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Genetic adaptations of marine invertebrates to hydrothermal vent habitats 海洋无脊椎动物对热液喷口生境的遗传适应性
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-09-13 DOI: 10.1016/j.tig.2024.08.004
Haibin Zhang, Yang Zhou, Zhuo Yang
{"title":"Genetic adaptations of marine invertebrates to hydrothermal vent habitats","authors":"Haibin Zhang, Yang Zhou, Zhuo Yang","doi":"10.1016/j.tig.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.tig.2024.08.004","url":null,"abstract":"<p>Hydrothermal vents are unique habitats like an oases of life compared with typical deep-sea, soft-sediment environments. Most animals that live in these habitats are invertebrates, and they have adapted to extreme vent environments that include high temperatures, hypoxia, high sulfide, high metal concentration, and darkness. The advent of next-generation sequencing technology, especially the coming of the new era of omics, allowed more studies to focus on the molecular adaptation of these invertebrates to vent habitats. Many genes linked to hydrothermal adaptation have been studied. We summarize the findings related to these genetic adaptations and discuss which new techniques can facilitate studies in the future.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertranscription: the invisible hand in stem cell biology 超转录：干细胞生物学中的无形之手
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-09-12 DOI: 10.1016/j.tig.2024.08.005
Yun-Kyo Kim, Evelyne Collignon, S. Bryn Martin, Miguel Ramalho-Santos
{"title":"Hypertranscription: the invisible hand in stem cell biology","authors":"Yun-Kyo Kim, Evelyne Collignon, S. Bryn Martin, Miguel Ramalho-Santos","doi":"10.1016/j.tig.2024.08.005","DOIUrl":"https://doi.org/10.1016/j.tig.2024.08.005","url":null,"abstract":"<p>Stem cells are the fundamental drivers of growth during development and adult organ homeostasis. The properties that define stem cells – self-renewal and differentiation – are highly biosynthetically demanding. In order to fuel this demand, stem and progenitor cells engage in hypertranscription, a global amplification of the transcriptome. While standard normalization methods in transcriptomics typically mask hypertranscription, new approaches are beginning to reveal a remarkable range in global transcriptional output in stem and progenitor cells. We discuss technological advancements to probe global transcriptional shifts, review recent findings that contribute to defining hallmarks of stem cell hypertranscription, and propose future directions in this field.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal ants reveal a potentially hidden meiotic feature 克隆蚂蚁揭示了一种潜在的隐性减数分裂特征
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-09-12 DOI: 10.1016/j.tig.2024.08.011
Hugo Darras, Qiaowei Pan
{"title":"Clonal ants reveal a potentially hidden meiotic feature","authors":"Hugo Darras, Qiaowei Pan","doi":"10.1016/j.tig.2024.08.011","DOIUrl":"https://doi.org/10.1016/j.tig.2024.08.011","url":null,"abstract":"<p>Meiosis is essential for eukaryotic reproduction and provides the basis for Mendel's segregation laws. A recent study by <span><span>Lacy <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> identified a significant deviation from these laws in a clonal ant, hinting at a potentially overlooked meiotic feature. This discovery may have broader implications for recombination in nonclonal eukaryotes.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Achieve your research goals: a project management toolkit for graduate studies 实现研究目标：研究生项目管理工具包
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-09-12 DOI: 10.1016/j.tig.2024.08.003
Sheetal Modi
{"title":"Achieve your research goals: a project management toolkit for graduate studies","authors":"Sheetal Modi","doi":"10.1016/j.tig.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.tig.2024.08.003","url":null,"abstract":"<p>How we work affects what we achieve. In this piece, we provide a project management toolkit for students to apply to their research, offering a structure to set goals, manage risks, prioritize work, and make effective decisions. With good planning, students can improve outcomes and make their journey more rewarding.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-09-09 DOI: 10.1016/s0168-9525(24)00191-4
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s0168-9525(24)00191-4","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00191-4","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 11.4 2区 生物学
Trends in Genetics Pub Date : 2024-09-09 DOI: 10.1016/s0168-9525(24)00188-4
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s0168-9525(24)00188-4","DOIUrl":"https://doi.org/10.1016/s0168-9525(24)00188-4","url":null,"abstract":"No Abstract","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":11.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Honeybees' novel complementary sex-determining system: function and origin. 蜜蜂的新型互补性决定系统：功能和起源。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-09-03 DOI: 10.1016/j.tig.2024.08.001
Jana Seiler, Martin Beye
