Irene de la Casa-Resino, Michael T. Empl, Sara Villa, Boris Kolar, Julia Fabrega, Adam D. Lillicrap, Xanthippos N. Karamanlis, Ricardo Carapeto-García
{"title":"Environmental risk assessment of veterinary medicinal products intended for use in aquaculture in Europe: the need for developing a harmonised approach","authors":"Irene de la Casa-Resino, Michael T. Empl, Sara Villa, Boris Kolar, Julia Fabrega, Adam D. Lillicrap, Xanthippos N. Karamanlis, Ricardo Carapeto-García","doi":"10.1186/s12302-021-00509-8","DOIUrl":"https://doi.org/10.1186/s12302-021-00509-8","url":null,"abstract":"<p>The current and future expansion of aquaculture production appears to be only manageable by using veterinary medicinal products (VMPs) to prevent and reduce disease outbreaks. However, only a very low number of VMPs are available for use in aquaculture systems. In addition, the environmental risk potentially emanating from the use of these products has gained increased attention in the last years. In this context, the present review represents an in-depth analysis of the current two-tiered (phase I and phase II) approach for the environmental risk assessment (ERA) of VMPs mandatory in the European Union and the European Economic Area (EU/EEA), and its applicability to medicinal products intended for use in aquaculture. The following conclusions are drawn: (i) the current regulatory guidance documents detailing the phase I and II ERA procedure should be updated and harmonised across Member States and simple approach(es) applicable to the assessment of the environmental exposure of VMPs intended for use in aquaculture facilities should be devised; (ii) current and future regulatory guidance documents detailing the phase II ERA procedure for VMPs intended for use in aquaculture should comprise advanced mathematical models suitable for addressing different exposure scenarios relevant across the whole EU/EEA (including scenarios addressing the exposure of VMPs to agricultural soils from fish sludge); and (iii) it is recommended that any updates of relevant ERA guidelines clearly detail the types of studies needed to determine potential adverse effects of VMPs used in aquaculture on non-target organisms. Furthermore, the application of risk mitigation measures tailored to the reduction of the environmental exposure of VMPs on an individual aquaculture farm level should be considered in any future or updated guideline. Finally, it is anticipated that the present analysis of the main drawbacks surrounding the current ERA regulatory framework will help competent authorities to harmonise and facilitate the approval process for VMPs intended for use in aquaculture.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"33 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4614364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalija Suhareva, Juris Aigars, Rita Poikāne, Juris Tunens
{"title":"The influence of feeding ecology and location on total mercury concentrations in Eurasian perch (Perca fluviatilis)","authors":"Natalija Suhareva, Juris Aigars, Rita Poikāne, Juris Tunens","doi":"10.1186/s12302-021-00523-w","DOIUrl":"https://doi.org/10.1186/s12302-021-00523-w","url":null,"abstract":"<p>Eurasian perch (<i>Perca fluviatilis</i>) is an ecologically significant fish species in the Baltic Sea and has been recognized as a suitable organism to measure concentrations of mercury (Hg) contamination. The adult species occupy a high trophic position; therefore, significant levels of the hazardous substances tend to bioaccumulate in their tissues. However, the ability of the species to inhabit a wide range of feeding ground raises concerns about the adequacy of monitoring data in relation to the representativeness of measured levels of Hg at specific locations. Accounting for the migratory characteristics of this species can shed light on the origin of the analyzed specimens and thus trace Hg uptake chain. Perch samples and potential perch prey were collected at three remote stations in a fully interlinked system river–lake–coastal/transitional waters of the Gulf of Riga. Total mercury (THg) concentration and stable isotope ratios were measured in each sampled item. The perch data were divided into three subgroups associated with specific feeding grounds and one mixed group. A Bayesian mixing model was implemented to quantify the feeding preferences of each group, and based on the results, influence of each food source on Hg uptake by perch was modeled by means of Gaussian GAM model.</p><p>Calculated carbon and nitrogen stable isotope values demonstrated clear evidence of perch specimens migrating between the sampling stations. Substantial proportion of specimens sampled in river and lake stations had isotopic signals consistent with feeding in the gulf. The group of perch associated with feeding in the river grounds exhibited the highest THg concentrations with mean value of 209?