health, public health and nutrition and food in general. Papers developed a sentiment or emotion analysis tool or used available open-source tools. Accuracy to predict sentiment ranged from 33·33% (open-source engine) to 98·53% (engine developed for the study). The average proportion of sentiment was 38·8% positive, 46·6% neutral and 28·0% negative. Additional data science techniques used included topic modelling and network analysis. Future research requires optimising data extraction processes from social media platforms, the use of interdisciplinary teams to develop suitable and accurate methods for the subject and the use of complementary methods to gather deeper insights into these complex data.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"43-78"},"PeriodicalIF":5.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9342228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-assessing the role of peri-operative nutritional therapy in patients with pancreatic cancer undergoing surgery: a narrative review. 术前营养治疗在癌症手术患者中的作用：叙述性综述。

IF 5.7 2区医学

Nutrition Research Reviews Pub Date : 2024-06-01 Epub Date: 2023-09-05 DOI: 10.1017/S0954422423000100

Zoi Bouloubasi, Dimitrios Karayiannis, Zoe Pafili, Avra Almperti, Konstantina Nikolakopoulou, Grigoris Lakiotis, George Stylianidis, Vasilios Vougas

{"title":"Re-assessing the role of peri-operative nutritional therapy in patients with pancreatic cancer undergoing surgery: a narrative review.","authors":"Zoi Bouloubasi, Dimitrios Karayiannis, Zoe Pafili, Avra Almperti, Konstantina Nikolakopoulou, Grigoris Lakiotis, George Stylianidis, Vasilios Vougas","doi":"10.1017/S0954422423000100","DOIUrl":"10.1017/S0954422423000100","url":null,"abstract":"Pancreatic cancer is the most common medical condition that requires pancreatic resection. Over the last three decades, significant improvements have been made in the conditions and procedures related to pancreatic surgery, resulting in mortality rates lower than 5%. However, it is important to note that the morbidity in pancreatic surgery remains r latively high, with a percentage range of 30-60%. Pre-operative malnutrition is considered to be an independent risk factor for post-operative complications in pancreatic surgery, such as impaired wound healing, higher infection rates, prolonged hospital stay, hospital readmission, poor prognosis, and increased morbidity and mortality. Regarding the post-operative period, it is crucial to provide the best possible management of gastrointestinal dysfunction and to handle the consequences of alterations in food digestion and nutrient absorption for those undergoing pancreatic surgery. The European Society for Clinical Nutrition and Metabolism (ESPEN) suggests that early oral feeding should be the preferred way to initiate nourishing surgical patients as it is associated with lower rates of complications. However, there is ongoing debate about the optimal post-operative feeding approach. Several studies have shown that enteral nutrition is associated with a shorter time to recovery, superior clinical outcomes and biomarkers. On the other hand, recent data suggest that nutritional goals are better achieved with parenteral feeding, either exclusively or as a supplement. The current review highlights recommendations from existing evidence, including nutritional screening and assessment and pre/post-operative nutrition support fundamentals to improve patient outcomes. Key areas for improvement and opportunities to enhance guideline implementation are also highlighted.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"121-130"},"PeriodicalIF":5.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10155332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review and evaluation of study design considerations for omega-3 fatty acid supplementation trials in physically trained participants. 回顾和评估针对体能训练参与者的欧米伽-3 脂肪酸补充剂试验的研究设计注意事项。

IF 5.7 2区医学

Nutrition Research Reviews Pub Date : 2024-06-01 Epub Date: 2023-01-09 DOI: 10.1017/S095442242300001X

Ryan Anthony, Michael J Macartney, Jeffery L Heileson, Peter L McLennan, Gregory E Peoples

