Pediatric and Developmental Pathology最新文献_第10页

Metastatic Lymphomas of the Placenta: A Literature Review With an Illustrative Case. 胎盘转移性淋巴瘤：文献综述及一例例证。

IF 1.9 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-01-01 Epub Date: 2023-09-28 DOI: 10.1177/10935266231200114

Marvin C Masalunga, Ronell L Basa, Karen B Damian, Jose M Carnate

{"title":"Metastatic Lymphomas of the Placenta: A Literature Review With an Illustrative Case.","authors":"Marvin C Masalunga, Ronell L Basa, Karen B Damian, Jose M Carnate","doi":"10.1177/10935266231200114","DOIUrl":"10.1177/10935266231200114","url":null,"abstract":"Lymphoma is the fourth most common tumor to display placental metastasis. This study aimed to report a case of high-grade lymphoma involving the placenta and review the literature on lymphomas metastatic to the placenta. A systematic review was performed following the PRISMA guidelines, using the keywords \"lymphoma\" AND \"placenta.\" All case reports and case series on lymphoma infiltrating the placenta were collected. Eight cases from 7 studies, including the present case, were synthesized. The mean patient age is 29.5 years. The clinical presentation is non-specific. Hematologic derangements included cytopenias or cytoses, and elevated prothrombin time. The mean gestational age (GA) when a diagnosis of lymphoma was rendered is 27 weeks. Five cases presented with either lymphadenopathy or visceral masses on imaging. Four of these cases eventually led to maternal demise. The mean GA when the fetus was delivered is 31 3/4 weeks. Grossly, most placentas had non-specific findings. Leukemic infiltrates were mostly seen within intervillous spaces. Intravillous infiltrates were associated with high-grade lymphomas, resulting in either maternal demise or stillborn fetuses. This study suggests that the placenta has mechanisms to guard against malignancies; however, these defense mechanisms are not foolproof and may be breached by tumor cells.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"67-76"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletal Growth Arrest Lines in Fetal Remains: Histopathology and Correlative Placental Pathology. 胎儿遗骸中的骨骼生长抑制系：组织病理学和相关胎盘病理学。

IF 1.9 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-01-01 Epub Date: 2023-10-11 DOI: 10.1177/10935266231195750

Tsz Wing Chu, Patrick Shannon, Tony Parks

{"title":"Skeletal Growth Arrest Lines in Fetal Remains: Histopathology and Correlative Placental Pathology.","authors":"Tsz Wing Chu, Patrick Shannon, Tony Parks","doi":"10.1177/10935266231195750","DOIUrl":"10.1177/10935266231195750","url":null,"abstract":"Introduction: Skeletal growth arrest lines (GAL) are transverse lines of metaphyseal radiodensity accompanying episodic severe physiological stress. They are poorly described in fetal remains.Materials and methods: We searched our autopsy practice for instances of fetal GAL in post mortem radiology, and correlated them with long bone histology and placental pathology. We describe the appearance, distribution, and pathology of GAL in a cohort of fetal autopsies, and compare the placental pathology accompanying GAL to the placental pathology of asymmetrical growth restriction (AGR) in the same time period.Results: In 2108 consecutive fetal post mortems, we found 20 cases with GAL. About 16 were in singletons with AGR. In these 16, the distribution of placental pathologies was similar to a contemporaneous cohort of 113 cases with AGR. Of the remaining 4, two twins out of 9 sets of monochorionic twins with AGR demonstrated GAL. One case of GAL had symmetrical growth restriction with cytomegalovirus infection, and one case had no AGR and an old, unexplained retroplacental hemorrhage. On histology, GAL are characterized by a region of mineralized chondroid, which is variably incorporated into irregular trabecular bone.Discussion: GALs accompany a variety of placental pathologies and twin-twin transfusion, suggesting episodic disease progression.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"23-31"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41220356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrahepatic Cholangiolitis in Cystic Fibrosis (ICCF): An Under-Appreciated Cause of Persistent Cholestasis in Infancy. 囊性纤维化（ICCF）肝内胆管炎：婴儿持续性胆汁淤积的一个未被充分认识的原因。

IF 1.9 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-01-01 Epub Date: 2023-10-06 DOI: 10.1177/10935266231201935

Anas Bernieh, Kevin Bove, Victor Garcia, Gregory Tiao, Lauren Lazar, Meghana Sathe, Julie Sanchez, Raquel Gonzalez, Ignacio Gonzalez-Gomez