μg?kg<sup>?1</sup> wet weight. The food items <i>C. harengus membras</i> and Crustacean showed significant mitigating effects on THg concentration. The rest of the food items showed a secondary influence on the variation of THg concentration.</p><p>The study clearly showed that the high mobility of perch along associated aquatic systems has a noticeable effect on Hg concentrations measured in the fish. Therefore, trophic position and isotopic signatures, along with identification of the food sources, can serve as important supplementary tools for more accurate data interpretation of Hg accumulation.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"33 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12302-021-00523-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4342423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sher Ahmad, Gabriela Vollet Marson, Waheed Ur Rehman, Mohammad Younas, Sarah Farrukh, Mashallah Rezakazemi
{"title":"Development of mass and heat transfer coupled model of hollow fiber membrane for salt recovery from brine via osmotic membrane distillation","authors":"Sher Ahmad, Gabriela Vollet Marson, Waheed Ur Rehman, Mohammad Younas, Sarah Farrukh, Mashallah Rezakazemi","doi":"10.1186/s12302-021-00520-z","DOIUrl":"https://doi.org/10.1186/s12302-021-00520-z","url":null,"abstract":"<p>In this research work, a coupled heat and mass transfer model was developed for salt recovery from concentrated brine water through an osmotic membrane distillation (OMD) process in a hollow fiber membrane contactor (HFMC).The model was built based on the resistance-in-series concept for water transport across the hydrophobic membrane. The model was adopted to incorporate the effects of polarization layers such as temperature and concentration polarization, as well as viscosity changes during concentration.</p><p>The modeling equations were numerically simulated in MATLAB? and were successfully validated with experimental data from literature with a deviation within the range of 1–5%. The model was then applied to study the effects of key process parameters like feed concentrations, osmotic solution concentration, feed, and osmotic solution flow rates and feed temperature on the overall heat and mass transfer coefficient as well as on water transport flux to improve the process efficiency. The mass balance modeling was applied to calculate the membrane area based on the simulated mass transfer coefficient. Finally, a scale-up for the MD process for salt recovery on an industrial scale was proposed.</p><p>This study highlights the effect of key parameters for salt recovery from wastewater using the membrane distillation process. Further, the applicability of the OMD process for salt recovery on large scale was investigated. Sensitivity analysis was performed to identify the key parameters. From the results of this study, it is concluded that the OMD process can be promising in salt recovery from wastewater.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"33 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12302-021-00520-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4301705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sha Lou, Hao Wang, Hongzhe Liu, Guihui Zhong, Larisa Dorzhievna Radnaeva, Elena Nikitina, Gangfeng Ma, Shuguang Liu
{"title":"Laboratory study of the effects of flexible vegetation on solute diffusion in unidirectional flow","authors":"Sha Lou, Hao Wang, Hongzhe Liu, Guihui Zhong, Larisa Dorzhievna Radnaeva, Elena Nikitina, Gangfeng Ma, Shuguang Liu","doi":"10.1186/s12302-021-00521-y","DOIUrl":"https://doi.org/10.1186/s12302-021-00521-y","url":null,"abstract":"<p>Flexible vegetation is an important part of the riverine ecosystem, which can reduce flow velocity, change turbulence structure, and affect the processes of solute transport. Compared with the flow with rigid vegetation, which has been reported in many previous studies, bending of flexible vegetation increases the complexity of the flow–vegetation–solute interactions. In this study, laboratory experiments are carried out to investigate the influence of flexible vegetation on solute transport, and methods for estimating the lateral and longitudinal diffusion coefficients in the rigid vegetated flow are examined for their applications to the flow with flexible vegetation.