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Perfusion Pressure and the Histology of Brain Death: A Unique Case in an Infant Maintained on Life Support. 灌注压与脑死亡组织学：靠生命维持系统维持生命的婴儿的独特病例。
IF 1.3 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-07-01 Epub Date: 2024-01-30 DOI: 10.1177/10935266231223276
Meagan Chambers, Gail Deutsch
{"title":"Perfusion Pressure and the Histology of Brain Death: A Unique Case in an Infant Maintained on Life Support.","authors":"Meagan Chambers, Gail Deutsch","doi":"10.1177/10935266231223276","DOIUrl":"10.1177/10935266231223276","url":null,"abstract":"<p><p>Brain death is a not uncommon phenomena in the adult and pediatric population. Most cases are removed from life support soon after brain death is declared. Less commonly, systemic perfusion is maintained by life support for some time after neurologic function stops. These cases present uncommon opportunities to explore the histology of necrosis and autolysis in the context of global hypoxic ischemic damage. Here, we describe the unusual case of an infant maintained on life support for 2 weeks after brain death was declared with an emphasis on the resulting gross and histologic findings including a discussion of their underlying physiology.</p>","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"364-368"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis. 经鼻内窥镜检查获取的食管活检样本足以对嗜酸性粒细胞食管炎患者进行全面病理评估
IF 1.3 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-07-01 Epub Date: 2024-05-25 DOI: 10.1177/10935266241255723
Oscar Lopez-Nunez, Anas Bernieh, Kara L Kliewer, Pratibha Kemtur, Scott M Bolton, Vincent A Mukkada, Ryan Schablein, Christopher Woods, Marc E Rothenberg, Margaret H Collins
{"title":"Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis.","authors":"Oscar Lopez-Nunez, Anas Bernieh, Kara L Kliewer, Pratibha Kemtur, Scott M Bolton, Vincent A Mukkada, Ryan Schablein, Christopher Woods, Marc E Rothenberg, Margaret H Collins","doi":"10.1177/10935266241255723","DOIUrl":"10.1177/10935266241255723","url":null,"abstract":"<p><strong>Background: </strong>Transnasal endoscopy (TNE) does not require general anesthesia, an attractive characteristic for monitoring eosinophilic esophagitis (EoE). We evaluated the adequacy of TNE-obtained esophageal biopsies using the EoE Histology Scoring System (EoEHSS).</p><p><strong>Methods: </strong>The Cincinnati Center for Eosinophilic Disorders database was searched for esophageal biopsies obtained by the same endoscopist, using either TNE or conventional endoscopy (CE). Whole-slide biopsy images were evaluated. The Mann-Whitney test was used for median (interquartile range) values and Fisher exact test for categorical variables. <i>P</i> ≤ .05 was considered significant.</p><p><strong>Results: </strong>Median age (<i>P</i> = .82) or height (<i>P</i> = .83) did not differ between TNE (n = 17) and CE (n = 17) groups. Although median largest piece size (mm<sup>2</sup>) differed between the groups (TNE: 0.59 (0.45, 0.86), CE: 2.24 (1.09, 2.82), <i>P</i> < .001), all 8 EoEHSS features were evaluated in each group; only 1 feature (lamina propria fibrosis) was missing in both groups (TNE: 19/34, CE: 11/34, <i>P</i> = .09). The median peak eosinophil count/high-power field differed (TNE: 3 (0, 29), CE: 16 (1, 66), <i>P</i> = .03), but overall grade (TNE: 0.17 (0.10, 0.29), CE: 0.22 (0.14, 0.46), <i>P</i> = .12), stage (TNE: 0.14 (0.10, 0.24), CE: 0.20 (0.10, 0.43), <i>P</i> = .15), and non-eosinophil-related individual EoEHSS scores did not differ.</p><p><strong>Conclusions: </strong>TNE- and CE-obtained esophageal biopsies are similarly sufficient for evaluation of key pathological features in EoE.</p>","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"327-334"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Rectosigmoid Atypical Juvenile Polyps Presenting With Rectal Prolapse and Acute Bleeding: A Case Report and a Comprehensive Literature Review. 小儿直肠乙状结肠非典型幼年息肉伴直肠脱垂和急性出血：病例报告和文献综述。