{"title":"Intrahepatic Cholangiolitis in Cystic Fibrosis (ICCF): An Under-Appreciated Cause of Persistent Cholestasis in Infancy.","authors":"Anas Bernieh, Kevin Bove, Victor Garcia, Gregory Tiao, Lauren Lazar, Meghana Sathe, Julie Sanchez, Raquel Gonzalez, Ignacio Gonzalez-Gomez","doi":"10.1177/10935266231201935","DOIUrl":"10.1177/10935266231201935","url":null,"abstract":"Liver histology in infants with cystic fibrosis (CF) and persistent cholestasis is seldom reported in detail. We extend previous observation of a distinctive intrahepatic cholangiopathy (ICCF) to 3 additional infants homozygous for CFTR pathological variants and a fourth infant with a heterozygous CFTR variant, summarizing our experience in 10 infants with CFTR variants and persistent cholestasis. Cholangiograms demonstrate abnormal extrahepatic ducts in 2 infants with CF, 1 with uniform dilatation interpreted as a choledochal cyst and the other with narrow patent ducts. Liver histology in 3 CF homozygotes had prominent ductular reaction with a focally destructive cholangiolitis (inflammation of small bile ducts). The CFTR heterozygote had generalized portal edema with ductular reaction and paucity but no cholangitis. Cholestasis slowly subsided in all infants. ICCF is characterized by severe ductular reaction, prominent cholangiocyte injury, and multifocal necrotizing cholangiolitis. Local aggregates of portal ceroid might suggest previous bile leakage from damaged ducts. ICCF in liver biopsies from infants with cystic fibrosis and persistent cholestasis is unrelated to the specific CFTR genotype. Liver biopsy findings and intraoperative cholangiogram help rule out biliary atresia. ICCF is an early manifestation of CF, a likely prototype for pathogenesis of cystic fibrosis liver disease later in life.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"13-22"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single Umbilical Artery Umbilical Cord Is Associated With High-Grade Distal Fetal Vascular Malperfusion. 单脐动脉脐带与胎儿远端高级别血管灌注不良有关。

IF 1.9 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-01-01 Epub Date: 2023-09-28 DOI: 10.1177/10935266231200013

Jerzy Stanek

{"title":"Single Umbilical Artery Umbilical Cord Is Associated With High-Grade Distal Fetal Vascular Malperfusion.","authors":"Jerzy Stanek","doi":"10.1177/10935266231200013","DOIUrl":"10.1177/10935266231200013","url":null,"abstract":"Purpose and context: Umbilical cord abnormalities with clinical signs of cord compromise are frequently associated with fetal vascular malperfusion (FVM). Single umbilical artery (SUA) has been reported to be associated with high-grade FVM in fetal growth restriction but not in an unselected population; our study aimed to address this issue.Methods: Clinical and placental phenotypes of 55 consecutive placentas with SUA (Group 1) were compared with those of 655 placentas with 3-vessel umbilical cord (Group 2) from patients who were in the second half of their pregnancy. The placentas were histologically examined using hematoxylin and eosin (H&E) staining and CD 34 immunostaining.Key results: Several umbilical cord phenotypes and high-grade distal FVM, based on H&E staining and endothelial fragmentation by CD34 were significantly more common in Group 1, whereas decidual clusters of multinucleate trophoblasts were more common in Group 2. Notably, H&E staining or CD34 immunostaining evaluated separately showed that high-grade distal FVM was more common in Group 1 than in Group 2, but the difference was not statistically significant.Conclusions: SUA predisposes to remote, advanced, and recent high-grade distal villous FVM, with a pathogenesis partly different from that of stasis-induced FVM, likely related to fetal anomalies associated with SUA.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"52-58"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Case of Extranodal Marginal Zone Lymphoma Mimicking Abdominal Cocoon Syndrome in an Adolescent Patient. 一例罕见的淋巴结外边缘区淋巴瘤模拟腹部茧综合征的青少年患者。

IF 1.9 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-01-01 Epub Date: 2023-10-30 DOI: 10.1177/10935266231205511

Timothy J D Ohlsen, Ryan J Morse, Hira Ahmad, Maria Cristina Pacheco, Katherine E Debiec, Sandra D Bohling

