Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis.

IF 1.3 4区医学 Q3 PATHOLOGY

Pediatric and Developmental Pathology Pub Date : 2024-07-01 Epub Date: 2024-05-25 DOI:10.1177/10935266241255723

Oscar Lopez-Nunez, Anas Bernieh, Kara L Kliewer, Pratibha Kemtur, Scott M Bolton, Vincent A Mukkada, Ryan Schablein, Christopher Woods, Marc E Rothenberg, Margaret H Collins

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引用次数: 0

Abstract

Background: Transnasal endoscopy (TNE) does not require general anesthesia, an attractive characteristic for monitoring eosinophilic esophagitis (EoE). We evaluated the adequacy of TNE-obtained esophageal biopsies using the EoE Histology Scoring System (EoEHSS).

Methods: The Cincinnati Center for Eosinophilic Disorders database was searched for esophageal biopsies obtained by the same endoscopist, using either TNE or conventional endoscopy (CE). Whole-slide biopsy images were evaluated. The Mann-Whitney test was used for median (interquartile range) values and Fisher exact test for categorical variables. P ≤ .05 was considered significant.

Results: Median age (P = .82) or height (P = .83) did not differ between TNE (n = 17) and CE (n = 17) groups. Although median largest piece size (mm²) differed between the groups (TNE: 0.59 (0.45, 0.86), CE: 2.24 (1.09, 2.82), P < .001), all 8 EoEHSS features were evaluated in each group; only 1 feature (lamina propria fibrosis) was missing in both groups (TNE: 19/34, CE: 11/34, P = .09). The median peak eosinophil count/high-power field differed (TNE: 3 (0, 29), CE: 16 (1, 66), P = .03), but overall grade (TNE: 0.17 (0.10, 0.29), CE: 0.22 (0.14, 0.46), P = .12), stage (TNE: 0.14 (0.10, 0.24), CE: 0.20 (0.10, 0.43), P = .15), and non-eosinophil-related individual EoEHSS scores did not differ.

Conclusions: TNE- and CE-obtained esophageal biopsies are similarly sufficient for evaluation of key pathological features in EoE.

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经鼻内窥镜检查获取的食管活检样本足以对嗜酸性粒细胞食管炎患者进行全面病理评估

背景：经鼻内镜检查（TNE）不需要全身麻醉，这是监测嗜酸性粒细胞食管炎（EoE）的一个诱人特点。我们使用嗜酸性粒细胞食管炎组织学评分系统（EoEHSS）评估了经鼻内镜获得的食管活检组织的充分性：方法：在辛辛那提嗜酸性粒细胞疾病中心（Cincinnati Center for Eosinophilic Disorders）数据库中搜索同一内镜医师使用TNE或传统内镜（CE）获得的食管活检组织。对整张活检图像进行了评估。中位数（四分位间）值采用曼-惠特尼检验，分类变量采用费雪精确检验。结果：结果：中位年龄（P = .82）或中位身高（P = .83）在TNE组（n = 17）和CE组（n = 17）之间没有差异。虽然两组的最大片数中位数（mm2）存在差异（TNE：0.59 (0.45, 0.86)，CE：2.24 (1.09, 2.82)，P = .09）。嗜酸性粒细胞计数峰值/高倍视野中位数存在差异（TNE：3（0，29），CE：16（1，66），P = .03），但总体分级（TNE：0.17（0.10，0.29），CE：0.22（0.14，0.46），P = .12）、分期（TNE：0.14（0.10，0.24），CE：0.20（0.10，0.43），P = .15）和非嗜酸性粒细胞相关的个体 EoEHSS 评分没有差异：结论：TNE和CE获得的食管活检样本同样足以评估EoE的主要病理特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric and Developmental Pathology 医学-病理学

CiteScore

3.70

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.