发布求助
文献互助 智能选刊 最新文献

Trends in Genetics最新文献

筛选
英文 中文
From genetic associations to genes: methods, applications, and challenges. 从基因关联到基因：方法、应用和挑战。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-05-11 DOI: 10.1016/j.tig.2024.04.008
Ting Qi, Liyang Song, Yazhou Guo, Chang Chen, Jian Yang
{"title":"From genetic associations to genes: methods, applications, and challenges.","authors":"Ting Qi, Liyang Song, Yazhou Guo, Chang Chen, Jian Yang","doi":"10.1016/j.tig.2024.04.008","DOIUrl":"10.1016/j.tig.2024.04.008","url":null,"abstract":"<p><p>Genome-wide association studies (GWASs) have identified numerous genetic loci associated with human traits and diseases. However, pinpointing the causal genes remains a challenge, which impedes the translation of GWAS findings into biological insights and medical applications. In this review, we provide an in-depth overview of the methods and technologies used for prioritizing genes from GWAS loci, including gene-based association tests, integrative analysis of GWAS and molecular quantitative trait loci (xQTL) data, linking GWAS variants to target genes through enhancer-gene connection maps, and network-based prioritization. We also outline strategies for generating context-dependent xQTL data and their applications in gene prioritization. We further highlight the potential of gene prioritization in drug repurposing. Lastly, we discuss future challenges and opportunities in this field.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"642-667"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140908983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A personality SNP? Behavioral genetics in African cichlids. 性格 SNP？非洲慈鲷的行为遗传学
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-06-15 DOI: 10.1016/j.tig.2024.06.001
Daniel F Hughes
{"title":"A personality SNP? Behavioral genetics in African cichlids.","authors":"Daniel F Hughes","doi":"10.1016/j.tig.2024.06.001","DOIUrl":"10.1016/j.tig.2024.06.001","url":null,"abstract":"<p><p>Speciation is familiar in radiations, but personality is not. In a recent article, Sommer-Trembo et al. linked exploratory behavior in African cichlids to a SNP in the promoter of a gene, the homolog of which is associated with human personality disorders, offering clues about the first fish of this radiation, with implications for vertebrate evolution.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"633-635"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tropical trees inherit low-frequency somatic mutations. 热带树木会遗传低频率的体细胞突变。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI: 10.1016/j.tig.2024.05.003
Sou Tomimoto, Akiko Satake
{"title":"Tropical trees inherit low-frequency somatic mutations.","authors":"Sou Tomimoto, Akiko Satake","doi":"10.1016/j.tig.2024.05.003","DOIUrl":"10.1016/j.tig.2024.05.003","url":null,"abstract":"<p><p>A new study by Schmitt et al. revealed that somatic mutations in tropical trees are passed on to their offspring. Furthermore, the study noted that the majority of inherited mutations were present at low allelic frequencies within the tree.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"636-637"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positive-strand RNA virus genome replication organelles: structure, assembly, control. 正链 RNA 病毒基因组复制细胞器：结构、组装和控制。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-05-08 DOI: 10.1016/j.tig.2024.04.003
Johan A den Boon, Masaki Nishikiori, Hong Zhan, Paul Ahlquist
{"title":"Positive-strand RNA virus genome replication organelles: structure, assembly, control.","authors":"Johan A den Boon, Masaki Nishikiori, Hong Zhan, Paul Ahlquist","doi":"10.1016/j.tig.2024.04.003","DOIUrl":"10.1016/j.tig.2024.04.003","url":null,"abstract":"<p><p>Positive-strand RNA [(+)RNA] viruses include pandemic SARS-CoV-2, tumor-inducing hepatitis C virus, debilitating chikungunya virus (CHIKV), lethal encephalitis viruses, and many other major pathogens. (+)RNA viruses replicate their RNA genomes in virus-induced replication organelles (ROs) that also evolve new viral species and variants by recombination and mutation and are crucial virus control targets. Recent cryo-electron microscopy (cryo-EM) reveals that viral RNA replication proteins form striking ringed 'crowns' at RO vesicle junctions with the cytosol. These crowns direct RO vesicle formation, viral (-)RNA and (+)RNA synthesis and capping, innate immune escape, and transfer of progeny (+)RNA genomes into translation and encapsidation. Ongoing studies are illuminating crown assembly, sequential functions, host factor interactions, etc., with significant implications for control and beneficial uses of viruses.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"681-693"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenome-metabolism nexus in the retina: implications for aging and disease. 视网膜的表观基因组-代谢关系：对衰老和疾病的影响。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-05-22 DOI: 10.1016/j.tig.2024.04.012
Anupam K Mondal, Mohita Gaur, Jayshree Advani, Anand Swaroop