{"title":"Honeybees' novel complementary sex-determining system: function and origin.","authors":"Jana Seiler, Martin Beye","doi":"10.1016/j.tig.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.tig.2024.08.001","url":null,"abstract":"<p><p>Complementary sex determination regulates female and male development in honeybees (Apis mellifera) via heterozygous versus homo-/hemizygous genotypes of the csd (complementary sex determiner) gene involving numerous naturally occurring alleles. This lineage-specific function offers a rare opportunity to understand an undescribed regulatory mechanism and the molecular evolutionary path leading to this mechanism. We reviewed recent advances in understanding how Csd recognizes different versus identical protein variants, how these variants regulate downstream pathways and sexual differentiation, and how this mechanism has evolved and been shaped by evolutionary forces. Finally, we highlighted the shared regulatory principles of sex determination despite the diversity of primary signals and demonstrated that lineage-specific mutations are very informative for characterizing newly evolved functions.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in lasso peptide discovery, biosynthesis, and function. 套索肽的发现、生物合成和功能方面的进展。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-31 DOI: 10.1016/j.tig.2024.08.002
Susanna E Barrett, Douglas A Mitchell
{"title":"Advances in lasso peptide discovery, biosynthesis, and function.","authors":"Susanna E Barrett, Douglas A Mitchell","doi":"10.1016/j.tig.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.tig.2024.08.002","url":null,"abstract":"<p><p>Lasso peptides are a large and sequence-diverse class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products characterized by their slip knot-like shape. These unique, highly stable peptides are produced by bacteria for various purposes. Their stability and sequence diversity make them a potentially useful scaffold for biomedically relevant folded peptides. However, many questions remain about lasso peptide biosynthesis, ecological function, and diversification potential for biomedical and agricultural applications. This review discusses new insights and open questions about lasso peptide biosynthesis and biological function. The role that genome mining has played in the development of new methodologies for discovering and diversifying lasso peptides is also discussed.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wheat genomics: genomes, pangenomes, and beyond. 小麦基因组学：基因组、泛基因组及其他。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-26 DOI: 10.1016/j.tig.2024.07.004
Vijay K Tiwari, Gautam Saripalli, Parva K Sharma, Jesse Poland
{"title":"Wheat genomics: genomes, pangenomes, and beyond.","authors":"Vijay K Tiwari, Gautam Saripalli, Parva K Sharma, Jesse Poland","doi":"10.1016/j.tig.2024.07.004","DOIUrl":"https://doi.org/10.1016/j.tig.2024.07.004","url":null,"abstract":"<p><p>There is an urgent need to improve wheat for upcoming challenges, including biotic and abiotic stresses. Sustainable wheat improvement requires the introduction of new genes and alleles in high-yielding wheat cultivars. Using new approaches, tools, and technologies to identify and introduce new genes in wheat cultivars is critical. High-quality genomes, transcriptomes, and pangenomes provide essential resources and tools to examine wheat closely to identify and manipulate new and targeted genes and alleles. Wheat genomics has improved excellently in the past 5 years, generating multiple genomes, pangenomes, and transcriptomes. Leveraging these resources allows us to accelerate our crop improvement pipelines. This review summarizes the progress made in wheat genomics and trait discovery in the past 5 years.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rewards and dangers of regulatory innovation. 监管创新的回报与危险。
IF 13.6 2区 生物学
Trends in Genetics Pub Date : 2024-08-20 DOI: 10.1016/j.tig.2024.07.010
Luca Comai
{"title":"Rewards and dangers of regulatory innovation.","authors":"Luca Comai","doi":"10.1016/j.tig.2024.07.010","DOIUrl":"https://doi.org/10.1016/j.tig.2024.07.010","url":null,"abstract":"<p><p>Adaptive evolution often involves structural variation affecting genes or cis-regulatory changes that engender novel and favorable gain-of-function gene regulation. Such mutation could result in a favorable dominant trait. At the same time, the gene product could be dosage sensitive if its change in concentration disrupts another trait. As a result, the mutant allele would display dosage-sensitive pleiotropy (DSP). By minimizing imbalance while conserving the favorable dominant effect, heterozygosity can increase fitness and result in heterosis. The properties of these alleles are consistent with evidence from multiple studies that indicate increased fitness of heterozygous regulatory mutations. DSP can help explain mysterious properties of heterosis as well as other effects of hybridization.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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