</p><p>The experimental observations find that vegetation can significantly reduce flow velocity, and the Manning coefficient increases with increasing vegetation density and decreases with inflow discharge. Under all the cases, the vertical peak of the solute concentration moves towards the bottom bed along the flow, and the values of vertical peak concentration longitudinally decreases from the injection point. The lateral diffusion coefficients <i>D</i><sub><i>y</i></sub> increase with vegetation density, while the longitudinal diffusion coefficients <i>D</i><sub><i>L</i></sub> are opposite. Both <i>D</i><sub><i>y</i></sub> and <i>D</i><sub><i>L</i></sub> increase with the inflow discharge. To estimate the <i>D</i><sub><i>y</i></sub> and <i>D</i><sub><i>L</i></sub> in the flow with flexible vegetation, an effective submerged vegetation height considering vegetation bending is incorporated in the methods proposed for flow with rigid vegetation (Lou et al. Environ Sci Eur 32:15, 2020). The modified approach can well predict the diffusion coefficients in the experiments with the relative errors in the range of 5%–12%.</p><p>The methods proposed in this study can be used to estimate the lateral and longitudinal diffusion coefficients in flows through both rigid and flexible vegetations using the effective submerged vegetation height.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"33 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2021-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4214438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
KeunOh Choi, Seunghye Sim, Junyeong Choi, Choa Park, Yoonhee Uhm, Eunkyung Lim, Augustine Yonghwi Kim, Seong Joon Yoo, YoungJoo Lee
{"title":"Changes in handwashing and hygiene product usage patterns in Korea before and after the outbreak of COVID-19","authors":"KeunOh Choi, Seunghye Sim, Junyeong Choi, Choa Park, Yoonhee Uhm, Eunkyung Lim, Augustine Yonghwi Kim, Seong Joon Yoo, YoungJoo Lee","doi":"10.1186/s12302-021-00517-8","DOIUrl":"https://doi.org/10.1186/s12302-021-00517-8","url":null,"abstract":"<p>The World Health Organization declared COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a global pandemic on March 11, 2020. Non-pharmaceutical interventions such as social distancing, handwashing, using hand sanitizer, and wearing facial masks are recommended as the first line of protection against COVID-19. Encouraging hand hygiene may be one of the most cost-effective means of reducing the global burden of disease.</p><p>This study uses a web-based questionnaire to evaluate the usage patterns and consumer perceptions of the effectiveness and health safety of bar soap, liquid hand soap, and hand sanitizer products before and after the spread of COVID-19.</p><p>The results show that since the outbreak of COVID-19, the number of consumers who primarily use bar soap has decreased from 71.8 to 51.4%, the number of those who primarily use liquid hand soap has increased from 23.5 to 41.3%, and the number of those who use and carry hand sanitizer has increased. The frequency of use, duration of use, and amount used of all three products have increased significantly since the COVID-19 outbreak. Finally, consumer perception of the products’ preventive effect against COVID-19 is higher for liquid hand soap and hand sanitizer than it is for bar soap.</p><p>Because use of hand sanitizers has increased, public health guidelines must address the potential risks associated them. Our data also show that the public is abiding by the recommendations of the regulatory authorities. As handwashing has become important in preventing COVID-19 infections, the results of our study will support the development of better handwashing guidelines and a public health campaign.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"33 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2021-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12302-021-00517-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4124685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rubí Medina-Mijangos, Samer Ajour El Zein, Hilda Guerrero-García-Rojas, Luis Seguí-Amórtegui
{"title":"The economic assessment of the environmental and social impacts generated by a light packaging and bulky waste sorting and treatment facility in Spain: a circular economy example","authors":"Rubí Medina-Mijangos, Samer Ajour El Zein, Hilda Guerrero-García-Rojas, Luis Seguí-Amórtegui","doi":"10.1186/s12302-021-00519-6","DOIUrl":"https://doi.org/10.1186/s12302-021-00519-6","url":null,"abstract":"<p>The waste sorting and treatment facilities play an important role in the management of Municipal Solid Waste (MSW), as they permit the materials to be prepared for their later reuse and recycling. The aim of this work is to carry out a technical–economic analysis of a sorting and treatment facility (STF) of light packaging and bulky waste in Gavà-Viladecans, Barcelona, Spain, by means of a methodology based on a social Cost–Benefit Analysis (sCBA), as it studies the private impacts and externalities (impacts related with environmental and social aspects) to determine the Total Benefit (the difference between revenues and costs) generated by the facility to decide whether it is operationally and economically profitable.