{"title":"Epigenome-metabolism nexus in the retina: implications for aging and disease.","authors":"Anupam K Mondal, Mohita Gaur, Jayshree Advani, Anand Swaroop","doi":"10.1016/j.tig.2024.04.012","DOIUrl":"10.1016/j.tig.2024.04.012","url":null,"abstract":"<p><p>Intimate links between epigenome modifications and metabolites allude to a crucial role of cellular metabolism in transcriptional regulation. Retina, being a highly metabolic tissue, adapts by integrating inputs from genetic, epigenetic, and extracellular signals. Precise global epigenomic signatures guide development and homeostasis of the intricate retinal structure and function. Epigenomic and metabolic realignment are hallmarks of aging and highlight a link of the epigenome-metabolism nexus with aging-associated multifactorial traits affecting the retina, including age-related macular degeneration and glaucoma. Here, we focus on emerging principles of epigenomic and metabolic control of retinal gene regulation, with emphasis on their contribution to human disease. In addition, we discuss potential mitigation strategies involving lifestyle changes that target the epigenome-metabolome relationship for maintaining retinal function.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"718-729"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A three-dimensional genomics view for speciation research. 用于物种研究的三维基因组学视图。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-06-15 DOI: 10.1016/j.tig.2024.05.009
Ashwini V Mohan, Paula Escuer, Camille Cornet, Kay Lucek
{"title":"A three-dimensional genomics view for speciation research.","authors":"Ashwini V Mohan, Paula Escuer, Camille Cornet, Kay Lucek","doi":"10.1016/j.tig.2024.05.009","DOIUrl":"10.1016/j.tig.2024.05.009","url":null,"abstract":"<p><p>Genomic information is folded in a three-dimensional (3D) structure, a rarely explored evolutionary driver of speciation. Technological advances now enable the study of 3D genome structures (3DGSs) across the Tree of Life. At the onset of 3D speciation genomics, we discuss the putative roles of 3DGSs in speciation.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"638-641"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Out of the dark: the emerging roles of lncRNAs in pain. 走出黑暗：lncRNA 在疼痛中的新作用。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-06-25 DOI: 10.1016/j.tig.2024.04.009
Abdella M Habib, James J Cox, Andrei L Okorokov
{"title":"Out of the dark: the emerging roles of lncRNAs in pain.","authors":"Abdella M Habib, James J Cox, Andrei L Okorokov","doi":"10.1016/j.tig.2024.04.009","DOIUrl":"10.1016/j.tig.2024.04.009","url":null,"abstract":"<p><p>The dark genome, the nonprotein-coding part of the genome, is replete with long noncoding RNAs (lncRNAs). These functionally versatile transcripts, with specific temporal and spatial expression patterns, are critical gene regulators that play essential roles in health and disease. In recent years, FAAH-OUT was identified as the first lncRNA associated with an inherited human pain insensitivity disorder. Several other lncRNAs have also been studied for their contribution to chronic pain and genome-wide association studies are frequently identifying single nucleotide polymorphisms that map to lncRNAs. For a long time overlooked, lncRNAs are coming out of the dark and into the light as major players in human pain pathways and as potential targets for new RNA-based analgesic medicines.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":"694-705"},"PeriodicalIF":13.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ribosome’s comeback: new role in body weight regulation 核糖体卷土重来：在体重调节中发挥新作用
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-07-31 DOI: 10.1016/j.tig.2024.07.006
{"title":"The ribosome’s comeback: new role in body weight regulation","authors":"","doi":"10.1016/j.tig.2024.07.006","DOIUrl":"https://doi.org/10.1016/j.tig.2024.07.006","url":null,"abstract":"<p>The recent discovery of an association between ribosomal DNA (rDNA) copy number and body mass index (BMI) by <span><span>Law <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> sheds light on a possible role of 45S rDNA in body-weight regulation. This finding opens new avenues for further investigations into the effect of rDNA on various human phenotypes.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"11 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141863304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-07-08 DOI: 10.1016/s0168-9525(24)00140-9
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0168-9525(24)00140-9","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00140-9","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"11 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141569420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-07-08 DOI: 10.1016/s0168-9525(24)00137-9
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0168-9525(24)00137-9","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00137-9","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":"61 1","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141569419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信