{"title":"An Unusual Case of Extranodal Marginal Zone Lymphoma Mimicking Abdominal Cocoon Syndrome in an Adolescent Patient.","authors":"Timothy J D Ohlsen, Ryan J Morse, Hira Ahmad, Maria Cristina Pacheco, Katherine E Debiec, Sandra D Bohling","doi":"10.1177/10935266231205511","DOIUrl":"10.1177/10935266231205511","url":null,"abstract":"Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is an indolent non-Hodgkin lymphoma rarely seen in pediatric patients. MALT lymphoma most commonly involves the gastrointestinal tract or peri-orbital tissues, potentially as sequela of chronic antigenic stimulation or immune dysregulation. Rare cases of MALT lymphoma arising from the gynecologic tract have been reported in older adult patients. We present the unique case of a 16-year-old postpubescent female with MALT lymphoma localized to the gynecologic tract, who initially presented with abdominal fullness, abnormal uterine bleeding, and obstructive acute kidney injury secondary to urinary outflow obstruction. Intraoperatively, dense fibrosis of the uterus and left fallopian tube was noted which mimicked abdominal cocoon syndrome. She was treated with 6 cycles of bendamustine and rituximab with complete anatomic and metabolic remission. In this report we highlight a very unusual presentation of a rare malignancy in the pediatric population as well as unique treatment considerations given this patient's young age and tumor location.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"96-101"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental Lesions Associated With Stillbirth by Gestational Age, as Related to Cause of Death: Follow-Up Results From the Stillbirth Collaborative Research Network. 妊娠年龄与死产相关的胎盘病变与死亡原因：死产合作研究网络的随访结果。

IF 1.9 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-01-01 Epub Date: 2023-09-25 DOI: 10.1177/10935266231197349

Tess E K Cersonsky, Rose K Cersonsky, Robert M Silver, Donald J Dudley, Halit Pinar

{"title":"Placental Lesions Associated With Stillbirth by Gestational Age, as Related to Cause of Death: Follow-Up Results From the Stillbirth Collaborative Research Network.","authors":"Tess E K Cersonsky, Rose K Cersonsky, Robert M Silver, Donald J Dudley, Halit Pinar","doi":"10.1177/10935266231197349","DOIUrl":"10.1177/10935266231197349","url":null,"abstract":"Background: We previously identified placental lesions associated with stillbirths of varying gestational ages (GA) using advanced feature analysis. We further investigated the relationships between placental lesions and cause of death in stillbirths within these GA ranges.Methods: Using data from the Stillbirth Collaborative Research Network, we derived a sample of stillbirths who underwent placental examination and Initial Causes of Fetal Death (INCODE) evaluation for determining cause of death. We then compared the rates of causes of death within and among GA ranges (extreme preterm stillbirth [PTSB] [<28 weeks], early PTSB [28-336/7 weeks], late PTSB [34-366/7 weeks], term stillbirth [≥37 weeks]) according to the presence of these lesions.Results: We evaluated 352 stillbirths. In extreme PTSB, obstetric complications and infections were associated with acute funisitis. In early PTSB, uteroplacental insufficiency was associated with parenchymal infarcts. In term stillbirth (vs early PTSB), increased syncytial knots were associated with umbilical cord causes and infection.Conclusions: Placental lesions of high importance in distinguishing stillbirths at different GAs are associated with specific causes of death. This information is important in relating the presence of placental lesions and fetal death and in helping to understand etiologies of stillbirths at different GAs.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"39-44"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Effect of TBX4 Germline Mutation on Pulmonary Clinico-Histopathologic Phenotype. TBX4种系突变对肺部临床组织病理表型的长期影响。

IF 1.9 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-01-01 Epub Date: 2023-10-06 DOI: 10.1177/10935266231199933

Elizabeth S Doughty, Christian Norvik, Alice Levin, Jenna Bodmer, Karin Tran-Lundmark, Steven H Abman, Csaba Galambos

引用次数: 0

Founders in Pediatric Pathology: Robert James Gorlin, DDS, PhD: Maxillofacial Pathologist, Geneticist, Academician, and Renaissance Man. 儿科病理学奠基人：罗伯特-詹姆斯-戈林（Robert James Gorlin）博士：颌面病理学家、遗传学家、院士和文艺复兴人。

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2023-11-01 Epub Date: 2023-02-08 DOI: 10.1177/10935266231153203

Juan Carlos Manivel, Miguel Reyes-Múgica

引用次数: 0

Pediatric Oral Pathology: Odontogenic Cysts. 小儿口腔病理学：牙源性囊肿

IF 1.9 4区医学

Pediatric and Developmental Pathology Pub Date : 2023-11-01 Epub Date: 2023-05-22 DOI: 10.1177/10935266231176245

Kurt F Summersgill

引用次数: 0

Pediatric Odontogenic Tumors. 儿童牙源性肿瘤。

IF 1.9 4区医学

Pediatric and Developmental Pathology Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.1177/10935266231200115

Yingci Liu, Molly Housley Smith, Paras B Patel, Elizabeth Ann Bilodeau

引用次数: 0