</p><p>The key point of the case study is the identification, frequency, quantification and monetary valuation of the impacts generated by the facility, as well as the sale of materials, the CO<sub>2</sub> emissions and the increase in the availability of materials, among others. By applying the methodology, it has been possible to show that this facility is operationally (<i>B</i><sub><i>P</i></sub>?=?7.06 €/ton) as well as economically (<i>B</i><sub><i>T</i></sub>?=?55.72 €/ton) profitable.</p><p>The plant is highly profitable from a social and environmental perspective, as can be seen from the monetary valuation of the externalities. The STF fulfils a primordial function for the city of Barcelona and its environs, as it treats waste for later reuse and recycling, preventing waste from being sent to landfills and reducing the CO<sub>2</sub> emissions from the extraction of virgin raw materials, thereby helping to reach the objectives set by the European Commission. Finally, this paper provides a guide for future researchers and decision makers interested in the economic analysis of MSW management systems.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"33 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2021-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12302-021-00519-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4085790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andre Patrick Heinrich, Timm Zöltzer, Leonard Böhm, Manuel Wohde, Sara Jaddoudi, Yassine El Maataoui, Abdelmalek Dahchour, Rolf-Alexander Düring
{"title":"Sorption of selected antiparasitics in soils and sediments","authors":"Andre Patrick Heinrich, Timm Zöltzer, Leonard Böhm, Manuel Wohde, Sara Jaddoudi, Yassine El Maataoui, Abdelmalek Dahchour, Rolf-Alexander Düring","doi":"10.1186/s12302-021-00513-y","DOIUrl":"https://doi.org/10.1186/s12302-021-00513-y","url":null,"abstract":"<p>Veterinary pharmaceuticals can enter the environment when excreted after application and burden terrestrial and aquatic ecosystems. However, knowledge about the basic process of sorption in soils and sediments is limited, complicating regulatory decisions. Therefore, batch equilibrium studies were conducted for the widely used antiparasitics abamectin, doramectin, ivermectin, and moxidectin to add to the assessment of their environmental fate.</p><p>We examined 20 soil samples and six sediments from Germany and Morocco. Analysis was based on HPLC-fluorescence detection after derivatization. For soils, this resulted in distribution coefficients <i>K</i><sub>D</sub> of 38–642?mL/g for abamectin, doramectin, and ivermectin. Moxidectin displayed <i>K</i><sub>D</sub> between 166 and 3123?mL/g. Normalized to soil organic carbon, log <i>K</i><sub>OC</sub> coefficients were 3.63, 3.93, 4.12, and 4.74?mL/g, respectively, revealing high affinity to organic matter of soils and sediments. Within sediments, distribution resulted in higher log <i>K</i><sub>OC</sub> of 4.03, 4.13, 4.61, and 4.97?mL/g for the four substances. This emphasizes the diverse nature of organic matter in both environmental media. The results also confirm a newly reported log K<sub>OW</sub> for ivermectin which is higher than longstanding assumptions. Linear sorption models facilitate comparison with other studies and help establish universal distribution coefficients for the environmental risk assessment of veterinary antiparasitics.</p><p>Since environmental exposure affects soils and sediments, future sorption studies should aim to include both matrices to review these essential pharmaceuticals and mitigate environmental risks from their use. The addition of soils and sediments from the African continent (Morocco) touches upon possible broader applications of ivermectin for human use. Especially for ivermectin and moxidectin, strong sorption further indicates high hydrophobicity and provides initial concern for potential aquatic or terrestrial ecotoxicological effects such as bioaccumulation. Our derived <i>K</i><sub>OW</sub> estimates also urge to re-assess this important regulatory parameter with contemporary techniques for all four substances.