IF 1.3 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-07-01 Epub Date: 2024-03-11 DOI: 10.1177/10935266241235383
Javier Arredondo Montero, Elena Carracedo Vega, Socorro Razquin Lizarraga, Mónica Bronte Anaut, Sara Hernández-Martín, Gina de Lima Piña, Rosa Guarch Troyas
{"title":"Pediatric Rectosigmoid Atypical Juvenile Polyps Presenting With Rectal Prolapse and Acute Bleeding: A Case Report and a Comprehensive Literature Review.","authors":"Javier Arredondo Montero, Elena Carracedo Vega, Socorro Razquin Lizarraga, Mónica Bronte Anaut, Sara Hernández-Martín, Gina de Lima Piña, Rosa Guarch Troyas","doi":"10.1177/10935266241235383","DOIUrl":"10.1177/10935266241235383","url":null,"abstract":"<p><p>Rectosigmoid solitary juvenile polyps are benign lesions, relatively frequent in childhood. The clinical debut of a pediatric polyp with bleeding is relatively frequent, but there are very few reports of rectal prolapse of polyps. We present the case of a 7-year-old female patient with no previous history who presented with rectal prolapse of a polyp with acute bleeding. An urgent endoscopic examination was performed and 2 rectosigmoid polypoid lesions were found and resected. The anatomopathological study showed that these were 2 hamartomatous polyps with mild dysplasia. The patient is asymptomatic and is being followed up. The literature concerning rectal prolapse of polyps in the pediatric population is scarce. In a pediatric patient with a rectal prolapse, this entity should be considered in the differential diagnosis.</p>","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"340-347"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Utero Extrahepatic Bile Duct Damage and Repair: Implications for Biliary Atresia. 胎儿肝外胆管损伤和修复：胆道闭锁的影响。
IF 1.3 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-07-01 Epub Date: 2024-05-19 DOI: 10.1177/10935266241247479
Iris E M de Jong, Rebecca G Wells
{"title":"In Utero Extrahepatic Bile Duct Damage and Repair: Implications for Biliary Atresia.","authors":"Iris E M de Jong, Rebecca G Wells","doi":"10.1177/10935266241247479","DOIUrl":"10.1177/10935266241247479","url":null,"abstract":"<p><p>Biliary atresia (BA) is a cholangiopathy affecting the extrahepatic bile duct (EHBD) of newborns. The etiology and pathophysiology of BA are not fully understood; however, multiple causes of damage and obstruction of the neonatal EHBD have been identified. Initial damage to the EHBD likely occurs before birth. We discuss how different developmental stages in utero and birth itself could influence the susceptibility of the fetal EHBD to damage and a damaging wound-healing response. We propose that a damage-repair response of the fetal and neonatal EHBD involving redox stress and a program of fetal wound healing could-regardless of the cause of the initial damage-lead to either obstruction and BA or repair of the duct and recovery. This overarching concept should guide future research targeted toward identification of factors that contribute to recovery as opposed to progression of injury and fibrosis. Viewing BA through the lens of an in utero damage-repair response could open up new avenues for research and suggests exciting new therapeutic targets.</p>","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"291-310"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author(s)' Reply: Is MYCN Overexpression Associated With Poor Outcome in MYCN Non-Amplified Neuroblastomas? 作者回复：MYCN过表达与MYCN非扩增神经母细胞瘤的不良预后有关吗？
IF 1.3 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-05-01 Epub Date: 2024-02-15 DOI: 10.1177/10935266231221898
Manli Zhao, Yan Shu, Weizhong Gu, Hongfeng Tang, Jianhua Mao
