Contributions of epigenomic and epitranscriptomic methylation to animal colouration.

IF 16.3 2区 生物学 Q1 GENETICS & HEREDITY
Nicholas Strowbridge, David R Vieites, Michael G Ritchie, Kathryn R Elmer
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引用次数: 0

Abstract

Due to its high variation and its diversity of functional roles, animal colouration has long been a fascinating phenotype for geneticists. While the loci underpinning colour are relatively well known, there remain components of unexplained variation. The contribution of DNA and RNA methylation to these molecular mechanisms of colouration is only now being explored. Recent research has shown that DNA (m5C) methylation plays a role in plastic colouration change, the development of colour, and adult intra- and interindividual colouration differences. Studies on RNA (m6A) methylation are few but suggest that it also contributes to colour differences. Emerging advances in native DNA and RNA sequencing will allow a novel understanding of methylation contributions to colour evolution and development.

表观基因组和表转录组甲基化对动物着色的贡献。
由于其高度变异和功能角色的多样性,动物着色长期以来一直是遗传学家的一个迷人的表型。虽然构成颜色的基因座已经相对为人所知,但仍然存在一些无法解释的变异成分。DNA和RNA甲基化对这些分子着色机制的贡献现在才被探索。最近的研究表明,DNA (m5C)甲基化在塑料颜色变化、颜色发育以及成人个体内和个体间颜色差异中起着重要作用。关于RNA (m6A)甲基化的研究很少,但表明它也有助于颜色差异。原生DNA和RNA测序的新进展将使甲基化对颜色进化和发展的贡献有新的理解。
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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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