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"33 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2021-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12302-021-00513-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4085782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ecotoxicological evaluation of construction products: inter-laboratory test with DSLT and percolation test eluates in an aquatic biotest battery","authors":"Ines Heisterkamp, Monika Ratte, Ute Schoknecht, Stefan Gartiser, Ute Kalbe, Outi Ilvonen","doi":"10.1186/s12302-021-00514-x","DOIUrl":"https://doi.org/10.1186/s12302-021-00514-x","url":null,"abstract":"<p>A European inter-laboratory test with 29 participating laboratories investigated whether a battery of four ecotoxicological tests is suitable for assessing the environmental compatibility of construction products. For this purpose, a construction product was investigated with the dynamic surface leaching test (DIN CEN/TS 16637-2) and the percolation test (DIN CEN/TS 16637-3). The eluates were produced centrally by one laboratory and were tested by the participants using the following biotests: algae test (ISO 8692), acute daphnia test (ISO 6341), luminescent bacteria test (DIN EN ISO 11348), and fish egg test (DIN EN ISO 15088). As toxicity measures, EC<sub>50</sub> and LID values were calculated.</p><p>Toxic effects of the eluates were detected by all four biotests. The bacteria test was by far the most sensitive, followed by the algae test and the daphnia test; the fish egg test was the least sensitive for eluates of both leaching tests. The toxicity level of the eluates was very high in the bacteria, daphnia, and algae test, with lowest ineffective dilution values of LID?=?70 to LID?=?13,000 and corresponding EC<sub>50</sub> values around or even below 1 volume percent. The reproducibility (<i>approximated by interlaboratory variability</i>) of the biotests was good (<?53%) to very good (<?20%), regardless of the toxicity level of the eluates. The reproducibility of the algae test was up to 80%, and thus still acceptable.</p><p>It can be confirmed that the combination of leaching and ecotoxicity tests is suitable to characterize with sufficient reproducibility the environmental impact posed by the release of hazardous substances from construction products.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"33 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12302-021-00514-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5118146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Celma, Geeta Mandava, Agneta Oskarsson, Juan Vicente Sancho, Lubertus Bijlsma, Johan Lundqvist
{"title":"In vitro bioanalytical assessment of toxicity of wetland samples from Spanish Mediterranean coastline","authors":"Alberto Celma, Geeta Mandava, Agneta Oskarsson, Juan Vicente Sancho, Lubertus Bijlsma, Johan Lundqvist","doi":"10.1186/s12302-021-00510-1","DOIUrl":"https://doi.org/10.1186/s12302-021-00510-1","url":null,"abstract":"<p>Fresh water bodies represent less than 1% of overall amount of water on earth and ensuring their quality and sustainability is pivotal. Although several campaigns have been performed to monitor the occurrence of micropollutants by means of chemical analysis, this might not cover the whole set of chemicals present in the sample nor the potential toxic effects of mixtures of natural and anthropogenic chemicals. In this sense, by selecting relevant toxicity endpoints when performing in vitro bioanalysis, effect-based methodologies can be of help to perform a comprehensive assessment of water quality and reveal biological activities relevant to adverse health effects. However, no prior bioanalytical study was performed in wetland water samples from the Spanish Mediterranean coastline.</p><p>Eleven samples from relevant water bodies from the Spanish Mediterranean coastline were collected to monitor water quality on 8 toxicity endpoints. Aryl hydrocarbon receptor (AhR), androgenicity (AR+?and AR?), estrogenicity (ER+?and ER?), oxidative stress response (Nrf2) and vitamin D receptor (VDR+?and VDR?) reporter gene assays were evaluated.</p><p>AhR was the reporter gene assay showing a more frequent response over the set of samples (activated by 9 out of 11 samples), with TCDD-eq in the range 7.7–22.2?pM. For AR, ER and VDR assays sporadic activations were observed. Moreover, no activity was observed on the Nrf2 reporter gene assay. Wastewater and street runaway streams from Valencia could be responsible for enhanced activities in one of the water inputs in the Natural Park ‘L’Albufera’.</p><p>Water quality of relevant wetlands from the Spanish Mediterranean coastline has been evaluated. The utilization of a panel of 5 different bioassays to cover for different toxicity endpoints has demonstrated to be a good tool to assess water quality.</p>","PeriodicalId":546,"journal":{"name":"Environmental Sciences Europe","volume":"33 1","pages":""},"PeriodicalIF":5.9,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12302-021-00510-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4575456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}