{"title":"Author(s)' Reply: Is MYCN Overexpression Associated With Poor Outcome in <i>MYCN</i> Non-Amplified Neuroblastomas?","authors":"Manli Zhao, Yan Shu, Weizhong Gu, Hongfeng Tang, Jianhua Mao","doi":"10.1177/10935266231221898","DOIUrl":"10.1177/10935266231221898","url":null,"abstract":"","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"284-285"},"PeriodicalIF":1.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is MYCN Overexpression Associated With Poor Outcome in MYCN Non-Amplified Neuroblastomas? MYCN 过度表达与 MYCN 非扩增神经母细胞瘤的不良预后有关吗？
IF 1.3 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-05-01 Epub Date: 2024-02-15 DOI: 10.1177/10935266231222321
Alicia Andrews, Jefferson Terry
{"title":"Is MYCN Overexpression Associated With Poor Outcome in <i>MYCN</i> Non-Amplified Neuroblastomas?","authors":"Alicia Andrews, Jefferson Terry","doi":"10.1177/10935266231222321","DOIUrl":"10.1177/10935266231222321","url":null,"abstract":"","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"282-283"},"PeriodicalIF":1.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mullerian Serous Cystadenoma Occurring in the Scrotum Post-Orchidopexy: A Rarely Reported Yet Distinctive Entity. 睾丸切除术后阴囊内发生的穆勒氏浆液性囊腺瘤：一种罕见但独特的实体。
IF 1.3 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-05-01 Epub Date: 2024-01-04 DOI: 10.1177/10935266231221029
Benjamin Champion, Tiffany Foo, Colin Kikiros, Adrian Charles
{"title":"Mullerian Serous Cystadenoma Occurring in the Scrotum Post-Orchidopexy: A Rarely Reported Yet Distinctive Entity.","authors":"Benjamin Champion, Tiffany Foo, Colin Kikiros, Adrian Charles","doi":"10.1177/10935266231221029","DOIUrl":"10.1177/10935266231221029","url":null,"abstract":"<p><p>Serous cystadenoma is a rare lesion in the para-testicular tissue, with even rarer reports of this entity occurring in the scrotum post-orchidopexy. We present such an occurrence, adding support for its existence as a distinct entity.</p>","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"266-269"},"PeriodicalIF":1.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience. 儿科胃肠道颗粒细胞瘤：多中心经验。
IF 1.9 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-05-01 Epub Date: 2024-01-05 DOI: 10.1177/10935266231220472
Muhammad Shaheen, Benjamin J Wilkins, Archana Shenoy, Kathleen Byrnes, Xiaoyi Tina Zhang, Iván A González
{"title":"Gastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience.","authors":"Muhammad Shaheen, Benjamin J Wilkins, Archana Shenoy, Kathleen Byrnes, Xiaoyi Tina Zhang, Iván A González","doi":"10.1177/10935266231220472","DOIUrl":"10.1177/10935266231220472","url":null,"abstract":"<p><strong>Background: </strong>Pediatric granular cell tumors (GCT) involving the gastrointestinal tract (GIT) are rare with limited case report/series reported to date.</p><p><strong>Methods: </strong>Multicenter retrospective study of pediatric GIT GCT.</p><p><strong>Results: </strong>A total of 10 cases were included in the study with a median age of 13.5 years (range: 7-18 years) and were predominantly female patients (60%). In half of the patients no significant medical history was present with the remaining 5 having Crohn disease (10%), eosinophilic esophagitis (EoE) (10%), Crohn disease and EoE (10%), growth hormone deficiency (10%), and aplasia cutis congenita (10%). The GCT median size was 1.3 cm (range: 1-1.6 cm) and were more commonly located in the esophagus (70%) followed by the stomach (20%) and rectum (10%). Most of the cases showed round/polygonal tumor cells with abundant granular cytoplasm, and none of the cases had nuclear atypia, increased mitotic activity, or tumor cell necrosis. None of our cases received specific therapy for GCT other than clinical follow-up, and none of the patients had evidence of local recurrence or metastatic disease.</p><p><strong>Conclusion: </strong>We present our multicenter experience with GIT GCT, all cases had a benign course. Interestingly, 4 of the esophageal GCT cases (including 2 patients with EoE) showed an eosinophil-rich esophagitis in the underlying mucosa.</p>","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"211-217"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidden Coronary Artery Ostium and Sudden Death. 隐藏的冠状动脉骨膜与猝死