{"title":"A review and evaluation of study design considerations for omega-3 fatty acid supplementation trials in physically trained participants.","authors":"Ryan Anthony, Michael J Macartney, Jeffery L Heileson, Peter L McLennan, Gregory E Peoples","doi":"10.1017/S095442242300001X","DOIUrl":"10.1017/S095442242300001X","url":null,"abstract":"Long-chain omega-3 polyunsaturated fatty acid (LC n-3 PUFA) supplements, rich in eicosapentaenoic acid and/or docosahexaenoic acid, are increasingly being recommended within athletic institutions. However, the wide range of doses, durations and study designs implemented across trials makes it difficult to provide clear recommendations. The importance of study design characteristics in LC n-3 PUFA trials has been detailed in cardiovascular disease research, and these considerations may guide LC n-3 PUFA study design in healthy cohorts. This systematic review examined the quality of studies and study design considerations used in evaluating the evidence for LC n-3 PUFA improving performance in physically trained adults. SCOPUS, PubMed and Web of Science electronic databases were searched to identify studies that supplemented LC n-3 PUFA in physically trained participants. Forty-six (n = 46) studies met inclusion. Most studies used a randomised control design. Risk of bias, assessed using the design-appropriate Cochrane Collaboration tool, revealed that studies had a predominant judgment of 'some concerns', 'high risk' or 'moderate risk' in randomised controlled, randomised crossover or non-randomised studies, respectively. A custom five-point quality assessment scale demonstrated that no study satisfied all recommendations for LC n-3 PUFA study design. This review has highlighted that the disparate range of study designs is likely contributing to the inconclusive state of outcomes pertaining to LC n-3 PUFA as a potential ergogenic aid. Further research must adequately account for the specific LC n-3 PUFA study design considerations, underpinned by a clear hypothesis, to achieve evidence-based dose, duration and composition recommendations for physically trained individuals.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"1-13"},"PeriodicalIF":5.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10639337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of polydatin against bone and joint disorders: the in vitro and in vivo evidence so far. 多糖对骨关节疾病的保护作用：迄今为止的体外和体内证据。

IF 5.7 2区医学

Nutrition Research Reviews Pub Date : 2024-06-01 Epub Date: 2023-04-24 DOI: 10.1017/S0954422423000082

Zhen Zhang, Zhicheng Sun, Runze Jia, Dingyu Jiang, Zhenchao Xu, Yilu Zhang, Yun-Qi Wu, Xiyang Wang

{"title":"Protective effects of polydatin against bone and joint disorders: the in vitro and in vivo evidence so far.","authors":"Zhen Zhang, Zhicheng Sun, Runze Jia, Dingyu Jiang, Zhenchao Xu, Yilu Zhang, Yun-Qi Wu, Xiyang Wang","doi":"10.1017/S0954422423000082","DOIUrl":"10.1017/S0954422423000082","url":null,"abstract":"Polydatin is an active polyphenol displaying multifaceted benefits. Recently, growing studies have noticed its potential therapeutic effects on bone and joint disorders (BJDs). Therefore, this article reviews recent in vivo and in vitro progress on the protective role of polydatin against BJDs. An insight into the underlying mechanisms is also presented. It was found that polydatin could promote osteogenesis in vitro, and symptom improvements have been disclosed with animal models of osteoporosis, osteosarcoma, osteoarthritis and rheumatic arthritis. These beneficial effects obtained in laboratory could be mainly attributed to the bone metabolism-regulating, anti-inflammatory, antioxidative, apoptosis-regulating and autophagy-regulating functions of polydatin. However, studies on human subjects with BJDs that can lead to early identification of the clinical efficacy and adverse effects of polydatin have not been reported yet. Accordingly, this review serves as a starting point for pursuing clinical trials. Additionally, future emphasis should also be devoted to the low bioavailability and prompt metabolism nature of polydatin. In summary, well-designed clinical trials of polydatin in patients with BJD are in demand, and its pharmacokinetic nature must be taken into account.","PeriodicalId":54703,"journal":{"name":"Nutrition Research Reviews","volume":" ","pages":"96-107"},"PeriodicalIF":5.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9422629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0