IF 1.3 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-05-01 Epub Date: 2024-01-14 DOI: 10.1177/10935266231221710
Luzern Tan, Karen Heath, Roger W Byard
{"title":"Hidden Coronary Artery Ostium and Sudden Death.","authors":"Luzern Tan, Karen Heath, Roger W Byard","doi":"10.1177/10935266231221710","DOIUrl":"10.1177/10935266231221710","url":null,"abstract":"<p><p>A 1-week-old girl died suddenly and unexpectedly. At autopsy the major finding was of a right dominant coronary artery circulation with an inapparent left coronary artery ostium. After careful examination, an anomalous origin of the left coronary artery was found with the ostium located in the non-coronary cusp immediately adjacent to the commissure of the non- and left coronary cusps. The ostium was of small caliber with an obliquely oriented artery (<45°) with no ostial ridges. The artery coursed anteriorly past the left coronary cusp between the aorta and the left atrial appendage to then follow its usual course inferiorly along the anterior aspect of the left ventricle. The reminder of the autopsy was unremarkable. Death was, therefore, attributed to an anomalous and hypoplastic left coronary artery (and ostium) with an acute angle of take-off. Tracing coronary arteries in the very young may be technically difficult due to their small size, thus identifying the location of ostia is important. This may be difficult when the ostium was located close to a commissure.</p>","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"275-277"},"PeriodicalIF":1.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granulomas in Pediatric Liver Biopsies: Single Center Experience. 小儿肝活检中的肉芽肿：单中心经验。
IF 1.9 4区 医学
Pediatric and Developmental Pathology Pub Date : 2024-05-01 Epub Date: 2024-01-14 DOI: 10.1177/10935266231221908
Muhammad Shaheen, Guang-Sheng Lei, Ryan F Relich, Chaowapong Jarasvaraparn, Kyla M Tolliver, Jean P Molleston, Iván A González
{"title":"Granulomas in Pediatric Liver Biopsies: Single Center Experience.","authors":"Muhammad Shaheen, Guang-Sheng Lei, Ryan F Relich, Chaowapong Jarasvaraparn, Kyla M Tolliver, Jean P Molleston, Iván A González","doi":"10.1177/10935266231221908","DOIUrl":"10.1177/10935266231221908","url":null,"abstract":"<p><strong>Background: </strong>Granulomas in pediatric liver biopsies (GPLB) are rare with the largest pediatric cohort reported over 25 years ago.</p><p><strong>Methods: </strong>Single-center retrospective study of GPLB.</p><p><strong>Results: </strong>Seventeen liver biopsies from 16 patients with granulomas were identified (9 boys, 56%) with a median age of 13 years (range: 1-18) for which the most common indication was the presence of a nodule/mass (47%). Significant comorbidities were seen in 13 patients (81%) and included: liver transplant (25%), history of a neoplasm (25%), autoimmune hepatitis (6%), Crohn disease (6%), bipolar disorder (6%), severe combined immunodeficiency (6%), and sickle cell disease (6%). Eleven patients were taking multiple medications at the time of biopsy. Granulomas were more commonly pan-acinar (11 cases) followed by subcapsular (4 cases), portal (1 case), and periportal (1 case). Necrosis was seen in 10 cases (59%). GMS stain was positive in 2 cases for <i>Histoplasma</i>-like yeast; microbiological cultures were negative in all cases (no: 4). A 18S and 16S rRNA gene sequencing performed in 15 cases revealed only 1 with a pathogenic microorganism, <i>Mycobacterium angelicum</i>.</p><p><strong>Conclusion: </strong>In our experience, GPLB are heterogenous with only 3 cases having an identifiable infectious etiology and many of the remaining cases being associated to multiple medications, suggesting drug-induced liver injury as possible etiology.</p>","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"218-227"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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